Fri.Aug 11, 2023

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Infectious diseases research fund will progress antibody therapies

Drug Discovery World

Liverpool School of Tropical Medicine (LSTM) and LifeArc are partnering to launch a new Translational Development Fund to help tackle infectious diseases. LifeArc will invest £2.7 ($3.4) million into the fund, which will support the progression of new technologies and treatments for emerging viral threats and neglected tropical diseases. The fund will be available to LSTM and iiCON partners and their collaborators, including research organisations in low- and middle- income countries (LMICs), an

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Antidote Partner Profile: A Q&A with Patients Rising

Antidote

Helping patients find out about clinical trials is one of the chief pillars of the work Antidote does, and one of the ways we do this is through our partners. By building a network of nonprofits and patient advocacy groups, we are able to reach patients where they are and help them find clinical trial opportunities that may be a good fit.

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This week in drug discovery (7-11 August)  

Drug Discovery World

News round-up for by DDW Digital Content Editor Diana Spencer. The news headlines this week reflect the level of interest in cell & gene therapies (CGT) in the sector, particularly CAR-T, but also the importance of research collaborations to bring these therapies to patients. Traditionally successful in treating blood cancers, it is positive to see companies pursuing CAR-T as an option for solid tumours, a potential new market for these treatments.

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Bad Sleep Can Harm Your Heart, and Weekend 'Catch-Up' Sleep Won't Help

Drugs.com

FRIDAY, Aug. 11, 2023 -- Poor sleep takes a toll, and catching up on the weekends just won't fix it, researchers report. A small new study showed that heart rate and blood pressure, important measures of cardiovascular health, worsen as the week.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Warfarin could be repurposed as a potent cancer drug

Drug Discovery World

A new study has shown that blood thinner warfarin could also treat cancer, as it stops tumours from interfering with a self-destruct mechanism that cells initiate when they detect mutations or other abnormalities (ferroptosis). The research by Columbia University researchers was conducted in human cells and in mice to uncover molecular processes that regulate ferroptosis.

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Advancing vaccine design: potential of peptide mimicry

Drug Target Review

In a new development, a recent paper published in Biology Methods & Protocols by Oxford University Press has highlighted a promising avenue for enhancing vaccine efficacy against infectious pathogens like the COVID-19 virus. Since December 2019, SARS-CoV-2 (COVID-19) infection has become a worldwide urgent public health concern. 1 The study reveals a novel bioinformatic approach and tool that holds the potential to empower researchers in designing vaccines capable of inducing a stronger immu

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AHA News: Confused About Carbs? This Might Help

Drugs.com

FRIDAY, Aug. 11, 2023 (American Heart Association News) -- If you get cross-eyed thinking about carbohydrates, that's understandable. They can be, quite literally, both simple and complex. They abound in snacks that nobody would call healthy but.

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Collaborators agree deal to develop CAR-T therapy for solid tumours

Drug Discovery World

GenScript Biotech and T-MAXIMUM Biotech have formed a strategic collaboration to develop T-MAXIMUM’s CAR-T cell therapy using GenScript’s CRISPR nucleic acid reagents. GenScript will provide various CRISPR reagents to support the development of the universal CAR-T products from discovery to commercialisation. T-MAXIMUM Biotech hopes to progress multiple products to the Phase II clinical research stage and deliver products to market within the next five years.

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Feds Warn Parents: Don't Use La-La-Me Infant Loungers Due to Suffocation Risk

Drugs.com

FRIDAY, Aug. 11, 2023 -- Parents and caregivers are being advised to immediately stop using La-La-Me Infant Loungers because they pose a risk to babies of suffocation and falling. The U.S. Consumer Product Safety Commission (CPSC) issued the warning.

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Interdisciplinary team studies decomposition effects on soil

SCIENMAG: Medicine & Health

Forensic researchers at the University of Tennessee Knoxville’s famous Anthropological Research Facility, popularly known as the “Body Farm,” have made headlines for decades in their discoveries of what happens to human bodies after death.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Brain 'Organoid' Study Hints at the Origins of Autism

Drugs.com

FRIDAY, Aug. 11, 2023 -- Research using three-dimensional replicas of the developing brain created in a lab dish is shedding new light on autism spectrum disorder. Yale researchers found two paths to autism in the developing brain. “It’s amazing.

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Digital as a Disguise: Beware the Illusion of an Automated Hub Experience

Drug Channels

Today’s guest post comes from Rebecca Cotton, Executive Director of Strategy & Product Innovation at Cardinal Health ™ Sonexus ™ Access and Patient Support Rebecca discusses the essential features biopharmaceutical manufacturers should seek in a digital hub that will help patients get their therapies faster. She argues that the most effective hub balances automation with the still-relevant value of human interactions.

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For labrum tears, regrowth rather than repair

SCIENMAG: Medicine & Health

Tears to the glenoid labrum—cartilage tissue that lines the shoulder where the arm joins—can be repaired with arthroscopic surgery, which significantly weakens the joint and involves a lengthy recovery.

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Family of Henrietta Lacks sues Ultragenyx over use of HeLa cell line

BioPharma Drive: Drug Pricing

Filed in Maryland district court, the lawsuit claims the biotech unjustly profited from using HeLa cells to develop AAV vectors for its gene therapy products.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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UTEP launches new research partnerships with Chihuahua universities

SCIENMAG: Medicine & Health

EL PASO, Texas (Aug. 11, 2023) – How are our region’s pecan farms affected by drought? Is there a better way to address domestic violence in Ciudad Juárez? These are a few of the big questions scientists are asking as they prepare to embark on a new cross-border research collaboration.

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Obesity a Key Factor When Kids Develop Sleep Apnea

Drugs.com

FRIDAY, Aug. 11, 2023 -- Childhood obesity is concerning for many reasons, among them that the severity of the sleep disorder known as obstructive sleep apnea (OSA) grows with obesity levels and age. A new study looked at the role of obesity in.

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Artificial intelligence designs advanced materials

SCIENMAG: Medicine & Health

In a world where annual economic losses from corrosion surpass 2.5 trillion US Dollars, the quest for corrosion-resistant alloys and protective coatings is unbroken. Artificial intelligence (AI) is playing an increasingly pivotal role in designing new alloys.

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Arrays of quantum rods could enhance TVs or virtual reality devices

Science Daily: Pharmacology News

Using scaffolds of folded DNA, engineers assembled arrays of quantum rods with desirable photonic properties that could enable them to be used as highly efficient micro-LEDs for televisions or virtual reality devices.

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Arctic monitoring program plays vital role in global pollution reduction efforts

SCIENMAG: Medicine & Health

Historically, the Arctic was considered a pristine region, but scientific research spanning the last three decades has revealed the harsh reality of long-range transported pollutants reaching the Arctic from different corners of the world.

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Researchers identify 135 new melanin genes responsible for pigmentation

Science Daily: Pharmacology News

The skin, hair and eye color of more than eight billion humans is determined by the light-absorbing pigment known as melanin. New research has identified 135 new genes associated with pigmentation.

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University of Chicago scientists invent smallest known way to guide light

SCIENMAG: Medicine & Health

Directing light from place to the place is the backbone of our modern world. Beneath the oceans and across continents, fiber optic cables carry light that encodes everything from YouTube videos to banking transmissions—all inside strands about the size of a hair.

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New patent expiration for Boehringer Ingelheim drug JENTADUETO XR

Drug Patent Watch

Annual Drug Patent Expirations for JENTADUETO+XR Jentadueto Xr is a drug marketed by Boehringer Ingelheim and is included in one NDA. It is available from one supplier. There are ten… The post New patent expiration for Boehringer Ingelheim drug JENTADUETO XR appeared first on DrugPatentWatch - Make Better Decisions.

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ORNL buildings researchers earn top ASHRAE honors

SCIENMAG: Medicine & Health

Kashif Nawaz and Mahabir Bhandari, building technologies researchers at the Department of Energy’s Oak Ridge National Laboratory, were recognized for research achievements in support of ASHRAE during the 2023 annual conference of the national heating, refrigerating, and air-conditioning engineering society. Credit: ORNL, U.S. Dept.

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New patent expiration for Boehringer Ingelheim drug GLYXAMBI

Drug Patent Watch

Annual Drug Patent Expirations for GLYXAMBI Glyxambi is a drug marketed by Boehringer Ingelheim and is included in one NDA. It is available from one supplier. There are thirteen patents… The post New patent expiration for Boehringer Ingelheim drug GLYXAMBI appeared first on DrugPatentWatch - Make Better Decisions.

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Zhong named Institute of Food Technologists fellow

SCIENMAG: Medicine & Health

Qixin Zhong, professor in the University of Tennessee Department of Food Science, has been named an Institute of Food Technologists (IFT) Fellow. Credit: UTIA Qixin Zhong, professor in the University of Tennessee Department of Food Science, has been named an Institute of Food Technologists (IFT) Fellow.

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New patent expiration for Boehringer Ingelheim drug TRIJARDY XR

Drug Patent Watch

Annual Drug Patent Expirations for TRIJARDY+XR Trijardy Xr is a drug marketed by Boehringer Ingelheim and is included in one NDA. It is available from one supplier. There are sixteen… The post New patent expiration for Boehringer Ingelheim drug TRIJARDY XR appeared first on DrugPatentWatch - Make Better Decisions.

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New insights into the potential for early steps of biological evolution on Mars

SCIENMAG: Medicine & Health

That the planet Mars had habitable surface environments early in its existence has been firmly established by the scientific community. These environments provided water, energy sources, elements like carbon, hydrogen, nitrogen, oxygen, phosphorus, and sulfur, as well as critical catalytic transition metals associated with life as we know it.

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New patent expiration for Boehringer Ingelheim drug TRADJENTA

Drug Patent Watch

Annual Drug Patent Expirations for TRADJENTA Tradjenta is a drug marketed by Boehringer Ingelheim and is included in one NDA. It is available from two suppliers. There are ten patents… The post New patent expiration for Boehringer Ingelheim drug TRADJENTA appeared first on DrugPatentWatch - Make Better Decisions.

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Hundred-year storms? That’s how long they last on Saturn.

SCIENMAG: Medicine & Health

The largest storm in the solar system, a 10,000-mile-wide anticyclone called the Great Red Spot, has decorated Jupiter’s surface for hundreds of years. Credit: NASA/JPL/Space Science Institute The largest storm in the solar system, a 10,000-mile-wide anticyclone called the Great Red Spot, has decorated Jupiter’s surface for hundreds of years.

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New patent expiration for Boehringer Ingelheim drug JENTADUETO

Drug Patent Watch

Annual Drug Patent Expirations for JENTADUETO Jentadueto is a drug marketed by Boehringer Ingelheim and is included in two NDAs. It is available from one supplier. There are twelve patents… The post New patent expiration for Boehringer Ingelheim drug JENTADUETO appeared first on DrugPatentWatch - Make Better Decisions.

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University of Tennessee extension wins “Employer of the Year” from international organization

SCIENMAG: Medicine & Health

Ask just about any person in the University of Tennessee Extension family what they like about their job, and they might mention the impact they have in their communities and the people they help.

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Take-Home Naloxone Does Not Lead To Riskier Drug Use

Common Sense for Drug Policy Blog

Take-Home Naloxone Does Not Lead To Riskier Drug Use "We did not find evidence that THN [Take-Home Naloxone] training was associated with risk compensation behavior in this cohort of people who inject drugs. Rather, there was no significant change in frequency of injecting any drugs, injecting opioids, or using benzodiazepines after accessing THN. There was also no change in the proportion of time that participants reported using drugs alone, a key indicator of overdose mortality risk. 30 , 38 ,

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Call for papers: Special theme issue: Artificial intelligence (AI) and ChatGPT in Asian and Pacific Islander (API) health

SCIENMAG: Medicine & Health

Asian/Pacific Island Nursing Journal (APINJ) Editor-in-Chief: Hyochol (Brian) Ahn, PhD, MSN, MS-ECE, MS-CTS, APRN, ANP-BC, FAAN and guest editor Shu-Fen Wung, Ph.D., RN, ACNP-BC, FAAN welcome submissions to a special theme issue examining “Artificial Intelligence (AI) and ChatGPT in Asian and Pacific Islander (API) Health.

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Stacey Donnelly

Broad Institute

Stacey Donnelly By Rose Circeo August 11, 2023 Stacey Donnelly, M.P.A., M.S. Senior Director, Strategic Operations Stacey Donnelly is the senior director of strategic operations at the Broad Institute of MIT and Harvard. In this role, she provides leadership and management for the large alliances, is the institutional official for the Broad’s animal facility and is the chief compliance officer for all human subject research.