Thu.Apr 25, 2024

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With hybrid brains, these mice smell like a rat

Science Daily: Pharmacology News

Mice lacking an olfactory system have had their sense of smell restored with neurons from rats, the first time scientists have successfully integrated the sensory apparatus of one species into another.

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A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic

Broad Institute

A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic By Allessandra DiCorato April 25, 2024 Breadcrumb Home A new viral surveillance system in West Africa is showing the world how to prevent the next pandemic Scientists from the US and West Africa have teamed up to build a better public health network that can quickly detect and respond to emerging viral threats.

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Bristol Myers to cut 6% of workforce, trim drug pipeline

BioPharma Drive: Drug Pricing

The layoffs will impact some 2,200 employees, the company said, as it repositions its business ahead of looming patent expirations for top-selling products.

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5 Thoughts on SUGCON Europe 2024 in Dublin, Ireland

Perficient: Drug Development

SUGCON (Sitecore User Group Conference) Europe 2024 was the second SUGCON I’ve attended, with the first just being six months ago in Minneapolis. There are few things that remind me how much I love my job more than being surrounded by the Sitecore Community. I’ve developed real friendships with folks from literally every corner of the world and it’s only once or twice a year we get the whole “Sitecore Family” together.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Regeneron expands in gene editing with Mammoth deal

BioPharma Drive: Drug Pricing

“With each passing year, we're more committed to becoming a serious player in the genetic medicine space,” a Regeneron executive said.

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Food in sight? The liver is ready!

Science Daily: Pharmacology News

What happens in the body when we are hungry and see and smell food? A team of researchers has now been able to show in mice that adaptations in the liver mitochondria take place after only a few minutes. Stimulated by the activation of a group of nerve cells in the brain, the mitochondria of the liver cells change and prepare the liver for the adaptation of the sugar metabolism.

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How do birds flock? Researchers do the math to reveal previously unknown aerodynamic phenomenon

Science Daily: Pharmacology News

How do birds fly in a coordinated and seemingly effortless fashion? Part of the answer lies in precise, and previously unknown, aerodynamic interactions, reports a team of mathematicians. Its breakthrough broadens our understanding of wildlife, including fish, who move in schools, and could have applications in transportation and energy.

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Could Heartburn Meds Raise Your Migraine Risk?

Drugs.com

THURSDAY, April 24, 2024 -- People taking heartburn meds have a higher risk of migraines and other types of severe headaches, a new study warns.All classes of acid-reducing drugs -- proton pump inhibitors, H2 blockers, and even antacids -- appear.

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BioMarin drops drug programs in pipeline cull

BioPharma Drive: Drug Pricing

The cuts of four pipeline prospects come as BioMarin resets its priorities following the slow launch of its hemophilia gene therapy Roctavian.

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Watchdog Group Says U.S. Food Recalls Rose Again Last Year

Drugs.com

THURSDAY, April 25, 2024 -- U.S. recalls of foods for salmonella, foreign objects or undeclared allergens are rampant nowadays and the highest they've been since 2020, a watchdog group warns.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Summer’s Superhero Story

KIF1A

“We love her just as she is and could never imagine not having her with us. She completes our family in a quirky kind of way. We won’t ever stop fighting to get her well. I believe in miracles, and she is one.” A message from Summer’s family: Summer was diagnosed with the kif1a gene (de novo) when she was just 2 years and 10 months old.

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FDA Approves New Antibiotic Against UTIs, Pivya (pivmecillinam)

Drugs.com

THURSDAY, April 25, 2024 -- As many patients already know, urinary tract infections (UTIs) can recur despite the use of antibiotics. So, it's welcome news that the U.S. Food and Drug Administration on Wednesday approved Pivya (pivmecillinam) to.

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Climate change could become the main driver of biodiversity decline by mid-century

Science Daily: Pharmacology News

Global biodiversity has declined between 2% and 11% during the 20th century due to land-use change alone, according to a large multi-model study. Projections show climate change could become the main driver of biodiversity decline by the mid-21st century.

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TikTok Riddled With Misleading Info on Health: Study

Drugs.com

THURSDAY, April 25, 2024 -- Young people researching health topics on TikTok will find an alarming amount of misinformation on the platform, a new study says.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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2024 NIOSH Science and Service Awards

NIOSH Science Blog: Drugs

Exemplary science is the foundation for all National Institute for Occupational Safety and Health (NIOSH) research and prevention activities. Each year, NIOSH recognizes outstanding science and service from our employees. This year’s Science and Service Awards took place on April 25, 2024. The awards booklet contains the finalists, awardees, and honorable mentions as well as information on the occupational safety and health pioneers whom many of the awards are named after.

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U.S. Births Declined in 2023, Marking End to Post-Pandemic Rise

Drugs.com

THURSDAY, April 25, 2024 -- The short post-pandemic uptick in U.S. births may be over, with 2023 numbers showing a decline in births.According to provisional data from the U.S. Centers for Disease Control and Prevention, just under 3.6 million.

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Embracing Serendipity: A Crucial Element in the PhD Journey

addgene Blog

In the pursuit of knowledge and groundbreaking discoveries, the world of academia often emphasizes structured methodologies and rigorous research plans. However, amidst the organized chaos of lab research and PhD studies, there lies a hidden gem that has the potential to redefine the course of one's research journey — serendipity. The best scientific breakthroughs often occur when the unexpected infiltrates the realm of focused exploration.

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Breast Cancer Survivors Face Higher Odds for Second Cancer

Drugs.com

THURSDAY, April 25, 2024 -- People lucky enough to survive a breast cancer may still face heightened risks for other cancers later, a new study shows.The researchers stressed that the absolute risk of a secondary cancer to any one survivor is still.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Revolutionizing Pharma: The Strategic Guide to AI Deployment

DrugBank

As the pharmaceutical industry is pushing to deliver new and better drugs while racing against time and budget constraints, it is becoming crucial to not just use artificial intelligence (AI) but truly maximize its potential. Currently, it is projected that AI could add between $60 billion and $110 billion in value each year to the pharmaceutical industry.

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FDA Approves New Antibiotic Against UTIs

Drugs.com

THURSDAY, April 25, 2024 -- As many patients already know, urinary tract infections (UTIs) can recur despite the use of antibiotics.So, it's welcome news that the U.S. Food and Drug Administration on Wednesday approved Pivya (pivmecillinam) to.

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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase

Covalent Modifiers

Kristen A. Baltgalvis, Kelsey N. Lamb, Kent T. Symons, Chu-Chiao Wu, Melissa A. Hoffman, Aaron N. Snead, Xiaodan Song, Thomas Glaza, Shota Kikuchi, Jason C. Green, Donald C. Rogness, Betty Lam, Maria E. Rodriguez-Aguirre, David R. Woody, Christie L. Eissler, Socorro Rodiles, Seth M. Negron, Steffen M. Bernard, Eileen Tran, Jonathan Pollock, Ali Tabatabaei, Victor Contreras, Heather N.

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Dairy Cows Moved Across State Lines Must Now Be Tested for Bird Flu

Drugs.com

THURSDAY, April 25, 2024 -- As bird flu continues to spread among dairy cows in the United States, the U.S. Department of Agriculture said Wednesday it will start requiring testing of the animals if they are moved across state lines. The "USDA has.

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Uncovering the genetic and cellular impacts of smoking

Drug Target Review

Researchers from the University of Chicago have analysed over 900 samples of different human tissue types to investigate the extent of cellular and genetic damage caused by smoking. Generating epigenetic data to assess the effects of smoking on DNA methylation (DNAm) discovered several new regions associated with smoking. Typically, epidemiological studies on the effects of exposure to environmental contaminants like smoke often use blood samples only, as they are easy to collect.

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Opioids During Pregnancy May Not Raise Psychiatric Risks for Offspring

Drugs.com

THURSDAY, April 24, 2024 -- Prescription opioids taken during pregnancy are not associated with a substantial increase in risk of developmental disorders like ADHD in children, a new study has found.“A slightly increased risk of neuropsychiatric.

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AstraZeneca’s earnings surprise investors as cancer drugs fuel growth

BioPharma Drive: Drug Pricing

The British drugmaker has bolstered its business with nearly $5 billion in acquisitions as attention turns to its pipeline of experimental medicines.

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Emulsifier Chemicals Are Everywhere in Foods. Could They Raise Diabetes Risk?

Drugs.com

THURSDAY, April 24, 2024 -- Emulsifiers -- substances that are essential ingredients in processed foods -- appear to increase people’s risk of type 2 diabetes, a new study finds.

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A Holistic Approach to Measuring Impact

H1 Blog

Medical Affairs Strategies that Demonstrate and Improve Impact Medical Affairs plays an essential role in evidence-based medicine, disease education, and driving better outcomes. Their knowledge is crucial as medications become more specialized and complex. They enable healthcare professional (HCP) education, which supports closing clinical care gaps.

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Drug, Alcohol Abuse Goes Untreated in Many Ex-Prisoners

Drugs.com

THURSDAY, April 25, 2024 -- Most ex-cons are unlikely to receive substance use treatment following their release from prison, even though odds are high they are struggling with addiction, a new study finds.National estimates suggest as many as 85%.

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Supply Chain Logistics in Pharma: Navigating Complexities for Optimal Delivery

DS in Pharmatics

The strength of the pharmaceutical industry relies on the high-quality production of medical products. All areas of the production process are important, from the beginning, when the key components and materials of medications are uncovered, to when they come together as a product and are sent to the patient.

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FDA’s Revised Draft Guidance on Biological Product Promotion Provides Additional Recommendations/Clarifications

FDA Law Blog: Biosimilars

By Sarah Wicks & Dara Katcher Levy — On April 24, 2024, the FDA issued a revised draft guidance, Promotional Labeling and Advertising Considerations for Prescription Biological Reference Products, Biosimilar Products, and Interchangeable Biosimilar Products – Questions and Answers , (the “Revised Draft Guidance”) which replaces the Agency’s initial draft guidance issued in February 2020 (the “Initial Draft Guidance”).

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New patent expiration for Aveo Pharms drug FOTIVDA

Drug Patent Watch

Annual Drug Patent Expirations for FOTIVDA Fotivda is a drug marketed by Aveo Pharms and is included in one NDA. It is available from one supplier.

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Structural Variation in Human Genomes

Broad Institute

Structural Variation in Human Genomes By Rose Circeo April 25, 2024 Breadcrumb Home Structural Variation in Human Genomes The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tutorials on tools for biostatistics, comput

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New patent for Springworks drug OGSIVEO

Drug Patent Watch

Annual Drug Patent Expirations for OGSIVEO Ogsiveo is a drug marketed by Springworks and is included in one NDA. It is available from one supplier.

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