Nvidia Developer: Drug Discovery

OCTOBER 2, 2024

A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. Called TxGNN, this zero-shot tool helps doctors find new uses for existing drugs for conditions that might otherwise go untreated.

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Drug Discovery Today

OCTOBER 2, 2024

Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer’s disease, and improve symptoms of neurodegeneration in mice.

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Therapies Disease Treatment 113

Science Daily: Pharmacology News

OCTOBER 2, 2024

A new study showed that reducing daily sitting prevented back pain from worsening over six months. The result strengthens the current understanding of the link between activity and back pain as well as the mechanisms related to back pain.

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Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- Scientists say they've discovered a protein that seems crucial to the onset of age-related macular degeneration (AMD), a common cause of blindness in older people.The research is in its very early stages, but it might.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Science Daily: Pharmacology News

OCTOBER 2, 2024

Dolphins are extremely playful, but little is known about how they -- and other marine mammals -- communicate during playtime. New research shows that bottlenose dolphins (Tursiops truncates) use the 'open mouth' facial expression -- analogous to a smile -- to communicate during social play. The dolphins almost always use the facial expression when they are in their playmate's field of view, and when playmates perceived a 'smile,' they responded in kind 33% of the time.

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Research 126

Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- Want to keep a stroke a bay? Drink water, nothing fizzy and skip fruit drinks.That's the key takeaway from a global review that also raises a red flag for people who drink more than four cups of coffee a day."While [high.

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Drug Target Review

OCTOBER 2, 2024

Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. However, innovation and scientific progress are rapidly broadening the scope of CGT applications, extending into non-oncological areas such as cardiology, where there is enormous potential for addressing unmet clinical needs.

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Science Daily: Pharmacology News

OCTOBER 2, 2024

Scientists have made an enormous step toward understanding the human brain by building a neuron-by-neuron and synapse-by-synapse roadmap -- scientifically speaking, a 'connectome' -- through the brain of an adult fruit fly (Drosophila melanogaster). Previous researchers have mapped the brain of a C. elegans worm, with its 302 neurons, and the brain of a larval fruit fly, which had 3,000 neurons, but the adult fruit fly is several orders of magnitude more complex, with almost 140,000 neurons and

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Research Disease 120

Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- The head of a Princeton team that mapped the brain of an adult fruit fly -- a watershed step in understanding the human brain -- explains the feat in a way that belies its complexity."Just like you wouldn't want to drive.

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Science Daily: Pharmacology News

OCTOBER 2, 2024

U.S. tropical cyclones, including hurricanes, indirectly cause thousands of deaths for nearly 15 years after a storm. Researchers estimate an average U.S. tropical cyclone indirectly causes 7,000 to 11,000 excess deaths. All told, they estimate tropical storms since 1930 have contributed to between 3.6 million and 5.2 million deaths in the U.S. -- more than all deaths nationwide from motor vehicle accidents, infectious diseases, or battle deaths in wars during the same period.

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Disease Research 120

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- Patients who lose the use of their hands and arms after a stroke or traumatic brain injury could regain some function through deep brain stimulation (DBS), new research demonstrates.DBS involves surgical placement of.

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Treatment Research 98

Science Daily: Pharmacology News

OCTOBER 2, 2024

'Future You' is a generative AI tool that enables users to have a simulated conversation with a potential version of their future selves. The chatbot is meant to reduce users' anxiety, improve positive emotions, and guide them toward making better everyday choices.

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Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- As the southeastern United States begins to recover from Helene's devastation, a new study suggests the health impact of major storms can linger for over a decade.So far, more than 120 people across six states have.

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Science Daily: Pharmacology News

OCTOBER 2, 2024

Researchers have known for several decades that thunderstorms can act as miniature particle accelerators that produce antimatter, gamma rays and other nuclear phenomena. But they did not know how common the phenomenon was. In observations taken by a retrofitted U2 spy plane, they've discovered essentially all large thunderstorms produce gamma rays in many dynamic, unexpected and unknown ways.

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Research 104

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- Most Americans are eating their way to inflammation that puts them at risk of cancer, heart disease and other serious health problems, a new study shows."Overall, 57% of U.S. adults have a pro-inflammatory diet and that.

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Disease 97

Science Daily: Pharmacology News

OCTOBER 2, 2024

Small iron-rich formations found within Western Australia's Pinnacles, which are part of the world's largest wind-blown limestone belt spanning more than 1000km, have provided new insights into Earth's ancient climate and changing landscape.

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Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- One in 14 hospital patients may be the victim of damaging diagnostic mistakes, new research suggests.The finding is from a study of 675 patients admitted to one large hospital in Boston at various periods between July.

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Hospitals Research 97

Science Daily: Pharmacology News

OCTOBER 2, 2024

Ever wish you could stop that fruit fly on your kitchen counter in its tracks? Scientists have created flies that halt under red light. In doing so, they discovered the precise neural mechanisms involved in stopping. Their findings, published this week in Nature, have implications far beyond controlling fly behavior. They demonstrate how the brain engages different neural mechanisms depending on environmental context.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- In a finding that illustrates the damage that laws targeting transgender people can cause, new research shows that trans and nonbinary youth in states with such laws are more likely to attempt suicide.How much more.

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Research 97

Science Daily: Pharmacology News

OCTOBER 2, 2024

Plants widen microscopic pores on their leaves in response to heat. But scientists lacked an understanding of the mechanisms behind this 'sweating' function. Now, biologists have unlocked the details behind these processes and identified two paths that plants use to handle rising temperatures.

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Research 99

Drug Patent Watch

OCTOBER 2, 2024

As an outsider, finding out the manufacturing capacity of a given pharmaceutical manufacturing plant can be challenging due to the proprietary nature of such information. However, you can employ several strategies to gather relevant data: Example: Pfizer’s 2022 Annual Report states, “Our manufacturing facilities are located in 39 countries across 6 continents.

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Pharmaceuticals 96

Science Daily: Pharmacology News

OCTOBER 2, 2024

Professional and amateur astronomers teamed up with artificial intelligence to find an unmatched stellar trio called TIC 290061484, thanks to cosmic 'strobe lights' captured by NASA's TESS (Transiting Exoplanet Survey Satellite).

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BioPharma Drive: Drug Pricing

OCTOBER 2, 2024

Biosimilar competition to aging blockbusters will erode a large chunk of the pharma giant’s top line over the next few years.

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Biosimilars 105

Science Daily: Pharmacology News

OCTOBER 2, 2024

A new study challenges the hypothesis that 'puppy dog eyes' evolved exclusively in dogs as a result of domestication.

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BioPharma Drive: Drug Pricing

OCTOBER 2, 2024

The biotech, which has now raised more than $200 million since launch, is advancing an eczema treatment that could start human trials next year.

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Science Daily: Pharmacology News

OCTOBER 2, 2024

Scientists have developed a new method to simulate the complex movements of animals with exceptional accuracy. The research team set out to solve a long-standing challenge in biology -- how to accurately model the intricate and seemingly unpredictable movements of living organisms. They focused on the nematode worm Caenorhabditis elegans, a model organism widely used in biological research.

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Research 59

FDA Law Blog: Biosimilars

OCTOBER 2, 2024

By Adrienne R. Lenz, Principal Medical Device Regulation Expert & Lisa M. Baumhardt, Senior Medical Device Regulation Expert & Gail H. Javitt — A recent draft guidance on predetermined change control plans (PCCP) for medical devices continues FDA’s effort to implement Section 515C of the Food and Drug Omnibus Reform Act of 2022 (FDORA), which Congress enacted to make it easier for manufacturers to make post-market device changes by avoiding the need for additional FDA authorization (se

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Science Daily: Pharmacology News

OCTOBER 2, 2024

By studying rare fossils of jaws and other skull parts of a long-extinct Caribbean monkey, a team of researchers says it has uncovered new evidence documenting the anatomy and ecology of an extinct primate once found on Hispaniola -- the Caribbean island on which Haiti and the Dominican Republic are located.

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Research 57

BioPharma Drive: Drug Pricing

OCTOBER 2, 2024

The company will permit six generic drugmakers to make and sell lenacapavir in 120 countries that have high incidence of the disease but limited resources.

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Licensing Licensing Disease Drugs 60

Broad Institute

OCTOBER 2, 2024

GTEx Portal: Retrieving GTEx Gene Expression Data via API By Rose Circeo October 2, 2024 Breadcrumb Home GTEx Portal: Retrieving GTEx Gene Expression Data via API This video tutorial demonstrates how to use the GTEx API to retrieve GTEx gene expression data. Documentation for the GTEx API Documentation for the Get Gene Expression web service First example API call Documentation for the Get Genes web service Get Genes API call Example Get Gene Expression API call filtered by tissue For more infor

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BioPharma Drive: Drug Pricing

OCTOBER 2, 2024

It’s the first time, according to the insurer, that this type of model has been used to bring a Humira biosimilar to market, and it yields a much lower cost than both the brand-name version of the drug and biologic copycats.

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Biosimilars Marketing Drugs 52

Perficient: Drug Development

OCTOBER 2, 2024

Spurred by recent AI advances and improvements made during the global pandemic, accessibility has become an integral component to an increasingly digital-first world. Ensuring that technology is accessible for everyone should be a high priority for all digital properties. Providing an outstanding experience for both customers and employees is crucial for business success, and directly meeting these needs opens opportunities for organizations to reach new markets and up to two billion people with

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Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- More and more, primary care doctors routinely ask patients a question that may come as a surprise: Do you ever have suicidal thoughts?Now, new research shows it's a simple intervention that can save lives.When suicide.

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