Drug Discovery World

MARCH 7, 2024

Research published in Cell Genomics has shown that prostate cancer includes two different subtypes of the disease, also known as evotypes. This discovery was made by using artificial intelligence (AI) to help unlock new discoveries about the evolution of prostate cancer which could lead to the development of new treatments. “Our research demonstrates that prostate tumours evolve along multiple pathways, leading to two distinct disease types,” said lead researcher Dr Dan Woodcock, of the Nuffield

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Disease Medical Schools DNA International 148

Chemical Biology and Drug Design

MARCH 7, 2024

Synthesis, in silico screening, and anti-epileptic activity of novel pyridine analogs. Abstract The research involves the synthesis of a series of new pyridine analogs 5(i-x) and their evaluation for anti-epileptic potential using in silico and in vivo models. Synthesis of the compounds was accomplished by using the Vilsmeier-Haack reaction principle.

Pharmacokinetics 100

Pharmacokinetics Research Drugs 100

Drug Discovery World

MARCH 7, 2024

Biotechnology company Akari Therapeutics and biopharmaceutical company Peak Bio have announced a definitive agreement to merge as equals in an all-stock transaction. The combined entity will operate as Akari Therapeutics, which is expected to continue to be listed and trade on the Nasdaq Capital Market as AKTX. Following closing, the company will have an expanded pipeline that contains multiple assets spanning early and late development stages.

Clinical Trials 148

Clinical Trials Licensing Licensing Clinical Development 148

Chemical Biology and Drug Design

MARCH 7, 2024

A new class of quinoxaline aryl ether compounds was designed and synthesized. These compounds were tested on HCT-116, MDA-MB-231, and DU-145 cancer lines. The three cancer cell lines responded best to FQ and MQ, which were investigated for apoptosis. Molecular docking/dynamic studies of FQ and MQ at c-Met kinase (PDB: 3F66) were also done. Abstract We designed and synthesized thirty novel quinoxaline aryl ethers as anticancer agents, and the structures of final compounds were confirmed with vari

Research 100

Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

MARCH 7, 2024

Ginkgo Bioworks has acquired Patch Biosciences, with the intention to strengthen its gene therapy services, cell therapy services, and RNA therapeutics services. Ginkgo provides R&D services across industries, including in biopharma, and will incorporate Patch’s machine learning models and downstream assays into its existing platform, making new capabilities in synthetic promoter and untranslated region (UTR) engineering available to partners.

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RNA Engineering Therapies Virus 130

Chemical Biology and Drug Design

MARCH 7, 2024

BMSCs were isolated from the femurs of SD rats aged 7–8 weeks and identified by flow cytometry. BMSCs were inoculated into Ag2O-TiO2-NTs and added into stem cell osteogenic induction differentiation culture medium. Extracellular LDH enzyme activity was detected at 7 and 14 days of induction, respectively, and osteogenic genes in BMSCs were detected by qRT-PCR.

Regulations 100

Regulations Research 100

Science Daily: Pharmacology News

MARCH 7, 2024

Sound waves thought to be from a 2014 meteor fireball north of Papua New Guinea were almost certainly vibrations from a truck rumbling along a nearby road, new research shows. The findings raise doubts that materials pulled last year from the ocean are alien materials from that meteor, as was widely reported.

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Research 123

Drugs.com

MARCH 7, 2024

THURSDAY, March 7, 2024 -- Some acne treatments may may banish blemishes but carry hidden dangers: A new report reveals high levels of the carcinogen benzene can form in products that contain the zit-fighting ingredient benzoyl peroxide.According.

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Treatment Production 122

Science Daily: Pharmacology News

MARCH 7, 2024

Four children have remained free of detectable HIV for more than one year after their antiretroviral therapy (ART) was paused to see if they could achieve HIV remission, according to new research. The children, who acquired HIV before birth, were enrolled in a clinical trial in which an ART regimen was started within 48 hours of birth and then closely monitored for drug safety and HIV viral suppression.

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Treatment Clinical Trials Therapies Trials 119

Drug Patent Watch

MARCH 7, 2024

LACTOSE-Free Medicines, 2024 is part of DrugPatentWatch’s deep library of business intelligence on biopharmaceutical drugs. Buy Lactose-Free Medicines from Amazon This guide is designed to provide information for healthcare providers to… The post LACTOSE-Free Medicines: Which Drugs Contain LACTOSE? appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs 111

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

MARCH 7, 2024

The results from the privately held biotech add to early evidence supporting the potential of an increasingly popular drug target known as NLRP3 inflammasomes.

Drugs 117

Drugs 117

Science Daily: Pharmacology News

MARCH 7, 2024

In a new study, researchers have used the fossil record to better understand what factors make animals more vulnerable to extinction from climate change. The results could help to identify species most at risk today from human-driven climate change.

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Research 106

BioPharma Drive: Drug Pricing

MARCH 7, 2024

The startup, which has raised nearly $254 million privately, is in early testing with drugs designed to target particularly tough-to-treat tumors.

Drugs 123

Drugs 123

Drug Patent Watch

MARCH 7, 2024

Annual Drug Patent Expirations for ULORIC Uloric is a drug marketed by Takeda Pharms Usa and is included in one NDA. It is available from one supplier. There are three… The post New patent expiration for Takeda Pharms drug ULORIC appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 105

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

MARCH 7, 2024

Early results from a Phase 1 study suggest the drug, amycretin, could be as potent as injectable medicines already sold by Novo and rival Eli Lilly.

Trials 120

Trials Drugs 120

Drugs.com

MARCH 7, 2024

THURSDAY, March 6, 2024 -- Athletes whose coaches are open, authentic and positive are more likely to have better mental health, a new study says.Athletes feel happier and deal with problems more easily if their coaches adopt an “authentic.

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Science Daily: Pharmacology News

MARCH 7, 2024

Gastrointestinal surgeries carry risk of fluid leaks, a potentially life-threatening complication. But no existing methods can reliably and non-invasively detect these leaks. To address this unmet need, researchers developed a tiny, soft, flexible sticker that changes in shape inside the body, enabling standard ultrasound tech to detect leaks for earlier detection and intervention.

Research 101

Research 101

Drugs.com

MARCH 7, 2024

THURSDAY, March 7, 2024 -- Nearly a quarter of Labrador retrievers are more likely to be obese due to a genetic “double-whammy,” a new study finds.This gene mutation causes Labradors to both feel hungry all the time and also burn fewer.

Research 98

Research 98

Drug Channels

MARCH 7, 2024

On March 19, 2024, Drug Channels Institute will release The 2024 Economic Report on U.S. Pharmacies and Pharmacy Benefit Managers. This report—our fifteenth edition—remains the most comprehensive, fact-based tool for understanding the entire U.S. drug pricing, reimbursement, and dispensing system. This unique, encyclopedic resource is your ultimate guide to the complex web of interactions within U.S. prescription drug channels. 12 chapters, 500+ pages, 262 exhibits, nearly 1,100 endnotes: There

Pharmacy 98

Pharmacy Licensing Licensing Drugs 98

Drugs.com

MARCH 7, 2024

THURSDAY, March 7, 2024 -- As more Americans pop over-the-counter melatonin to help them sleep, their young children are increasingly showing up in ERs after accidentally ingesting the supplements.A new report of data from 2012 through 2021 finds a.

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Science Daily: Pharmacology News

MARCH 7, 2024

For many hundreds of millions of years, the average temperature at the surface of the Earth has varied by not much more than 20 degrees Celsius, facilitating life on our planet. To maintain such stable temperatures, Earth appears to have a 'thermostat' that regulates the concentration of atmospheric carbon dioxide over geological timescales, influencing global temperatures.

Regulations 95

Regulations 95

Drugs.com

MARCH 7, 2024

THURSDAY, March 7, 2024 -- Just three weeks after the Alabama Supreme Court ruled that frozen embryos should be considered children, lawmakers in that state passed legislation that shields both patients and providers who use in vitro fertilization.

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SCIENMAG: Medicine & Health

MARCH 7, 2024

FRANKFURT. Bettina Stark-Watzinger, Germany’s Federal Minister of Education and Research, emphasizes: “The rapid and successful development of active substances against the SARS-CoV-2 virus illustrated the importance of good and trusting international cooperation among scientists, especially in the field of integrated structural biology.

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Research International Virus 92

Drugs.com

MARCH 7, 2024

THURSDAY, March 7, 2024 -- Abortion rights will play a pivotal role in determining how people will vote in the 2024 election, a new KFF poll has found.About one in eight voters (12%) now say abortion is the most important issue for their vote in.

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SCIENMAG: Medicine & Health

MARCH 7, 2024

A “game-changing” $1.3m cash injection has been awarded to researchers exploring if doctors can prescribe fishing to treat PTSD. Credit: University of Essex A “game-changing” $1.3m cash injection has been awarded to researchers exploring if doctors can prescribe fishing to treat PTSD.

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Treatment Doctors Research 91

Drugs.com

MARCH 7, 2024

THURSDAY, March 6, 2024 -- Even a little physical activity can cut a person’s stroke risk compared to being a complete couch potato, a new review shows.Folks whose physical activity levels fell short of recommended guidelines still had a lower.

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Science Daily: Pharmacology News

MARCH 7, 2024

The oldest fossilized forest known on Earth -- dating from 390 million years ago -- has been found in the high sandstone cliffs along the Devon and Somerset coast of South West England.

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Drugs.com

MARCH 7, 2024

THURSDAY, March 7, 2024 -- There's more good news around the diabetes and weight-loss drug Ozempic: It might help ease fatty liver disease in people living with HIV, new research shows.Six months of weekly injections of Ozempic (semaglutide).

Disease 97

Disease Research Drugs 97

SCIENMAG: Medicine & Health

MARCH 7, 2024

Antimicrobial resistance is a story of constantly moving parts and players. With every new or tweaked antibiotic or antimicrobial drug, the targeted pathogens begin the evolutionary dance of acquiring resistance, prompting researchers to constantly develop workarounds or entirely new classes of medicine.

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Disease Research Drugs 87

Drugs.com

MARCH 7, 2024

THURSDAY, March 7, 2024 -- The perpetrator of a mass shooting in Maine last fall had extensive brain damage from "thousands of low-level blasts" tied to his work at an Army Reserve hand grenade training range, a new report shows.On Oct. 25, Robert.

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DrugBank

MARCH 7, 2024

The landscape of weight loss drugs has been rapidly evolving, and 2024 is poised to be another transformative year in this market. Despite challenges such as supply issues, insurance coverage discrepancies, and side effects, the demand for these medications continues to surge. Pharmaceutical researchers, in particular, have a keen interest in understanding the unfolding dynamics of this market.

Pharmaceutical Companies 81

Pharmaceutical Companies Pharmaceuticals Clinical Trials Pharmacokinetics 81

Drugs.com

MARCH 7, 2024

THURSDAY, March 7, 2024 -- Food allergies are difficult to manage at any age, but college students face complex challenges when it comes to navigating the dangers posed by the possibility of life-threatening anaphylaxis. A recent review published.

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addgene Blog

MARCH 7, 2024

The PAM… that sneaky little bit of sequence that you hope is present next to the "perfect" guide sequence for your genome engineering experiment. With CRISPR entering the clinic for correction of disease-causing alleles, and the growing need for gene editing in research, the old PAM constraints just won’t cut it anymore. Say hello to PAM-free and PAM-flexible nucleases!

Engineering 79

Engineering Disease Research 79

Drugs.com

MARCH 7, 2024

THURSDAY, March 7, 2024 -- The “selfie” culture on social media appears to be intensifying people’s desires to undergo cosmetic procedures, a new study suggests.Time spent on Snapchat or Instagram seems to heighten a person’s interest in.

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