Science Daily: Pharmacology News
MARCH 24, 2025
Maintaining a healthy diet rich in plant-based foods, with low to moderate intake of healthy animal-based foods and lower intake of ultra-processed foods, was linked to a higher likelihood of healthy aging -- defined as reaching age 70 free of major chronic diseases and with cognitive, physical, and mental health maintained, according to a new study.
Covalent Modifiers
MARCH 24, 2025
Yoav Shamir, Nir London bioRxiv 2025.03.19.642201; doi: [link] Recent years have seen an explosion in the prominence of covalent inhibitors as research and therapeutic tools. However, a lag in application of computational methods for covalent docking slows progress in this field. AI models such as AlphaFold3 have shown accuracy in ligand pose prediction but were never assessed for virtual screening.
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Science Daily: Pharmacology News
MARCH 24, 2025
Researchers have discovered that chimpanzees living in Gombe Stream National Park in Tanzania employ a degree of engineering when making their tools, deliberately choosing plants that provide materials that produce more flexible tools for termite fishing.
Covalent Modifiers
MARCH 24, 2025
L. Mader and J. W. Keillor, RSC Med. Chem., 2025 DOI: 10.1039/D5MD00050E Potent reversible covalent inhibitors are often slow in establishing their covalent modification equilibrium, resulting in time-dependent inhibition. While these inhibitors are commonly assessed using IC50 values, there are no methods available to analyze their time-dependent IC50 data to provide their inhibition (Kiand Ki*) and covalent modification rate (k5and k6) constants, leading to difficulty in accurately ranking dru
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Science Daily: Pharmacology News
MARCH 24, 2025
Researchers have developed a new material that, by harnessing the power of sunlight, can clear water of dangerous pollutants.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
MARCH 24, 2025
The longest organic molecules identified to date on Mars have recently been detected. These long carbon chains, containing up to 12 consecutive carbon atoms, could exhibit features similar to the fatty acids produced on Earth by biological activity. The lack of geological activity and the cold, arid climate on Mars have helped preserve this invaluable organic matter in a clay-rich sample for the past 3.7 billion years.
Drugs.com
MARCH 24, 2025
MONDAY, March 24, 2025 -- A fake web page designed to look like the U.S. Centers for Disease Control and Prevention's (CDC) vaccine safety site has been taken down on orders from health secretary Robert F. Kennedy Jr.The site was linked to.
Science Daily: Pharmacology News
MARCH 24, 2025
Investigators have developed a long-acting contraceptive implant that can be delivered through tiny needles to minimize patient discomfort and increase the likelihood of medication use. Their findings in preclinical models provide the technological basis to develop self-administrable contraceptive shots that could mimic the long-term drug release of surgically implanted devices.
BioPharma Drive: Drug Pricing
MARCH 24, 2025
Speed vs. success in oncology trials: Discover data-driven strategies to accelerate drug development.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
MARCH 24, 2025
Mathematicians studied the flow of human crowds and developed a way to predict when pedestrian paths will transition from orderly to entangled. Their findings may help inform the design of public spaces that promote safe and efficient thoroughfares.
BioPharma Drive: Drug Pricing
MARCH 24, 2025
The big biotech signed a 15-year lease for approximately 580,000-square-feet of space in “Kendall Commons,” a development project spearheaded by MIT.
Science Daily: Pharmacology News
MARCH 24, 2025
Researchers developed olfactory tests -- in which participants sniff odor labels that have been placed on a card -- to assess people's ability to discriminate, identify and remember odors. They found that participants could successfully take the test at home and that older adults with cognitive impairment scored lower on the test than cognitively normal adults.
Drugs.com
MARCH 24, 2025
MONDAY, March 24, 2025 -- A rare red meat allergy, usually linked to a bite from the lone star tick, may also be caused by other tick species found in different parts of the U.S., a new report shows.Alpha-gal syndrome is relatively rare, but those.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Science Daily: Pharmacology News
MARCH 24, 2025
To mitigate global climate change, emissions of the primary culprit, carbon dioxide, must be drastically reduced. A newly developed process helps solve this problem: CO2 is directly split electrochemically into carbon and oxygen. Oxygen could also be produced in this way under water or in space -- without requiring stringent conditions such as pressure and temperature.
Drugs.com
MARCH 24, 2025
MONDAY, March 24, 2025 -- Colon cancers have been steadily increasing among people younger than 50, even as cases have declined among seniors.Thats why guidelines now recommend that colon cancer screening start at 45, five years earlier than p.
Science Daily: Pharmacology News
MARCH 24, 2025
New research is reshaping our understanding of one of nature's most stunning yet destructive phenomena -- massive locust swarms moving together.
Drugs.com
MARCH 24, 2025
MONDAY, March 24, 2025 -- A small urine leak might prompt a woman to worry shell need an uncomfortable and invasive bladder test to treat her incontinence.But good news -- such bladder pressure tests probably arent necessary, according to results.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
MARCH 24, 2025
Scientists used light to control how a starfish egg cell jiggles and moves during its earliest stage of development. Their optical system could guide the design of synthetic, light-activated cells for wound healing or drug delivery.
Drugs.com
MARCH 24, 2025
MONDAY, March 24, 2025 -- The best evidence yet that cutting-edge Alzheimers disease drugs might indeed ward off the degenerative brain disease has emerged from a small-scale study.An experimental drug that clears amyloid beta from the brain cut t.
BioPharma Drive: Drug Pricing
MARCH 24, 2025
The licensing pact adds a second so-called "triple agonist" to the Danish drugmaker's portfolio as competition with Lilly and other contenders heats up.
Drugs.com
MARCH 24, 2025
MONDAY, March 24, 2025 -- The U.S. Food and Drug Administration has approved Tremfya (guselkumab) for adult patients with moderately to severely active Crohn disease.This approval is the fourth indication for this dual-acting interleukin-23.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drug Target Review
MARCH 24, 2025
Sujeegar Jeevanandam, an expert with 13 years of experience in life sciences R&D, offers valuable insights into the current state and future trajectory of artificial intelligence in drug discovery. Having previously drawn parallels with industry adoption of electronic lab notebooks in part 1 , this article expands on his vision for the future of the industry, sharing his forward-thinking ideas and practical recommendations.
SugarCone Biotech
MARCH 24, 2025
Aleta Bio recently announced that their scientists have created, characterized and validated novel classes of Immune Cell Engager therapeutics including T Cell Engagers (TCE) and CAR T Cell Engagers (Ref. 1). In this post we describe the technology in more detail. Weve published extensively on the CAR-T Engager class, exemplified by our Phase 1/2 clinical program that is evaluating the safety and efficacy of ALETA-001, a therapeutic that binds CD19-directed CAR-T cells to a second antigen, CD20
BioPharma Drive: Drug Pricing
MARCH 24, 2025
The company expects next quarter to read out initial data from its Heart-2 trial, which is testing a one-time treatment for people with genetically elevated cholesterol.
Drugs.com
MARCH 24, 2025
MONDAY, March 24, 2025 -- Folks frequently use their smartwatches to monitor their daily step count, aiming to get enough physical activity to improve their health.But smartwatches are tracking another measure of health that could prove even more.
BioPharma Drive: Drug Pricing
MARCH 24, 2025
The Series B round will help the Aditum Bio-backed startup fund two mid-stage clinical trials in people with alcohol and cocaine use disorders.
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