Drug Hunter

AUGUST 18, 2023

The First Disclosures sessions at the 2023 ACS Fall Meeting in San Francisco, organized by Nikki Goodwin , presented a variety of new orally available small molecules. The standing room-only sessions were so highly attended that many attendees were unfortunately kicked out due to the fire code. In case you missed any of these exciting molecules, from Scorpion’s mutant-selective PI3Kα inhibitor to Nurix’s CNS-penetrant BTK degrader, here we share the structures and targets of all the novel molecu

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Small Molecule Drugs 238

Drug Discovery World

AUGUST 18, 2023

The UK government has announced up to £210 ($267) million of funding to partner with countries across Asia and Africa to tackle antimicrobial resistance (AMR) and reduce the threat posed to the UK. The announcement follows the £39 ($48) million investment through the Global AMR Innovation Fund (GAMRIF) in May. The money is intended to pay for new laboratories, disease surveillance systems, and a bigger global workforce.

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Laboratories Government International Hospitals 236

Drugs.com

AUGUST 18, 2023

FRIDAY, Aug. 18, 2023 -- A new COVID variant with very few known cases but many mutations has been swiftly moved into the World Health Organization’s "variant under monitoring" classification. Four known cases of the variant, dubbed BA.2.86, have.

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Drug Discovery World

AUGUST 18, 2023

News round-up for 14-18 August by DDW Digital Content Editor Diana Spencer. My chosen news stories this week all discuss pre-clinical research studies that could have a huge impact on our therapeutic approach to several hard-to-treat diseases, helping to overcome drug-resistance and make treatments more targeted in the future. Next-generation antivirals could target virus membranes Researchers have shown that a group of novel molecules inspired by our own immune system inactivates viruses like Z

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Small Molecule Virus Drugs Clinical Research 130

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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BioPharma Drive: Drug Pricing

AUGUST 18, 2023

BSCA has kicked CVS Caremark, the largest pharmacy benefit manager in the country, to the curb and is electing to carve out various pharmacy functions with companies like Amazon instead.

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Pharmacy 98

Drug Discovery World

AUGUST 18, 2023

Thermo Fisher Scientific has completed its acquisition of CorEvitas, a provider of real-world evidence for approved medical treatments and therapies, for $912.5 million. Real-world evidence is a high growth market segment as pharmaceutical and biotechnology customers, as well as regulating bodies, are increasingly looking to monitor and evaluate the safety of approved therapies and examine their effectiveness and value in the post approval setting.

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Laboratories Clinical Research Therapies Regulations 130

Drug Discovery World

AUGUST 18, 2023

The US Food and Drug Administration (FDA) has granted accelerated approval to Pfizer’s Elrexfio (elranatamab-bcmm) for the treatment of adult patients with relapsed or refractory multiple myeloma (RRMM). The drug is approved in patients who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody.

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FDA Clinical Trials Trials Therapies 130

Drugs.com

AUGUST 18, 2023

FRIDAY, Aug. 18, 2023 -- Phillip Durst was working near an industrial dishwasher when something went awry, and the machinery spewed caustic chemicals into his eyes. “If I had been standing a foot left or right, it wouldn't have hit me right where.

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Drug Channels

AUGUST 18, 2023

Today’s guest post is from Divya Iyer, Vice President of Strategy & Business Development, Pharma Manufacturer Solutions, at GoodRx. Divya discusses the challenges patients face in accessing specialty therapies prescribed by their healthcare providers. She suggests how the pharma industry can leverage GoodRx to help patients with access and affordability.

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Treatment Therapies Drugs 98

Drugs.com

AUGUST 18, 2023

FRIDAY, Aug. 18, 2023 – The 15th century prince who inspired the literary vampire Dracula may have had medical issues that caused him to cry tears of blood, according to researchers unearthing this ancient mystery. The prince, who was also a.

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Research 98

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

SCIENMAG: Medicine & Health

AUGUST 18, 2023

Carbon capture and utilization (CCU) technologies are crucial for addressing climate change while ensuring economic viability. MES has emerged as a promising approach for CO2 reduction to biofuels and platform chemicals. However, the industrial adoption of MES has been hindered by low-value products like acetate or methane and high electric power demand.

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Production Science Engineering 97

Drugs.com

AUGUST 18, 2023

FRIDAY, Aug. 18, 2023 (American Heart Association News) -- Five days after giving birth to her second child, Lauren Lowrey woke up with a sharp pain in her upper back. She couldn't draw in a deep breath. The TV news anchor, who was living in.

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SCIENMAG: Medicine & Health

AUGUST 18, 2023

LA JOLLA, CA—According to new research in the journal Immunity, T cells have a nuclear receptor doing something very odd—but very important—to help them fight pathogens and destroy cancer cells.

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Research 93

Drugs.com

AUGUST 18, 2023

FRIDAY, Aug. 18, 2023 -- Damaged teeth could one day be repaired with “living fillings” created from stem cells, a new study reports. In the lab, researchers induced stem cells to form small, multicellular mini-organs that secrete the.

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Research 98

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

biobide

AUGUST 18, 2023

Cruelty-free cosmetics have emerged as a powerful statement within the beauty industry and Fast Moving Consumer Goods (FMCG), reflecting a growing consumer consciousness on the ethical treatment of animals. With an increased focus on animal welfare , the beauty industry has undergone a shift towards the 3Rs Principle application and all surrounding regulations.

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Regulations Animal Testing Production Treatment 92

Drugs.com

AUGUST 18, 2023

FRIDAY, Aug. 18, 2023 -- More than 1 out of every 10 patients who land in an ICU with a potentially deadly heart emergency test positive for recreational drug use, a new French study reports. About 11% of nearly 1,500 patients admitted to a French.

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Drugs 98

SCIENMAG: Medicine & Health

AUGUST 18, 2023

Medical students who reported a disability to their school increased by more than 25% during the COVID-19 pandemic, a study shows. The proportion of students reporting attention deficit hyperactivity disorder or chronic health and/or psychological disabilities has increased between 2015 and 2021.

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addgene Blog

AUGUST 18, 2023

Viruses are simple – a genome packaged in a protein shell (Taylor, 2014). They’re so simple that we can’t even decide if they’re alive or not. Yet these simple, small particles have quite the outsized impact – and not just on the disease front.

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Virus Packaging Disease 70

SCIENMAG: Medicine & Health

AUGUST 18, 2023

A new study highlights the potential of artificial DNA structures that, when fitted with antibodies, instruct the immune system to specifically target cancerous cells. Immunotherapy is viewed as an exceptionally promising weapon in the fight against cancer.

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DNA 91

Drugs.com

AUGUST 18, 2023

FRIDAY, Aug. 18, 2023 -- Teens’ desire to start smoking, and later to keep smoking, may be linked to differences in gray matter in their brains, a new study reveals. Researchers found that reduced gray matter in the left frontal lobe was found in.

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Research 75

SCIENMAG: Medicine & Health

AUGUST 18, 2023

AMES, Iowa – Midwest researchers want to take some of the greenhouse gas emissions out of crop fertilizer. Credit: Photo by Liang Dong/Iowa State University. AMES, Iowa – Midwest researchers want to take some of the greenhouse gas emissions out of crop fertilizer.

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Research Science 90

Science Daily: Pharmacology News

AUGUST 18, 2023

A new study has demonstrated that the atlatl (i.e. spear thrower) functions as an 'equalizer', a finding which supports women's potential active role as prehistoric hunters.

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SCIENMAG: Medicine & Health

AUGUST 18, 2023

AUBURN, AL – In July, as many enjoyed the hot weather at Alabama’s gulf coast beaches, in the Leach Science Center, Auburn University’s Department of Physics hosted an engaging scientific event.

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Science 88

Drugs.com

AUGUST 18, 2023

FRIDAY, Aug. 18, 2023 -- Heavy screen users often buy blue light-filtering eyeglasses to protect their eyes -- but they may be wasting their money, a new study suggests. A new research review suggests these blue light-filtering glasses probably make.

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Research 74

SCIENMAG: Medicine & Health

AUGUST 18, 2023

Oak Brook, IL – The August 2023 issue of SLAS Technology, the open access journal emphasizing scientific and technical advances across the life sciences, is now available. Volume 28, Issue 4, contains a review from the literature and eight full-length articles covering nanodiamonds, automated buffer exchange, epidermal growth factor (EGF) and other laboratory automation-related research.

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Science Laboratories Research Engineering 88

Science Daily: Pharmacology News

AUGUST 18, 2023

Novel stem cell therapy called a CALEC transplant was performed safely in four patients with serious chemical burns tracked in a phase I clinical trial for 12 months. The patients experienced early clinical gains: two were able to undergo a corneal transplant and two reported significant improvements in vision without additional treatment. CALEC procedure takes small amount of stem cells from healthy eye, grows and expands stem cells on a graft, before it is transplanted into the patient's damag

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Therapies Trials Clinical Trials Treatment 65

SCIENMAG: Medicine & Health

AUGUST 18, 2023

CHICAGO—August 18, 2023—A paper recently published in Nature Energy based on pioneering research done at Illinois Institute of Technology reveals a promising breakthrough in green energy: an electrolyzer device capable of converting carbon dioxide into propane in a manner that is both scalable and economically viable.

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Common Sense for Drug Policy Blog

AUGUST 18, 2023

Stimulants "Stimulants are a class of performance-enhancing substances some bodybuilders use to increase focus, alertness, and energy during their workouts. Some of the most commonly used stimulants in bodybuilding include amphetamines, caffeine, ephedrine, and clenbuterol. These substances are believed to enhance mental and physical performance, reduce fatigue, and improve endurance [ 25 ].

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SCIENMAG: Medicine & Health

AUGUST 18, 2023

The U.S. Department of Energy has awarded an LSU-led consortium a $4.9 million grant to support the first phase of the Pelican Gulf Coast Carbon Removal project. The Pelican Consortium, which includes Shell and the University of Houston, will evaluate the feasibility of building a direct air capture (DAC) hub in Louisiana.

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Agency IQ

AUGUST 18, 2023

A deep dive into MDR and IVDR implementation: Where we are and where we’re going Late last summer, AgencyIQ took a close look at how the European Commission had been meeting its goals in implementing the medical device and IVD regulations (MDR and IVDR, respectively). Today, we’re revisiting that deep dive to see what progress has been made since then.

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Regulations Science 52

SCIENMAG: Medicine & Health

AUGUST 18, 2023

Researchers at the National University of Singapore (NUS) have developed a novel aero-elastic pressure sensor, called ‘eAir’. This technology can be applied to minimally-invasive surgeries and implantable sensors by directly addressing the challenges associated with existing pressure sensors.

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Research 87

Agency IQ

AUGUST 18, 2023

FDA’s informed consent guidance gets a 21st century makeover The FDA has issued a new, final guidance on informed consent for clinical investigations – the first update since 1998. The new guidance offers recommendations for institutional review boards (IRBs), investigators and sponsors on key aspects of informed consent, significantly expanding FDA’s recommendations on several key topics, including reimbursement for research participation.

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FDA Clinical Trials Clinical Research Regulations 52

SCIENMAG: Medicine & Health

AUGUST 18, 2023

FINDINGS Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have identified how low levels of the TET2 gene fuel the rapid growth of acute myeloid leukemia in animal models. Cell Stem Cell recently published the study.

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Agency IQ

AUGUST 18, 2023

EPA labs lack proper inspections, watchdog says The Environmental Protection Agency’s Office of Inspector General has published a new report finding that the agency has consistently failed to verify whether agency laboratories comply with hazardous waste requirements. The OIG and hazardous waste The Environmental Protection Agency’s (EPA) Office of Inspector General (OIG) is the agency’s independent investigation group.

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