Tue.Nov 07, 2023

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“Game changing” concussion drug study shows positive early results  

Drug Discovery World

Oxeia Biopharmaceuticals, a clinical stage biotech company developing a drug treatment for concussion to address underlying neuro-metabolic dysfunction and axonal injury, has announced “game-changing” results of a Phase IIa pilot study of OXE103 at the University of Kansas Medical Center (KUMC). The study results suggest a potentially effective treatment for concussion, which could change the lives of thousands that suffer from post-concussion symptoms for sometimes months and years after inj

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Cancer Research UK and the KWF Dutch Cancer Society enter partnership to bring multiple drugs into clinical development

Drug Discovery Today

Cancer Research UK, and the KWF Dutch Cancer Society (KWF), two of the world’s largest charitable funders of cancer research, announce a new multi-project strategic partnership to advance promising therapeutic agents for cancer through early clinical development.

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UK women to benefit from drug to prevent breast cancer

Drug Discovery World

The UK’s Medicines and Healthcare products Regulatory Agency (MHRA) has authorised a new indication for anastrozole, to prevent breast cancer in post-menopausal women at moderate or high risk of developing the disease. The hormone treatment was already authorised for use in the treatment of breast cancer in post-menopausal women and has been used off-label for prevention.

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Groundbreaking treatment for Alcohol Use Disorder shown to halve alcohol consumption amongst heavy drinkers in three months at phase II: a new hope for patients

Drug Discovery Today

The trial showed that KT-110 has superior efficacy in reducing alcohol consumption. KT-110 will be deliverable in a once-daily tablet (proprietary formulation). KT-110’s mode of action is novel to Alcohol Use Disorder (AUD) and works by simultaneously modulating the noradrenergic and serotonergic brain receptors that counteract the neurobiological processes involved in addictionAlcohol dependence, or AUD, is a serious public health issue and the medical need for the treatment of alcoholism is co

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Selective degradation of cancer target WDR5 — Evaluation of PROTACs binary and ternary affinities with Spectral Shift

Drug Discovery World

As more and more R&D pipelines include PROTAC candidates — the race to bring successful and efficient protein degraders to the clinic is on. These targets present challenges in the biophysical characterisation of binary and ternary complexes, making developing effective degraders complicated. Watch this on-demand webinar to learn: How Spectral Shift technology lets you take measurements in-solution and immobilisation free What the data from a Spectral Shift experiment characterising protein

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How AI is Transforming Drug Discovery: Bio-IT World Europe Participants to Share Groundbreaking Advances 29-30 November in London

Drug Discovery Today

Bio-IT World Conference & Expo to Foster Collaboration Among Life Sciences, IT and Healthcare Leaders Who are Redefining Precision Medicine

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MHRA authorises enzyme inhibitor Anastrozole to prevent breast cancer in post-menopausal women

Drug Discovery Today

Anastrozole is now authorised as a preventative treatment for post-menopausal women at moderate or high risk of breast cancer.

Treatment 113
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As demand for mRNA surges, Australia and US launch new facilities

Drug Discovery World

As demand for mRNA continues to surge, two new facilities have been launched to boost production in Australia and the US. Work is underway at The University of Queensland’s (UQ) BASE facility which has become Australia’s leading provider of mRNA for research and pilot studies since its launch in 2021. The Commonwealth Government’s Medical Research Future Fund (MRFF) National Critical Research Infrastructure scheme will contribute $4.3 million, with Sanofi and UQ each committing $1 mi

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An obesity drug biotech gets buy-in from Eli Lilly, venture firms

BioPharma Drive: Drug Pricing

Startup OrsoBio raised $60 million in a Series A round co-led by Longitude Capital and Enavate Sciences, and joined by the pharma’s venture arm.

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Marijuana Use Could Raise Odds for Heart Attack, Heart Failure

Drugs.com

MONDAY, Nov. 6, 2023 -- People who regularly smoke medical marijuana may be increasing their risk for a heart attack, heart failure or stroke, new research suggests. One study found that cannabis use among older patients increases the risk of heart.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Biogen, Sage set price of postpartum depression pill at $15,900

BioPharma Drive: Drug Pricing

The price is below what some analysts had predicted and significantly less than $34,000 Sage initially set for its earlier postpartum infusion, Zulresso.

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More U.S. Children Enter Foster Care in States With Abortion Restrictions

Drugs.com

TUESDAY, Nov. 7, 2023 -- When states have restrictive abortion laws in place, more children end up in foster care, new research finds. This happened even before the U.S. Supreme Court overturned Roe v. Wade in June 2022, the investigators.

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Anticipating the disruption of regenerative medicine

Fierce BioTech

Travis McCready is an individual with immense experience in the biotech arena. | While AI is undoubtedly driving key progress in biotech, Travis McCready sees disruptive opportunity elsewhere. Discover why the Head of Life Sciences for Americas Markets at JLL is excited for regenerative medicine and tissue engineering in this interview.

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U.S. Syphilis Cases in Newborns Rose 10-fold Over a Decade

Drugs.com

TUESDAY, Nov. 7, 2023 -- An old scourge, syphilis, is returning with a vengeance in the United States, affecting not only adults but also the most vulnerable -- newborns. Rates of congenital syphilis soared 10-fold between 2012 and 2022, according.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Vertical Integration Lessons: The Economics and Strategies of Hospital-Owned Specialty Pharmacies

Drug Channels

As many of you know, hospitals and health systems have emerged as significant participants in the specialty pharmacy industry. A new American Society of Hospital Pharmacists (ASHP) survey provides fresh insights into these specialty pharmacies. Below, I review key findings on the economics and operations of these specialty pharmacies. I then highlight how hospitals steer prescriptions to their internal specialty pharmacies.

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FDA Expands Investigation of Pureed Fruit Pouches

Drugs.com

MONDAY, Nov. 6, 2023 -- Amid reports of more illnesses and additional product recalls, U.S. health officials have expanded their investigation into potentially lead-tainted pouches of apple cinnamon pureed fruit. The U.S. Food and Drug.

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Groundbreaking Auburn University study unveils brain’s remarkable recycling system!

SCIENMAG: Medicine & Health

AUBURN, AL – Researchers at Auburn University have made a groundbreaking discovery that sheds light on how our brain cells manage to efficiently replace older proteins. This process is crucial for maintaining effective neural communication and ensuring optimal cognitive function. Credit: Auburn University Department of Physics.

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Cardiac Arrest? Drones Might Someday Come to the Rescue

Drugs.com

MONDAY, Nov. 6, 2023 -- Drones might prove a feasible way to deliver lifesaving defibrillators to cardiac arrests in remote areas, a new research simulation suggests. Delivering automated external defibrillators (AEDs) by drone could dramatically.

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Bisphenol A and asthma in mice

SCIENMAG: Medicine & Health

The “hygiene hypothesis” posits that allergic asthma can be triggered by a childhood environment that is too clean and sterile. One studied mechanism underlying this relationship is the influence of microbial lipopolysaccharides (LPS), which train the immune system.

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Gun Violence Takes Huge Mental, Financial Toll on Kids & Their Families

Drugs.com

TUESDAY, Nov. 7, 2023 -- Gun violence causes a ripple effect that creates a lasting impact on young people lucky enough to survive being shot, as well as their families, a comprehensive new study finds. Child and teenaged gunshot survivors carry.

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Flagship expands into Asia-Pacific with new Singapore hub

BioPharma Drive: Drug Pricing

The biotech company creator hopes its new office will help its portfolio companies grow and strike partnerships in the region.

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Depression Can Be a Killer for People With Diabetes

Drugs.com

TUESDAY, Nov. 7, 2023 -- Many people with type 2 diabetes also struggle with depression, and this combination can lead to premature death, researchers say. “More than 35 million Americans have diabetes, and more than 95 million have.

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Online shopping for tobacco products rises with California flavor restrictions

SCIENMAG: Medicine & Health

Online shopping for cigarettes and vaping products increased significantly in the weeks following the implementation of SB-793, a 2022 California law prohibiting the sale of flavored tobacco products.

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Caregiving's Financial Toll Is Often Hidden

Drugs.com

TUESDAY, Nov. 7, 2023 -- A growing number of people have become unpaid caregivers for loved ones, and a new report says many are overlooking the financial consequences of their selflessness. One in five adults now provide uncompensated care to.

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Previous genetic association studies involving people with European ancestry may be inaccurate

SCIENMAG: Medicine & Health

Researchers have found that previous studies analyzing the genomes of people with European ancestry may have reported inaccurate results by not fully accounting for population structure.

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DrugBank adds ASHP data to knowledgebase, improving user experience and data reliability

DrugBank

EDMONTON, CANADA, November 1st, 2023— DrugBank today kicked off their role as a key distributor of the American Society for Health-System Pharmacists’s (ASHP) data. ASHP’s full suite of drug information has been integrated into and made available through DrugBank, bringing together both company’s offerings to provide streamlined access to a broader range of high quality products.

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Window to the past: New microfossils suggest earlier rise in complex life

Science Daily: Pharmacology News

Microfossils may capture a jump in the complexity of life that coincided with the rise of oxygen in Earth's atmosphere and oceans, according to an international team of scientists.

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The annual economic burden of urinary incontinence could reach €87 billion in 2030 if no action is taken

SCIENMAG: Medicine & Health

Brussels, 8 November 2023 – New international research on the economic burden of urinary incontinence reveals that the cost of continence care will reach an estimated €69.1 billion in 2023.

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Is Your 18-Year-Old Really 'Mature'? New Brain Study Has Answers

Drugs.com

MONDAY, Nov. 6, 2023 -- An adolescent starts thinking like an adult right around the age of 18, according to new research. That provides some of the first definitive evidence that executive function matures by that time. Executive function is a.

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Digital health ethics for precision medicine in palliative care

SCIENMAG: Medicine & Health

A new article in the peer-reviewed OMICS: A Journal of Integrative Biology examines the ethical, equity, and societal/relational implications of digital health technologies for precision medicine in end-of-life care. Click here to read the article now. Credit: Mary Ann Liebert Inc.

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Many New Moms Can't Access Good Health Care, Report Finds

Drugs.com

TUESDAY, Nov. 7, 2023 -- Many new moms, particularly those on Medicaid, struggle to get health care and social support in the year following their baby's birth, new research reveals. “Most people think of labor and birth as the most dangerous.

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CEO Anne Wojcicki on turning 23andMe into a ‘full-fledged biotech’

BioPharma Drive: Drug Pricing

23andMe always had larger aims than at-home genetics testing. In this in-depth interview, Wojcicki explains the company’s foray into drug R&D.

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Screening sharply improves lung cancer long-term survival

SCIENMAG: Medicine & Health

OAK BROOK, Ill. – Diagnosing early-stage lung cancer with low-dose CT screening dramatically improves the long-term survival rate of cancer patients, according to a large-scale, 20-year international study published today in Radiology, a journal of the Radiological Society of North America (RSNA).

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Ventyx revises TYK2 drug plans after lackluster study data

BioPharma Drive: Drug Pricing

The biotech will terminate studies of its drug in psoriasis and psoriatic arthritis after the “magnitude of efficacy” reported in one was less than Ventyx’s target.

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