Chemical Biology and Drug Design

MAY 17, 2024

The study screened and identified furochromenones that impact tyrosinase activity. One of the furochromenones ( 3k ) inhibited while another ( 4f ) stimulated tyrosinase. Abstract Tyrosinase is a copper-containing enzyme involved in the biosynthesis of melanin pigment. While the excess production of melanin causes hyperpigmentation of human skin, hypopigmentation results in medical conditions like vitiligo.

Biochemical Assays 100

Biochemical Assays Regulations Production Research 100

Science Daily: Pharmacology News

MAY 17, 2024

The latest findings forecast that global life expectancy will increase by 4.9 years in males and 4.2 years in females between 2022 and 2050. Increases are expected to be largest in countries where life expectancy is lower, contributing to a convergence of increased life expectancy across geographies. The trend is largely driven by public health measures that have prevented and improved survival rates from cardiovascular diseases, COVID-19, and a range of communicable, maternal, neonatal, and nut

Disease 131

Disease 131

Drugs.com

MAY 17, 2024

FRIDAY, May 17, 2024 -- Mice, rats and other wildlife can pick up bacteria called leptospira from water or soil and excrete it in urine. If your dog contacts any soil or water contaminated by the germ (especially if they have an open wound) they.

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Science Daily: Pharmacology News

MAY 17, 2024

An HIV vaccine candidate triggered low levels of an elusive type of broadly neutralizing HIV antibodies among a small group of people enrolled in a 2019 clinical trial.

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Vaccine Trials Clinical Trials 131

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

MAY 17, 2024

FRIDAY, May 17, 2024 -- Cutting-edge cancer treatments are essentially useless for patients barely clinging to life, a new study shows.Chemotherapies, immunotherapies, targeted therapies and hormone therapies do not improve survival rates in.

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Treatment Therapies 111

Science Daily: Pharmacology News

MAY 17, 2024

The patterns of dispersal of early humans across continents and islands are hotly debated, but researchers have found that Pleistocene hunter-gatherers settled in Cyprus thousands of years earlier than previously thought. In examining the timing of the first human occupation of Cyprus, research found that large islands in the Mediterranean Sea were attractive and favorable destinations for palaeolithic peoples.

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Research 98

Collaborative Drug

MAY 17, 2024

View assay ontology branches Protocol forms in CDD Vault facilitate assay informatics. Vault administrators create protocol forms under the Settings->Vault->Protocol Forms page. Utilize fields from two public ontologies: ‘Common assay template’ and ‘Pistoia Alliance assay template’. Click the ‘view’ link next to the field name to see the terms for that specific branch.

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Drugs.com

MAY 17, 2024

FRIDAY, May 17, 2024 -- People with asthma who vape tend to develop the respiratory disease earlier in life than folks who never vaped, new research shows. Overall, asthmatic adults who said they'd vaped over the past month were over three times as.

Disease 105

Disease Research 105

BioPharma Drive: Drug Pricing

MAY 17, 2024

Imdelltra, a bispecific antibody targeting a protein called DLL3, is cleared for use following chemotherapy in treating extensive-stage small cell lung cancer.

FDA Approval 76

FDA Approval FDA Drugs 76

Drugs.com

MAY 17, 2024

FRIDAY, May 17, 2024 -- The smell of food is appetizing when you’re hungry. At the same time, it can be a turnoff if you’re full.That’s due to the interaction between two different parts of the brain involving sense of smell and behavior.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

MAY 17, 2024

The cancer biotech is laying off one-fifth of its staff and scrapping three drugs. Elsewhere, Novartis secured sufficient support for its $3B buyout and Bristol Myers won a new CAR-T approval.

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Drugs 67

Drugs.com

MAY 17, 2024

FRIDAY, May 17, 2024 -- Kids and young adults who use social media for seven or more hours per day have double the risk of taking up vaping or smoking or both, new research shows.The study is based on a survey of almost 11,000 young British people.

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Research 98

Agency IQ

MAY 17, 2024

BY WALKER LIVINGSTON, ESQ In March, the EPA published its draft toxicological review for perfluorononanoic acid (PFNA), a chemical commonly used in firefighting foams and plastic production, soliciting comments on the veracity of its research. This AgencyIQ analysis covers insights in comments that may impact the EPA’s finalized review. Perfluorononanoic acid (PFNA) (CAS RN 375-95-1) is part of a wider class of chemicals called per- and polyfluoroalkyl substances (PFAS).

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Government Production Research 59

Drugs.com

MAY 17, 2024

FRIDAY, May 17, 2024 -- Men are more vulnerable than women to the debilitating effects of diabetes, a new long-term study finds.Overall rates of diabetes are similar between men and women, according to the report published May 16 in the Journal of.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Agency IQ

MAY 17, 2024

BY RACHEL COE, MSC Under GDUFA III, the scope and purpose of pre-submission meetings for generic drug developers has changed. During a meeting this week, FDA speakers highlighted the uniqueness of this redesigned meeting type in allowing sponsors to explain how they’ve addressed challenges encountered during product development. Fill out the form to read the full article.

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FDA Drug Development Drugs Production 59

Drugs.com

MAY 17, 2024

FRIDAY, MAY 17, 2024 -- The U.S. Food and Drug Administration on Thursday approved a new drug to treat patients with an advanced form of deadly lung cancer. Importantly, tarlatamab (Imdelltra) is only for patients who have exhausted all other.

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FDA Approval FDA Drugs 112

Agency IQ

MAY 17, 2024

BY WALKER LIVINGSTON, ESQ On May 9, 2024, Maryland Governor WES MOORE approved the Protecting State Waters From PFAS Pollution Act. The bill will set a variety of timelines for state regulators to identify industrial uses of PFAS and develop action levels for PFAS in state waters by mid-2025. Per- and polyfluoroalkyl substances (PFAS) are a class of synthetic organic chemicals used in many different industrial and commercial applications.

Regulations 59

Regulations 59

Drugs.com

MAY 17, 2024

FRIDAY, MAY 17, 2024 -- The U.S. Food and Drug Administration on Thursday approved a new drug to treat patients with an advanced form of deadly lung cancer. Importantly, tarlatamab (Imdelltra) is only for patients who have exhausted all other.

FDA Approval 98

FDA Approval FDA Drugs 98

Agency IQ

MAY 17, 2024

BY ALEXANDER GAFFNEY, MS, RAC The House of Representative’s Energy and Commerce Committee is set to convene this week for a markup hearing of 23 pieces of legislation, including four bills related to priority review vouchers, pediatric oncology drug testing requirements, cellular and tissue therapies, and orphan drug exclusivity eligibility. AgencyIQ has an explainer of all four bills and what you need to know.

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Disease Therapies Drugs 59

Drugs.com

MAY 17, 2024

FRIDAY, May 17, 2024 -- Life expectancy around the world is expected to increase by nearly 5 years in men and more than 4 years in women during the next three decades, researchers predict.These increases are expected to be in countries where life.

Research 69

Research 69

Perficient: Drug Development

MAY 17, 2024

Hello Trailblazers! In the area of Salesforce data management, ensuring data accuracy and integrity is paramount. One of the critical aspects of maintaining clean data is identifying and merging duplicate records efficiently. This is where Matching Rules come into play. In this blog, we’ll learn Matching Rules in Salesforce, exploring their significance and implementation.

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Production 59

Drugs.com

MAY 17, 2024

FRIDAY, May 17, 2024 -- An experimental drug can help patients better live with a genetic condition that causes the heart to enlarge and thicken, a new clinical trial shows.People with the condition, hypertrophic cardiomyopathy (HCM), were able to.

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Clinical Trials Drugs Trials 59

Perficient: Drug Development

MAY 17, 2024

Hello Trailblazers! In the area of Salesforce data management, maintaining data accuracy and integrity is paramount. Duplicate records not only clutter databases but also lead to inefficiencies in sales, marketing, and customer service processes. To address this challenge, Salesforce offers Duplicate Rules, a powerful feature designed to identify and prevent the creation of duplicate records.

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Marketing 59

Drugs.com

MAY 17, 2024

FRIDAY, May 17, 2024 -- Sleepaway camp can be a lot of fun for kids, but only if they’re ready for the experience.And that’s the tough part -- figuring out as a parent when a child is ready to stay away from home, and what they’ll need while.

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Drug Patent Watch

MAY 17, 2024

Annual Drug Patent Expirations for NEXLETOL Nexletol is a drug marketed by Esperion Theraps Inc and is included in one NDA. It is available from one supplier.

Drugs 59

Drugs Marketing 59

Sygnature Discovery

MAY 17, 2024

Understanding the solid form properties of a material can significantly impact other studies. For instance, small scale batches from chiral SFC might be amorphous and dissolve readily, but process chemistry and scale-up could produce a crystalline form, affecting solubility and in vivo performance.

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Process Chemistry 52

Drug Patent Watch

MAY 17, 2024

Annual Drug Patent Expirations for NEXLIZET Nexlizet is a drug marketed by Esperion Theraps Inc and is included in one NDA. It is available from one supplier.

Drugs 59

Drugs Marketing 59

Fierce BioTech

MAY 17, 2024

Genetic Counseling Accelerates Trial Success pesurya Fri, 05/17/2024 - 19:26 Wed, 06/26/2024 - 14:00 Resource Type Webinar Ashley Cannon, PhD, MS, CGC Duration 60 Minutes Telehealth genetic counseling is a proven method of clinical genomics care delivery, but little has been published regarding its use to support clinical trials. With over 10 years of dedicated experience in the Life Sciences market, InformedDNA has perfected the approach.

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Trials Clinical Trials Science Marketing 52

Drug Patent Watch

MAY 17, 2024

Annual Drug Patent Expirations for GIVLAARI Givlaari is a drug marketed by Alnylam Pharms Inc and is included in one NDA. It is available from one supplier.

Drugs 59

Drugs Marketing 59

Agency IQ

MAY 17, 2024

BY KIRSTEN MESSMER, PHD, RAC A new EMA reflection paper reviews expectations for real-world data from non-interventional studies that are used to generate real-world evidence for regulatory purposes. The draft paper drills into specifics for sponsors, including considerations for bias assessment, data quality and statistical analysis. Real-world data (RWD) are data generated through general clinical practice or from other sources outside the controlled environment of clinical trials.

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Clinical Trials Trials 52

Drug Patent Watch

MAY 17, 2024

Annual Drug Patent Expirations for GALAFOLD Galafold is a drug marketed by Amicus Therap Us and is included in one NDA. It is available from one supplier.

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Drugs Marketing 59

Perficient: Drug Development

MAY 17, 2024

Autism Awareness Month at our office in downtown Lafayette, Louisiana started a new campaign to spread awareness and support of the cause. We aimed to send out newsletters twice a week with educational resources, encourage donations to a local fundraiser called “Bowling for Autism”, and host a guest speaker. Let’s dive in and explore how we managed our campaign.

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Therapies Treatment 52

Antidote

MAY 17, 2024

For medications to work effectively for all who need them, clinical trials need to include a diverse cross-section of the population. However, although nearly 40% of the United States population is racial and ethnic minorities, estimated rates of research participation for these groups range from just 2% to 16%.

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Clinical Trials Trials Research 52

Perficient: Drug Development

MAY 17, 2024

Welcome to the latest installment of our Universal Design Series, where we explore the invaluable benefits that Education Accessibility brings to educators. In this edition, we’ll delve into how embracing Universal Design principles not only enhances teaching practices but also empowers educators to create inclusive learning environments that support the diverse needs of all students.

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Production 52