Mon.Feb 05, 2024

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Study challenges the classical view of the origin of the Antarctic Circumpolar Current and warns of its vulnerability

Science Daily: Pharmacology News

The Circumpolar Current works as a regulator of the planet's climate. Its origins were thought to have caused the formation of the permanent ice in Antarctica about 34 million years ago. Now, a study has cast doubt on this theory, and has changed the understanding of how the ice sheet in Antarctic developed in the past, and what this could mean in the future as the planet's climate changes.

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Capsaicin derivatives: Synthesis and biological activity

Chemical Biology and Drug Design

The synthesis, biological activity, and the structure–activity relationship of capsaicin and its derivatives are reviewed. Furthermore, we detailly describe the combination mechanism between capsaicin and TRPV1, TRPV1 related capsaicin derivatives as well. Abstract Capsaicin is the main active ingredient of chili peppers and the most pungent alkaloid.

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Scientist shows focused ultrasound can reach deep into the brain to relieve pain

Science Daily: Pharmacology News

Scientists have found soundwaves from low-intensity focused ultrasound aimed at a place deep in the brain called the insula can reduce both the perception of pain and other effects of pain, such as heart rate changes.

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Weight-Loss Med Zepbound Lowers High Blood Pressure in Obese People

Drugs.com

MONDAY, Feb. 5, 2024 -- The weight-loss drug Zepbound provides more health benefits than dropping pounds and controlling diabetes, a new study shows.It also appears to help people with obesity manage their high blood pressure, results show.Patients.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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One person can supervise 'swarm' of 100 unmanned autonomous vehicles

Science Daily: Pharmacology News

Research involving has shown that a 'swarm' of more than 100 autonomous ground and aerial robots can be supervised by one person without subjecting the individual to an undue workload.

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J&J says top drug prospect works across autoimmune disorders

BioPharma Drive: Drug Pricing

The pharma disclosed positive results from two studies testing its antibody drug nipocalimab in generalized myasthenia gravis or Sjögren's disease.

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More Trending

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Novo Holdings to buy contract drugmaker Catalent for $16.5B

BioPharma Drive: Drug Pricing

In a related deal, Novo Holdings subsidiary Novo Nordisk will buy three major Catalent factories for $11 billion as it works to keep pace with demand for its obesity and diabetes medicines.

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FDA Panel Tackles Faulty Pulse Oximeter Readings That Come With Darker Skin

Drugs.com

MONDAY, Feb. 5, 2024 -- A U.S. Food and Drug Administration advisory panel on Friday addressed a continuing issue with pulse oximeters -- that they give less accurate readings for folks with darker skin.The devices are designed to measure oxygen.

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Ryman Hospitality Migrates to Oracle ERP Cloud!

Perficient: Drug Development

ERP | Enterprise Resource Planning Migration to the Cloud – July 2023 Go Live! Ryman Hospitality Properties, Inc. (NYSE: RHP) Business Challenge + Opportunity Migrate existing footprint and well-established business processes from Oracle EBS and NetSuite financials into Oracle ERP Cloud (Fusion), with over 500 custom reports written across different tool sets (FSGs, Discoverer, GL Wand, and other BI type or reports) Achievements: Sunset/Archive Oracle EBS and GL Wand Migrated Receivables and Col

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U.S. Prescription Drug Prices Nearly Triple Those of Other Nations

Drugs.com

MONDAY, Feb. 5, 2024 -- Americans pay nearly three times as much for their prescription drugs as residents of other nations do, new research shows.Drug prices in the United States average nearly 2.8 times those seen in 33 other countries, the.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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In a warming world, climate scientists consider category 6 hurricanes

Science Daily: Pharmacology News

For more than 50 years, the National Hurricane Center has used the Saffir-Simpson Windscale to communicate the risk of property damage; it labels a hurricane on a scale from Category 1 (wind speeds between 74 -- 95 mph) to Category 5 (wind speeds of 158 mph or greater). But as increasing ocean temperatures contribute to ever more intense and destructive hurricanes, climate scientists wondered whether the open-ended Category 5 is sufficient to communicate the risk of hurricane damage in a warming

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Healthy Living Builds 'Cognitive Reserve' in Brain That May Prevent Dementia

Drugs.com

MONDAY, Feb. 5, 2024 -- New research suggests healthy lifestyles can help stave off dementia, perhaps by building a resilient 'cognitive reserve' in the aging brain. The study was based on the brain autopsies on 586 people who lived to an average.

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It's true, happiness doesn't cost much

Science Daily: Pharmacology News

Many Indigenous peoples and local communities around the world are leading very satisfying lives despite having very little money. This research shows that many societies with very low monetary income have remarkably high levels of life satisfaction, comparable to those in wealthy countries.

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Even Mild Cases of COVID Can Leave Lingering Insomnia

Drugs.com

MONDAY, Feb. 5, 2024 -- Even mild cases of COVID can trigger insomnia in most people, a new study reports.About three out of four people with mild COVID (76%) reported experiencing insomnia following their illness.Further, nearly one in four (23%).

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Extra fingers and hearts: pinpointing changes to our genetic instructions that disrupt development

SCIENMAG: Medicine & Health

Our genomes provide the instructions for proper growth and development. Millions of genomic switches, known as enhancers, control the location and timing of gene expression, which in turn ensures the correct proteins are made in the right cells at the right time throughout our lives.

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King Charles III Diagnosed With Cancer

Drugs.com

MONDAY, Feb. 5, 2024 -- Follow-up from recent surgery for an enlarged prostate has revealed that Britain's King Charles III has cancer, Buckingham Palace announced Monday.The palace did not disclose the type of cancer that was discovered."During.

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$1.9 million NIH grant to support research on impacts of the microbiome on human health

SCIENMAG: Medicine & Health

UNIVERSITY PARK, Pa. — The bacteria and microorganisms that live within the human body — the microbiota — can impact human health, disease risk and even how the body absorbs medications, but the details of these processes are unclear.

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Hearing Troubles Can Affect the Mind, Too

Drugs.com

MONDAY, Feb. 5, 2024 -- If you're over 65, you likely struggle sometimes to hear conversations clearly, but ignoring that may prompt even more serious health problems, experts say. If left unchecked, hearing loss can lead to social isolation and.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Prevention Through Design to Address Continuing Construction Workplace Deaths and Injuries

NIOSH Science Blog: Drugs

Nearly 1 in 5 of all workplace fatalities occur in the construction industry (BLS, 2024). In 2022 there were 1,092 fatalities in the construction industry (BLS, 2024); in 2021 and 2022 there were 144,480 cases of construction industry workers missing days away from work from a non-fatal injury or illness (BLS, 2023). These and other statistics show that construction remains one of the most dangerous industries for workers.

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Black Americans Lose Sleep After High-Profile Police Killings

Drugs.com

MONDAY, Feb. 5, 2024 -- Police killings of unarmed Black people are robbing the Black community of a precious commodity – sleep. Black adults across the United States suffer from sleep problems after they’re exposed to news of killings.

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Which pharmaceutical companies have the most drug patents in Croatia?

Drug Patent Watch

This chart shows the pharmaceutical companies with the most patents in Croatia. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is… The post Which pharmaceutical companies have the most drug patents in Croatia? appeared first on DrugPatentWatch - Make Better Decisions.

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Need Mental Health Services Via Telehealth? Many Clinics Still Don't Offer It

Drugs.com

MONDAY, Jan. 5, 2024 -- Accessing mental health care via telehealth boomed during the pandemic, and it continues to be a valuable resource for patients. However, it could still be tough to find, depending on the clinics available in your area, new.

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Discovered how to predict whether patients with leukemia will be sensitive to epigenetic drugs

SCIENMAG: Medicine & Health

Alterations in the chemical modifications that control gene expression, known as Epigenetics, have proven to be one of the most characteristic properties of all human tumors. This realization has generated the development of very intense pharmacological research to find drugs that act at this level against cancer.

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Shark Bites Are Up Worldwide

Drugs.com

MONDAY, Feb. 5, 2024 -- Unprovoked shark attacks increased slightly worldwide last year, but twice as many people died from shark bites as the year before, new data show.There were 69 unprovoked shark attacks in 2023, higher than the five-year.

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Beyond the pedals: testing upper limb feasibility of cardiopulmonary exercise testing

SCIENMAG: Medicine & Health

How can inclusivity be achieved in cardiopulmonary exercise tests for individuals facing lower limb injuries or disabilities that make it impossible to pedal a bicycle?

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New species of Jurassic pterosaur discovered on the Isle of Skye

Science Daily: Pharmacology News

A new species of pterosaur from specimens found on the Isle of Skye, Scotland, has been announced.

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Mobile patient lifts help ICU patients recover

SCIENMAG: Medicine & Health

Tokyo, Japan – A recent randomized controlled trial in Tokyo, Japan, has unveiled the positive impact of early mobilization, assisted by mobile patient lifts, on the recovery of ventilated intensive care unit (ICU) patients. The debate surrounding the efficacy of early mobilization in ICU has persisted for an extended period. Credit: Dr.

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Mystery of moths' warning sound production explained in new study

Science Daily: Pharmacology News

The workings of the ultrasonic warning sounds produced by the wings of a species of moth have been revealed.

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Unlocking precision medicine for inflammatory bowel disease

SCIENMAG: Medicine & Health

The prevalence of inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn’s disease (CD), is rapidly increasing worldwide, affecting an estimated 6.8 million people. This surge brings significant economic burdens, with annual healthcare costs exceeding $12,000 and $7,000 for CD and UC patients, respectively.

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New patent for Aveo Pharms drug FOTIVDA

Drug Patent Watch

Annual Drug Patent Expirations for FOTIVDA Fotivda is a drug marketed by Aveo Pharms and is included in one NDA. It is available from one supplier. There are three patents… The post New patent for Aveo Pharms drug FOTIVDA appeared first on DrugPatentWatch - Make Better Decisions.

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Understanding how macrophages direct tissue regeneration

Drug Target Review

Scientists from Cincinnati Children’s Hospital and the University of Kentucky have investigated how spiny mice can regenerate lost tissue. They are using this new understanding to initiate regeneration in other types of mice, which could be translated into humans in the future. Adult laboratory mice heal injuries with scar tissue, but spiny mice have the unique ability to regrow lost skin and regenerate musculoskeletal tissues in their body.

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New patent for Akarx Inc drug DOPTELET

Drug Patent Watch

Annual Drug Patent Expirations for DOPTELET Doptelet is a drug marketed by Akarx Inc and is included in one NDA. It is available from one supplier. There are three patents… The post New patent for Akarx Inc drug DOPTELET appeared first on DrugPatentWatch - Make Better Decisions.

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Valneva sells regulatory ‘fast pass’ for $103M

BioPharma Drive: Drug Pricing

The company said it will invest the sale proceeds into testing of an experimental Lyme disease shot and of Ixchiq, its new chikungunya vaccine.

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