Drug Discovery World
JANUARY 24, 2024
Oxitope Pharma and Arxx Therapeutics, companies with a shared goal of leveraging the innate immune system to discover and develop disease modulating therapies, has announced their merger to form Calluna Pharma. Calluna has raised €75 million in a series A financing and is backed by Oxitope and Arxx’s existing lead investors, Forbion, Sarsia, p53, and Investinor.
Chemical Biology and Drug Design
JANUARY 24, 2024
Compound 9i, a derivative of harmine with anticancer activity, was synthesized and characterized. The results of molecular docking and molecular dynamics simulations the complex (9i and DYRK1A kinase) was compact and stable. In addition, Compound 9i may be useful as a pro-oxidant for cancers caused by Ras over-activation. Abstract Modifications at the harmine (HAM) 9-N position demonstrated effective antitumor activity in previous studies.
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Drug Discovery World
JANUARY 24, 2024
The Phase IIa ACCENT trial has launched to explore the activity of focal adhesion kinase (FAK) inhibitor narmafotinib in combination with standard-of-care chemotherapy in advanced pancreatic cancer patients. In November 2023, Amplia Therapeutics announced completion of the Phase Ib stage of the ACCENT trial where ascending doses of narmafotinib, in combination with the standard-of-care chemotherapy regime of gemcitabine and Abraxane, were dosed to first-line patients with advanced pancreatic can
Chemical Biology and Drug Design
JANUARY 24, 2024
YH complex, consisting C. cassia and A. membranaceus , effectively promoted hair regeneration through the network pharmacology-derived prediction and experimental confirmation in testosterone-induced AGA mice. A new herbal formula, YH complex, might be an effective treatment for androgenetic alopecia. Abstract Cinnamomum cassia and Astragalus membranaceus have been used as traditional medicines as well as functional foods worldwide, but its hair growth properties have been verified yet.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
JANUARY 24, 2024
WEDNESDAY, Jan. 24, 2024 (Healthday News) -- The U.S. Food and Drug Administration has told drugmakers to add a boxed warning to a type of cancer treatment called CAR-T therapy, saying the treatment itself may sometimes cause a secondary.
Chemical Biology and Drug Design
JANUARY 24, 2024
Baicalin alleviates OGD/R-induced SK-N-SH cell apoptosis, inflammation, and ferroptosis in vitro, and brain injury in MCAO mice in vivo, via the regulation of miR-556-3p/ACSL4 pathway. Abstract Baicalin (BCL) has been found to have neuroprotective effects in ischemic stroke (IS), but its underlying molecular mechanisms are unknown. SK-N-SH cells were treated with BCL and then induced by oxygen–glucose deprivation/reoxygenation (OGD/R).
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
JANUARY 24, 2024
WEDNESDAY, Jan. 24, 2024 -- Strange visual disturbances occur early in about 10% of Alzheimer's cases, and when this happens it almost always signals the impending arrival of the disease, a new study finds.The condition is called posterior cortical.
Science Daily: Pharmacology News
JANUARY 24, 2024
Analysis of the remains of 24 individuals from the Wilamaya Patjxa and Soro Mik'aya Patjxa burial sites in Peru shows that early human diets in the Andes Mountains were composed of 80 percent plant matter and 20 percent meat.
Drugs.com
JANUARY 24, 2024
WEDNESDAY, Jan. 24, 2024 -- Heart disease remains the United States’ top cause of death, but progress is being made and more lives are being saved, a new report finds.There were 931,578 heart-related deaths in 2021, an increase of less than 3,000.
Science Daily: Pharmacology News
JANUARY 24, 2024
Scientists have found a way to reprogram T cells to fight aging. After using them to eliminate specific cells in mice, the scientists discovered they lived healthier lives and didn't develop aging-associated conditions like obesity and diabetes. Just one dose provided young mice with lifelong benefits and rejuvenated older mice.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
JANUARY 24, 2024
WEDNESDAY, Jan. 24, 2024 -- The American Lung Association’s annual report on smoking blasts President Joe Biden for failing to finalize rules that would end the sale of menthol cigarettes and flavored cigars.Last month, the Biden.
Perficient: Drug Development
JANUARY 24, 2024
Before I begin, I just want to caveat everything with the fact that HIPAA is a complex regulation open to interpretation, and in the end your legal and compliance teams need to be comfortable with how you handle data and the risk associated with those methods. With that being said, I’ve had a lot of experience with healthcare companies, both payers, providers and life sciences organizations dealing with HIPAA regulations over the last decade and having seen the direction Sitecore has been
Drugs.com
JANUARY 24, 2024
WEDNESDAY, Jan. 24, 2024 -- Reiterating a plea it made earlier this month, the American Red Cross is urging people to roll up their sleeves and give blood. A series of severe winter storms this month have exacerbated an already bad situation, as a.
Science Daily: Pharmacology News
JANUARY 24, 2024
Engineers have created a new lithium battery that can charge in under five minutes -- faster than any such battery on the market -- while maintaining stable performance over extended cycles of charging and discharging.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
JANUARY 24, 2024
WEDNESDAY, Jan. 24, 2024 -- JN.1, the COVID variant sweeping the country this winter, is not prompting more severe disease than earlier variants did, early U.S. government data suggests.While it does not appear to be more deadly than its.
Science Daily: Pharmacology News
JANUARY 24, 2024
Despite strict EU regulations on plastic recycling, there is little oversight on plastic waste shipped from the EU to Vietnam. A large percentage of the exported European plastic cannot be recycled and gets dumped in nature, according to recent research.
Drugs.com
JANUARY 24, 2024
WEDNESDAY, Jan. 24, 2024 -- If you decide to see a therapist, finding one who’s right for you presents one of the biggest early hurdles.“The field of psychology, psychiatry and psychotherapy has advanced over the years, and one of the ways it.
SCIENMAG: Medicine & Health
JANUARY 24, 2024
HOUSTON – (Jan. 24, 2024) – The Newborn Essential Solutions and Technologies (NEST360) international alliance launched Phase 2 of its groundbreaking mission to reduce newborn mortality in sub-Saharan Africa with $65 million in funding from the Bill & Melinda Gates Foundation, the Children’s Investment Fund Foundation, The ELMA Foundation, and generous individual contributions.
Drugs.com
JANUARY 24, 2024
WEDNESDAY, Jan. 24, 2024 -- Alcoholics Anonymous is a key means by which millions of Americans deal with drinking problems.
Collaborative Drug
JANUARY 24, 2024
Date: February 3rd to 7th 2024 Location: Boston Convention and Exhibition Center Boston, MA, Collaborative Drug Discovery (CDD) is excited to announce our participation in SLAS 2024 International Conference & Exhibition , from February 3rd to 7th at the Boston Convention and Exhibition Center. Join us at Booth #1168 for an immersive experience in one of the most dynamic gatherings in our industry.
Drugs.com
JANUARY 24, 2024
WEDNESDAY, Jan. 24, 2024 -- Could a blood pressure drug thats been around since the 1960s help ease anxiety in people with autism? That's the main finding from a small study where 69 people between the ages of 7 and 24 who had autism were given the.
Science Daily: Pharmacology News
JANUARY 24, 2024
A new advancement in theoretical physics could, one day, help engineers develop new kinds of computer chips that might store information for longer in very small objects.
SCIENMAG: Medicine & Health
JANUARY 24, 2024
Flinders University researchers say that cohesive and collaborative action from preventive health communicators and organisations is needed to inform young people about the devastating harms of vaping.
Science Daily: Pharmacology News
JANUARY 24, 2024
Scientists have succeeded in achieving the world's first pregnancy of a rhinoceros after an embryo transfer. The southern white rhino embryo was produced in vitro from collected egg cells and sperm and transferred into a southern white rhino surrogate mother at the Ol Pejeta Conservancy in Kenya on September 24, 2023. The BioRescue team confirmed a pregnancy of 70 days with a well-developed 6.4 cm long male embryo.
SCIENMAG: Medicine & Health
JANUARY 24, 2024
A good shoe can make a huge difference for runners, from career marathoners to couch-to-5K first-timers. But every runner is unique, and a shoe that works for one might trip up another.
Science Daily: Pharmacology News
JANUARY 24, 2024
Cryptocurrency is usually 'mined' through the blockchain by asking a computer to perform a complicated mathematical problem in exchange for tokens of cryptocurrency. But now a team of chemists have repurposed this process, asking computers to instead generate the largest network ever created of chemical reactions which may have given rise to prebiotic molecules on early Earth.
SCIENMAG: Medicine & Health
JANUARY 24, 2024
Hydrogen gas is the smallest and lightest of all known molecules, and its colorless and odorless nature makes it easy to leak. Also when concentrated above 4% in a confined space, it poses a risk of ignition or explosion.
Science Daily: Pharmacology News
JANUARY 24, 2024
Groundwater is rapidly declining across the globe, often at accelerating rates. Researchers now present the largest assessment of groundwater levels around the world, spanning nearly 1,700 aquifers. In addition to raising the alarm over declining water resources, the work offers instructive examples of where things are going well, and how groundwater depletion can be solved.
SCIENMAG: Medicine & Health
JANUARY 24, 2024
LA JOLLA (January 22, 2024)—Salk Professor Ronald Evans has been named the 2024 recipient of the Japan Prize in the field of Medical Science and Pharmaceutical Science. The Japan Prize Foundation awards this prestigious international award annually to “express Japan’s gratitude to international society.
Science Daily: Pharmacology News
JANUARY 24, 2024
Microorganisms were the first forms of life on our planet. The clues are written in 3.5 billion-year-old rocks by geochemical and morphological traces, such as chemical compounds or structures that these organisms left behind. However, it is still not clear when and where life originated on Earth and when a diversity of species developed in these early microbial communities.
BioPharma Drive: Drug Pricing
JANUARY 24, 2024
The sector’s first IPO of 2024 could be positive signal for the handful of other companies that have recently laid out plans for initial public offerings.
SCIENMAG: Medicine & Health
JANUARY 24, 2024
The Fukushima Daiichi nuclear disaster, triggered by the earthquake and tsunami on March 11, 2011, resulted in a severe release of radioactive materials, including cesium, from the damaged nuclear reactors.
Conversations in Drug Development Trends
JANUARY 24, 2024
Written By: Derek Ansel, MS, CCRA, Executive Director, Therapeutic Strategy Lead, Rare Disease Given that 80% of rare diseases have a genetic etiology, genetic implications should be addressed at the onset of a clinical program to support trial enrollment. Many of the rare disease studies we support at Worldwide have a genetic etiology, and we discuss genetics and genetic testing with these sponsors.
Drugs.com
JANUARY 24, 2024
WEDNESDAY, Jan. 24, 2024 -- Could a blood pressure drug thats been around since the 1960s help ease anxiety in people with autism?That's the main finding from a small study where 69 people between the ages of 7 and 24 who had autism were given the.
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