ASPET

JANUARY 30, 2024

Mast cell stabilizers including disodium cromoglycate (DSCG) were found to have potential as the agonists of an orphan G protein-coupled receptor, GPR35, although it remains to be determined whether GPR35 is expressed in mast cells and involved in suppression of mast cell degranulation. Our purpose in this study is to verify the expression of GPR35 in mast cells, and to clarify how GPR35 modulates the degranulation.

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BioPharma Drive: Drug Pricing

JANUARY 30, 2024

Since a landmark paper in 2022, drugmakers have begun nearly a dozen trials of cell therapies for lupus, with more set to start. Here’s why their efforts are worth watching.

Therapies 141

Therapies Disease Trials 141

Broad Institute

JANUARY 30, 2024

Battling antibiotic resistance in the lab and the clinic By Leah Eisenstadt January 30, 2024 Breadcrumb Home Battling antibiotic resistance in the lab and the clinic Physician-scientist Roby Bhattacharyya uses genomics and his experiences treating patients to study how “superbugs” evade drugs and find better ways to combat these dangerous pathogens.

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Hospitals Medical Schools Virus Science 137

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- The maker of a drug used to treat ADHD and narcolepsy has recalled one lot of the medication after a pill mixup was discovered.The recall notice, issued by Azurity Pharmaceuticals Inc., states that one lot of Zenzedi.

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Drugs Pharmaceuticals 138

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

ASPET

JANUARY 30, 2024

Heightened excitability of vagal sensory neurons in inflammatory visceral diseases contributes to unproductive and difficult-to-treat neuronally based symptoms such as visceral pain and dysfunction. Identification of targets and modulators capable of regulating the excitability of vagal sensory neurons may lead to novel therapeutic options. KCNQ1-5 genes encode K V 7.1-7.5 potassium channel α-subunits.

Regulations 100

Regulations Treatment Disease 100

BioPharma Drive: Drug Pricing

JANUARY 30, 2024

The company plans to soon ask the FDA for approval of the drug, which it has pitched as a safer alternative to addictive opioid painkillers.

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Trials FDA Drugs 136

BioPharma Drive: Drug Pricing

JANUARY 30, 2024

Roche, Pfizer and Bristol Myers Squibb have all invested in the startup, which is using nanoparticle technology to retrain the body’s immune system.

Disease 122

Disease 122

Perficient: Drug Development

JANUARY 30, 2024

If you’re interested in learning a robust, efficient, and scalable enterprise-level server-side framework, you’ve landed on the right blog ! We’ll start with a quick introduction, and in this post and the ones to follow, we’ll dive straight into the practical part. Together, we’ll build an application that covers various Nest JS fundamental and advanced topics, such as Services, Controllers, Modules, Repository, Pipes, Dependency Injection, and database connectivi

Production 105

Production 105

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- The first new kind of pain medication in over two decades could be on the horizon for patients, with promising results announced Tuesday from a company trial. For now, the drug from Vertex Pharmaceuticals is called VX-548.

Pharmaceuticals 119

Pharmaceuticals Trials Drugs 119

Science Daily: Pharmacology News

JANUARY 30, 2024

Not all plastics are created the same, and some last longer in the ocean than others. Scientists have been working for years to quantify the environmental lifetimes of a wide range of plastic goods to see which have the shortest and longest lifespans in the ocean. To determine what plastics persist in the ocean, the team tests different products in large tanks that recreate the natural ocean environment.

Production 107

Production 107

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- Opdivo, one of the new generation of immunotherapy cancer treatments, appears to help kidney cancer patients equally well when given as a quick injection versus the current method of intravenous delivery, a new study.

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Treatment 111

SCIENMAG: Medicine & Health

JANUARY 30, 2024

An observational study found links between prenatal substance exposure and mental health in children 10–12, but also found that controlling for environment and genetics eliminated many associations.

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Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- U.S. cases of syphilis have soared past numbers seen just a decade ago, new government statistics show. The grim numbers are for 2022, the latest year for which an accurate tally is available. More than 202,000 cases were.

Government 105

Government 105

Drug Patent Watch

JANUARY 30, 2024

The recent paper published in PLOS ONE presents a novel approach for efficiently retrieving a substantial number of patents related to specific technologies. The authors enhance an automated patent landscaping… The post Revolutionizing Patent Landscaping: A Human-Supervised AI Approach to Identify Tech Clusters appeared first on DrugPatentWatch - Make Better Decisions.

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95

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- Pregnant women exposed to flame-retardant chemicals could face an increased risk of premature birth, a new study warns.Organophosphate esters (OPEs) are commonly used as flame retardants in products like furniture, baby.

Production 98

Production 98

Antidote

JANUARY 30, 2024

Facilitating medical research relies on patient participation, yet research protocols often overlook the patient perspective. Improving patient centricity in clinical trials demands prioritizing the patient experience.

Clinical Trials 90

Clinical Trials Trials Research 90

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- A surge in breast cancers for women younger than 50 has puzzled medical experts, but a new study provides some new information that could help halt this trend.The steady increase in diagnoses during the past two decades.

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addgene Blog

JANUARY 30, 2024

Cellular communication and function depend on potential energy. Cellular activities like action potentials, muscle contractions, and the control of voltage gated ion channels all depend on transmitting and sensing electrical potential. Thankfully, there is a tool to measure these electrical events! Voltage indicators are voltmeters for cells! In this blog we will review how these indicators work, their general applications, and why viruses are essential to their use as biological tools.

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Virus 88

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- Deaths related to ozone air pollution will rise significantly around the world during the next two decades due to climate change, a new study warns.Cities in North America, Europe, Asia, Australia and Africa can expect to.

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SCIENMAG: Medicine & Health

JANUARY 30, 2024

Excessive administration of analgesic drugs frequently results in medical accidents. To prevent the occurrence of these accidents, a drug infusion pump featuring a technology for safely detecting medication administration has been developed for the first time in the world.

Hospitals 81

Hospitals Drugs 81

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- U.S. approval of over-the-counter emergency contraception like “Plan B” has had an unintended but positive side effect for America’s hospitals, a new study shows.Emergency room visits related to “morning-after”.

FDA Approval 107

FDA Approval FDA Hospitals 107

SCIENMAG: Medicine & Health

JANUARY 30, 2024

PITTSBURGH – The University of Pittsburgh School of Pharmacy’s Program Evaluation and Research Unit (PERU) has received a five-year, $7.8 million grant from the National Institute on Drug Abuse to improve quality of care for patients with opioid use disorder across Pennsylvania. Credit: Renee Cloutier, Ph.D.

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Treatment Research Drugs 76

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- New research is helping confirm smoking as a risk factor for the devastating brain illness amyotrophic lateral sclerosis (ALS).

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Research 98

SCIENMAG: Medicine & Health

JANUARY 30, 2024

A new study co-led by Associate Professor Kristin Cleverley of the Lawrence Bloomberg Faculty of Nursing has found evidence that Psychosis Spectrum Symptoms (PSS) are often present in youth accessing mental health services.

Nurses 76

Nurses Research 76

Drugs.com

JANUARY 30, 2024

TUESDAY, Jan. 30, 2024 -- A white winter landscape might look magical, but the cold and snow and ice can make even the simplest of tasks potentially dangerous.“It’s slip and fall season,” said Dr. Letitia Bradford, an orthopedic surgeon who.

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Covalent Modifiers

JANUARY 30, 2024

Guillaume Compain, Clément Monsarrat, Julie Blagojevic, Karl Brillet, Philippe Dumas, Philippe Hammann, Lauriane Kuhn, Isabelle Martiel, Sylvain Engilberge, Vincent Oliéric, Philippe Wolff, Dominique Y. Burnouf, Jérôme Wagner, and Gilles Guichard JACS Au 2024 DOI: 10.1021/jacsau.3c00572 Peptide-based covalent inhibitors targeted to nucleophilic protein residues have recently emerged as new modalities to target protein–protein interactions (PPIs) as they may provide some benefits over more classi

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DNA 71

Science Daily: Pharmacology News

JANUARY 30, 2024

Scientists have succeeded in cultivating and characterizing tomato varieties with higher water use efficiency without compromising yield. The researchers, employing CRISPR genetic editing technology, were able to grow tomatoes that consume less water while preserving yield, quality, and taste.

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Research 79

BioPharma Drive: Drug Pricing

JANUARY 30, 2024

About 150 of the smaller company's employees will also transition to Regeneron, which is setting up a new cellular medicines research and development unit.

Therapies 72

Therapies Research 72

SCIENMAG: Medicine & Health

JANUARY 30, 2024

The prevalence of Alzheimer’s disease and related dementias (ADRD) is disproportionately high among rural, racially/ethnically diverse older residents. In fact, they face up to an 80 percent greater risk of cognitive impairment in older age, and 2.5 times potentially preventable ADRD-related hospitalizations compared to urban dwellers.

Hospitals 68

Hospitals Disease 68

BioPharma Drive: Drug Pricing

JANUARY 30, 2024

The companies said the deal shows their “continued conviction in the TIGIT pathway,” an area of research that so far has not lived up to expectations.

Drugs 69

Drugs Research 69

Drug Patent Watch

JANUARY 30, 2024

Annual Drug Patent Expirations for CHLORAPREP+ONE-STEP Chloraprep One-step is a drug marketed by Becton Dickinson Co and is included in two NDAs. It is available from two suppliers. There are… The post New patent expiration for Becton Dickinson drug CHLORAPREP ONE-STEP appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Perficient: Drug Development

JANUARY 30, 2024

Aloha Trailblazers, Embarking on the journey into the vast landscape of Salesforce, this blog serves as your guide to understanding and conquering the challenges of Large Data Volumes (LDV). In the dynamic world of Salesforce, businesses encounter the complexities of managing extensive datasets. As organizations grow, navigating and optimizing performance in the face of Large Data Volumes becomes paramount.

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Production 59

Drug Patent Watch

JANUARY 30, 2024

Annual Drug Patent Expirations for TUKYSA Tukysa is a drug marketed by Seagen and is included in one NDA. It is available from one supplier. There are six patents protecting… The post New patent for Seagen drug TUKYSA appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59