Drug Discovery World

NOVEMBER 6, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The news highlights this week feature a variety of exciting clinical trial results and launches that are examining therapies for much-needed disease areas, new drug approvals and even a space mission with a pharma twist.

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Clinical Trials Trials Therapies Disease 130

Chemical Biology and Drug Design

NOVEMBER 6, 2023

General structure of the synthesized thiazole-derived antiglycators, with substituents introduced into the indicated positions. We have synthesized and assessed compounds that are derived from the original phenacyl thiazolium. The objective was to increase antiglycation activity while maintaining the designated interaction regions of the active molecule with carbonyl compounds.

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Production Research 100

Drug Discovery World

NOVEMBER 6, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The news highlights this week feature a variety of exciting clinical trial results and launches that are examining therapies for much-needed disease areas, new drug approvals and even a space mission with a pharma twist.

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Clinical Trials Therapies Trials Disease 130

Perficient: Drug Development

NOVEMBER 6, 2023

It’s no secret: the digital world is moving to composable. Moving from the traditional monolithic CMS model to composable does allow you to pick and choose “best in breed” products, but it can lead to confusion and uncertainty. How do you determine what the ideal mix is? When do you start to migrate to these tools? Here are three steps to establish a composable roadmap in your organization.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

NOVEMBER 6, 2023

The UK regulator has approved a new treatment for non-small cell lung cancer (NSCLC) in adults that has a mutation and produces a rare protein called KRAS G12C. The Medicines and Healthcare products Regulatory Agency (MHRA) has authorised Krazati (adagrasib) to treat patients whose disease is advanced or has spread to other parts of the body, and where previous treatments have failed.

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Therapies Drugs Hospitals Treatment 130

Drug Target Review

NOVEMBER 6, 2023

Advances in research and development and the utilisation of combination treatment strategies are revolutionising the haematology care landscape, but more must be done to address patients’ individual needs. There are more than 150 identified types of leukaemia’s, lymphomas and myelomas 1 and given that each blood cancer is unique, their heterogenous nature makes them some of the most challenging cancers to treat. 2 To redefine standards of care in haematology and close gaps to improve

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Small Molecule Therapies Treatment Immune Response 111

Drug Patent Watch

NOVEMBER 6, 2023

A paper titled “Analysis of Strategy for Extending Patent Protection of Rucaparib” by Zhifeng Wang. discusses the strategies employed by pharmaceutical companies to extend the patent protection period of the… The post Maximizing Intellectual Property Value in the Biomedical Sector: A Case Study on Rucaparib Patents appeared first on DrugPatentWatch - Make Better Decisions.

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Pharmaceutical Companies Pharmaceuticals 111

FDA Law Blog: Biosimilars

NOVEMBER 6, 2023

By Douglas B. Farquhar & Richard A. Lewis, Senior Regulatory Device & Biologics Expert — We were preparing this blogpost about FDA’s draft guidance on “Remote Interactive Evaluations” when we learned something. A phone call to FDA requested information about the number of Remote Interactive Evaluations (RIEs) that FDA has performed at drug manufacturing facilities since it announced in April 2021 that it would start using them as an alternative to on-site inspections.

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FDA Compliance Clinical Trials Drugs 105

Science Daily: Pharmacology News

NOVEMBER 6, 2023

A team has developed a new step to improve the process for creating insulin-producing pancreatic cells from a patient's own stem cells, bringing the prospect of injection-free treatment closer for people with diabetes.

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Treatment 107

Fierce BioTech

NOVEMBER 6, 2023

In this interview, Charles Chase, PhD, the VP and Technical Business Development at Asymchem, a technology-focused pharmaceutical manufacturing company, discusses the significant impact of RNA vacc | Diversifying manufacturing and investing into emerging technologies improves cost effectiveness, reproducibility, and environmentally friendly processes.

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Pharmaceuticals RNA 100

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

NOVEMBER 6, 2023

A speech prosthetic developed by a collaborative team of Duke neuroscientists, neurosurgeons, and engineers can translate a person's brain signals into what they're trying to say. The new technology might one day help people unable to talk due to neurological disorders regain the ability to communicate through a brain-computer interface.

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Engineering 105

Fierce BioTech

NOVEMBER 6, 2023

“The future of drug discovery in biotechnology is dependent on achieving scale, speed and cost efficiency,” according to Dr. | Dr. Sharon Benzeno, Chief Commercial Officer of Immune Medicine at Adaptive Biotechnologies, shines a spotlight on the key immune-driven medicine advancements that show immense promise in transforming diagnoses, treatments, and patient outcomes.

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Drugs Treatment 97

Science Daily: Pharmacology News

NOVEMBER 6, 2023

Over the past few decades, algae have been slowly edging corals out of their native reefs across the globe by blocking sunlight, wearing the corals down physically, and producing harmful chemicals. But in recent years, a new type of algal threat has surfaced in tropical regions like the Caribbean -- one that spreads quickly and forms a crust on top of coral and sponges, suffocating the organisms underneath and preventing them from regrowing.

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NIOSH Science Blog: Drugs

NOVEMBER 6, 2023

Oil and gas extraction (OGE) workers play an important role in supporting the U.S. economy. In 2021, 326,160 workers were employed by OGE companies to help meet U.S. energy needs.1 This work is not done without risk. Workers in the OGE industry regularly face hazardous exposures such as flammable and toxic gases and vapors, and high-risk environments such as working at heights, around heavy equipment, below suspended loads, with explosive materials, and around pressurized lines and vessels.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

NOVEMBER 6, 2023

Researchers have used fossil evidence to engineer a soft robotic replica of pleurocystitids, a marine organism that existed nearly 450 million years ago and is believed to be one of the first echinoderms capable of movement using a muscular stem.

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Engineering Research 96

SCIENMAG: Medicine & Health

NOVEMBER 6, 2023

The Pandemic-related Traumatic Stress Scale (PTSS) can be used to effectively measure stress related to the COVID-19 pandemic and identify children and adults with higher levels of stress who may need additional mental health support, according to a new study funded by the Environmental influences on Child Health Outcomes Program (ECHO) at the National Institutes […]

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Science Daily: Pharmacology News

NOVEMBER 6, 2023

The hunter-gatherers who settled on the banks of the Haine, a river in southern Belgium, 31,000 years ago were already using spearthrowers to hunt their game. The material found at the archaeological site of Maisières-Canal permits establishing the use of this hunting technique 10,000 years earlier than the oldest currently known preserved spearthrowers.

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SCIENMAG: Medicine & Health

NOVEMBER 6, 2023

The fight against dengue fever has a new weapon: a mosquito infected with the bacteria Wolbachia, which prevents the spread of the virus. These mosquitoes have now been deployed in several trials demonstrating their potential in preventing disease transmission.

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Virus Trials Disease 89

Science Daily: Pharmacology News

NOVEMBER 6, 2023

Paleontologists have shed light on the long-standing saga of Ekgmowechashala, based on fossil teeth and jaws found in both Nebraska and China. Ekgmowechashala is the last primate found in the fossil record before humans.

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SCIENMAG: Medicine & Health

NOVEMBER 6, 2023

BIRMINGHAM, Ala. – Yabing Chen, Ph.D., has been awarded two National Institutes of Health grants totaling more than $5 million to further her research into vascular diseases ranging from hardening of the arteries to dementia. Credit: UAB BIRMINGHAM, Ala. – Yabing Chen, Ph.D.

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Disease Research 85

Science Daily: Pharmacology News

NOVEMBER 6, 2023

Over 100 letters sent to French sailors by their fiancées, wives, parents and siblings -- but never delivered -- have been opened and studied for the first time since they were written in 1757-8.

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DrugBank

NOVEMBER 6, 2023

Recently, the NIH announced it is discontinuing its drug-drug interaction API and associated features in RxNav. Up until now, DrugBank’s data has fed directly into the RxNav API—more specifically, the drug interaction API offered by RxNav was powered, in part, by DrugBank’s drug-drug interaction dataset. The interaction data available through RxNav API was a limited version of DrugBank’s complete interaction data that did not include information on interaction severit

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Drugs Production 84

Science Daily: Pharmacology News

NOVEMBER 6, 2023

Almost every large galaxy has a supermassive black hole at its center. An international research team has recently observed the Circinus galaxy, which is one of the closest galaxies to the Milky Way, with high enough resolution to gain further insights into the gas flows to and from the black hole at its galactic nucleus.

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International Research 90

SCIENMAG: Medicine & Health

NOVEMBER 6, 2023

Ann Arbor, November 6, 2023 – Current participation rates in the US federal Child and Adult Care Food Program (CACFP) by licensed child care centers point to program underutilization and unequal access, according to the first nationwide analysis of data on CACFP participation in the American Journal of Preventive Medicine, published by Elsevier.

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Licensing Licensing 83

Science Daily: Pharmacology News

NOVEMBER 6, 2023

Researchers conducted a study to determine if replacing dietary fats from palm oil, soy and other agricultural crops with fats created synthetically in chemical or biological processes could help reduce climate change-causing greenhouse gases. The researchers' analysis finds a reduction in carbon emissions and other benefits, such the opening of agricultural lands to reforestation which benefits biodiversity and creates a carbon sink.

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Research 89

SCIENMAG: Medicine & Health

NOVEMBER 6, 2023

WINSTON-SALEM, N.C. – Nov. 6, 2023 – A new study from researchers at Wake Forest University School of Medicine shows that frailty is associated with higher rates of death and major morbidity after surgery. Credit: Wake Forest University School of Medicine WINSTON-SALEM, N.C. – Nov.

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Research 73

Science Daily: Pharmacology News

NOVEMBER 6, 2023

Researchers investigated belly flop mechanics and found surprising insights about air-to-water impacts that could be useful for marine engineering applications. They set up a belly flop-like water experiment using a blunt cylinder but added an important vibrating twist to it.

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Research Engineering 79

Antidote

NOVEMBER 6, 2023

As the third most common type of cancer in the world, colon cancer is a significant public health concern. Because of the lack of early-stage symptoms in colon cancer and the common confusion about screening requirements, it is often a type of cancer that remains undetected until it reaches advanced stages. This delayed diagnosis can have a significant impact on a person’s prognosis.

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Science Daily: Pharmacology News

NOVEMBER 6, 2023

The path a cell takes from healthy to metastatic cancer is mostly driven by epigenetic changes, according to a new computational study.

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Fierce BioTech

NOVEMBER 6, 2023

In this interview, Chuck Donnelly, CEO and co-founder of RockStep Solutions, discusses the significance of lab digitalization and future trends in the biotech industry. | Emerging technologies and scientific advancements, specifically, artificial intelligence, robotics, and automation will impact industry in the industry in the next decade.

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Science Daily: Pharmacology News

NOVEMBER 6, 2023

Researchers have discovered several factors that affect field mouse behavior using seeds from dwarf bamboo plants, a plant that flowers once in a century. Their findings not only suggest the previously underappreciated role of mice in the forest ecosystem, but also show that they store small sasa seeds for later use. These challenge a previously held model of mouse behavior.

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Research 77

Perficient: Drug Development

NOVEMBER 6, 2023

Perficient’s Generative AI Lab is consistently developing POCs to help clients explore use cases for generative AI and helping them operationalize it with policies, advocacy, controls, and enablement. Our team recently built a POC for Internal ChatGPT that offers a secure and efficient way for companies to leverage the power of chatbots while maintaining control over their internal data.

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Science Daily: Pharmacology News

NOVEMBER 6, 2023

They say two heads are better than one. But in the world of fish, it appears two fins are better than one. Researchers have produced a theoretical model that demonstrates the underlying mechanisms behind how fish will synchronize their fin movements to ride each other's vortices, thereby saving energy.

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Research 70

Covalent Modifiers

NOVEMBER 6, 2023

Léa N. C. Rochet, Calise Bahou, Jonathan P. Wojciechowski, Ilias Koutsopetras, Phyllida Britton, Richard J. Spears, ORCID logo a Ioanna A. Thanasi, Baihao Shao, Lisha Zhong, Dejan-Krešimir Bučar, Abil E. Aliev, Michael J. Porter, Molly M. Stevens, James R. Baker, and Vijay Chudasama Chem. Sci. 2023 [link] Reversible cysteine modification has been found to be a useful tool for a plethora of applications such as selective enzymatic inhibition, activity-based protein profiling and/or cargo release

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