Drug Discovery Today
DECEMBER 6, 2023
DPV has plans to further expand the fund up to £25m in the next three years with a focus on companies developing novel and disruptive technologies that have strong collaborative relationships with Discovery Park.
BioPharma Drive: Drug Pricing
DECEMBER 6, 2023
The deal hands AbbVie a portfolio of psychiatric medicines that originated within Pfizer, among them a closely watched schizophrenia treatment that’s in late-stage testing.
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Drug Discovery Today
DECEMBER 6, 2023
• BugBiome wins a business support package worth over £100,000, including one year of free lab space at Discovery Park and £50,000 investment from Discovery Park Ventures• BioMavericks awarded the wildcard prize as voted for by the audience at the GIANT Health Healthcare Investment Show on 5th December
Chemical Biology and Drug Design
DECEMBER 6, 2023
let-7g sensitized the response of liver cancer cells to 5-FU by targeting ABCC10, prolonging the G1 phase and promoting apoptosis. These findings provide new insights into the chemotherapy resistance of HCC. Abstract Patients with advanced liver cancer may benefit from 5-fluorouracil (5-FU) therapy. However, most of them eventually faced drug resistance, resulting in a poor prognosis.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
ASPET
DECEMBER 6, 2023
Organophosphates (OP) and nerve agents are potent neurotoxic compounds that cause seizures, status epilepticus, brain injury or death. There are persistent long-term neurological and neurodegenerative effects that manifest months to years after the initial exposure. Current antidotes are ineffective in preventing these long-term neurobehavioral and neuropathological changes.
Chemical Biology and Drug Design
DECEMBER 6, 2023
To sum up, guided by network pharmacological analysis and previous literature research, a p53 interfering cell model has been established with the help of shRNA interference technology to investigate the anti-HS effect of SP-FC dependent on p53 in this study. Finally, we discover that that SP-FC may promote apoptosis of HSFs by up-regulating the expression of p53 protein.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
DECEMBER 6, 2023
The pharma is developing Fabhalta, now cleared for paroxysmal nocturnal hemoglobinuria, for several other rare, complement-driven diseases.
Science Daily: Pharmacology News
DECEMBER 6, 2023
Two nanotechnology approaches converge by employing a new generation of fabrication technology. It combines the scalability of semiconductor technology with the atomic dimensions enabled by self-assembly.
Drug Discovery Today
DECEMBER 6, 2023
Researchers have established a first potential therapeutic target for a type of early-onset dementia.
Drugs.com
DECEMBER 6, 2023
WEDNESDAY, Nov. 6, 2023 -- States that ban abortion could be headed to a brain drain when it comes to up-and-coming medical professionals.Three out of four future U.S. doctors say state access to abortion is a key factor in choosing where they’ll.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
SCIENMAG: Medicine & Health
DECEMBER 6, 2023
Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics.
Drugs.com
DECEMBER 6, 2023
WEDNESDAY, Dec. 6, 2023 -- Neurologist Dr. Deborah Holder says she often has parents come to her with kids who've experienced what they call "funny spells." “Sometimes I start talking to a parent and find out the parent has [also] had.
SCIENMAG: Medicine & Health
DECEMBER 6, 2023
Detailed insights into muscle and tendon movement mechanisms during stretching are essential to improve our overall mobility and flexibility. It is not only important for optimum athletic performance, but also crucial for preventing musculoskeletal injuries. When an individual stretches, 50% to 70% of the elongation is absorbed into the muscle belly, i.e.
Drugs.com
DECEMBER 6, 2023
WEDNESDAY, Dec. 6, 2023 -- Folks with a family history of heart disease might benefit from eating more oily fish like salmon, mackerel, herring and sardines, a new study finds.Oily fish contain high levels of omega-3 fatty acids, which cannot be.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
SCIENMAG: Medicine & Health
DECEMBER 6, 2023
Human fingers and toes do not grow outward; instead, they form from within a larger foundational bud, as intervening cells recede to reveal the digits beneath. This is among many processes captured for the first time as scientists unveil a spatial cell atlas of the entire developing human limb, resolved in space and time.
Drugs.com
DECEMBER 6, 2023
WEDNESDAY, Dec. 6, 2023 -- Folks with a family history of heart disease might benefit from eating more oily fish like salmon, mackerel, herring and sardines, a new study finds. Oily fish contain high levels of omega-3 fatty acids, which cannot be.
BioPharma Drive: Drug Pricing
DECEMBER 6, 2023
Data collected by the research firm suggests venture funding totals are still sliding amid a "strategic shift" by investors towards fewer, but more substantial deals.
Drugs.com
DECEMBER 6, 2023
WEDNESDAY, Dec. 6, 2023 -- Girls whose periods begin before the age of 13 are at higher risk of becoming adult women with diabetes, compared to girls who start menstruation later, new research shows.An earlier onset of periods also appears to hike.
Eye on FDA
DECEMBER 6, 2023
For those working closely with the development of new medicines for FDA approval, it can be informative respecting the future to look back at recent activity and take note of any potential changes from years past. Now, with no more AdComms scheduled for 2023 – and it being highly unlikely that any will be – it is that time of year to do just that.
Drugs.com
DECEMBER 6, 2023
WEDNESDAY, Dec. 6, 2023 -- Few people look forward to doctor visits, but a new survey shows that many minorities feel a deep sense of dread. Some even try to dress especially well for their visit, to try and ward off the possibility they'll face.
Covalent Modifiers
DECEMBER 6, 2023
Brett Cosgrove, Emma K. Grant, Sophie Bertrand, Kenneth D. Down, Don O. Somers, John P. Evans d, Nicholas C. O. Tomkinson and Michael D. Barker RSC Chem. Biol. , 2023, 4, 1111-1122 DOI: 10.1039/D3CB00142C The synthesis and characterisation of fluorosulfate covalent inhibitors of the lipid kinase PI4KIIIβ is described. The conserved lysine residue located within the ATP binding site was targeted, and optimised compounds based upon reversible inhibitors with good activity and physicochemical profi
Drugs.com
DECEMBER 6, 2023
WEDNESDAY, Dec. 6, 2023 -- The newly approved weight-loss medication known as Zepbound is now available for patients to take, drug maker Eli Lilly announced Tuesday. "Today opens another chapter for adults living with obesity who have been looking.
SCIENMAG: Medicine & Health
DECEMBER 6, 2023
In an effort to improve the health of Tribal communities and Indigenous people, the National Institutes of Health (NIH) has awarded $9 million in funding for Native scientists at Arizona State University and elsewhere to create the first Indigenous-led Tribal Data Repository.
Science Daily: Pharmacology News
DECEMBER 6, 2023
New research has found that two similar species of birds behave very differently around their favorite food when they have company. Biologists compared the behavior of two species of corvids, Eurasian jays and New Caledonian crows, both capable of displaying self-control through delayed gratification. The researchers found that jays will settle for an immediate, less preferred food option when another bird is present, while crows will always hold out for their favorite food, regardless of the so
Drug Channels
DECEMBER 6, 2023
Is the world ready for new ways to price pharmacy and pharmacy benefit manager (PBM) services? CVS Health thinks so, as evidenced by two new initiatives that it announced yesterday. Below you'll find details and links to source documents. I commend CVS Health for attempting to address key economic challenges facing the retail pharmacy industry and for tackling the hidden complexities of PBM pricing models.
Science Daily: Pharmacology News
DECEMBER 6, 2023
Scientists reveal unprecedented insights into human limb development, including the many intricate processes that govern their formation.
Covalent Modifiers
DECEMBER 6, 2023
Qinhong Luo, Yaqi Wang, Zhanfeng Hou, Huiting Liang, Licheng Tu, Yun Xing, Chuan Wan, Jianbo Liu, Rui Wang, Lizhi Zhu, Wei Han, Jianlong Wu, Fei Lu, Feng Yin and Zigang Li Chem. Commun. , 2024 DOI: 10.1039/D3CC05127G Covalent proteolysis-targeting chimeras (PROTACs) offer enhanced selectivity, prolonged action, and increased efficacy against challenging target proteins.
Drug Target Review
DECEMBER 6, 2023
Dear readers, Welcome to this report on cancer research, where we explore the latest breakthroughs in cancer research. In three comprehensive chapters, we explore recent developments that promise to reshape the landscape of cancer treatment. Expert insights Patrick Kendall, Artelo Biosciences through his consulting company, KendallPharma ltd Dr Benjamin Neuditschko, Postdoc at IMC University of Applied Sciences Krems’ Institute Krems Bioanalytics Dr Andy Souers, Research Fellow on the Oncology
Drug Patent Watch
DECEMBER 6, 2023
Annual Drug Patent Expirations for ZEGALOGUE Zegalogue is a drug marketed by Zealand Pharma and is included in one NDA. It is available from two suppliers. There is one patent… The post New patent for Zealand Pharma drug ZEGALOGUE appeared first on DrugPatentWatch - Make Better Decisions.
Cytel
DECEMBER 6, 2023
Chemistry, Manufacturing, and Controls (CMC) is a critical component of drug product development. As a Senior Consultant in Drug Development, I serve as a representative for sponsors with the Contract Development and Manufacturing Organization (CDMO). The CDMO manufactures drug substances or drug formulations for safety studies and investigational drugs for clinical trials.
BioPharma Drive: Drug Pricing
DECEMBER 6, 2023
The funds are meant to boost Fujifilm’s capacity to manufacture cell therapies, a market it expects to grow substantially in the coming years.
SCIENMAG: Medicine & Health
DECEMBER 6, 2023
Light therapy leads to significant improvements in sleep and psycho-behavioral symptoms for patients with Alzheimer’s disease, according to a new study published this week in the open-access journal PLOS ONE by Qinghui Meng of Weifang Medical University, China, and colleagues.
BioPharma Drive: Drug Pricing
DECEMBER 6, 2023
The results dim the outlook of so-called BTK inhibitors as potential autoimmune disease treatments and could have ramifications for Roche, Sanofi and Novartis.
Drug Target Review
DECEMBER 6, 2023
Dear readers, Today’s drug screening methods predominantly rely on one or two types of data, limiting their ability to replicate the intricate nature of disease biology. However, the advent of advanced screening techniques capable of processing numerous data sources simultaneously has unearthed novel hits that have eluded us throughout the history of medicine.
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