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Dennis H. Kim and Watson J. Lees Biochemistry 2025 DOI: 10.1021/acs.biochem.4c00522 The antibiotic fosfomycin is an epoxy-phosphonate natural product with a broad spectrum of antibacterial activity and distinct mechanism of action that has been in clinical use for 50 years. Fosfomycin is an irreversible covalent inhibitor of UDP-GlcNAc enolpyruvyl transferase (MurA), which catalyzes the first committed step in bacterial peptidoglycan biosynthesis.
Heavy drinkers who have eight or more alcoholic drinks per week have an increased risk of brain lesions called hyaline arteriolosclerosis, signs of brain injury that are associated with memory and thinking problems, according to a new study.
WEDNESDAY, April 9, 2025 -- An experimental drug can help patients with advanced multiple sclerosis (MS) delay the progressive disability that comes with their disorder, a new clinical trial suggests.The drug, tolebrutinib, delayed disability.
Evidence shows that hunter-gatherers were crossing at least 100 kilometers (km) of open water to reach the Mediterranean island of Malta 8,500 years ago, a thousand years before the arrival of the first farmers.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
WEDNESDAY, April 9, 2025 -- Americas emergency rooms are near the breaking point, causing long wait times and boarding of patients awaiting care, a new study says.Essentially, ERs are being asked to serve as health care hubs that offer services f.
In a cave overlooking the ocean on the southern coast of South Africa, archaeologists discovered thousands of stone tools, created by ancient humans roughly 20,000 years ago. By examining tiny details in the chipped edges of the blades and stones, archaeologists are able to tell how the tools were made -- which revealed that people were sharing crafting techniques over wide distances.
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In a cave overlooking the ocean on the southern coast of South Africa, archaeologists discovered thousands of stone tools, created by ancient humans roughly 20,000 years ago. By examining tiny details in the chipped edges of the blades and stones, archaeologists are able to tell how the tools were made -- which revealed that people were sharing crafting techniques over wide distances.
WEDNESDAY, April 9, 2025 -- Food additive mixtures commonly found in diet drinks, soups, dairy desserts and sauces may slightly increase a persons risk of type 2 diabetes, a new study says.A mixture of additives commonly found in artificially s.
From a tiny sample of tissue no larger than a grain of sand, scientists have come within reach of a goal once thought unattainable: building a complete functional wiring diagram of a portion of the brain.
WEDNESDAY, April 9, 2025 -- In an effort to address high maternal and infant mortality rates plaguing many of the Southern U.S. states, legislators in Alabama have passed a bill that will allow Medicaid to be more easily accessible for pregnant.
FLUID, an open-source, 3D-printed robot, offers an affordable and customizable solution for automated material synthesis, making advanced research accessible to more scientists.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
WEDNESDAY, April 9, 2025 -- People with heart implants could be in trouble if theyre hit with a powerful handheld taser, a new study says.A heavy electrical charge delivered by a taser could cause a pacemaker or implanted defibrillator to m.
WEDNESDAY, April 9, 2025 -- Brain diseases like stroke, dementia and depression share common risk factors, and changing any can lower a persons risk of all three conditions, a new study says.Addressing factors as varied as blood pressure, blood s.
Researchers have discovered a way to get anti-inflammatory medicine across the blood-brain barrier, opening the door to potential new therapies for a range of conditions, including Alzheimer's disease, multiple sclerosis, Parkinson's disease and cancer cachexia.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
In its first full year on the U.S. market, bladder cancer treatment Adstiladrin earned about $77 million. Elsewhere, Lilly backed a cancer drug startup and Bristol Myers won a new Opdivo approval.
A medical breakthrough could result in the first treatment for rare but serious diseases in which genetic defects disrupt cellular energy production. Researchers have identified a molecule that helps more mitochondria function properly.
WEDNESDAY, April 9, 2025 -- A health care program focused on suicide prevention has helped lower suicides and attempts, a new study shows.The program, called the "Zero Suicide Model," relies on screening, safety planning and mental health support.
Rsearchers have developed the first wearable device for measuring gases emitted from and absorbed by the skin. By analyzing these gases, the device offers an entirely new way to assess skin health, including monitoring wounds, detecting skin infections, tracking hydration levels, quantifying exposure to harmful environmental chemicals and more.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
WEDNESDAY, April 9, 2025 -- Folks with low back pain can use their minds to effectively cope with their suffering, a new clinical trial says.Mindfulness meditation and cognitive-behavioral therapy (CBT) both significantly reduced pain among people.
Engineers have hit the trifecta of sustainability technology: A group has developed a low-cost method to produce carbon-free 'green' hydrogen via solar-powered electrolysis of seawater. A happy byproduct of the process? Potable water.
This study illustrates the protective effects of Echinacoside on non-alcoholic fatty liver disease (NAFLD) in rats. Echinacoside activates AMPK, which promotes ULK1-mediated cell autophagy, increasing levels of LC-3 I/II and Beclin-1. Additionally, Echinacoside significantly reduces serum levels of TG, TC, LDL-C, ALT, AST, and ALP while increasing HDL-C levels, indicating its potential therapeutic benefits for NAFLD.
Investigators have developed STITCHR, a new gene editing tool that can insert therapeutic genes into specific locations without causing unwanted mutations. The system can be formulated completely as RNA, dramatically simplifying delivery logistics compared to traditional systems that use both RNA and DNA. By inserting an entire gene, the tool offers a one-and-done approach that overcomes hurdles from CRISPR gene editing technology -- which is programmed to correct individual mutations -- offerin
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Aryl boronic acids endowed with alkylated sulfonyl hydrazone tails were synthesized and tested against a focused panel of human carbonic anhydrases, showing a selective profile against the tumor-associated isoform IX. ABSTRACT Recently, a rising interest in boronic acids and their derivatives was recorded in the Medicinal Chemistry field due to their high versatility and broad applicability as bioactive compounds in several diseases, including cancer and microbial infections.
Astronomers have peered back in time to find what looks like a population of 'hidden' galaxies that could hold the key to unlocking some of the universe's secrets. If their existence is confirmed it would 'effectively break current models of galaxy numbers and evolution'. The possible galaxies may also provide the missing piece of the puzzle for the energy generation in the universe in infrared light.
It's time for Drug Channels annual update of vertical integration among insurers, PBMs, specialty pharmacies, and healthcare services within U.S. drug channels. As you can see below, we have revised, renovated, and refurbished our infamous illustration of the major vertical business relationships among the largest companies. Proponents of these vertical integration arrangements argue that they create opportunities to mine healthcare costs.
A hopping, insect-sized robot can jump over gaps or obstacles, traverse rough, slippery, or slanted surfaces, and perform aerial acrobatic maneuvers, while using a fraction of the energy required for flying microbots.
"Unlocking New Hope for Neurological Disorders As we continue to push the boundaries of medical innovation, I'm excited to share with you a game-changing development in the fight against neurological disorders. At the forefront of this revolution is AI-based drug repurposing. By leveraging cutting-edge technology, researchers are re-examining existing medications to identify new uses for treating conditions such as Alzheimer's, Parkinson's, and multiple sclerosis.
New findings provide a greater understanding of plate subduction, or how tectonic plates slide beneath one another. This recycling of surface materials and volatile elements deep into the Earth's interior, can impact long-term climate stability, atmospheric balance, and the habitability of our planet over billions of years.
Patient-Centric Approaches to Maintaining Brand Value As the pharmaceutical industry continues to evolve, one thing remains clear: patients are at the forefront of every decision. At DrugPatentWatch, we've seen firsthand how patient-centric approaches can make all the difference in maintaining brand value. In our latest blog post, we explore the importance of putting patients first in brand strategy.
Agronomists question statistical methods used to predict yield potential and 'yield gaps' for major crops. In some cases, yield potential is overestimated, while in others it can be underestimated. It's important to have accurate information so that worldwide agriculture can meet the food demands of the growing global population.
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