Thu.Jul 25, 2024

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New study shows at-home colon cancer screening test reduces risk of colorectal cancer death, as effective as screening colonoscopy

Science Daily: Pharmacology News

A noninvasive colorectal cancer screening test that can be done at home could reduce the risk of colorectal cancer death by 33%, according to a new study.

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The Curse of Perfection – Toil and Trouble

Perficient: Drug Development

“Double, double toil and trouble,” is a line repeated by the witches in Macbeth as they lay out the ominous prophecies of greatness and dire consequences for the titular character. Macbeth’s ambition envisions a perfect ending though desperate actions and moral weakness ruin it. So too are the misguided actions in pursuit of perfection which can set expectations and pressure that lead to unwanted results.

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A recipe for zero-emissions fuel: Soda cans, seawater, and caffeine

Science Daily: Pharmacology News

Engineers discovered that when the aluminum in soda cans is purified and mixed with seawater, the solution produces hydrogen -- which can power an engine or fuel cell without generating carbon emissions. The reaction can be sped up by adding caffeine.

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Sanofi’s immunology bet starts to pay off

BioPharma Drive: Drug Pricing

Some analysts described Sanofi’s pipeline of immune system therapies, which includes more than half a dozen drugs in mid- to late-stage testing, as “underappreciated” by investors, as sales of Dupixent rose over the last quarter.

Therapies 118
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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New drug shows promise in clearing HIV from brain

Science Daily: Pharmacology News

An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a major challenge in HIV treatment.

Virus 131
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Bird Flu Is Now Transmitting Mammal-to-Mammal: Study

Drugs.com

THURSDAY, July 25, 2024 -- The bird flu is now jumping between species of mammals, a step that draws the virus closer to hopping into human beings, a new study warns.Researchers have tracked transmission of avian influenza between dairy cows in.

Virus 116

More Trending

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'Two-Target' Antibiotics Could Make Bacterial Resistance Much Tougher

Drugs.com

THURSDAY, July 25, 2025 -- Synthetic antibiotics that attack bacteria in two directions at once could be the solution for combatting antimicrobial-resistant bugs, a new study claims.These dual-action antibiotics, called macrolones, disrupt.

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How evolution tamed a deadly virus and why we should still worry

Science Daily: Pharmacology News

Over the last century, a once-deadly mosquito-borne virus has evolved so that it no longer sickens humans. New research shows that changes in the virus's ability to target human cells paralleled the decline in illness and death. The findings offer important lessons in virology that may help guide better preparedness for future outbreaks of other viral diseases.

Virus 116
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Need a Good Medicare Advantage Plan? They're Tough to Find for Poorer Americans

Drugs.com

THURSDAY, July 25, 2024 -- Medicare Advantage plans are touted as a great alternative to traditional Medicare, offering seniors easier access to doctors, hospitals and prescription drugs.But access to a good Medicare Advantage plan relies heavily.

Doctors 105
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New Zealand's flightless birds are retreating to moa refuges

Science Daily: Pharmacology News

Researchers have found New Zealand's endangered flightless birds are seeking refuge in the locations where six species of moa last lived before going extinct.

Research 112
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Comparison Guide: huNOG® & huNSG™ Humanized Models

Crown Bioscience

Humanized mice, encompassing human tumors and human immune cells engrafted on immunodeficient mice, have been widely used for many years in immuno-oncology, with developments to improve both the humanization and the translational value central to the next generation of models.

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Nitrogen emissions have a net cooling effect: But researchers warn against a climate solution

Science Daily: Pharmacology News

An international team of researchers has found that nitrogen emissions from fertilizers and fossil fuels have a net cooling effect on the climate. But they warn increasing atmospheric nitrogen has further damaging effects on the environment, calling for an urgent reduction in greenhouse gas emissions to halt global warming.

Research 100
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Wildfires in Western U.S., Canada Create Hazardous Air Conditions

Drugs.com

THURSDAY, July 25, 2024 -- Wildfires raging in several states and Canada are triggering air quality alerts and evacuation orders across the western parts of the United States.Smoke and haze have filled the skies in California, Oregon, Arizona.

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Chemical analyses find hidden elements from renaissance astronomer Tycho Brahe's alchemy laboratory

Science Daily: Pharmacology News

Danish Tycho Brahe was most famous for his contributions to astronomy. However, he also had a well-equipped alchemical laboratory where he produced secret medicines for Europe's elite.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Dengue May Be Bigger Threat to Obese Children

Drugs.com

THURSDAY, July 25, 2024 -- Obese kids infected with dengue are significantly more likely to suffer severe illness requiring hospitalization, a new study warns.A new analysis of nearly 5,000 dengue-infected Sri Lankan children found that weight.

Hospitals 104
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How to Navigate the Generic Drug Market Post-COVID

Drug Patent Watch

The generic drug market has been significantly impacted by the COVID-19 pandemic, with both challenges and opportunities arising from the crisis.

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U.S. Infant Deaths Rise for First Time in Decades

Drugs.com

THURSDAY, June 25, 2024 -- For the first time in two decades, the infant mortality rate in the United States has risen, new government data shows.In a report released Thursday by the U.S. Centers for Disease Control and Prevention, researchers.

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CDD Vault Update (July 2024)

Collaborative Drug

Inventory Search Interface: The new CDD Vault Inventory tab can be enabled by the CDD Support Team. If you wish to enable this tab in your vault please have your vault administrator contact support@collaborativedrug.com.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Pesticides Can Equal Smoking in Hiking Risks for Cancer

Drugs.com

THURSDAY, July 25, 2024 -- Farmers and folks living in agricultural areas may be exposed to levels of pesticides that confer cancer risks that are higher than if they smoked, new research shows.These extra risks were most pronounced for certain.

Research 103
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Q&A: How a stem cell bank is helping scientists understand psychiatric disorders

Broad Institute

Q&A: How a stem cell bank is helping scientists understand psychiatric disorders By Allessandra DiCorato July 25, 2024 Breadcrumb Home Q&A: How a stem cell bank is helping scientists understand psychiatric disorders Ralda Nehme, director of Broad’s stem cell program, talks about how stem cells can be a model for disease in a dish and what scientists can learn from these experiments.

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New Insights Into How Sleep Apnea Affects the Brain

Drugs.com

THURSDAY, July 24, 2024 -- Millions of Americans deal with the sleep deficits brought on by sleep apnea, and many turn to one of the few treatments out there, continuous positive airway pressure (CPAP) machines.But what if new neurochemical targets.

Treatment 103
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How to Develop a Competitive Edge in Generic Drug Development

Drug Patent Watch

Developing a competitive edge in generic drug development is crucial for companies to gain a significant market share and dominate the market.

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Where Your Body Stores Fat Could Affect Odds for Parkinson's, Alzheimer's

Drugs.com

THURSDAY, July 25, 2024 -- Finding yourself packing on the pounds around your waist and arms? If so, you might be at heightened risk for neurological illnesses like Alzheimer's or Parkinson's, new research suggests.There was one other physical.

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NASA's Fermi finds new feature in brightest gamma-ray burst yet seen

Science Daily: Pharmacology News

In October 2022, astronomers were stunned by what was quickly dubbed the BOAT -- the brightest-of-all-time gamma-ray burst (GRB). Now an international science team reports that data from NASA's Fermi Gamma-ray Space Telescope reveals a feature never seen before.

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Roche says it’ll move quickly with ‘differentiated’ obesity drugs

BioPharma Drive: Drug Pricing

CEO Thomas Schinecker claimed the company has “many opportunities” to stand out in the competitive field, and can get to market “much faster” than investors expect.

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Antibodies 101: The Four ELISAs and When to Use Them

addgene Blog

An enzyme-linked immunosorbent assay (ELISA) is a versatile method used to quantify the level of target antigen in a sample. While Engvall et al. originally developed the ELISA assay to measure antibody levels, scientists have since adapted it for a host of different proteins and small molecules from a variety of sample types (Engvall 1971). Scientists value ELISAs for their accuracy, specificity, and sensitivity (a good ELISA can detect picogram quantities of the target!

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Viking shares jump on plans to speed obesity drug into late-stage testing

BioPharma Drive: Drug Pricing

The drug’s advancement continued what one analyst described as a “torrid” pace for Viking’s closely watched medicine, which started human testing in 2022 and could reach a Phase 3 trial next year.

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Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor

Covalent Modifiers

Darragh P O’Brien, Hannah BL Jones, Yuqi Shi, Franziska Guenther, Iolanda Vendrell, Rosa Viner, Paul E Brennan, Emma Mead, Tryfon Zarganes-Tzitzikas, John B Davis, Adán Pinto-Fernández, Katherine S England, Emma J Murphy, Andrew P Turnbull, Benedikt M Kessler bioRxiv 2024.07.20.604388; doi: [link] Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorde

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Researchers identify cheap and effective biomarkers for DCIS tumor stage

Broad Institute

Researchers identify cheap and effective biomarkers for DCIS tumor stage By Tom Ulrich July 25, 2024 Breadcrumb Home Researchers identify cheap and effective biomarkers for DCIS tumor stage New study shows how leveraging unsupervised learning can decode DCIS progression from chromatin images. By Nadya Karpova, Eric and Wendy Schmidt Center July 25, 2024 Credit: Sarahkayb, distributed under a CC BY-SA 4.0 license A microscope image of the cribiform variant of ductal carcinoma in situ (DCIS) Relat

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Michelson Philanthropies & Science Prize for Immunology ePanel, September 10, 2024

keypoint

On September 10, 2024, Keystone Symposia will host a free ePanel event featuring the recipients of the Michelson Philanthropies & Science Prize for Immunology. This international prize is a collaboration between the Michelson Medical Research Foundation and Science to support young investigators doing transformative research in human immunology, based on work done in the past three years.

Science 70
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Rock art and archaeological record reveal man's complex relationship with Amazonian animals

Science Daily: Pharmacology News

Rock art explored by archaeologists in the Colombian Amazon has provided an insight into the complex relationship between the earliest settlers on the continent and the animals they encountered.

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How to Find Key Starting Materials (KSMs) for Pharmaceutical APIs

Drug Patent Watch

To identify Key Starting Materials (KSMs) for Active Pharmaceutical Ingredients (APIs), pharmaceutical companies and regulatory bodies follow a systematic approach […] Source

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Ancient marine animal had inventive past despite being represented by few species

Science Daily: Pharmacology News

Brachiopods were evolving in new directions but this did not turn into evolutionary success in terms of the numbers of species, researchers have found.