BioPharma Drive: Drug Pricing
DECEMBER 8, 2023
In addition to clearing Vertex Pharmaceuticals and CRISPR Therapeutics’ Casgevy, the FDA also granted an early OK to Bluebird bio’s sickle cell treatment Lyfgenia.
Drugs.com
DECEMBER 8, 2023
FRIDAY, Dec. 8, 2023 -- The U.S. Food and Drug Administration on Friday approved two milestone gene therapies for sickle cell disease, including the first treatment ever approved that uses gene-editing technology. Casgevy, developed by Vertex.
Chemical Biology and Drug Design
DECEMBER 8, 2023
BoNT/A (30 U/kg) promoted cl-SNAP-25 expression in DRG of RTX-induced rats and reversed RTX-induced decrease of rat paw withdrawal thresholds and CAMP expression and increase of pyroptosis-associated protein and inflammatory factor expression in rat DRG. CAMP interacted with ELANE in rat DRG neurons. BoNT/A (1 nM) attenuated LPS/ATP-stimulated inhibition of viability and CAMP expression and upregulation of inflammatory mediators, pyroptosis-related proteins, and ELANE expression in rat DRG neuro
Drugs.com
DECEMBER 8, 2023
FRIDAY, Dec. 8, 2023 -- Could blockbuster diabetes and weight-loss meds such as Ozempic, Wegovy, Mounjaro and Zepbound also lower users' odds for colon cancer? New research suggests they might.All of these medications (and more) fall into a class.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
DECEMBER 8, 2023
A landmark study has shown that severe asthma can be controlled using biologic therapies, without the addition of regular high-dose inhaled steroids which can have significant side effects.
BioPharma Drive: Drug Pricing
DECEMBER 8, 2023
Casgevy, the first CRISPR therapy approved by the FDA, will cost $2.2 million, while a competing genetic medicine also cleared Friday is priced at $3.1 million.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
DECEMBER 8, 2023
The setbacks for Merck demonstrate the challenge drug developers face in improving on Keytruda, which has brought in at least $18 billion so far this year for its maker.
Science Daily: Pharmacology News
DECEMBER 8, 2023
A challenge among three housemates to identify species around their inner-Brisbane home has resulted in an academic research paper, showcasing the rich biodiversity in urban landscapes.
biobide
DECEMBER 8, 2023
Ensuring the reliability and accuracy of processes and equipment is paramount In scientific research and manufacturing, Two key concepts that play a crucial role in this assurance are qualification and validation. While these terms are often used interchangeably, they signify different procedures with unique purposes and methods. Qualification and validation are crucial processes in various industries, especially those involving R&D, manufacturing, and regulated sectors such as Pharmaceutica
Drugs.com
DECEMBER 8, 2023
FRIDAY, Dec. 8, 2023 (Healthday News) -- A salmonella outbreak tied to tainted cantaloupes keeps expanding, with cases doubling since the last tally, U.S. health officials reported Thursday. "Since the last update [on] November 30, 2023, an.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Antidote
DECEMBER 8, 2023
At Antidote, matching individuals to clinical trials is our driving force — and one of the key ways we do this is by prioritizing our connection to patients. Understanding the real-world impact of our work allows us to continually improve our processes and approach clinical trial recruiting from a patient-centric perspective.
Drugs.com
DECEMBER 8, 2023
FRIDAY, Dec. 8, 2023 -- As the war in the Ukraine rages on, new research shows that hospitals there are waging a battle of their own against a different kind of enemy: antibiotic-resistant "superbugs" that are spreading at an alarming rate.In a.
Science Daily: Pharmacology News
DECEMBER 8, 2023
Record breaking marine heatwaves will cause devastating mass coral bleaching worldwide in the next few years, according to a coral reef scientist.
Drugs.com
DECEMBER 8, 2023
FRIDAY, Dec. 8, 2023 -- The U.S. Food and Drug Administration on Friday approved two milestone gene therapies for sickle cell disease, including the first treatment ever approved that uses gene-editing technology.Casgevy, developed by Vertex.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
SCIENMAG: Medicine & Health
DECEMBER 8, 2023
CHAPEL HILL, NC — Eating food and absorbing its nutrients is an everyday occurrence, but this normal activity can look different for someone who suffers from inflammatory bowel disease. IBD, which includes Crohn’s disease and ulcerative colitis, can cause chronic inflammation of the digestive tract – which for many reasons can lead to malnutrition.
Drugs.com
DECEMBER 8, 2023
FRIDAY, Dec. 8, 2023 -- Sydnee Meth survived breast cancer, but she wasn’t prepared for the aftereffects of her treatment.Doctors removed the lymph nodes from Meth’s right armpit during her second bout with breast cancer in 2014, and as a.
SCIENMAG: Medicine & Health
DECEMBER 8, 2023
Nearly 39 million people worldwide are carriers of human immunodeficiency virus (HIV), and 1.3 million people contracted HIV in 2022[1]. Forty years after the virus was discovered at the Institut Pasteur, HIV research is still active – the aim is to elucidate the mechanisms of infection so that the virus can be eradicated.
Drugs.com
DECEMBER 8, 2023
FRIDAY, Dec. 8, 2023 -- Suicide rates for Black women and girls ages 15 to 24 have more than doubled over the past two decades, a new report finds.“Suicides are rapidly increasingly among young, Black females in the U.S.,” said study first.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
SCIENMAG: Medicine & Health
DECEMBER 8, 2023
Researchers from Helmholtz Munich and the LMU have discovered that, in the case of brain injuries, specific cells in the brain become active in disease situations, exhibiting properties of neural stem cells.
Drug Channels
DECEMBER 8, 2023
Today’s guest post comes from Kelly Martin, Vice President of Product Management at CoverMyMeds. Kelly discusses the obstacles that patients face when attempting to access, afford, and adhere to specialty therapies. She describes how CoverMyMeds improves the patient experience by blending technology with human expertise and connection. Click here to learn about CoverMyMed’s next-generation patient support services.
Science Daily: Pharmacology News
DECEMBER 8, 2023
The complexity of living organisms is encoded within their genes, but where do these genes come from? Researchers resolved outstanding questions regarding the origin of small regulatory genes, and described a mechanism that creates their DNA palindromes. Under suitable circumstances, these palindromes evolve into microRNA genes.
SCIENMAG: Medicine & Health
DECEMBER 8, 2023
A study looking at 15 years of HIV transmission and suppression in Uganda reveals how closing gender gaps in treatment could slash infection rates. Credit: Rakai Health Sciences Program A study looking at 15 years of HIV transmission and suppression in Uganda reveals how closing gender gaps in treatment could slash infection rates.
Covalent Modifiers
DECEMBER 8, 2023
Yasir S. Raouf, Abootaleb Sedighi, Mulu Geletu, Geordon A. Frere, Rebecca G. Allan, Nabanita Nawar, Elvin D. de Araujo, and Patrick T. Gunning Journal of Medicinal Chemistry 2023 DOI: 10.1021/acs.jmedchem.3c01236 Histone deacetylases (HDACs) have emerged as powerful epigenetic modifiers of histone/non-histone proteins via catalyzing the deacetylation of ε-N-acetyl lysines.
SCIENMAG: Medicine & Health
DECEMBER 8, 2023
SAN FRANCISCO—December 8, 2023—It only takes holding your breath for slightly too long to understand that too little oxygen is bad for you. But can you also have too much? Indeed, breathing air with a higher oxygen level than your body needs can cause health problems or even death.
Perficient: Drug Development
DECEMBER 8, 2023
Historically, it was quite challenging to add custom languages to the sitecore, as it was dependent on the cultures registered in the.net framework on the OS level. Of course, there were a few workarounds like registering the custom culture on Windows, but it only added other challenges for scenarios such as having more than one Content Delivery Server.
SCIENMAG: Medicine & Health
DECEMBER 8, 2023
Exclusive breastfeeding for the first six months of life is proven to protect both mother and child health. According to the World Health Organization (WHO), between 2015 and 2021, 48% of mothers exclusively breastfed, meaning that their babies were not given any other food or liquids.
Science Daily: Pharmacology News
DECEMBER 8, 2023
According to anthropologists and geologists, it's time to acknowledge humans have become the dominant force shaping the moon's environment by declaring a new geological epoch for the moon: the Lunar Anthropocene. They argue the new epoch may have dawned in 1959 when the USSR's unmanned spacecraft Luna 2 alighted on the lunar surface.
SCIENMAG: Medicine & Health
DECEMBER 8, 2023
Each year, an estimated 101,000 children below the age of 5 years die across the globe due to infections caused by respiratory syncytial virus (RSV). Worldwide, RSV is a main cause of hospitalisation among young children.
Drugs.com
DECEMBER 8, 2023
FRIDAY, Dec. 8, 2023 -- More than half of night shift workers have at least one sleep disorder, as nocturnal labor plays havoc with body rhythms, a new study shows.
Science Daily: Pharmacology News
DECEMBER 8, 2023
New miniature virtual reality (VR) goggles provide more immersive experiences for mice living in laboratory settings. By more faithfully simulating natural environments, the researchers can more accurately and precisely study the neural circuitry that underlies behavior. Compared to current state-of-the-art systems, which simply surround mice with computer or projection screens, the new goggles provide a leap in advancement.
Drug Patent Watch
DECEMBER 8, 2023
This chart shows the drugs with the most patents in Denmark. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.… The post Which pharmaceutical drugs have the most drug patents in Denmark? appeared first on DrugPatentWatch - Make Better Decisions.
Science Daily: Pharmacology News
DECEMBER 8, 2023
A team has realized a key milestone in the quest for stable, scalable quantum computing. For the first time, the team has created a programmable, logical quantum processor, capable of encoding up to 48 logical qubits, and executing hundreds of logical gate operations. Their system is the first demonstration of large-scale algorithm execution on an error-corrected quantum computer, heralding the advent of early fault-tolerant, or reliably uninterrupted, quantum computation.
Drug Patent Watch
DECEMBER 8, 2023
Annual Drug Patent Expirations for AUVI-Q Auvi-q is a drug marketed by Kaleo Inc and is included in one NDA. It is available from three suppliers. There are thirty-one patents… The post New patent for Kaleo Inc drug AUVI-Q appeared first on DrugPatentWatch - Make Better Decisions.
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