Drug Discovery World

JANUARY 10, 2024

The biotech market is heading to recovery in 2024, following a marked downturn in investment in 2022 and 2023, according to healthcare industry professionals. A GlobalData survey ‘The State of the Biopharmaceutical Industry 2024’ found that more than 40% of the healthcare industry professionals surveyed globally expressed an optimistic or very optimistic sentiment on biotech funding starting to bounce back over the next 12 months.

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Pharmaceutical Companies Marketing International Pharmaceuticals 289

BioPharma Drive: Drug Pricing

JANUARY 10, 2024

Many drugmakers hope to compete in obesity, while others seek to win oncology’s next era. In the background, a contentious drug pricing law looms.

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Drugs 120

Drug Discovery World

JANUARY 10, 2024

The International Society for Cell & Gene Therapy (ISCT) has announced the publication in Nature Medicine of an expert consortium commentary addressing a recent statement from the US Food & Drug Administration (FDA) that it is investigating serious risk of T-cell malignancy in patients who received treatment with BCMA- or CD19-directed autologous CAR-T cell immunotherapy.

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Drugs.com

JANUARY 10, 2024

WEDNESDAY, Jan. 10, 2024 -- Weight gain has long been an unwanted side effect of medicines commonly used to treat psychiatric conditions such as bipolar disorder or schizophrenia. Some patients may quit their meds to avoid piling on pounds. Or.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JANUARY 10, 2024

New understanding of a gene that is linked to some forms of dementia and other age-related diseases gives scientists fresh hope that action can be taken against these diseases long before the onset of symptoms. The gene – called Angiogenin or ANG – is associated with a number of neurodegenerative diseases commonly associated with old age, including frontotemporal dementia (FTD), motor neurone disease (MND) and Parkinson’s disease.

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Research Disease Science Therapies 148

Science Daily: Pharmacology News

JANUARY 10, 2024

Combining a biological heart and a silicone robotic pump, researchers created a biorobotic heart that beats like a real one, with a focus on a valve on the left side of the heart. The heart valve simulator can mimic the structure, function, and motion of a healthy or diseased heart, allowing surgeons and researchers to demonstrate various interventions while collecting real-time data.

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Antidote

JANUARY 10, 2024

One of the most important results of the work we do at Antidote is directly impacting the lives of patients — and getting to hear their stories is a constant reminder of why we do what we do.

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Research 105

Perficient: Drug Development

JANUARY 10, 2024

If you’ve worked with Optimizely CMS, you might be pretty familiar with TinyMCE. Its the amazing rich text editor that works seamlessly with Optimizely CMS. And some of you may have worked with some or other form of customization with it in projects, be it adding additional styles, work with different plugins, format the toolbar to suit your clients’ requirements and more.

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Drug Target Review

JANUARY 10, 2024

There is extensive crosstalk between the DNA damage response (DDR) and innate immune pathways. Both are a focus for exciting new small-molecule drug therapeutics that target cancers and autoimmune disorders. The Transcreener HTS Assay platform accelerates these efforts by providing robust and easy-to-use biochemical assays for key enzymes in the pathways.

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DNA Biochemical Assays Small Molecule Drugs 104

Drugs.com

JANUARY 10, 2024

WEDNESDAY, Jan. 10, 2024 -- The number of American teens who smoke or have even tried smoking has dropped dramatically compared to a generation ago, with less than 1% now saying they light up cigarettes daily. Researchers tracked data on students.

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Research 97

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

NIOSH Science Blog: Drugs

JANUARY 10, 2024

In 2022, approximately 110,000 Americans died from a drug overdose. At the same time, 46 million Americans aged 18 or older experienced a substance use disorder in 2022. Nearly two thirds of those people (30.1 million) were employed. The drug overdose epidemic is occurring in and impacting workplaces. Unintentional overdose from the nonmedical use of drugs resulted in 388 worker deaths in 2020, an increase of nearly 500 percent from 2012.

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Drugs.com

JANUARY 10, 2024

WEDNESDAY, Jan. 10, 2024 -- Heart disease deaths linked with alcohol or drug use have been steadily increasing in the United States, a new study has found.Deaths from heart disease in which substance use was cited as contributor rose an average of.

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Drugs Disease 97

Science Daily: Pharmacology News

JANUARY 10, 2024

The North Arabian Desert oases were inhabited by sedentary populations in the 4th and 3rd millennia BCE. A fortification enclosing the Khaybar Oasis -- one of the longest known going back to this period -- was just revealed by a team of scientists. This new walled oasis is, along with that of Tayma, one of the two largest in Saudi Arabia.

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SCIENMAG: Medicine & Health

JANUARY 10, 2024

PITTSBURGH, Jan. 10, 2024 – University of Pittsburgh Schools of Medicine researchers uncovered a fundamental mechanism that controls the body’s response to limited oxygen and regulates blood vessel disease of the lung. Credit: Johnathan Wright PITTSBURGH, Jan.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

JANUARY 10, 2024

Teens from larger families have poorer mental health than those with fewer siblings, according to a large analysis of children in the United States and China. The details of the pattern vary depending on factors such as the spacing of sibling ages and the age of the siblings. But the fact that the overall pattern was found in both countries is striking.

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SCIENMAG: Medicine & Health

JANUARY 10, 2024

Forward-thinking biochemist Vincent Tagliabracci, Ph.D., Associate Professor at UT Southwestern Medical Center, is the recipient of the 2024 Edith and Peter O’Donnell Award in Biological Sciences from TAMEST (Texas Academy of Medicine, Engineering, Science and Technology). He was chosen for his potentially life-saving research in understanding how enzymes work.

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Research Engineering Science 78

Covalent Modifiers

JANUARY 10, 2024

Dr. Luís A. R. Carvalho, Bárbara B. Sousa, Daniel Zaidman, Hannah Kiely-Collins, Prof. Gonçalo J. L. Bernardes Nat Commun 10 , 5811 (2019). [link] PROTAC linker design remains mostly an empirical task. We employed the PRosettaC computational software in the design of sulfonyl-fluoride-based PROTACs targeting acyl protein thioesterase 1 (APT1). The software efficiently generated ternary complex models from empirically-designed PROTACs and suggested alkyl linkers to be the preferred type of linker

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Drugs.com

JANUARY 10, 2024

WEDNESDAY, Jan. 10, 2024 -- Vegetarian diets have been tied to a variety of health benefits – lower blood pressure, better blood sugar control and weight loss among them.Now a new study suggests those benefits might even extend to a person’s.

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BioPharma Drive: Drug Pricing

JANUARY 10, 2024

Radiopharma drugmakers spoke with BioPharma Dive about chasing Novartis in the hot field, while investors debated the impact of a surprise FTC challenge.

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Drugs.com

JANUARY 10, 2024

WEDNESDAY, Jan. 10, 2024 -- A bout of depression can trigger a bump in body weight among people struggling with obesity, a new study has found.People who had an increase in symptoms related to depression experienced an increase in their weight a.

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Science Daily: Pharmacology News

JANUARY 10, 2024

The largest ever primate Gigantopithecus blacki went extinct when other Asian great apes were thriving, and its demise has long been a mystery. A massive regional study of 22 caves in southern China explores a species on the brink of extinction between 295,000 and 215,000 years ago. As the environment became more seasonal, forest plant communities changed Primates such as orangutans adapted their eating habits and behaviors in response but G. blacki showed signs of stress, struggled to adapt and

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Drugs.com

JANUARY 10, 2024

WEDNESDAY, Jan. 10, 2024 -- Professional guitarist Christian Nolen took his stage show to an operating room last month, strumming out Deftones tunes for surgeons as they worked to remove a tumor from his brain.Nolen’s performance wasn’t just.

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Drug Patent Watch

JANUARY 10, 2024

Annual Drug Patent Expirations for AUVI-Q Auvi-q is a drug marketed by Kaleo Inc and is included in one NDA. It is available from three suppliers. There are thirty-one patents… The post New patent for Kaleo Inc drug AUVI-Q appeared first on DrugPatentWatch - Make Better Decisions.

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Science Daily: Pharmacology News

JANUARY 10, 2024

A new study confirms that spring snowpacks across the Northern Hemisphere have shrunk significantly over the past 40 years due to human-driven climate change, putting hundreds of millions of people worldwide at risk of a water crisis. The Southwestern and Northeastern U.S. saw among the steepest declines, with more than 10% of the spring snowpack lost per decade, which the researchers expect will accelerate with further warming.

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Research 64

Drug Patent Watch

JANUARY 10, 2024

Annual Drug Patent Expirations for TOBI+PODHALER Tobi Podhaler is a drug marketed by Mylan Speciality Lp and is included in one NDA. It is available from one supplier. There are… The post New patent expiration for Mylan Speciality drug TOBI PODHALER appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Perficient: Drug Development

JANUARY 10, 2024

Automotive innovation is only speeding up as we head into 2024, but it might not look that way when focusing on electric vehicles. In the last few months of 2023, it seemed the headlines were only filled with bad news about OEMs who had invested in EVs and struggled to get them off the lots. It’s important to lose our tunnel vision when thinking about the EV transformation – it is too limiting to only think about EVs when assessing the broader landscape of automotive innovation, even though it i

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Drug Patent Watch

JANUARY 10, 2024

Annual Drug Patent Expirations for TAVALISSE Tavalisse is a drug marketed by Rigel Pharms Inc and is included in one NDA. It is available from one supplier. There are fourteen… The post New patent for Rigel Pharms drug TAVALISSE appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Marketing 59

Fierce BioTech

JANUARY 10, 2024

Revolutionizing the clinical trial patient experience with IQVIA IQVIA’s new technologies are changing clinical trials, reducing the administrative burden on staff and improving insights for sponsors. jpiatt Wed, 01/10/2024 - 13:56 IQVIA’s new technologies are changing clinical trials, reducing the administrative burden on staff and improving insights for sponsors.

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Clinical Trials Trials 52

Drug Patent Watch

JANUARY 10, 2024

Annual Drug Patent Expirations for SEZABY Sezaby is a drug marketed by Sun Pharm Inds Inc and is included in one NDA. It is available from one supplier. The generic… The post New patent for Sun Pharm drug SEZABY appeared first on DrugPatentWatch - Make Better Decisions.

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Advarra

JANUARY 10, 2024

There’s no doubt eSource has the potential to streamline the process of clinical research by improving efficient and accurate data collection. Eliminating the requirement for manual data transcription leads to significant savings in terms of the costs and time spent on a study. However, adopting eSource is challenging for many research facilities. Successfully implementing eSource requires sites to shift from paper-based data to electronic data records in a way to preserve data integrity and pat

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Drugs.com

JANUARY 10, 2024

WEDNESDAY, Jan. 10, 2024 — When you're looking for a cheap and easy way to get around town, which is safer — a scooter or a bike?A nationwide look at injuries related to both suggests biking may be the safer way to go. UCLA researchers.

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Research 52

Cytel

JANUARY 10, 2024

A clinical development strategy is a comprehensive plan designed to establish the safety and efficacy of new therapeutics. Developing an effective plan requires multidisciplinary expertise and adapting to accumulating learning and changes in clinical practice and the market environment. Effective clinical development strategy is adaptive by nature. Though it mainly focuses on achieving regulatory approval, it also needs to pave the way to reimbursement and integration of new therapeutics into cl

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Drugs.com

JANUARY 10, 2024

WEDNESDAY, Jan. 10, 2024 -- Could the immune system play a role in why some women become depressed during and after a pregnancy? Swedish researchers have uncovered a "bidirectional relationship" between pregnancy-linked depression and.

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Perficient: Drug Development

JANUARY 10, 2024

In Spark with Scala, creating DataFrames is fundamental for data manipulation and analysis. There are several approaches for creating DataFrames, each offering its unique advantages. You can create DataFrames from various data sources like CSV, JSON, or even from existing RDDs (Resilient Distributed Datasets). In this blog we will see some approaches towards creating dataframe with examples.

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Engineering 52