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Hui Tao, Bo Yang, Atena Farhangian, Ke Xu, Tongtong Li, Zhong-Yin Zhang, and Jianing Li Journal of Medicinal Chemistry 2025 DOI: 10.1021/acs.jmedchem.4c02760 Covalent-allosteric inhibitors (CAIs) may achieve the best of both worlds: increased potency, long-lasting effects, and reduced drug resistance typical of covalent ligands, along with enhanced specificity and decreased toxicity inherent in allosteric modulators.
Who hasn't been there? The big meal is over, you're full, but the craving for sweets remains. Researchers have now discovered that what we call the 'dessert stomach' is rooted in the brain. The same nerve cells that make us feel full after a meal are also responsible for our craving for sweets afterwards.
One of the ultimate aims of protein design has long been to build entirely new enzymes — proteins that perform specific chemical reactions — from scratch. These molecular machines power various cellular processes, from converting sugar into energy to switching genes on and off. Both Cas9 and hydrolases (widely used in the dairy and laundry industries) are also enzymes.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
THURSDAY, Feb. 13, 2025 -- If you've got a big belly, diabetes or high blood pressure, you may want to limit your alcohol, experts warn, as drinking could significantly raise your odds for serious liver disease.The research, published recently in.
What if time is not as fixed as we thought? Imagine that instead of flowing in one direction -- from past to future -- time could flow forward or backward due to processes taking place at the quantum level. This is the thought-provoking discovery made by researchers, as a new study reveals that opposing arrows of time can theoretically emerge from certain quantum systems.
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
What if time is not as fixed as we thought? Imagine that instead of flowing in one direction -- from past to future -- time could flow forward or backward due to processes taking place at the quantum level. This is the thought-provoking discovery made by researchers, as a new study reveals that opposing arrows of time can theoretically emerge from certain quantum systems.
THURSDAY, Feb. 13, 2025 -- New numbers have been released by the Texas Department of State Health Services (DSHS) in an update on the measles outbreak in Gaines County: 22 children and two adults have been infected as of Feb. 11.All cases have been.
A new study by marine biologists reports that seals can essentially act as 'smart sensors' for monitoring fish populations in the ocean's eerily dim 'twilight zone.
Early CRISPR applications were often limited by the low editing efficiency of homology-directed repair (HDR) , the pathway for resolving DNA double-strand breaks (DSBs) preferred by researchers. Compared to non-homologous end joining (NHEJ) , HDR occurs at a relatively low frequency, especially in nondividing cells. Scientists everywhere wistfully imagined being able to specify and correct single-base mutations without introducing DSBs at all.
Researchers have developed a reactor that pulls carbon dioxide directly from the air and converts it into sustainable fuel, using sunlight as the power source.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
THURSDAY, Feb. 13, 2025 -- The most common formulation of birth control pills has been linked to a doubling of relative risk of heart attack and stroke, a new study finds.Contraceptive vaginal rings and skin patches formulated in the same way were.
Traditional black holes, as predicted by Albert Einstein's theory of General Relativity, contain what are known as singularities, i.e. points where the laws of physics break down. Identifying how singularities are resolved in the context of quantum gravity is one of the fundamental problems in theoretical physics. Now, a team of experts has described the creation of regular black holes from gravitational effects and without the need for the existence of exotic matter required by some previous mo
THURSDAY, Feb. 13, 2025 -- You may be less likely to develop an especially lethal form of colon cancer if you're a longtime consumer of yogurt, new research finds.Folks who ate two or more servings of yogurt per week for years had a 20% lower odds.
Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
THURSDAY, Feb. 13, 2025 -- A legal loophole is allowing marijuana ads to slip past regulations and land right in front of kids on social media, a new report shows.Although the federal Controlled Substances Act prohibits advertising the sale or use.
A research team has developed two new autonomous navigation systems for cyborg insects to better navigate unknown, complex environments. The algorithms utilized only simple circuits that leveraged natural insect behaviors, like wall-following and climbing, to navigate challenging terrain, such as sandy, rock-strewn surfaces. For all difficulties of terrain tested, the cyborg insects were able to reach their target destination, demonstrating the potential of cyborg insects for surveillance, disas
Backed by Goldman Sachs, Novo Nordisk’s parent company and others, Newleos Therapeutics debuted Thursday with $94 million and a plan to develop drugs for brain function and health.
Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
THURSDAY, Feb. 13, 2025 -- Robert F. Kennedy Jr., a vocal vaccine skeptic and activist lawyer, was confirmed Thursday as the nation's new health secretary.The Senate voted largely along party lines to put Kennedy at the helm of the $1.7 trillion.
New research has revealed that birds, reptiles, and mammals have developed complex brain circuits independently, despite sharing a common ancestor. These findings challenge the traditional view of brain evolution and demonstrate that, while comparable brain functions exist among these groups, embryonic formation mechanisms and cell types have followed divergent evolutionary trajectories.
The Unsung Heroes of Generic Drug Development: The Power of Partnerships As we navigate the complex landscape of pharmaceuticals, it's easy to overlook the crucial role that partnerships play in bringing affordable, life-saving medications to market. But the truth is, partnerships are the backbone of generic drug development, and their impact cannot be overstated.
Astronomers used a 3D global computer model to compare the climates of exoplanets in different stellar and orbital configurations. They found that a planet orbiting a white dwarf star would offer a warmer climate than one orbiting a main sequence star.
Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
THURSDAY, Feb. 13, 2025 -- Depression hits the whole body, speeding the onset of long-term physical ills as people age, new research contends.People whove experienced depression are more likely to develop long-term physical health conditions such.
Researchers have made a breakthrough in the development of 'life-like' synthetic materials which are able to move by themselves like worms. Scientists have been investigating a new class of materials called 'active matter', which could be used for various applications from drug delivery to self-healing materials.
THURSDAY, Feb. 13, 2025 -- Children who develop multiple sclerosis appear to fare better if they were exposed to safe amounts of summer sunshine as infants, new research shows.If their moms got some summer sun while pregnant, that seemed to help.
Researchers have mapped and catalogued more than 70,000 synaptic connections from about 2,000 rat neurons, using a silicon chip capable of recording small yet telltale synaptic signals from a large number of neurons. The research is a major advance in neuronal recording and may help bring scientists a step closer to drawing a detailed synaptic connection map of the brain.
Henry Gosebruch, Neumora’s CEO since 2023, will depart. Elsewhere, Biogen dropped two antisense drugs in a pipeline cull and Voyager hit a setback for its ALS gene therapy.
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