Drug Discovery World
OCTOBER 2, 2024
The Cystic Fibrosis Antimicrobial Resistance (CF AMR) Syndicate has announced the first cohort of drug discovery projects to receive its Collaborative Discovery Programme (CDP) funding. The £3 ($3.9) million programme, funded by LifeArc, will support six early-stage novel antimicrobial projects over two years to accelerate new treatments for lung infections in people with CF.
Drug Discovery Today
OCTOBER 2, 2024
Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer’s disease, and improve symptoms of neurodegeneration in mice.
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Drug Discovery World
OCTOBER 2, 2024
Three drugs have been granted ‘rare paediatric disease designation’ (RPDD) in the US by the Food and Drug Administration (FDA). The FDA grants RPDD for serious or life-threatening diseases that affect fewer than 200,000 people in the United States and primarily affect patients less than 18 years of age. ETD001 ETD001 is a novel, first in class blocker of the epithelial sodium channel (ENaC) aimed at treating people with cystic fibrosis (pwCF) without current effective therapies.
Science Daily: Pharmacology News
OCTOBER 2, 2024
U.S. tropical cyclones, including hurricanes, indirectly cause thousands of deaths for nearly 15 years after a storm. Researchers estimate an average U.S. tropical cyclone indirectly causes 7,000 to 11,000 excess deaths. All told, they estimate tropical storms since 1930 have contributed to between 3.6 million and 5.2 million deaths in the U.S. -- more than all deaths nationwide from motor vehicle accidents, infectious diseases, or battle deaths in wars during the same period.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
OCTOBER 2, 2024
This advertorial appeared in DDW Volume 25 – Issue 4, Fall 2024 Read the digital issue Earlier this year, DDW hosted a webinar, ‘From patient to petri dish: Replicating disease with patient-derived organoids’, supported by HUB Organoids. The event explored how patient-derived organoids are revolutionising drug discovery by overcoming the limitations of traditional preclinical models.
Science Daily: Pharmacology News
OCTOBER 2, 2024
Scientists have made an enormous step toward understanding the human brain by building a neuron-by-neuron and synapse-by-synapse roadmap -- scientifically speaking, a 'connectome' -- through the brain of an adult fruit fly (Drosophila melanogaster). Previous researchers have mapped the brain of a C. elegans worm, with its 302 neurons, and the brain of a larval fruit fly, which had 3,000 neurons, but the adult fruit fly is several orders of magnitude more complex, with almost 140,000 neurons and
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
OCTOBER 2, 2024
Ever wish you could stop that fruit fly on your kitchen counter in its tracks? Scientists have created flies that halt under red light. In doing so, they discovered the precise neural mechanisms involved in stopping. Their findings, published this week in Nature, have implications far beyond controlling fly behavior. They demonstrate how the brain engages different neural mechanisms depending on environmental context.
Drugs.com
OCTOBER 2, 2024
WEDNESDAY, Oct. 2, 2024 -- Scientists say they've discovered a protein that seems crucial to the onset of age-related macular degeneration (AMD), a common cause of blindness in older people.The research is in its very early stages, but it might.
Science Daily: Pharmacology News
OCTOBER 2, 2024
Inside every cell, inside every nucleus, your continued existence depends on an incredibly complicated dance. Proteins are constantly wrapping and unwrapping DNA, and even minor missteps can lead to cancer. A new study reveals a previously unknown part of this dance -- one with significant implications for human health.
Drugs.com
OCTOBER 2, 2024
WEDNESDAY, Oct. 2, 2024 -- Want to keep a stroke a bay? Drink water, nothing fizzy and skip fruit drinks.That's the key takeaway from a global review that also raises a red flag for people who drink more than four cups of coffee a day."While [high.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Science Daily: Pharmacology News
OCTOBER 2, 2024
A new study showed that reducing daily sitting prevented back pain from worsening over six months. The result strengthens the current understanding of the link between activity and back pain as well as the mechanisms related to back pain.
Drugs.com
OCTOBER 2, 2024
WEDNESDAY, Oct. 2, 2024 -- In a finding that illustrates the damage that laws targeting transgender people can cause, new research shows that trans and nonbinary youth in states with such laws are more likely to attempt suicide.How much more.
Science Daily: Pharmacology News
OCTOBER 2, 2024
Plants widen microscopic pores on their leaves in response to heat. But scientists lacked an understanding of the mechanisms behind this 'sweating' function. Now, biologists have unlocked the details behind these processes and identified two paths that plants use to handle rising temperatures.
Drugs.com
OCTOBER 2, 2024
WEDNESDAY, Oct. 2, 2024 -- Most Americans are eating their way to inflammation that puts them at risk of cancer, heart disease and other serious health problems, a new study shows."Overall, 57% of U.S. adults have a pro-inflammatory diet and that.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
OCTOBER 2, 2024
Professional and amateur astronomers teamed up with artificial intelligence to find an unmatched stellar trio called TIC 290061484, thanks to cosmic 'strobe lights' captured by NASA's TESS (Transiting Exoplanet Survey Satellite).
Nvidia Developer: Drug Discovery
OCTOBER 2, 2024
A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. Called TxGNN, this zero-shot tool helps doctors find new uses for existing drugs for conditions that might otherwise go untreated.
Science Daily: Pharmacology News
OCTOBER 2, 2024
'Future You' is a generative AI tool that enables users to have a simulated conversation with a potential version of their future selves. The chatbot is meant to reduce users' anxiety, improve positive emotions, and guide them toward making better everyday choices.
Drugs.com
OCTOBER 2, 2024
WEDNESDAY, Oct. 2, 2024 -- Patients who lose the use of their hands and arms after a stroke or traumatic brain injury could regain some function through deep brain stimulation (DBS), new research demonstrates.DBS involves surgical placement of.
Science Daily: Pharmacology News
OCTOBER 2, 2024
Dolphins are extremely playful, but little is known about how they -- and other marine mammals -- communicate during playtime. New research shows that bottlenose dolphins (Tursiops truncates) use the 'open mouth' facial expression -- analogous to a smile -- to communicate during social play. The dolphins almost always use the facial expression when they are in their playmate's field of view, and when playmates perceived a 'smile,' they responded in kind 33% of the time.
Drugs.com
OCTOBER 2, 2024
WEDNESDAY, Oct. 2, 2024 -- As the southeastern United States begins to recover from Helene's devastation, a new study suggests the health impact of major storms can linger for over a decade.So far, more than 120 people across six states have.
Science Daily: Pharmacology News
OCTOBER 2, 2024
Researchers have known for several decades that thunderstorms can act as miniature particle accelerators that produce antimatter, gamma rays and other nuclear phenomena. But they did not know how common the phenomenon was. In observations taken by a retrofitted U2 spy plane, they've discovered essentially all large thunderstorms produce gamma rays in many dynamic, unexpected and unknown ways.
Drugs.com
OCTOBER 2, 2024
WEDNESDAY, Oct. 2, 2024 -- One in 14 hospital patients may be the victim of damaging diagnostic mistakes, new research suggests.The finding is from a study of 675 patients admitted to one large hospital in Boston at various periods between July.
BioPharma Drive: Drug Pricing
OCTOBER 2, 2024
The biotech, which has now raised more than $200 million since launch, is advancing an eczema treatment that could start human trials next year.
Science Daily: Pharmacology News
OCTOBER 2, 2024
Scientists have developed a new method to simulate the complex movements of animals with exceptional accuracy. The research team set out to solve a long-standing challenge in biology -- how to accurately model the intricate and seemingly unpredictable movements of living organisms. They focused on the nematode worm Caenorhabditis elegans, a model organism widely used in biological research.
Drug Patent Watch
OCTOBER 2, 2024
As an outsider, finding out the manufacturing capacity of a given pharmaceutical manufacturing plant can be challenging due to the proprietary nature of such information. However, you can employ several strategies to gather relevant data: Example: Pfizer’s 2022 Annual Report states, “Our manufacturing facilities are located in 39 countries across 6 continents.
BioPharma Drive: Drug Pricing
OCTOBER 2, 2024
The company will permit six generic drugmakers to make and sell lenacapavir in 120 countries that have high incidence of the disease but limited resources.
Science Daily: Pharmacology News
OCTOBER 2, 2024
A new study challenges the hypothesis that 'puppy dog eyes' evolved exclusively in dogs as a result of domestication.
BioPharma Drive: Drug Pricing
OCTOBER 2, 2024
It’s the first time, according to the insurer, that this type of model has been used to bring a Humira biosimilar to market, and it yields a much lower cost than both the brand-name version of the drug and biologic copycats.
Perficient: Drug Development
OCTOBER 2, 2024
Spurred by recent AI advances and improvements made during the global pandemic, accessibility has become an integral component to an increasingly digital-first world. Ensuring that technology is accessible for everyone should be a high priority for all digital properties. Providing an outstanding experience for both customers and employees is crucial for business success, and directly meeting these needs opens opportunities for organizations to reach new markets and up to two billion people with
Drugs.com
OCTOBER 2, 2024
WEDNESDAY, Oct. 2, 2024 -- The head of a Princeton team that mapped the brain of an adult fruit fly -- a watershed step in understanding the human brain -- explains the feat in a way that belies its complexity."Just like you wouldn't want to drive.
PPD
OCTOBER 2, 2024
Efficient and effective clinical operations are the backbone of successful clinical trials, and today’s biopharmaceutical, biotech and medical device organizations have a range of options to meet their needs in this critical area. A recent white paper from the PPD™ clinical research business of Thermo Fisher Scientific details how these functions have evolved over the years, moving from capabilities that were previously built up and maintained in-house, to the multiple outsourcing mo
Drugs.com
OCTOBER 2, 2024
WEDNESDAY, Oct. 2, 2024 -- More and more, primary care doctors routinely ask patients a question that may come as a surprise: Do you ever have suicidal thoughts?Now, new research shows it's a simple intervention that can save lives.When suicide.
Fierce BioTech
OCTOBER 2, 2024
The benefits of 5,000L single-use bioreactors for biologics manufacturing As the market for complex biologics continues to grow, effective capacity planning becomes more important. The entry of the 5,000L single-use bioreactor (SUB) into biologics manufacturing is providing an important bridge between small-scale and large-scale production. Learn more about this new choice, and how it offers more flexibility than ever before. tharilall Wed, 10/02/2024 - 09:35 As the market for complex biologics
Drugs.com
OCTOBER 2, 2024
WEDNESDAY, Oct. 2, 2024 -- The short but much-loved life of a French bulldog named George leaves a legacy of learning for those who care for animals and humans.George's owner Louis Tavares, of Windemere, Fla., brought him to doctors at the.
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