Mon.Apr 07, 2025

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What if we find nothing in our search for life beyond Earth?

Science Daily: Pharmacology News

What if we spend decades building advanced telescopes to search for life on other planets and come up emptyhanded? A recent study exploring what we can learn about life in the universe -- even if we don't detect signs of life or habitability. Using advanced statistical modeling, the research team sought to explore how many exoplanets scientists should observe and understand before declaring that life beyond Earth is either common or rare.

Research 209
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RFK Jr. won’t appear before Senate panel this week

BioPharma Drive: Drug Pricing

HELP committee chair Bill Cassidy, R-La., had invited Kennedy to testify April 10 on the sweeping layoffs of federal health workers Kennedy ordered last month. A hearing could still take place later.

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Chatbot opens computational chemistry to nonexperts

Science Daily: Pharmacology News

A web platform uses a chatbot to enable any chemist -- including undergraduate chemistry majors -- to configure and execute complex quantum mechanical simulations through chatting.

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Health Secretary Says Some Cuts to CDC Will Be Reversed

Drugs.com

MONDAY, April 7, 2025 -- Some recent cuts at U.S. government health agencies may be reversed, including a key program that tracks lead exposure in children, U.S. Health and Human Services Secretary Robert F. Kennedy Jr. said last week.The lead.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Researchers demonstrate the UK's first long-distance ultra-secure communication over a quantum network

Science Daily: Pharmacology News

Researchers have successfully demonstrated the UK's first long-distance ultra-secure transfer of data over a quantum communications network, including the UK's first long-distance quantum-secured video call.

Research 300

More Trending

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The new season of The Last of Us has a spore-ting chance at realism

Science Daily: Pharmacology News

The Last of Us is back on April 13 and this season is more realistic than ever. The trailer for the hit HBO series appears to show the 'zombie fungus' cordyceps infecting humans by releasing air-borne spores, instead of through tentacles -- closer to scientific reality. And it's not the only thing the show gets right.

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The rising impact of biomarkers in early clinical development

Drug Target Review

As our understanding of the underlying biology of disease grows more sophisticated, emerging therapies operate on increasingly complex biopathological systems and mechanisms. Advanced strategies and tools are being implemented to establish the safety and efficacy of new therapeutic modalities, with the development of new biomarkers becoming one of the most relevant approaches for enhancing the precision and utility of early-stage studies.

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Saturn's moon Titan could harbor life, but only a tiny amount, study finds

Science Daily: Pharmacology News

Despite its uniquely rich inventory of organic molecules, Saturn's largest moon, Titan, may be able to support only a minuscule amount of biomass, if life exists on the moon, according to a study using bioenergetic modeling.

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Tango Therapeutics cuts nearly one-fifth of staff

BioPharma Drive: Drug Pricing

“We, like so many others, have been forced to take steps to extend our cash runway,” said Tango’s CEO, citing the “extremely challenging financial markets.

Marketing 184
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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The lush past of the world's largest desert

Science Daily: Pharmacology News

The vast desert of the Arabian Peninsula was not always an arid landscape. A recent study reveals that this region was once home to a vast lake and river system. These favorable conditions fostered grasslands and savannahs, enabling human migration -- until drought returned, forcing populations to move. This research highlights the impact of climate cycles on landscapes and human societies.

Research 201
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Some Folks Hit With Fees for Using Health Care Message Portals

Drugs.com

MONDAY, April 7, 2025 -- Dont be surprised if you get a bill for that note your doctor sent you through his clinics patient portal.About 1 in 7 patients have been billed for messages sent to them through a patient portal, according to a new study.

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Rare crystal shape found to increase the strength of 3D-printed metal

Science Daily: Pharmacology News

Researchers have found special atomic patterns called quasicrystals in 3D-printed aluminum alloys. Quasicrystals increase the strength of 3D-printed aluminum, the researchers discovered, making it possible to use in lightweight, high-strength objects such as airplane parts. Once thought impossible, quasicrystals led to a 2011 Nobel Prize in Chemistry.

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GSK targets neurodegenerative diseases with latest licensing deal

BioPharma Drive: Drug Pricing

The pharma giant is wagering potentially billions of dollars on technology from ABL Bio that’s designed to get drugs across the blood-brain barrier.

Licensing 167
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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CDC Cuts Key Smoking Programs Despite Success in Curbing Smoking Rates

Drugs.com

MONDAY, April 7, 2025 -- The U.S. government has shut down or paused several major anti-smoking efforts.Public health leaders say the cuts could reverse decades of progress that have smoking rates in the country at all-time lows.Last week, the.

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Obesity drug data helps Rhythm defy market slide

BioPharma Drive: Drug Pricing

Study results in a rare form of obesity could help the company expand use of Imcivree, which is approved for two genetically driven forms of excess weight.

Marketing 144
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Avoiding Metadata Contention in Unity Catalog

Perficient: Drug Development

Metadata contention in Unity Catalog can occur in high-throughput Databricks environments, slowing down user queries and impacting performance across the platform. Our Finops strategy shifts left on performance. However, we have found scenarios where clients are still experiencing query slowdowns intermittently and even on optimized queries. As our client’s lakehouse footprint grows, we are seeing an emerging pattern where stress on Unity Catalog can have a downstream drag on performance a

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A predictive model for thiol reactivity of N-heteroaryl α-methylene–γ-lactams—a medicinally relevant covalent reactive group

Covalent Modifiers

Meehan, M.; Scofield, G.; Stahl, C.; Wolfe, J.; Horne, W. S.; Liu, P.; Brummond, K. ChemRxiv 2025. [link] Herein, we present a systematic study on the effects of electronically diverse heteroarenes on the rate of glutathione (GSH) addition to novel N-heteroaryl methylene-lactam covalent reactive groups (CRGs). Despite their unique electronic and drug-like properties, heteroarenes have not been extensively studied as handles for systematically tuning the reactivity of CRGs.

Drugs 133
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Advancements in hit identification for membrane protein drug discovery

Drug Target Review

The challenge of GPCR drug discovery G protein-coupled receptors (GPCRs) are one of the most desirable and challenging target classes in drug discovery, as their mutation can lead to a wide range of diseases such as cancer, cardiovascular disorders and neurological conditions. GPCRs are a large family of cell surface receptors that play a key role in transmitting signals from the outside of a cell to its interior.

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Ozone Pollution Increases Risk Of Childhood Asthma

Drugs.com

MONDAY, April 7, 2025 -- Ozone air pollution increases the risk of asthma among preschoolers and kindergarteners, a new study says.Relatively small increases in ozone smog in a childs first two years of life is associated with an increased risk of.

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ACI’s 23rd Advanced Summit on Life Sciences Patents

FDA Law Blog: Biosimilars

Come together with leaders from the pharmaceutical, biotechnology, and diagnostic industries to unpack huge changes at the American Conference Institutes 23rd Advanced Summit on Life Sciences Patents , which is scheduled to take place from May 19-20, 2025 at the New York Bar Association in New York, NY. In a year of major change and outstanding questions, growing scrutiny on patent protection and drug pricing, and uncertainty around global price control measures and the Inflation Reduction Act,

Science 59
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Wildfire Smoke Increases Risk Of Mental Health Problems

Drugs.com

MONDAY, April 7, 2025 -- Smoke from wildfires driving you mad?Youre not alone, a new study says.Short-term exposure to air choked with wildfire smoke increases peoples risk of mental health problems, according to findings published April 4 in JAM.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Why speed and clinical accuracy of information and data is critical for physicians

Fierce BioTech

Why speed and clinical accuracy of information and data is critical for physicians Learn how speed and accuracy of clinical information is transforming healthcare delivery and how your brand can become part of these high-value clinical conversations at the point of decision-making. Download now. sdees Mon, 04/07/2025 - 10:57 Learn how speed and accuracy of clinical information is transforming healthcare delivery and how your brand can become part of these high-value clinical conversations at the

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Most Eligible Smokers Not Getting Lung Cancer Screening

Drugs.com

MONDAY, April 7, 2025 -- Lung cancer screening can save the lives of former and current smokers, but most arent taking advantage of it, a new study says.Fewer than 1 in 5 people eligible for lung cancer screening go through with a chest CT scan, a.

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Isoxazole and Pyrazole Derivatives of 28‐Oxo‐Allobetulone Target Viral Membrane Glycoprotein Hemagglutinin

Chemical Biology and Drug Design

The [2,3]-isoxazole 4 and [2,3]-pyrazole 5 of 28-oxo-allobetulone exhibited high inhibitory activity against the Flu A/Puerto Rico/8/34 (H1N1) virus, with hemagglutinin HA IC 50 values of 7.3M (SI 86) and 62.1M (SI 10), respectively, acting primarily at the early stages of the viral cycle. Molecular docking revealed their binding near the HA1-HA2 interface of hemagglutinin, preventing virion binding to cell receptors.

Virus 100
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ELRIG Appoints Dr Del Trezise as Chair

Elrig

ELRIG Appoints Dr Del Trezise as Chair ELRIG Appoints Dr Del Trezise as Chair New leadership to drive continued growth and collaboration in drug discovery Cambridge, UK, 08 April 2025: ELRIG, a not-for-profit, volunteer-led organisation dedicated to the drug discovery community, has appointed Dr Del Trezise as Chair of the Board. In this role, he will lead ELRIGs mission to foster collaboration, innovation, and knowledge-sharing through scientific conferences, networking events, webinars, and di

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Researchers use AI to improve diagnosis of drug-resistant infections

Science Daily: Pharmacology News

Scientists have developed an artificial intelligence-based method to more accurately detect antibiotic resistance in deadly bacteria such as tuberculosis and staph. The breakthrough could lead to faster and more effective treatments and help mitigate the rise of drug-resistant infections, a growing global health crisis.

Research 201
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Antibody Drug Conjugates

Sygnature Discovery

Introducing a novel payload -focused approach to next generation ADC development NewPath ADC offers integrated solutions for antibody drug conjugates, designed by highly skilled multidisciplinary teams covering medicinal chemistry and protein sciences, as well as in vitro and in vivo assessment (including DMPK). While other providers focus on a conventional, well-trodden development pathway, Sygnature Discovery’s ADC solutions prioritize payload optimization to enhance a drugs efficacy a

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Heart-Related Deaths More Likely During Day/Night Heatwaves

Drugs.com

MONDAY, April 7, 2025 -- More people die from heart problems during heatwaves where high temperatures stretch through both the day and night, a new study says.Heatwaves that offer no relief at night -- known as compound heatwaves -- are much more.

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Every Claim You Make, Every Step You Take…CVM Will Be Watching You

FDA Law Blog: Biosimilars

By Sara W. Koblitz & Dara Katcher Levy Promotional claims do not receive the most attention with respect to FDA enforcement these days, and veterinary promotion is no exception. Indeed, most Center for Veterinary Medicine (CVM) Warning Letters arise because products advertised are actually new animal drugs. But this year, CVM has issued two notable warning letters and one Untitled Letter concerning the promotion of animal drugs that caught our attention because of the level of detail and sp

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