Tue.Mar 12, 2024

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2024 predictions: Experts comment on monoclonal antibodies 

Drug Discovery World

DDW’s Megan Thomas speaks to experts from the drug discovery industry about their predictions on what 2024 holds for our sector. This is part of a series of predictions based on different themes. Here, experts weigh in on the future of monoclonal antibodies (mAbs). Amanda Halford, President Bioprocess, Cytiva “In 2024, the emphasis will remain on novel mAbs, specifically antibody drug conjugates.

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After surprise trial failure, ALS doctors brace for one less treatment option

BioPharma Drive: Drug Pricing

Physicians are preparing for tough conversations with patients on Amylyx Pharmaceuticals’ drug, Relyvrio, while holding out hope it still may help some with the disease.

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Tackling pain and mental health with plant-based medicines

Drug Discovery World

DDW Editor Reece Armstrong speaks to Michael Krogh Jensen , Co-founder and CEO of Biomia, about developing plant-based medicines and what recent investment and support from the Bio Studio programme means for its pipeline. RA: How has being part of the Bio Studio programme helped you develop your pipeline? MJ : The Bio Studio programme has offered Biomia a ‘cloud’ of key opinion leaders providing constructive feedback and authoritative direction on our technology, working hypothesis, business mod

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Alaska dinosaur tracks reveal a lush, wet environment

Science Daily: Pharmacology News

A large find of dinosaur tracks and fossilized plants and tree stumps in far northwestern Alaska provides new information about the climate and movement of animals near the time when they began traveling between the Asian and North American continents roughly 100 million years ago.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Collaborators investigate novel T-cell receptor therapy

Drug Discovery World

Elicera Therapeutics has entered a Material Transfer Agreement (MTA) with a prominent US cancer centre to evaluate the enhancing effect of the iTANK-technology in a novel T-cell receptor therapy targeting skin cancer and lung cancer. Elicera Therapeutics will make parts of its technology iTANK available to a medical oncologist and researcher at the undisclosed US cancer centre, whose investigation focuses on the development of novel immunotherapies.

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What do volunteers for research studies do after finding a trial?

Antidote

For many people, participating in a research study presents an interesting opportunity with many benefits to volunteering. While there are many types of clinical research, all with distinct goals and timelines, trial volunteers will follow a similar path when taking part. Read on to learn more about the process.

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More Trending

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Vitamin D Plus Calcium: Good News, Bad News for Older Women

Drugs.com

TUESDAY, March 12, 2024 -- Women who've gone through menopause and hope that supplemental vitamin D plus calcium might shield them from disease may be disappointed by new data.A follow-up analysis of data from the landmark Women's Health Initiative.

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Exploring the potential of a new class of drug candidates

Drug Discovery World

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Ahmed Mousa, CEO of Vicore Pharma. Vicore Pharma is exploring the potential of a new class of drug candidates, angiotensin II type 2 receptor agonists (ATRAGs), and here Mousa provides DDW with an overview of the company’s unique approach, its challenge

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Scientists propose new theory that explains sand ripples on Mars and on Earth

Science Daily: Pharmacology News

Sand ripples are symmetrical. Yet wind -- which causes them -- is very much not. Furthermore, sand ripples can be found on Mars and on Earth. They would be even more fascinating if the same effect found on Mars could be found here on Earth as well. What if one unified theory could explain their formation on both planets?

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Bile acids and the microbiome: revolutionising disease approaches

Drug Target Review

Scientists from the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have discovered thousands of bile acids. The study’s findings offer new insights into the biochemical language microbes use to influence distant organ systems, which could revolutionise the way researchers approach disease. Dr Pieter Dorrestein, senior author, professor at the Skaggs School and professor of pharmacology and paediatrics at UC San Diego School of Medicine, stated: “B

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Mars attracts: How Earth's interactions with the red planet drive deep-sea circulation

Science Daily: Pharmacology News

Scientists have used the geological record of the deep sea to discover a connection between the orbits of Earth and Mars, past global warming patterns and the speeding up of deep ocean circulation. The patterns they discover suggest that warming seas could produce deep whirpools in ocean currents.

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Use of Legal 'Delta-8-THC' Is Rising Among Teens - Is it Safe?

Drugs.com

TUESDAY, March 12, 2024 -- They're cheap, easy to buy and now new research shows they have become the buzz of choice for American teens. Delta-8-THC products, which include gummies and vapes, are legal in 22 states and Washington, D.C. There is no.

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The Event-Driven Data Layer: Unifying Analytics and Development Teams

Perficient: Drug Development

One common way of implementing tags through Adobe Launch is using a data layer, which is a JSON object (key/value pair) that is loaded onto the page from which attributes are passed through as the user navigates through the website or completes certain objectives. This can be extended further into using an Event-Driven Data Layer (EDDL), which serves to load Custom Events within JavaScript that are passed to the data layer upon an action being completed on the website, and can be loaded on any e

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ADHD Meds Cut Odds for Early Death, Especially by Overdose

Drugs.com

TUESDAY, March 12, 2024 -- People diagnosed with attention-deficit hyperactivity disorder (ADHD) show a marked decline in their two-year risk for death once they start taking medication, new research shows. That was particularly true for deaths due.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Perficient Achieves Government Specialization Distinction with Pegasystems

Perficient: Drug Development

Perficient is excited to announce that we have earned the Government Specialization Distinction (Americas) in the new Pega Partners program. Specialized partners are thoroughly vetted by Pega to bring deep vertical knowledge or specialized expertise to clients. Pega Partners that achieve a Specialization have a demonstrated ability to help customers build more innovative businesses, and have a significant impact on their customers, stakeholders, and their partners.

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Measles Cases Climb to 4 at Chicago Migrant Shelter Outbreak

Drugs.com

TUESDAY, MARCH 12, 2024 -- As the number of measles cases at a migrant shelter in Chicago climbed to four on Monday, a team from the U.S. Centers for Disease Control and Prevention has headed to that city to help contain the outbreak.The Chicago.

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Study: Best way to memorize stuff? It depends.

Science Daily: Pharmacology News

Recent experiments by psychologists shed new light on how we learn and how we remember our real-world experiences. In two experiments, researchers asked participants to repeatedly study pairs of items and scenes that were either identical on each repetition or in which the item stayed the same but the scene changed each time. Researchers found that spaced learning benefited item memory, but they also found that memory was better for the items that had been paired with different scenes compared w

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Johnsonville Sausages Recalled Due to Rubber Pieces

Drugs.com

TUESDAY, March 12, 2024 -- Be sure to check your fridge for any Johnsonville turkey kielbasa sausage -- over 35,000 pounds of the product is under recall due to some customers finding "pieces of rubber" in the packaged meat. Denmark, Wisc.-based.

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The Top 15 U.S. Pharmacies of 2023: Market Shares and Revenues at the Biggest Chains and PBMs

Drug Channels

Next week, Drug Channels Institute (DCI) will release our 2024 Economic Report on U.S. Pharmacies and Pharmacy Benefit Managers. It’s the 15th edition of our popular and comprehensive examination of the entire U.S. drug pricing, reimbursement, and dispensing system. For 2023, DCI estimates that U.S. prescription dispensing revenues reached $621 billion in 2023, driven by accelerating GLP-1 prescriptions and an expanding post-pandemic market.

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Permissive Gun Laws Linked to Higher Suicide Rates

Drugs.com

TUESDAY, March 12, 2024 -- When states let gun owners carry a firearm openly without a permit, death rates soar.Significantly more people died by firearms and suicides in states that have relaxed open carry laws, a nine-year study of death data.

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A coral superhighway in the Indian Ocean

Science Daily: Pharmacology News

Despite being scattered across more than a million square kilometers, new research has revealed that remote coral reefs across the Seychelles are closely related. Using genetic analyses and oceanographic modelling, researchers demonstrated for the first time that a network of ocean currents scatter significant numbers of larvae between these distant islands, acting as a 'coral superhighway.

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Christina Applegate Opens Up About the Agony of Fighting MS

Drugs.com

TUESDAY, March 12, 2024 -- Actress Christina Applegate, who has been battling multiple sclerosis (MS) since 2021, shared her struggles with the debilitating disease on Monday.“I live kind of in hell. I’m not out a lot, so this is a little.

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Plasmids 101: Modular Cloning

addgene Blog

As a plasmid repository, we are no strangers to cloning. If you’re reading this, then chances are you have been in the cloning trenches yourself. Modular cloning, or MoClo, is a systematic cloning strategy designed by synthetic biologists to perform large scale, one-tube cloning reactions. In this blog, we’ll cover the basics of what MoClo is and what types of experiments it enables.

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Military Service Can Bring Melanoma Danger

Drugs.com

TUESDAY, March 12, 2024 — U.S. military veterans, especially those who served in the Air Force, are at high risk for one of the deadliest skin cancers, melanoma.The risk owes to work hazards associated with service in countries near the equator.

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Is Generative AI The Future of Equitable Healthcare?

DrugBank

For years we’ve been hearing about the potential for AI to revolutionize healthcare and health outcomes in a number of ways. As we continue to see an impressive and rapid growth of generative AI, we are starting to understand just how significant of an impact it may have on our healthcare. Recently, Mass General Brigham published findings in npj Digital Medicine demonstrating the ability of finely-tuned generative AI models to identify 93.8% of patients with at least one adverse social de

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LGBT People Can Face Unique Skin Health Challenges

Drugs.com

TUESDAY, March 12, 2024 -- Gay and bisexual people, as well as those undergoing gender transition, could face unique dermatological issues, an expert says.Board-certified dermatologist Dr. John Zampella, who runs a clinic in New York City that.

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Cheetahs' unrivalled speed explained by their 'sweet spot' size, finds Imperial study

Science Daily: Pharmacology News

A new study has answered a long-held question about why medium-sized land animals like cheetahs tend to be fastest.

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Early Menopause Can Mean Earlier Retirements for Women

Drugs.com

TUESDAY, March 12, 2024 -- Early menopause influences how working women feel about their ability to do a good job. That's the key takeaway from a study of more than 2,600 Finnish women recently published online in the journal Menopause, a.

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Allogene taps Arbor in pursuit of ‘off-the-shelf’ CAR-T therapies for autoimmune disease

BioPharma Drive: Drug Pricing

Allogene’s partnership with Arbor is designed to help the company stand out in what’s quickly become one of the industry’s hottest areas of drug research.

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Shortage of Primary Care Doctors Could Bring Crowded ERs: Study

Drugs.com

TUESDAY, March 12, 2024 — Americans living in areas where primary care doctors and nurse practitioners are in short supply face a greater risk for emergency surgeries and complications, new research shows.They're also more likely to wind up back.

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New patent expiration for Array Biopharma drug MEKTOVI

Drug Patent Watch

Annual Drug Patent Expirations for MEKTOVI Mektovi is a drug marketed by Array Biopharma Inc and is included in one NDA. It is available from one supplier. There are seven… The post New patent expiration for Array Biopharma drug MEKTOVI appeared first on DrugPatentWatch - Make Better Decisions.

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Diabetes Care Falters for Rural Patients: Study

Drugs.com

TUESDAY, March 12, 2024 -- If you live in a small town and have diabetes, you're more likely to suffer serious setbacks than your cousin in the big city.New research shows that people in towns with fewer than 50,000 people have a significantly.

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New patent for Norton Waterford drug QVAR REDIHALER

Drug Patent Watch

Annual Drug Patent Expirations for QVAR+REDIHALER Qvar Redihaler is a drug marketed by Norton Waterford and is included in one NDA. It is available from three suppliers. There are fourteen… The post New patent for Norton Waterford drug QVAR REDIHALER appeared first on DrugPatentWatch - Make Better Decisions.

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Healthcare Insights We’re Exploring at HIMSS 2024

Perficient: Drug Development

HIMSS24 draws together a vibrant and diverse community of healthcare trailblazers from around the world. And it’s all happening right now in Orlando. Howard Krain | LinkedIn Attendees include visionary healthcare leaders, innovative disruptors, and dynamic market suppliers, among many, many other movers and shakers. Perficient’s Howard Krain , is excited to attend again this year, and shared, “HIMSS provides a unique opportunity to network with like-minded executives and learn