Science Daily: Pharmacology News
MARCH 7, 2024
Sound waves thought to be from a 2014 meteor fireball north of Papua New Guinea were almost certainly vibrations from a truck rumbling along a nearby road, new research shows. The findings raise doubts that materials pulled last year from the ocean are alien materials from that meteor, as was widely reported.
Chemical Biology and Drug Design
MARCH 7, 2024
Synthesis, in silico screening, and anti-epileptic activity of novel pyridine analogs. Abstract The research involves the synthesis of a series of new pyridine analogs 5(i-x) and their evaluation for anti-epileptic potential using in silico and in vivo models. Synthesis of the compounds was accomplished by using the Vilsmeier-Haack reaction principle.
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ASPET
MARCH 7, 2024
Renal fibrosis is distinguished by the abnormal deposition of extracellular matrix (ECM) and progressive loss of nephron function, with a lack of effective treatment options in clinical practice. In this study, we discovered that the Beclin-1-derived peptide MP1 significantly inhibits the abnormal expression of fibrosis and Epithelial-mesenchymal transition (EMT)-related markers, including α-Smooth muscle actin (α-SMA), Fibronectin (FN), Collagen I (Col I), Matrix metallopeptidase 2 (M
Chemical Biology and Drug Design
MARCH 7, 2024
A new class of quinoxaline aryl ether compounds was designed and synthesized. These compounds were tested on HCT-116, MDA-MB-231, and DU-145 cancer lines. The three cancer cell lines responded best to FQ and MQ, which were investigated for apoptosis. Molecular docking/dynamic studies of FQ and MQ at c-Met kinase (PDB: 3F66) were also done. Abstract We designed and synthesized thirty novel quinoxaline aryl ethers as anticancer agents, and the structures of final compounds were confirmed with vari
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ASPET
MARCH 7, 2024
The drug-drug interaction (DDI) between Amiodarone (AMIO) and Sofosbuvir (SOF), a direct-acting Hepatitis-C NS5B Nucleotide Polymerase Inhibitor, has been associated with severe bradyarrhythmia in patients. Recent Cryo-EM data has revealed that this DDI occurs at the α-subunit of L-type Cav channels (LTCC), with AMIO binding at the fenestration site and SOF (or MNI-1: analog of SOF) binding at the central cavity of the conductance pathway.
Chemical Biology and Drug Design
MARCH 7, 2024
BMSCs were isolated from the femurs of SD rats aged 7–8 weeks and identified by flow cytometry. BMSCs were inoculated into Ag2O-TiO2-NTs and added into stem cell osteogenic induction differentiation culture medium. Extracellular LDH enzyme activity was detected at 7 and 14 days of induction, respectively, and osteogenic genes in BMSCs were detected by qRT-PCR.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
MARCH 7, 2024
Four children have remained free of detectable HIV for more than one year after their antiretroviral therapy (ART) was paused to see if they could achieve HIV remission, according to new research. The children, who acquired HIV before birth, were enrolled in a clinical trial in which an ART regimen was started within 48 hours of birth and then closely monitored for drug safety and HIV viral suppression.
ASPET
MARCH 7, 2024
The advent of HER2-targeted monoclonal antibodies such as trastuzumab has significantly improved the clinical outcomes for patients with breast cancer overexpressing HER2, and more recently also for gastric cancers. However, the development of resistance, as is frequently the case for other antineoplastic modalities, constrains clinical efficacy. Multiple molecular mechanisms and signaling pathways have been investigated for their potential involvement in the development of resistance to HER2-ta
Drugs.com
MARCH 7, 2024
THURSDAY, March 7, 2024 -- Some acne treatments may may banish blemishes but carry hidden dangers: A new report reveals high levels of the carcinogen benzene can form in products that contain the zit-fighting ingredient benzoyl peroxide.According.
ASPET
MARCH 7, 2024
The benzimidazole opioids (BO, substituted nitazenes) are highly potent MOR agonists with heroin- or fentanyl-like effects. These compounds have caused hospitalizations and fatal overdoses. We characterized the in vitro pharmacology and structure-activity relationships of 19 nitazenes with substitutions at three positions of the benzimidazole core. Affinities were assessed using agonist radioligand binding assays at human mu, kappa, and delta opioid receptors (MOR, KOR, and DOR, respectively) he
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
BioPharma Drive: Drug Pricing
MARCH 7, 2024
The results from the privately held biotech add to early evidence supporting the potential of an increasingly popular drug target known as NLRP3 inflammasomes.
FDA Law Blog: Drug Discovery
MARCH 7, 2024
By Mark A. Tobolowsky & Véronique Li, Senior Medical Device Regulation Expert & David B. Clissold — The trio of CDER, CBER, and CDRH released a new draft guidance titled “ Use of Data Monitoring Committees in Clinical Trials ” that revises the 2006 guidance “Establishment and Operation of Clinical Trial Data Monitoring Committees” and, when final, will replace the 2006 guidance.
BioPharma Drive: Drug Pricing
MARCH 7, 2024
The startup, which has raised nearly $254 million privately, is in early testing with drugs designed to target particularly tough-to-treat tumors.
Science Daily: Pharmacology News
MARCH 7, 2024
In a new study, researchers have used the fossil record to better understand what factors make animals more vulnerable to extinction from climate change. The results could help to identify species most at risk today from human-driven climate change.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
MARCH 7, 2024
Early results from a Phase 1 study suggest the drug, amycretin, could be as potent as injectable medicines already sold by Novo and rival Eli Lilly.
Science Daily: Pharmacology News
MARCH 7, 2024
Gastrointestinal surgeries carry risk of fluid leaks, a potentially life-threatening complication. But no existing methods can reliably and non-invasively detect these leaks. To address this unmet need, researchers developed a tiny, soft, flexible sticker that changes in shape inside the body, enabling standard ultrasound tech to detect leaks for earlier detection and intervention.
Drug Target Review
MARCH 7, 2024
Researchers from the University of California, San Francisco have designed a candidate drug that modifies the cancer-causing mutation K-Ras G12D, which could turn pancreatic cancer into a treatable condition. K-Ras G12D is responsible for almost half of all pancreatic cancer cases, and appears in lung, breast and colon cancers. The G12D alteration is the most common mutation in lung cancer patients with no history of cigarette smoking. 1 Although pancreatic cancer is rarer than the abovementione
Drugs.com
MARCH 7, 2024
THURSDAY, March 7, 2024 -- Nearly a quarter of Labrador retrievers are more likely to be obese due to a genetic “double-whammy,” a new study finds.This gene mutation causes Labradors to both feel hungry all the time and also burn fewer.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
MARCH 7, 2024
For many hundreds of millions of years, the average temperature at the surface of the Earth has varied by not much more than 20 degrees Celsius, facilitating life on our planet. To maintain such stable temperatures, Earth appears to have a 'thermostat' that regulates the concentration of atmospheric carbon dioxide over geological timescales, influencing global temperatures.
SCIENMAG: Medicine & Health
MARCH 7, 2024
FRANKFURT. Bettina Stark-Watzinger, Germany’s Federal Minister of Education and Research, emphasizes: “The rapid and successful development of active substances against the SARS-CoV-2 virus illustrated the importance of good and trusting international cooperation among scientists, especially in the field of integrated structural biology.
Drug Patent Watch
MARCH 7, 2024
LACTOSE-Free Medicines, 2024 is part of DrugPatentWatch’s deep library of business intelligence on biopharmaceutical drugs. Buy Lactose-Free Medicines from Amazon This guide is designed to provide information for healthcare providers to… The post LACTOSE-Free Medicines: Which Drugs Contain LACTOSE? appeared first on DrugPatentWatch - Make Better Decisions.
SCIENMAG: Medicine & Health
MARCH 7, 2024
A “game-changing” $1.3m cash injection has been awarded to researchers exploring if doctors can prescribe fishing to treat PTSD. Credit: University of Essex A “game-changing” $1.3m cash injection has been awarded to researchers exploring if doctors can prescribe fishing to treat PTSD.
Drugs.com
MARCH 7, 2024
THURSDAY, March 7, 2024 -- As more Americans pop over-the-counter melatonin to help them sleep, their young children are increasingly showing up in ERs after accidentally ingesting the supplements.A new report of data from 2012 through 2021 finds a.
SCIENMAG: Medicine & Health
MARCH 7, 2024
Antimicrobial resistance is a story of constantly moving parts and players. With every new or tweaked antibiotic or antimicrobial drug, the targeted pathogens begin the evolutionary dance of acquiring resistance, prompting researchers to constantly develop workarounds or entirely new classes of medicine.
Drugs.com
MARCH 7, 2024
THURSDAY, March 6, 2024 -- Athletes whose coaches are open, authentic and positive are more likely to have better mental health, a new study says.Athletes feel happier and deal with problems more easily if their coaches adopt an “authentic.
Science Daily: Pharmacology News
MARCH 7, 2024
The oldest fossilized forest known on Earth -- dating from 390 million years ago -- has been found in the high sandstone cliffs along the Devon and Somerset coast of South West England.
Drug Patent Watch
MARCH 7, 2024
Annual Drug Patent Expirations for ULORIC Uloric is a drug marketed by Takeda Pharms Usa and is included in one NDA. It is available from one supplier. There are three… The post New patent expiration for Takeda Pharms drug ULORIC appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
MARCH 7, 2024
THURSDAY, March 7, 2024 -- Just three weeks after the Alabama Supreme Court ruled that frozen embryos should be considered children, lawmakers in that state passed legislation that shields both patients and providers who use in vitro fertilization.
DrugBank
MARCH 7, 2024
The landscape of weight loss drugs has been rapidly evolving, and 2024 is poised to be another transformative year in this market. Despite challenges such as supply issues, insurance coverage discrepancies, and side effects, the demand for these medications continues to surge. Pharmaceutical researchers, in particular, have a keen interest in understanding the unfolding dynamics of this market.
Drugs.com
MARCH 7, 2024
THURSDAY, March 6, 2024 -- Even a little physical activity can cut a person’s stroke risk compared to being a complete couch potato, a new review shows.Folks whose physical activity levels fell short of recommended guidelines still had a lower.
addgene Blog
MARCH 7, 2024
The PAM… that sneaky little bit of sequence that you hope is present next to the "perfect" guide sequence for your genome engineering experiment. With CRISPR entering the clinic for correction of disease-causing alleles, and the growing need for gene editing in research, the old PAM constraints just won’t cut it anymore. Say hello to PAM-free and PAM-flexible nucleases!
Drugs.com
MARCH 7, 2024
THURSDAY, March 7, 2024 -- There's more good news around the diabetes and weight-loss drug Ozempic: It might help ease fatty liver disease in people living with HIV, new research shows.Six months of weekly injections of Ozempic (semaglutide).
Eye on FDA
MARCH 7, 2024
Back in December 2023, FDA announced intention in the Federal Register and in a press release to form a new FDA Advisory Committee to be called the Genetic Metabolic Diseases Advisory Committee (GeMDAC). As noted in a recent posting here , last year saw a marked increase not only in the number of advisory committee meetings, but in the proportion of recommendations for approval.
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