Drug Discovery World

OCTOBER 3, 2024

The US Food and Drug Administration (FDA) has announced seven new clinical trial grants awarded under the Orphan Products Grants Program for clinical trials to address the unmet needs of people affected by rare diseases. In total, clinical researchers will receive approximately $17.2 million over the next four years. Newly funded projects: Palvella Therapeutics received $2.6 million to fund a Phase III study of PTX-022 (Sirolimus) for the treatment of microcystic lymphatic malformations.

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Drug Discovery Today

OCTOBER 3, 2024

Kate Shaw, founder and CEO of Innovative Trials, a global clinical trial patient recruitment and retention company, has been crowned a top ‘Woman in Pharma’ at the Pharma Industry Awards UK. She was given the award at a ceremony in Birmingham on Wednesday 18th September.

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Trials Clinical Trials 113

Drug Discovery World

OCTOBER 3, 2024

This article is sponsored by SGS. Join SGS’s Health Science team at booth 5D82 to explore their integrated drug development solutions, from analytical testing to clinical research, formulation and manufacturing development. SGS is excited to announce its participation as an exhibitor where it will present its extensive range of quality and compliance services for the health science industry.

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Drug Development Clinical Research Drugs Compliance 147

Science Daily: Pharmacology News

OCTOBER 3, 2024

Comamonadacae is a family of bacteria often found growing on plastics in water. New study finds a bacterium in this family can break down the plastic for food. Researchers also identified the enzyme the bacterium use to degrade plastic. The discovery opens new possibilities for developing bacteria-based engineering solutions to help clean up difficult-to-remove plastic waste.

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Engineering Research 125

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

OCTOBER 3, 2024

New data from the Phase III BouNDless trial and its ongoing open-label extension (OLE) support the long-term efficacy of ND0612 in people with Parkinson’s disease (PD) experiencing motor fluctuations. The new clinical trial data was shared at the 2024 International Congress of Parkinson’s Disease and Movement Disorders (MDS). ND0612 is being studied as a 24-hour, continuous, subcutaneous (SC) infusion of liquid levodopa/carbidopa (LD/CD).

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Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024, HealthDay News -- The Southern Hemisphere's flu season is winding down, and new data shows this year's flu shot was 34.5% effective in keeping folks there who got influenza from needing hospital care. Most (68.3%) of those.

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Hospitals Vaccine 111

Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 -- Americans who turn to online pharmacies to find cheaper versions of expensive prescription medications, especially opioids, may instead be buying themselves dangerous drugs that could trigger an overdose, U.S. health.

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Online Pharmacies Pharmacy Drugs 109

Drug Discovery World

OCTOBER 3, 2024

In this case study, learn how Dr Elsa Wagner from Pierre Fabre Laboratories put together a comprehensive developability platform for monoclonal antibodies (mAbs), using combined thermal and colloidal stability parameters from the Prometheus Panta instrument. You’ll learn about: How Pierre Fabre Laboratories approaches developability assessment for mAbs candidates The criteria that guided her decision for the Prometheus Panta as a solution for her developability platform The benefits of combinin

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Laboratories Drugs 130

Science Daily: Pharmacology News

OCTOBER 3, 2024

The extinction of hundreds of bird species caused by humans over the last 130,000 years has led to substantial reductions in avian functional diversity -- a measure of the range of different roles and functions that birds undertake within the environment -- and resulted in the loss of approximately 3 billion years of unique evolutionary history, according to a new study.

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Drug Discovery World

OCTOBER 3, 2024

A new case study is now free to download entitled ‘ How Pierre Fabre Laboratories enhances their antibody developability platform with NanoTemper’s Prometheus Panta.’ In this case study, learn how Dr Elsa Wagner from Pierre Fabre Laboratories put together a comprehensive developability platform for monoclonal antibodies (mAbs), using combined thermal and colloidal stability parameters from the Prometheus Panta instrument.

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Laboratories Drugs 130

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

OCTOBER 3, 2024

According to a new study, colonies of ants began farming fungi when an asteroid struck Earth 66 million years ago. This asteroid impact caused a global mass extinction but also created ideal conditions for fungi to thrive. Innovative ants began cultivating the fungi, creating an evolutionary partnership that became even more tightly intertwined 27 million years ago and continues to this day.

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Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 -- Japanese researchers have successfully used a transplant of human stem cells to close a hole in a key part of a monkey's retina. They say the achievement could pave the way for better treatment of small gaps that form in.

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Therapies Treatment Research 103

addgene Blog

OCTOBER 3, 2024

If the fall colors are inspiring you to paint your cells in equally vivid colors, you'll want to check out the 34 new preps available in the Addgene viral vector repository! This includes the first Addgene prep packaged in the AAV9-X1.1 serotype.

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Packaging 102

Science Daily: Pharmacology News

OCTOBER 3, 2024

Government subsidies for business practices and processes should be approached with caution, even when they seem to be environmentally friendly, writes a group of scientists and economists. They argue that subsidies can alter market pressures, leading to unintended consequences that not only perpetuate harmful subsidies over time but also diminish the overall effectiveness of those intended to promote environmental sustainability.

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Government Marketing 102

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 -- In yet another sign that childhood vaccinations can't be taken for granted, new government data shows that a record number of kindergartners were exempted from the required shots during the last school year. That leaves.

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Vaccine Government 98

BioPharma Drive: Drug Pricing

OCTOBER 3, 2024

Removal of Lilly’s in-demand drugs from the FDA’s shortage list ramps up pressure on the companies selling compounded versions.

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FDA Drugs 112

Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 -- If you sweat excessively, you're likely to have sensitive skin as well, with new research confirming the two go hand-in-hand. A team led by Adam Friedman of George Washington University and Linqing Zhang of Virginia Tech.

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Science Research 96

Science Daily: Pharmacology News

OCTOBER 3, 2024

Deposits of ice in lunar dust and rock (regolith) are more extensive than previously thought, according to a new analysis of data from NASA's LRO (Lunar Reconnaissance Orbiter) mission. Ice would be a valuable resource for future lunar expeditions. Water could be used for radiation protection and supporting human explorers, or broken into its hydrogen and oxygen components to make rocket fuel, energy, and breathable air.

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Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 -- Avoiding couches and chairs might be a good way of keeping your back pain from getting worse, new research suggests. Finnish researchers found that when people with back pain sat even a little less each day, their pain was.

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Research 96

Drug Patent Watch

OCTOBER 3, 2024

Humira, used to treat various autoimmune diseases, has become the world’s best-selling drug. AbbVie has fiercely protected its patent through a strategy known as “patent thickets,” filing over 100 additional patents related to the drug’s manufacturing process, formulation, and methods of treatment[1].

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Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 22024 -- A small dose of the nutritional supplement lithium asparate may not ease the fatigue and brain fog of Long COVID, a small, new trial involving 52 patients has found. Still, it's possible that a larger dose of the.

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Trials 93

Science Daily: Pharmacology News

OCTOBER 3, 2024

Looking deep into the early universe with NASA's James Webb Space Telescope, astronomers have found something unprecedented: a galaxy with an odd light signature, which they attribute to its gas outshining its stars. Found approximately one billion years after the big bang, galaxy GS-NDG-9422 (9422) may be a missing-link phase of galactic evolution between the universe's first stars and familiar, well-established galaxies.

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Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 -- Sharing a book with your baby will build her vocabulary fast, but time with screens likely won't, Norwegian researchers report. Their new study on shared reading and vocabulary size dovetails with a new policy statement.

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Research 92

Science Daily: Pharmacology News

OCTOBER 3, 2024

Human stem cell transplants successfully repaired macular holes in a monkey model, researchers report. After transplantation, the macular holes were closed by continuous filling of the space with retinal tissue.

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Research 83

Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 -- Nearly 8 in 10 Americans go through the day in a fog that interferes with their jobs, their moods and their relationships. Chalk it up to sleepiness: A new survey shows that 54% of Americans think they just don't get.

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Science Daily: Pharmacology News

OCTOBER 3, 2024

Toddlers in the UK obtain nearly half (47%) of their calories from ultra-processed foods (UPFs), and this rises to 59% by the age of seven, according to a new study. The most common UPFs consumed by the toddlers -- who were 21 months when their parents recorded their diets -- were flavored yogurts and wholegrain breakfast cereals, products typically seen as healthy.

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Production 76

Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 -- Even air pollution levels considered safe by U.S. standards appear to cause differences in the brains of growing children, a new review suggests. "We're seeing differences in brain outcomes between children with higher.

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Science Daily: Pharmacology News

OCTOBER 3, 2024

Researchers have developed a noninvasive way of using bioluminescent optogenetics to activate parts of the brain.

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Research 100

Broad Institute

OCTOBER 3, 2024

Largest-ever genetic study of epilepsy finds possible therapeutic targets By Ari Navetta October 3, 2024 Breadcrumb Home Largest-ever genetic study of epilepsy finds possible therapeutic targets Scientists have uncovered new genetic links to different types of epilepsy, which could lead to more tailored treatments. By Ari Navetta October 3, 2024 Credit: Ricardo Job-Reese, Broad Communications Related people Benjamin Neale Related programs Stanley Center for Psychiatric Research Related news DNA

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Science Daily: Pharmacology News

OCTOBER 3, 2024

Pockets of microbes have been found living within a sealed fracture in 2-billion-year-old rock. The rock was excavated from the Bushveld Igneous Complex in South Africa, an area known for its rich ore deposits. This is the oldest example of living microbes being found within ancient rock so far discovered. The team involved in the study built on its previous work to perfect a technique involving three types of imaging -- infrared spectroscopy, electron microscopy and fluorescent microscopy -- to

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Research 76

Reprocell

OCTOBER 3, 2024

This blog is the second in a series exploring the critical role of safety pharmacology in drug discovery. In our previous post, we discussed the importance of human tissue studies in ensuring drug safety. Today, we’ll dive into real-world case studies that highlight our innovative approaches and successes in utilizing human tissue models for safety assessment, demonstrating how these models have impacted drug development outcomes.

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Research Drug Development Drugs 59

KIF1A

OCTOBER 3, 2024

September was packed with informational meetings, grant submissions, global connections with scientists, impact reports, awards, and outstanding community fundraising achievements! Keep reading to discover these amazing milestones and learn how you can get involved to make an IMPACT too! UPCOMING MEETINGS *Times are Eastern Time Zone. Oct 16 KIF1A.ORG Dylan Verden Office Hours These office hours provide an opportunity for you to bring any questions and discuss them in an open, informal setting.

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Perficient: Drug Development

OCTOBER 3, 2024

In today’s world, automation and self-service is all around us. From self-order tablets at restaurants to self-checkout lanes at grocery stores and self-check in kiosks at airports, the ability to complete tasks without requiring additional human assistance is incredibly valuable, saving both time and resources. For organizations utilizing ServiceNow as their IT Service Management (ITSM) platform, the ServiceNow Virtual Agent offers a powerful solution to streamline support and enhance the self-

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Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 (HeathDay News) -- Moms-to-be have long known about breast milk's multiple benefits. Now, a global study confirms that antibodies passed from to baby in breast milk can indeed shield against disease. Immune system antibodies.

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Disease 52