Drug Discovery World

OCTOBER 26, 2023

Megan Thomas speaks to Dr Martin Main , Chief Scientific Officer, Medicines Discovery Catapult. MT: What do you do, and how did you get here? MM: I am Chief Scientific Officer (CSO) at Medicines Discovery Catapult (MDC). MDC is an independent, not-for-profit, national innovation centre reshaping drug discovery for patient benefit by transforming great UK science into better treatments through partnership.

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Science Doctors Drugs Treatment 148

BioPharma Drive: Drug Pricing

OCTOBER 26, 2023

Executives at the biotech say they’re trying to get ahead of the payer and production challenges that will face their gene editing treatment exa-cel, which is now under FDA review.

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Therapies FDA Production Treatment 123

Drug Discovery World

OCTOBER 26, 2023

Register for the DDW Turning Science into Business Summit, ‘Cancer research opportunities and advances’, to hear insight and expertise from leading figures. It will be hosted by DDW and sponsored by Taconic. The event will take place online on 16 November at 7AM PST / 10AM EST / 3PM GMT / 4PM CET and will also be available on-demand. Register for free to secure your place and to receive your exclusive download link after the event.

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Science Daily: Pharmacology News

OCTOBER 26, 2023

An international study has identified for the first time the optimal number of steps at which most people obtain the greatest benefits, and also shows that the pace at which you walk provides additional benefits.

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International 111

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

OCTOBER 26, 2023

This is the latest episode of the free DDW narrated podcast, “Important therapies for the future of immunotherapy”, which covers two articles written for Volume 23, Issue 3 – Summer 2022 of DDW. They are called “ Improving quality control for CAR T cell therapies ”, and “ The importance of LAG-3 to the future of immunotherapy ”. The first article includes insight from Mark White, Associate Director of Biopharma Product Marketing at Bio-Rad and Marwan Alsarraj, Biopharma Segment Manager, Di

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Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. Alipogene tiparvovec and voretigene neparvovec-rzyl, two recombinant AAV-based gene therapy products, were approved by the European Medicines Agency (EMA) to treat lipoprotein lipase deficiency in 2012 2 and by the US Food a

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BioPharma Drive: Drug Pricing

OCTOBER 26, 2023

The partners announced the trial had succeeded weeks after Moderna disclosed positive results from a study of its similar combination vaccine.

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Vaccine Trials 112

Drug Discovery World

OCTOBER 26, 2023

Register now to hear from neuroscience industry experts at ‘Innovative advances in neuroscience’, hosted by DDW and sponsored by ACRO Biosystems. The online event will be free to attend on 8 November 2023 at 7AM PDT / 10AM EST / 3PM GMT / 4PM CET. You will hear from Fiona Elwood, VP, Disease Area Stronghold Lead, Neurodegeneration, Janssen, and Jenny Barnett, CEO of Monument TX, as well as Rosanna Zhang, Vice President of Corporate Development at ACROBiosystems.

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Disease Science Drug Development Drugs 130

Science Daily: Pharmacology News

OCTOBER 26, 2023

Smart, stretchable and highly sensitive, a new soft sensor opens the door to a wide range of applications in robotics and prosthetics. When applied to the surface of a prosthetic arm or a robotic limb, the sensor skin provides touch sensitivity and dexterity, enabling tasks that can be difficult for machines such as picking up a piece of soft fruit.

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Engineering 104

Drug Discovery World

OCTOBER 26, 2023

This article is sponsored by Evotec. To enable Evotec’s precision medicine approach, we have been building technology platforms that allow PanOmics or multi-omics data generation at an industrialised scale. The technologies cover the whole range of biomolecules from genes to protein to metabolites. While we are using standard commercially available processes for genomics, we have invested massively into high-throughput and high-resolution transcriptomics, proteomics, and metabolomics methods.

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Drugs RNA Bioinformatics Disease 130

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

OCTOBER 26, 2023

Scrape, cluck, lay eggs -- that's it? Anyone involved in chicken farming knows that the animals are capable of much more. Researchers have found evidence that roosters could recognize themselves in a mirror. Whether this is successful, however, depends on the experimental conditions -- a finding that points beyond the experiment with roosters and could also be of importance for other animal species.

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Research 93

Drug Discovery World

OCTOBER 26, 2023

SLAS 2024 International Conference & Exhibition will take place on 3-7 February 2024 at the Boston Convention and Exhibition Center in Boston, MA, USA. Discounted rates for SLAS members are currently available until 31 October 2023. New for this year will be the SLAS Ignite Theater, curated by Drug Discovery World and sponsored by Integra Biosciences and Hammatsu.

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Assay Development International Science Pharmaceuticals 130

Science Daily: Pharmacology News

OCTOBER 26, 2023

Making one small diet change -- chicken instead of beef, plant milk instead of cow's milk -- could significantly curb carbon emissions and increase the healthfulness of your diet, according to a new study.

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Drug Discovery World

OCTOBER 26, 2023

Are you missing out on the easier way to do flow cytometry? In this new handbook, Sartorius introduces the value of advanced flow cytometry, so every scientist feels empowered to run an experiment and analyse the data with confidence. This easy-to-use digital guide includes an introduction to the iQue ® Advanced Flow Cytometry Platform and multiplexed analysis of cell phenotype and secreted proteins.

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Therapies Drugs Drug Development 130

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

OCTOBER 26, 2023

Quantum physicists have shown that it's possible to control and manipulate spin waves on a chip using superconductors for the first time. These tiny waves in magnets may offer an alternative to electronics in the future, interesting for energy-efficient information technology or connecting pieces in a quantum computer, for example. The breakthrough primarily gives physicists new insight into the interaction between magnets and superconductors.

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Drug Discovery World

OCTOBER 26, 2023

Download the ‘ Advanced Flow Cytometry Handbook ‘ to discover the easier way to do flow cytometry. In this new handbook, Sartorius introduces the value of advanced flow cytometry, to ensure that every scientist feels empowered to run an experiment and analyse the data with confidence. This easy-to-use digital guide includes an introduction to the iQue Advanced Flow Cytometry Platform and multiplexed analysis of cell phenotype and secreted proteins.

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Therapies Drugs Drug Development 130

keypoint

OCTOBER 26, 2023

2018 Nobel Laureate Dr. Jim Allison, and organizer of the 2024 Keystone Symposia on Cancer Immunotherapy, has been a regular at the Keystone Symposia meetings since 1987, predating the existence of cancer immunotherapy itself! In fact, when Dr. Jim Allison first attended as a post-doctoral fellow, he presented at a workshop in the Tumor Immunology conference, which at the time was focused on investigating the involvement of the immune system in cancer progression.

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Doctors 79

Science Daily: Pharmacology News

OCTOBER 26, 2023

The explosion of the underwater volcano Kolumbo in the Aegean Sea in 1650 triggered a destructive tsunami that was described by historical eye witnesses. A group of researchers has now surveyed Kolumbo's underwater crater with modern imaging technology and reconstructed the historical events. They found that the eyewitness accounts of the natural disaster can only be described by a combination of a landslide followed by an explosive eruption.

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Research 84

BioPharma Drive: Drug Pricing

OCTOBER 26, 2023

“Data is king and it’s something that is really standing true in this market,” said William Blair’s Kevin Eisele in one of two panels hosted Wednesday by BioPharma Dive.

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Marketing 78

Science Daily: Pharmacology News

OCTOBER 26, 2023

Scientists at NCAR have identified two entirely different modes of hurricane rapid intensification. The findings may lead to better understanding and prediction of these dangerous events.

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BioPharma Drive: Drug Pricing

OCTOBER 26, 2023

Backed by like Atlas, Cormorant and OrbiMed, Triveni is developing an antibody drug for eczema and asthma that takes aim at a different kind of target.

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Disease Drugs 76

Science Daily: Pharmacology News

OCTOBER 26, 2023

Noctilionoid bat species evolved wildly different faces as they adapted to exploit diverse food sources -- including insects, fruit, nectar, blood and fish. New research shows that those adaptations include dramatic, but also consistent, modifications to tooth number, size, shape and position.

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Research 80

BioPharma Drive: Drug Pricing

OCTOBER 26, 2023

Company shares fell Thursday as the company adjusted its medium-term guidance for sales of new products like Reblozyl, Camzyos and Abecma.

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Production Drugs 70

Science Daily: Pharmacology News

OCTOBER 26, 2023

Researchers have developed a new hydrogen energy carrier material capable storing hydrogen energy efficiently and potentially more cheaply. Each molecule can store one electron from hydrogen at room temperature, store it for up the three months, and can be its own catalyst to extract said electron. Moreover, as the compound is made primarily of nickel, its cost is relatively low.

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Research 79

Covalent Modifiers

OCTOBER 26, 2023

Giavana R. Prucha, Sean Henry, Klarissa Hollander, Zachary J. Carter, Krasimir A. Spasov, William L. Jorgensen, Karen S. Anderson, European Journal of Medicinal Chemistry , 2023, 262, 115894, [link] Reverse transcriptase (RT) is one of three key proteins responsible for the replication cycle of HIV-1 in the host. Several classes of inhibitors have been developed to target the enzyme, with non-nucleoside reverse transcriptase inhibitors forming first-line treatment.

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Treatment Drugs 59

Science Daily: Pharmacology News

OCTOBER 26, 2023

The search is on for better semiconductors. A team of chemists describes the fastest and most efficient semiconductor yet: a superatomic material called Re6Se8Cl2.

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Fierce BioTech

OCTOBER 26, 2023

The clinical trial landscape has witnessed a seismic shift in recent years, spurred by technology-driven data collection methods. | The clinical trial landscape has seen a seismic shift in recent years, spurred by technology-driven data collection.

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Clinical Trials Trials 59

Science Daily: Pharmacology News

OCTOBER 26, 2023

Researchers introduce a pioneering breakthrough in the world of nanomotors -- the DNA origami nanoturbine. This nanoscale device could represent a paradigm shift, harnessing power from ion gradients or electrical potential across a solid-state nanopore to drive the turbine into mechanical rotations. The core of this pioneering discovery is the design, construction, and driven motion of a 'DNA origami' turbine, which features three chiral blades, all within a minuscule 25-nanometer frame, operati

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DNA Research 78

Fierce BioTech

OCTOBER 26, 2023

Introducing Free Energy Perturbation: An effective method for calculating and predicting ligand binding affinities | Learn how Free Energy Perturbation (FEP) methods were used to accurately predict ligand binding affinities for 30 ligands that bind to the lipid and GPCR interface in P2Y1.

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Science Daily: Pharmacology News

OCTOBER 26, 2023

FibeRobo is a liquid crystal elastomer fiber that can change its shape in response to thermal stimuli. Compatible with existing textile manufacturing machinery, it could be used to make morphing textiles, like a jacket that changes its insulating properties.

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H1 Blog

OCTOBER 26, 2023

As the pharmaceutical industry becomes increasingly competitive, speed and efficiency are crucial for getting drugs to market faster. This is where mobile apps come in. And at the heart of this rapid-fire evolution are Medical Science Liaisons (MSLs) who play a pivotal role in the delivery of credible, cutting-edge information to healthcare professionals and key opinion leaders (KOLs).

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Drug Development Science Pharmaceuticals Marketing 59

Science Daily: Pharmacology News

OCTOBER 26, 2023

Astronomers confirm the existence of an infrared (IR) aurora on Uranus. This could help astronomers identify exoplanets that might support life, a large number of which are icy worlds.

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Drug Patent Watch

OCTOBER 26, 2023

Sugammadex sodium is the generic ingredient in two branded drugs marketed by Msd Sub Merck, Aspiro, Mylan, and Sandoz and, and is included in four NDAs. There is one patent… The post New tentative approval for Sandoz drug sugammadex sodium appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Science Daily: Pharmacology News

OCTOBER 26, 2023

An electric knifefish shimmies in the water for the same reason a dog sniffs or a human glances around a new place -- to make sense of their surroundings. For the first time, scientists demonstrate that a wide range of organisms, even microbes, perform the same pattern of movements in order to sense the world.

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