Covalent Modifiers

SEPTEMBER 9, 2023

3c05161 The stabilization of protein–protein interactions (PPIs) has emerged as a promising strategy in chemical biology and drug discovery. Here, we show the structure-based optimization of the nonselective fragment toward selective and highly potent small-molecule stabilizers of the 14-3-3σ/ERα complex.

Small Molecule 200

Small Molecule Biophysical Assays Production Drugs 200

Covalent Modifiers

FEBRUARY 15, 2024

Herein, we use afatinib as a lead to undertake a structure-based drug design approach, aided by mass-spectrometry and x-ray crystallography, to develop DHC-156, a small molecule that more selectively binds brachyury and downmodulates it as potently as afatinib.

Small Molecule 162

Small Molecule FDA Approval FDA Therapies 162

Science Daily: Pharmacology News

APRIL 5, 2024

The active ingredient in many drugs is what's known as a small molecule: bigger than water, much smaller than an antibody and mainly made of carbon. It's tough, however, to make these molecules if they require a quaternary carbon -- a carbon atom bonded to four other carbon atoms.

Small Molecule 329

Small Molecule Drugs 329

Chemical Biology and Drug Design

FEBRUARY 6, 2025

Analysis of prevalence of ring, nonring, sp 3 -, and sp 2 -hybridized oxygen in approved drugs. For the first time, analysis of distribution of different types of oxygen from center of mass of a molecule. In approved drugs, majority of oxygen atoms are present within 4 from the COM of the molecule.

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FDA Approval FDA Small Molecule Pharmacokinetics 100

Forbes: Drug Truths

MARCH 6, 2024

There is another aspect of this provision of the IRA that is starting to be felt – "the small molecule penalty"

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Small Molecule Drugs 296

Drug Hunter

APRIL 20, 2023

We asked the global drug discovery community to nominate and vote on their favorite molecule from 2022, and the results are in. Here, we highlight what makes deucravacitinib so impressive to the drug discovery community. Here, we highlight what makes deucravacitinib so impressive to the drug discovery community.

Small Molecule 130

Small Molecule Clinical Trials Trials Licensing 130

Covalent Modifiers

FEBRUARY 6, 2024

Fibroblast growth factor receptor (FGFR) kinase inhibitors have been shown to be effective in the treatment of intrahepatic cholangiocarcinoma and other advanced solid tumors harboring FGFR2 alterations, but the toxicity of these drugs frequently leads to dose reduction or interruption of treatment such that maximum efficacy cannot be achieved.

Small Molecule 223

Small Molecule Treatment Science Therapies 223

Broad Institute

OCTOBER 29, 2024

New drug triggers rapid cell death in cancer models By Karen Zusi-Tran October 29, 2024 Breadcrumb Home New drug triggers rapid cell death in cancer models BRD-810 inhibits the MCL1 protein and reactivates apoptosis in tumor cells, displaying therapeutic potential in animal models. The result was the compound named BRD-810.

Drugs 133

Drugs Small Molecule Pharmacokinetics Clinical Trials 133

BioPharma Drive: Drug Pricing

AUGUST 28, 2024

Under a collaboration with NextRNA Therapeutics, Bayer will access the biotech’s platform to target long, non-coding RNA interactions with small molecule drugs.

RNA 280

RNA Small Molecule Therapies Drugs 280

Chemical Biology and Drug Design

MARCH 17, 2025

This review highlights recent advancements in small molecule inhibitors targeting Cdc2-like kinase 4 (Clk4), emphasizing their potential in treating cancers and neurodegenerative diseases. It explores SARs, binding modes, and challenges in developing selective Clk4 inhibitors, offering insights for future therapeutic strategies.

Small Molecule 100

Small Molecule Disease Drugs 100

Nvidia Developer: Drug Discovery

DECEMBER 3, 2024

Their specificity reduces the likelihood of off-target effects, making them safer and often more effective than small-molecule drugs for complex conditions. As a result… Source

Small Molecule 113

Small Molecule Disease Drugs Science 113

Science Daily: Pharmacology News

NOVEMBER 13, 2023

A compound -- one of 27 million screened in a library of potential new drugs -- reversed four types of chronic pain in animal studies, according to new research.

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Small Molecule Regulations Drugs Research 224

Science Daily: Pharmacology News

MARCH 26, 2025

A small molecule shaped like a lasso may be a powerful tool in the fight against infectious diseases.

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Small Molecule Disease Drugs 168

Collaborative Drug

AUGUST 29, 2023

a new Italian incubator dedicated to the discovery and development of small molecule-based treatments for neurodegenerative diseases, announced today that it has adopted Collaborative Drug Discovery’s CDD Vault as its platform of choice for managing drug discovery data.

Small Molecule 246

Small Molecule Treatment Disease Research 246

DrugBaron

JULY 19, 2022

Despite the current hype around so called “advanced therapies”, which range from gene editing to cell therapies, and the inexorable advance of biologic therapeutics such as monoclonal antibodies, even in 2022 the majority of drugs in development and reaching patients are still small organic molecules.

Small Molecule 100

Small Molecule Drugs DNA Pharma Companies 100

Covalent Modifiers

JANUARY 29, 2024

3c01835 Building on recent advances in peptide science, medicinal chemists have developed a hybrid class of bioconjugates, called peptide–drug conjugates, that demonstrate improved efficacy compared to peptides and small molecules independently. Moore Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01835

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Small Molecule Drugs Science Disease 173

Drug Hunter

AUGUST 18, 2023

The First Disclosures sessions at the 2023 ACS Fall Meeting in San Francisco, organized by Nikki Goodwin , presented a variety of new orally available small molecules. The post ACS Fall 2023 First Disclosures appeared first on Drug Hunter. Stay tuned!

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Small Molecule Drugs 238

ASPET

OCTOBER 8, 2024

However, drug resistance and side effects, particularly those affecting hemostasis, continue to pose significant challenges for TKI therapies. imatinib and nilotinib), and second-generation ABL inhibitors including ponatinib and bosutinib designed to mitigate drug resistance. Our study included standard-of-care agents (e.g.,

Small Molecule 100

Small Molecule Therapies Drugs 100

PPD

NOVEMBER 11, 2024

It is hard to ignore some of the most pressing, long-term trends driving the push to accelerate innovation and progress in drug development. As a result, biopharma and biotech companies working to bring their drug pipelines to the market require deep expertise from trusted partners to help deliver critical therapies for their patients.

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Drug Development Clinical Trials Drugs Small Molecule 97

Covalent Modifiers

OCTOBER 3, 2023

3c06622 Targeted protein degradation relies on small molecules that induce new protein–protein interactions between targets and the cellular protein degradation machinery. Most of these small molecules feature specific ligands for ubiquitin ligases.

Targeted Protein Degradation 182

Targeted Protein Degradation Small Molecule Drugs 182

Drug Hunter

AUGUST 15, 2023

LRRK2 has been a hotly pursued drug target for Parkinson’s Disease based on human genetics. Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples. appeared first on Drug Hunter. Get ahead now by requesting a trial. already a member?

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Small Molecule Trials Treatment Disease 229

Covalent Modifiers

FEBRUARY 1, 2024

link] Proteins labelled site-specifically with small molecules are valuable assets for chemical biology and drug development. Nat Commun 15 , 859 (2024). The unique reactivity profile of the 1,2-aminothiol moiety of N -terminal cysteines ( N -Cys) of proteins renders it highly attractive for regioselective protein labelling.

Biophysical Assays 200

Biophysical Assays Small Molecule Drug Development Production 200

Covalent Modifiers

MARCH 22, 2024

This capability becomes particularly valuable in addressing challenges such as the low affinity frequently encountered between therapeutic proteins and their targets, as well as the limited availability of small molecules for specific protein targets.

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Small Molecule Engineering Treatment Drugs 237

Covalent Modifiers

SEPTEMBER 9, 2023

3c00297 Falling in between traditional small molecules and antibodies in size, peptides are emerging as a privileged therapeutic modality, one that can harness the benefits of both small molecule and antibody drugs. Mengmeng Zheng and Jianmin Gao ACS Chemical Biology 2023 DOI: 10.1021/acschembio.3c00297

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Small Molecule International Drugs 195

Drug Target Review

JULY 4, 2023

Over the last two decades, an increasing number of Antibody Drug Conjugate (ADC) therapeutics have been approved for oncology indications. These therapies have broadened treatment options for patients to expand beyond the more traditional small molecule drug alternatives. 3D rendering of Antibody Drug Conjugate Molecules.

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Small Molecule Drugs Clinical Pharmacology Trials 145

BioPharma Drive: Drug Pricing

APRIL 22, 2024

billion, is the latest research collaboration involving small molecule drugs that modify RNA. The deal, which could be worth up to $1.8

RNA 156

RNA Small Molecule Disease Research 156

Covalent Modifiers

FEBRUARY 29, 2024

Currently, all FDA-approved covalent small molecules feature one electrophile, leaving open a facile route to acquired resistance. Therefore, molecular bidents represent a new pharmacological modality with the potential for improved selectivity, potency, and drug resistance profile.

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Small Molecule FDA Approval FDA Science 217

Covalent Modifiers

NOVEMBER 9, 2023

Baggelaar bioRxiv 2023.10.19.562725; doi: [link] Comparative, dose-dependent analysis of interactions between small molecule drugs and their targets, as well as off-targets, in complex proteomes is crucial for selecting optimal drug candidates.

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Small Molecule Drugs 147

Covalent Modifiers

JANUARY 13, 2024

Thomas Kodadek Angewandte Chemie International Edition 2024 e202316726 [link] Many of the highest priority targets in a wide range of disease states are difficult-to-drug proteins. This has engendered interest in strategies to increase the potency of a given protein inhibitor by routes other than further improvement in gross affinity.

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Small Molecule International Disease Drugs 195

Chemical Biology and Drug Design

JANUARY 27, 2025

ABSTRACT Docetaxel (DTX) is the preferred chemotherapeutic drug for prostate cancer (Pca), but the emergence of resistance has significantly reduced its efficacy. Polyphyllin VII (PPVII), a small molecule natural product derived from the traditional herb Paris polyphylla, has shown anticancer potential.

Small Molecule 100

Small Molecule Treatment Production Drugs 100

Metabolite Tales Blog

APRIL 10, 2024

Where data was publicly available, the routes of human metabolism for each of the drugs in this subset is listed in Table 1. Metabolites found in humans are also observed in monkeys, and all metabolites were found to possess <10% of the activity of the parent drug. of the administered radiolabel in the human ADME study.

Small Molecule 59

Small Molecule FDA Approval FDA Pharmacokinetics 59

Drug Hunter

MAY 31, 2023

This article compiles 20+ recent small molecules of general interest in the news in April 2023, with structures where they are available. Drug Hunter Premium is drug discovery, distilled, so you can quickly catch up and make informed decisions based on industry examples. Get ahead now by requesting a trial.

Small Molecule 196

Small Molecule Clinical Trials Trials Drugs 196

Drug Hunter

JUNE 29, 2023

The talk covered: Theoretical advantages of targeted protein degradation over traditional small molecules Recent highlights throughout the industry illustrating these advantages Areas to watch in targeted protein degradation on the horizon Some of the highlights mentioned in the talk include: IV STAT3 degraders from Kymera Therapeutics (e.g.

Targeted Protein Degradation 221

Targeted Protein Degradation Small Molecule Drugs 221

Covalent Modifiers

OCTOBER 25, 2024

We demonstrated the employability of ring-opening chemistry in isatoic anhydride as a drug delivery modality for the release of a small molecule and doxorubicin in cancer cells. Broadly, the tunable reactivity of isatoic anhydride could be leveraged for developing lysine-selective probes and drug delivery cargos.

Small Molecule 133

Small Molecule Drugs Science 133

Covalent Modifiers

MAY 21, 2024

A DNA-encoded chemical library (DEL) screen against Bfl-1 identified the first known reversible covalent small-molecule ligand for Bfl-1. This represented the first identification of a cyano-acrylamide reversible covalent compound from a DEL screen and highlights further opportunities for covalent drug discovery through DEL screening.

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DNA Small Molecule Drugs 182

Practical Cheminformatics

JANUARY 16, 2024

Property Prediction Machine Learning Methods for Small Data Challenges in Molecular Science [link] Practical guidelines for the use of gradient boosting for molecular property prediction [link] Application of message passing neural networks for molecular property prediction [link] Molecular Similarity Molecular Similarity: Theory, Applications, and (..)

Targeted Protein Degradation 139

Targeted Protein Degradation Small Molecule Computational Chemistry Bioinformatics 139

The ChEMBL-og

OCTOBER 23, 2024

In the quest to develop new drugs, understanding the 3D structure of molecules is crucial. Resources like the Protein Data Bank in Europe (PDBe) and the Cambridge Structural Database (CSD) provide these 3D blueprints for many biological molecules. ChEMBL is a treasure trove of bioactivity data for countless drug-like molecules.

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Small Molecule Drugs Research Science 117