Remove Drugs Remove Protein Production Remove Small Molecule
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Target-directed cancer: protein-ligand interactions  

Drug Target Review

Could you provide an overview of your research on target directed cancer drug discovery, particularly your focus on protein lagging interactions. I work in the Centre for Cancer Drug Discovery (CCDD) at The Institute of Cancer Research in London, which is an academic drug discovery centre. 2013) 56, 2059-2073.

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The Active Ingredient Stands Alone

FDA Law Blog: Biosimilars

Koblitz — One of the most important questions FDA has to answer is whether a given product is appropriately characterized as a drug, biologic, device, food, cosmetic, or something entirely different. As we have explained before , that distinction is critical to assigning a particular product to the appropriate regulatory scheme.

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A Look Back

Dark Matter Blog

I wanted to use molecular biology to create drugs. Both companies were founded to explore new space for drug discovery related to RNA, representing the revolution in RNA-focused drug discovery that has happened in the past decade or so. My last stop at Arrakis Therapeutics is with a company targeting RNA with small molecules.

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Eloxx Pharmaceuticals to Report Third Quarter 2020 Financial Results and Provide Business Update on November 5, 2020

The Pharma Data

is a clinical-stage biopharmaceutical company developing novel RNA-modulating drug candidates (designed to be eukaryotic ribosomal selective glycosides) that are formulated to treat rare and ultra-rare premature stop codon diseases. Premature stop codons are point mutations that disrupt protein synthesis from messenger RNA.

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Targeting a human protein may stop Ebola virus in its tracks

The Pharma Data

Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives. The researchers discovered that Ebola virus polymerase hijacks a cellular protein called GSPT1.

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Codon Digest: Bacteria Resist Every Virus

Codon

Point-of-care peptide hormone production enabled by cell-free protein synthesis. Marine biofilm engineered to produce current in response to small molecules. Peroxisomal metabolic coupling improves fatty alcohol production from sole methanol in yeast. DeWinter MA. ACS Synthetic Biology. ACS Synthetic Biology.

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Codon Digest: Discovering Antibiotics with Deep Learning

Codon

Read Programming inactive RNA-binding small molecules into bioactive degraders. Read Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approaches. Read *MISATO - Machine learning dataset of protein-ligand complexes for structure-based drug discovery.

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