Broad Institute
NOVEMBER 23, 2023
Search algorithm reveals nearly 200 new kinds of CRISPR systems By Allessandra DiCorato November 23, 2023 Breadcrumb Home Search algorithm reveals nearly 200 new kinds of CRISPR systems By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.
Chemical Biology and Drug Design
NOVEMBER 23, 2023
Dopaminergic pathways influence positive and negative symptoms. Upregulation of the D1 receptor in the striatal region results in positive signs, while downregulation of the D2 receptor in PFC results in negative symptoms. Abstract Schizophrenia is a severe psychological disorder in which reality is interpreted abnormally by the patient. The symptoms of the disease include delusions and hallucinations, associated with extremely disordered behavior and thinking, which may affect the daily lives o
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Drug Target Review
NOVEMBER 23, 2023
How does the structure of the neuropeptide network in C. elegans differ from wired connectomes in more complex organisms? One important difference is that the neuropeptide network is much more decentralised than wired connectomes, both in worms and bigger brains. In wired connectomes there tend to be a small number of hubs that have many more connections than the average neuron, and these play a big role in organising and coordinating the rest of the network.
Science Daily: Pharmacology News
NOVEMBER 23, 2023
For 200 years, scientists have failed to grow a common mineral in the laboratory under the conditions believed to have formed it naturally. Now, researchers have finally pulled it off, thanks to a new theory developed from atomic simulations. Their success resolves a long-standing geology mystery called the 'Dolomite Problem.' Dolomite -- a key mineral in the Dolomite mountains in Italy, Niagara Falls, the White Cliffs of Dover and Utah's Hoodoos -- is very abundant in rocks older than 100 milli
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The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drugs.com
NOVEMBER 23, 2023
THURSDAY, Nov. 23, 2023 (Healthday News) -- Thanksgiving marks the start of the holiday eating season, when everyone is constantly tempted by sweet treats, rich foods and fancy, high-calorie drinks.But before diving into decadent eating, consider.
Science Daily: Pharmacology News
NOVEMBER 23, 2023
Exposure to fine particulate air pollutants from coal-fired power plants (coal PM2.5) is associated with a risk of mortality more than double that of exposure to PM2.5 from other sources, according to a new study. Examining Medicare and emissions data in the U.S. from 1999 to 2020, the researchers also found that 460,000 deaths were attributable to coal PM2.5 during the study period -- most of them occurring between 1999 and 2007, when coal PM2.5 levels were highest.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
NOVEMBER 23, 2023
In 1991, an experiment detected the highest-energy cosmic ray ever observed. Later dubbed the Oh-My-God particle, the cosmic ray’s energy shocked astrophysicists. Nothing in our galaxy had the power to produce it, and the particle had more energy than was theoretically possible for cosmic rays traveling to Earth from other galaxies. Simply put, the particle should not exist.
Drugs.com
NOVEMBER 23, 2023
THURSDAY, Nov. 23, 2023 -- It’s common to find yourself stuffed at some point during Thanksgiving Day festivities, but experts say staying active can help you burn some calories and feel a little less sluggish after the big meal.Kicking off.
Science Daily: Pharmacology News
NOVEMBER 23, 2023
Experiments have provided the first direct evidence that electricity seems to flow through 'strange metals' in an unusual liquid-like form.
National Drug & Alcohol Research Centre Blog
NOVEMBER 23, 2023
Ms Daisy Gibbs, Evaluation Officer, Burnet Institute; A/Prof Caitlin Hughes, Associate Professor in Criminology and Drug Policy, Centre for Crime Policy and Research, Flinders University; Dr Rachel Sutherland, Senior Research Fellow, NDARC How long have drug detection dogs been used, why were they introduced, and how common are they? Drug detection dogs are a street-level policing strategy that has been used in Australia for over 25 years.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Perficient: Drug Development
NOVEMBER 23, 2023
Challenge: In Sitecore 10.2 with SXA, enhance the Sitemap with the following: Limit Sitemap content size to 50MB (uncompressed) and URL count to 50,000. If the limit is exceeded, split into multiple Sitemaps and reference them in a Sitemap Index. If you are on Sitecore 10.3, regarding this enhancement, check out the post – Split SXA Sitemap into Multiple Sitemaps if the Size Limit is Exceeded.
Zobio
NOVEMBER 23, 2023
Recent years have seen a surge of interest in the use of covalent compounds in small molecule drug discovery. Much of this interest has been driven by the success of covalent compounds for “undruggable” targets such as kRAS. While it is relatively easy to buy or build a library of cysteine reactive compounds and screen them using mass spectrometry (MS), does this really provide all the information to decide whether a “hit” is a good starting point for a drug discovery campaign?
Perficient: Drug Development
NOVEMBER 23, 2023
What are Props? In Vue.js, “props” are like messengers that help share information from a parent component to its children. They allow different parts of your web app to talk to each other by passing along essential data. Declaring Props Props are defined using the props option: Let’s Explore an Example to Grasp How Props Work. Child Component: The ChildComponent’s template sets the visual structure using HTML, displaying an h2 with “Child Component” and an h6 to sh
Broad Institute
NOVEMBER 23, 2023
A new method for prenatal genetic testing relies on just a blood draw By Tom Ulrich November 23, 2023 Breadcrumb Home A new method for prenatal genetic testing relies on just a blood draw Non-invasive method has the potential to survey the entire fetal exome without the need for amniocentesis By Mass General Brigham Communications November 23, 2023 Related people Michael Talkowski Related programs Center for Mendelian Genomics Program in Medical and Population Genetics A team of investigators
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Perficient: Drug Development
NOVEMBER 23, 2023
What’s this ref in Vue.js? The ref attribute is like giving a name to an HTML element or a part of your Vue template. This name lets you directly interact with and tweak these elements or components using JavaScript. A Practical Example Let’s make things crystal clear by diving into a simple example. Imagine you have a button that, when clicked, changes the text in a paragraph.
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