Drug Discovery World

SEPTEMBER 19, 2024

Arsenal Biosciences has closed an oversubscribed $325 million Series C financing round to support its development of CAR T-cell therapies for solid tumours. The funding round included new investors ARCH Venture Partners, Milky Way Investments Group, Regeneron Ventures, NVentures (NVIDIA’s venture capital arm), Luma Group, funds and accounts advised by T Rowe Price Associates, Rock Springs Capital, among others.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

A new study provides a list of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. The study is based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC). The data come from more than 800 samples collected in and around the Huanan Seafood Wholesale market beginning on January 1, 2020, and from viral genomes reported from early COVID-19 pa

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Drug Discovery World

SEPTEMBER 19, 2024

Scientists have pinpointed thousands of genetic changes in a gene that may increase a person’s risk of developing breast and ovarian cancer and also identified new potential therapeutic targets. Researchers from the Wellcome Sanger Institute and their collaborators focused on the ‘cancer protection’ gene RAD51C, known to increase ovarian cancer risk six-fold and risk of aggressive subtypes of breast cancer four-fold.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Researchers have uncovered key insights into the dangerous phenomenon of 'river avulsion,' offering a way to predict when and where rivers may suddenly and dramatically change course.

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Research 119

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

SEPTEMBER 19, 2024

This is the latest episode of the free DDW narrated podcast, titled “How technology is impacting drug discovery”, which covers two articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: Immunotherapy offers survival extension for brain tumour patients and The evolution of assays for immuno-oncology research. The first article looks into why data from a Phase III clinical trial offers promise for patients with a deadly form of brain cancer.

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Clinical Trials Trials Research Assay Development 130

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

A new study offers the most detailed glimpse yet into how Earth's surface temperature has changed over the past 485 million years. The data show that Earth has been and can be warmer than today -- but humans and animals cannot adapt fast enough to keep up with human-caused climate change.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Ice may look safe for a game of pick-up hockey on the lake, but as a new study has found, looks can be deceiving. Warming winters are not only affecting ice thickness and timing -- when a lake freezes and thaws -- but also quality, making it potentially unstable and unsafe. The problem, say researchers, is that the unpredictable and warmer winter weather is creating thinner layers of black ice and sometimes a corresponding thicker layer of white ice, the unstable kind.

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Research 112

Drug Discovery World

SEPTEMBER 19, 2024

The US Food and Drug Administration (FDA) has granted Regenerative Medicine Advanced Therapy (RMAT) designation to Roche and Poseida Therapeutics’ P-BCMA-ALLO1. P-BCMA-ALLO1 is an investigational stem cell memory T cell (TSCM)-based allogeneic CAR-T cell therapy in Phase I/Ib clinical development for the treatment of patients with relapsed/refractory multiple myeloma.

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Therapies FDA Clinical Development International 130

Drugs.com

SEPTEMBER 19, 2024

THURSDAY, Sept. 19, 2024 -- A specific class of diabetes drug appears to lower people’s risk for dementia and Parkinson’s disease, a new study shows.Sodium-glucose cotransporter-2 (SGLT2) inhibitors, also known as gliflozins, lower blood sugar by pr.

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Disease Drugs 104

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Ancient DNA has provided spectacular insights into human history, particularly in Europe and Asia, where researchers have reconstructed the genomes of thousands of people. However, fewer than two dozen ancient genomes have been recovered from southern Africa -- specifically Botswana, South Africa and Zambia -- which has some of the world's earliest evidence of modern humans, with the oldest genomes dating back around 2,000 years.

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DNA Research 104

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Drug Patent Watch

SEPTEMBER 19, 2024

The generic drug market in the United States is characterized by significant price volatility and shortages, driven by the structure of the market and the incentives for manufacturers. To address these issues, several market-based proposals have been put forth to optimize generic drug cost and availability.

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Drugs Marketing 102

Drugs.com

SEPTEMBER 19, 2024

THURSDAY, Sept. 19, 2024 -- The Hunan Seafood Wholesale wet market in Wuhan, China, has long been considered the most likely source of the coronavirus that caused the COVID-19 pandemic. That theory is now supported by a new study analyzing more.

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Marketing 98

BioPharma Drive: Drug Pricing

SEPTEMBER 19, 2024

According to the company, the results are the first time an antiviral drug has reduced transmission of a respiratory virus in a global Phase 3 trial.

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Virus Trials Drugs 105

Drugs.com

SEPTEMBER 19, 2024

THURSDAY, SEPT. 19, 2024 -- It's called the MIND diet and its primary aim is to help guard against thinking and memory declines as you age. But does it work?Yes, claims new research that found following the MIND diet for 10 years produced a small.

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Research 98

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

An international group of researchers says two decades of research have generated sufficient knowledge about the sources and effects of microplastics to allow world leaders to agree measures to address them. The argument comes 20 years after the first ever study to coin the term microplastics to describe the microscopic fragments of plastics in our ocean.

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International Research 84

Drugs.com

SEPTEMBER 19, 2024

THURSDAY, Sept. 19, 2024 -- The Los Angeles area is seeing a troubling increase in local dengue fever cases, health officials warned Wednesday. In a public notice posted on its website, the Los Angeles County Public Health Department said at least.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Human breast milk regulates a baby's mix of microbes, or microbiome, during the infant's first year of life. This in turn lowers the child's risk of developing asthma, a new study shows.

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Regulations 86

Drugs.com

SEPTEMBER 19, 2024

THURSDAY, Sept. 19, 2024 -- Breastfeeding through the first year of infants' lives can lower their risk of asthma by colonizing their bodies with a healthy mix of microbes, a new study finds. Results show that breastfeeding beyond three months.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Lavas from hotspots - -whether erupting in Hawaii, Samoa or Iceland -- likely originate from a worldwide, uniform reservoir in Earth's mantle, according to an evaluation of volcanic hotspots.

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Research 77

Drugs.com

SEPTEMBER 19, 2024

THURSDAY, Sept. 19, 2024 -- An extensive look at wastewater samples taken across the United States from May to July found traces of the H5N1 bird flu popping up -- but only in areas populated by farm animals. The avian flu virus has been widespread.

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Virus 81

BioPharma Drive: Drug Pricing

SEPTEMBER 19, 2024

Industry insiders hope the Fed’s decision to cut rates for the first time in years will boost biotech investment. But the long-awaited move won’t cure all that ails the sector, others cautioned.

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Drugs.com

SEPTEMBER 19, 2024

THURSDAY, Sept. 19, 2024 -- Consumers should be aware that some chocolate labeled as “dairy-free” actually contains milk, the U.S. Food and Drug Administration warns.This inaccurate labeling could put people with milk allergies in danger, the FDA no.

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FDA Production Drugs 80

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

By staring into the hellish landscape of Jupiter's moon Io -- the most volcanically active location in the solar system -- astronomers have been able to study a fundamental process in planetary formation and evolution: tidal heating.

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BioPharma Drive: Drug Pricing

SEPTEMBER 19, 2024

GC Therapeutics claims it can create off-the-shelf therapies from induced pluripotent stem cells faster than by current methods with a simpler process.

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Therapies 72

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

The beliefs we hold develop from a complex dance between our internal and external lives. A recent study uses well-known formalisms in statistical physics to model multiple aspects of belief-network dynamics. This multidimensional approach to modeling belief dynamics could offer new tools for tackling various real-world problems such as polarization or the spread of disinformation.

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International 66

addgene Blog

SEPTEMBER 19, 2024

If you’re looking for the best way to improve your lab techniques — but perhaps are a little limited on time — check out Addgene’s new Quick Tip series on YouTube!

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

A new study compared survey results of parents with identical or non-identical twins in England and Wales from the ages of 16 months to 13 years. The study found that fussy eating is mainly influenced by genes and is a stable trait lasting from toddlerhood to early adolescence.

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Drugs.com

SEPTEMBER 19, 2024

THURSDAY, Sept 19, 2024 -- Exercise, whether moderate- or high-intensity, can help ease Parkinson's symptoms, including fatigue, new research shows.As study lead author Dr. Philip Millar explained, Parkinson's patients are too often overwhelmed by.

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Research 64

Reprocell

SEPTEMBER 19, 2024

The biological license application (BLA) is one of the many requests for marketing approval received by the FDA. Unlike the New Drug Application (NDA) which is usually the go-to submission for chemically synthesized, low molecular weight drugs BLAs grant sponsors the ability to introduce Biologics into interstate commerce. BLAs are evaluated by the Center for Biologics Evaluation and Research (CBER), an entity distinct from the Center for Drug Evaluation and Research (CDER) but the regulation of

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BenchSci

SEPTEMBER 19, 2024

As pharmaceutical research and development (R&D) continues to evolve at a rapid pace, AI assistants—software powered by artificial intelligence (AI) that responds to inquiries in human-like text or voice—hold the promise of significantly enhancing efficiency. These tools claim to support tasks like data analysis, due diligence, risk assessment, and even clinical translation.

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Drugs.com

SEPTEMBER 19, 2024

THURSDAY, Sept. 19, 2024 -- One of the most common diabetes drugs, metformin, might deliver an added bonus: Lowering users' odds for Long COVID.Long COVID can present with symptoms including chronic fatigue, brain fog and chest pain and it may last.

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Drugs 59

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Researchers have developed a Martian atmospheric evolution model to propose a new theory about Mars's past.

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Research 72

Drugs.com

SEPTEMBER 19, 2024

THURSDAY, Sept. 19, 2024 -- Americans have the worst health care among the world’s wealthy nations, a new report says.People in the United States die the earliest and live the sickest lives out of 10 developed countries, even though the United S.

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BioPharma Drive: Drug Pricing

SEPTEMBER 19, 2024

Shares dropped by as much as one-quarter Thursday after the biotech shared longer-term results for a gene therapy it’s developing for wet AMD.

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