Nvidia Developer: Drug Discovery

DECEMBER 19, 2023

Enzymes are vital biological catalysts for a multitude of processes, from cellular metabolism to industrial manufacturing. The applications of artificial. Enzymes are vital biological catalysts for a multitude of processes, from cellular metabolism to industrial manufacturing. The applications of artificial intelligence for enzyme generation is an exciting field of research with direct applications in the life sciences.

Science 131

Science Small Molecule Bioinformatics Research 131

Chemical Biology and Drug Design

DECEMBER 19, 2023

Modified oligos and ‘central dogma’ using recombinant enzymes. Abstract Synthetic genomics is a novel field of chemical biology where the chemically modified genetic alphabets have been considered in central dogma of life. Tweaking of chemical compositions of natural nucleotide bases could be developed as novel building blocks of DNA/RNA. The modified bases (dP, dZ, dS, and dB etc.) have been demonstrated to be adaptable for replication, transcription and follow Darwinism law of evolution.

RNA 100

RNA DNA Research 100

Science Daily: Pharmacology News

DECEMBER 19, 2023

Are we able to differentiate between the vocal emissions of certain primates? A team asked volunteers to categorize the vocalizations of three species of great apes (Hominidae) and humans. During each exposure to these ''onomatopoeia'', brain activity was measured. Unlike previous studies, the scientists reveal that phylogenetic proximity -- or kinship -- is not the only factor influencing our ability to identify these sounds.

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Chemical Biology and Drug Design

DECEMBER 19, 2023

In this study, PS was searched through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and SYMMAP database. Then search for HCC targets in the five major databases. Next, we created a network and performed Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. In addition, molecular docking and molecular dynamics simulation were used for verification.

Regulations 100

Regulations Research Treatment Production 100

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Science Daily: Pharmacology News

DECEMBER 19, 2023

Early in the 1970s, paleontologists discovered strange fossilized fruits between hardened rock from one of the largest volcanic eruptions in Earth's history. The identity of these fossils remained elusive for the next several decades. Using CT scanning, scientists have now determined they are the oldest fossils from species in the Frankincense and Myrrh family.

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121

Drugs.com

DECEMBER 19, 2023

TUESDAY, Dec. 19, 2023 -- Probiotics might be able to help people dodge the worst effects of COVID-19, new clinical trial results show.Unvaccinated people who took a lactobacillus-laced probiotic had reduced COVID symptoms and even delayed.

Clinical Trials 111

Clinical Trials Trials 111

Drugs.com

DECEMBER 19, 2023

TUESDAY, Dec. 19, 2023 -- A person’s toothbrush could be a true lifesaver if they land in a hospital ICU, according to new evidence review.Regular toothbrushing is associated with lower rates of death in the intensive care unit (ICU), shorter.

Hospitals 105

Hospitals 105

Elrig

DECEMBER 19, 2023

Relive Drug Discovery 23 with SelectScience’s hub that features exclusive content from the event. The post ELRIG Drug Discovery 2023 meeting highlights first appeared on ELRIG.

Drugs 98

Drugs Science 98

Drugs.com

DECEMBER 19, 2023

TUESDAY, Dec. 19, 2023 -- Cinnamon samples gathered at a facility in Ecuador linked to tainted applesauce pouches were found to contain levels of toxic lead that were 2,000 times higher than proposed standards, according to U.S. Food and Drug.

FDA 105

FDA Drugs 105

Collaborative Drug

DECEMBER 19, 2023

The Research Informatics and Development groups at CDD are continually developing computational tools within CDD Vault to help accelerate drug discovery. The newest addition to this suite of features is a novel Deep Learning model to aid medicinal chemists.

Research 96

Research Drugs 96

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

DECEMBER 19, 2023

TUESDAY, Dec. 19, 2023 -- Early results from a trial of a new kidney disease medication show it significantly reduces levels of a urine marker of kidney damage.The experimental drug -- called BI 690517 for now -- cut levels of the liver protein.

Disease 105

Disease Drugs Trials 105

BioPharma Drive: Drug Pricing

DECEMBER 19, 2023

The biotechnology company’s share price fell more than 10% Tuesday after the disclosure of more data from a small study.

Therapies 118

Therapies 118

Drugs.com

DECEMBER 19, 2023

TUESDAY, Dec. 19, 2023 -- Cases keep rising in an outbreak of salmonella illness tied to cantaloupes that began last month, with 302 people now sickened across 42 states, federal officials said.As of Dec. 15, four people had died and 129 had been.

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105

BioPharma Drive: Drug Pricing

DECEMBER 19, 2023

The company’s shot targets 21 strains of pneumococcal bacteria and, if approved, would compete with Pfizer’s Prevnar 20.

Vaccine 113

Vaccine FDA 113

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Clinical Trials

Drugs.com

DECEMBER 19, 2023

TUESDAY, Dec. 19, 2023 -- At-home tests for colon cancer make this important screening readily available to folks who can’t afford or would rather not go through a colonoscopy.Unfortunately, more than 1 in 10 at-home tests sent to a lab are.

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105

Science Daily: Pharmacology News

DECEMBER 19, 2023

Humans have wiped out around 1,400 bird species -- twice as many as previously thought -- with major implications for the ongoing biodiversity crisis, a new study has found. The estimated extinctions would mean almost 12 per cent of bird species have died out over modern human history, since the Late Pleistocene around 130,000 years ago, with the vast majority of them becoming extinct directly or indirectly due to human activity.

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100

Drugs.com

DECEMBER 19, 2023

TUESDAY, Dec. 19, 2023 -- Hospital coffee machines have received some side-eye as a potential source of spreading infection, but a new study debunks the belief.“To our great relief…a general ban on coffee makers doesn’t seem necessary,”.

Hospitals 105

Hospitals 105

SCIENMAG: Medicine & Health

DECEMBER 19, 2023

Kyoto, Japan — Down syndrome, a congenital disorder stemming from abnormal cell division and differentiation, is most common in newborns fated to neurodevelopmental delays and other health complications.

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86

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Clinical Trials

Drugs.com

DECEMBER 19, 2023

TUESDAY, Dec. 19, 2023 -- Elite athletes who suffer a sudden cardiac arrest might have genetics that make them more vulnerable to heart disease, a new study suggests.Analysis of more than 280 top-level endurance athletes revealed that 1 in 6 have.

Disease 104

Disease 104

SCIENMAG: Medicine & Health

DECEMBER 19, 2023

David Kaplan, the Stern Family Endowed Professor of Engineering, has been named a fellow of the National Academy of Inventors (NAI). Election as an academy fellow is the highest professional distinction awarded solely to inventors. The NAI was founded to recognize and encourage inventors with U.S. patents and enhance the visibility of academic technology and innovation.

Engineering 85

Engineering 85

Drugs.com

DECEMBER 19, 2023

TUESDAY, Dec. 19, 2023 -- COVID-19 appears to have paralyzed a teen girl’s vocal cords, blocking her breathing to the point that surgery was required, a new case report says.The case suggests that vocal cord paralysis might be a rare complication.

Doctors 104

Doctors 104

SCIENMAG: Medicine & Health

DECEMBER 19, 2023

Kyoto, Japan – December 2023 Credit: credit: Kalyani B. Karunakaran/WPI-ASHBi Kyoto, Japan – December 2023 Anxiety disorders (ADs) affect more than 280 million people worldwide, making them one of the most common mental health conditions.

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Covalent Modifiers

DECEMBER 19, 2023

Kevin A. Scott, Hiroyuki Kojima, Nathalie Ropek, Charles D. Warren, Tiffany L. Zhang, Simon J. Hogg, Caroline Webster, Xiaoyu Zhang, Jahan Rahman, Bruno Melillo, Benjamin F. Cravatt, Jiankun Lyu, Omar Abdel-Wahab, Ekaterina V Vinogradova bioRxiv 2023.12.18.572199; doi: [link] Despite significant interest in therapeutic targeting of splicing, few chemical probes are available for the proteins involved in splicing.

Protein Expression 81

Protein Expression Regulations 81

SCIENMAG: Medicine & Health

DECEMBER 19, 2023

The University of Tennessee Research Foundation (UTRF) celebrated the researchers whose achievements are making life better locally, nationally, and globally at its annual Innovation Awards ceremony, held December 14 at the Mooney Library at the University of Tennessee Health Science Center (UTHSC) in Memphis.

Research 82

Research Science 82

BioPharma Drive: Drug Pricing

DECEMBER 19, 2023

A decision by European regulators to revoke approvals for five generic versions of Biogen's multiple sclerosis medicine helps cement the drug's monopoly there through early 2025.

Marketing 69

Marketing Regulations Drugs 69

SCIENMAG: Medicine & Health

DECEMBER 19, 2023

The Department of Audiology and Speech Pathology at the University of Tennessee Health Science Center and the Department of Hearing and Speech Sciences at Vanderbilt University have secured a $2,399,454 grant to fund a five-year project to address the need for diversity in highly trained professionals in speech-language pathology.

Science 80

Science 80

Covalent Modifiers

DECEMBER 19, 2023

Daniela Krummenacher, Weiping He, Bernd Kuhn, Christian Schnider, Angélica Beurier, Virginie Brom, Thulase Sivasothy, Christine Marty, Andreas Tosstorff, David S. Hewings, Stefanie Mesch, Emmanuel Pinard, Mathis Brändlin, Remo Hochstrasser, Paul Westwood, Judith Rothe, Alexandra Kronenberger, Federica Morandi, Simon Gutbier, Angelika Schuler, Dominik Heer, Ludivine Esteves Gloria, Lisa Joedicke, Markus G.

Disease 63

Disease 63

SCIENMAG: Medicine & Health

DECEMBER 19, 2023

Assisted reproductive technologies not associated with body mass index in children, except when using frozen embryos – according to new Danish study Credit: Kristina Laugesen (CC-BY 4.

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79

NIOSH Science Blog: Drugs

DECEMBER 19, 2023

The pandemic has brought attention to the safety, health, and well-being of workers in healthcare. Recent efforts to address these issues include, the Office of the Surgeon General’s Addressing Health Worker Burnout,(1) an “Advisory on Building a Thriving Health Workforce,” from the National Academy of Medicine’s National Plan for Healthcare Workforce Wellbeing (2) and the NIOSH Health Worker Mental Health Initiative (3).

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68

SCIENMAG: Medicine & Health

DECEMBER 19, 2023

The widespread use of cannabis (marijuana) and its increased potency are associated with a rise in cannabis-related psychiatric conditions, according to a new University of Maryland School of Medicine (UMSOM) review article that was recently published in the New England Journal of Medicine.

Doctors 75

Doctors 75

The ChEMBL-og

DECEMBER 19, 2023

2023 has been a productive year for the ChEMBL team, with two separate releases of ChEMBL, an overhaul of the ChEBI data schema, and the release of the new SureChEMBL. We introduced some new features in ChEMBL, including a flag for Natural Products and Chemical Probes and updated our Natural Product-likeness score. Drug data in ChEMBL and drug warning information has been updated for ChEMBL 32.

Production 62

Production Drugs 62

Molecular Design

DECEMBER 19, 2023

I’ll be taking a look at H2023 (Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes) in this post and this article has also been discussed In The Pipeline. I’ll primarily be discussing the quality criteria for covalent probes in this post although I’ll also comment briefly on chemical matter criteria proposed for degrader probes.

Small Molecule 66

Small Molecule Biochemical Assays Cell Based Assays Drugs 66

Drug Patent Watch

DECEMBER 19, 2023

Annual Drug Patent Expirations for ARNUITY+ELLIPTA Arnuity Ellipta is a drug marketed by Glaxosmithkline and is included in one NDA. It is available from one supplier. There are six patents… The post New patent for Glaxosmithkline drug ARNUITY ELLIPTA appeared first on DrugPatentWatch - Make Better Decisions.

Drugs 59

Drugs Marketing 59