Mon.Sep 30, 2024

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Frequent fizzy or fruit drinks and high coffee consumption linked to higher stroke risk

Science Daily: Pharmacology News

Frequent drinking of fizzy drinks or fruit juice is associated with an increased risk of stroke, according to new findings. The research also found that drinking more than four cups of coffee per day also increases the risk of stroke.

Research 318
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Roche turns to a startup in search for new breast cancer drugs

BioPharma Drive: Drug Pricing

The Swiss pharma is paying Regor Therapeutics $850 million to buy a pair of prospects it sees as potential successors to blockbuster medicines from Pfizer and Eli Lilly.

Drugs 281
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The Vikings were part of a global network trading in ivory from Greenland

Science Daily: Pharmacology News

New research shows that the Vikings traveled more than 6,000 kilometers to the Arctic to hunt for walrus. DNA analyses reveal that walrus ivory from Greenland was brought to Europe and probably as far as the Middle East [M1] via extensive trade networks.

DNA 308
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Synthetic THC May Calm Agitation in Alzheimer's Patients

Drugs.com

MONDAY, Sept. 30, 2024 -- A synthetic form of the active ingredient in cannabis helps reduce agitation in people with Alzheimer's, new research shows.Synthetic THC (dronabinol) also gave patients' caregivers a boost, according to findings presented.

Research 264
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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A river is pushing up Mount Everest's peak

Science Daily: Pharmacology News

Mount Everest is about 15 to 50 meters taller than it would otherwise be because of uplift caused by a nearby eroding river gorge, and continues to grow because of it.

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Tongan volcanic eruption triggered by explosion as big as 'five underground nuclear bombs'

Science Daily: Pharmacology News

The Hunga Tonga underwater volcano was one of the largest volcanic eruptions in history, and now, two years later, new research has revealed its main trigger.

Research 296
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Falling Linked to Raised Risk of Dementia in Older People

Drugs.com

MONDAY, Sept. 30, 2024 -- More than 14 million seniors a year take a tumble, and those falls can be life-changing. "The relationship between falls and dementia appears to be a two-way street," said Molly Jarman, senior author of a new study showing.

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Could a bout of COVID protect you from a severe case of flu?

Science Daily: Pharmacology News

New findings on how past viral respiratory infections affect future, unrelated ones could lead to therapies for boosting general antiviral immunity -- and potentially pandemic preparedness.

Therapies 294
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Cluster of 8 Possible Human Bird Flu Cases Now Reported in Missouri

Drugs.com

MONDAY, Sept. 30, 2024 -- In what could be the first cases of bird flu spreading between humans in the United States, a group of potential H5N1 infections in Missouri has now grown to eight.Antibody tests to confirm any H5N1 infection are still.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Watch water form out of thin air

Science Daily: Pharmacology News

Palladium, a rare metallic element, can rapidly generate water from hydrogen and oxygen. Researchers witnessed this process at the nanoscale for the first time with an electron microscope. By viewing the process with extreme precision, researchers discovered how to optimize it to generate water at a faster rate. Process could be used to generate water on-demand in arid environments, including on other planets.

Research 286
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America's Pediatricians Want You to Read a Book With Your Child

Drugs.com

MONDAY, Sept. 30, 2024 -- Read to your little ones.That's the American Academy of Pediatrics' (AAP) prescription for fostering loving, nurturing relationships during early infancy and early childhood -- a time of critical brain development."Reading.

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Most accurate ultrasound test could detect 96% of women with ovarian cancer

Science Daily: Pharmacology News

Head-to-head study of diagnostic test accuracy found IOTA ultrasound ADNEX model had 96% sensitivity and acceptable specificity in first study of its kind.

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Black Babies With Heart Abnormalities Face Higher Death Risk

Drugs.com

MONDAY, Sept. 30, 2024 -- Black American infants born with congenital heart disease are less likely to survive to the age of 1, compared to white babies with the condition, a new study finds.The research suggests that Black infants aren't reaping.

Disease 246
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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First data from XRISM space mission provides new perspective on supermassive black holes

Science Daily: Pharmacology News

Data from an international space mission is confirming decades worth of speculation about the galactic neighborhoods of supermassive black holes.

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Despite Progress, America's Fight Against Toxic Lead Far From Over

Drugs.com

MONDAY, Sept. 30, 2024 -- Toxic lead continues to pose a danger to U.S. consumers despite years of progress to reduce exposure, claims a study spanning four states."Consumer products were consistently identified as one of the main sources of lead.

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New synthesis strategy could speed up PFAS decontamination

Science Daily: Pharmacology News

Engineers have developed an innovative way to make covalent organic frameworks, special materials that can be used to trap gases, filter water and speed up chemical reactions.

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What Do Families Fight About Most? New Study Finds Out

Drugs.com

MONDAY, Sept. 30, 2024 -- In a world where families may be more apt to interact with technology than with one another, some things never change.Many still struggle to get along. But just what do 21st century families fight about?A new survey of.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Prime to narrow gene editing research as it strikes deal with Bristol Myers

BioPharma Drive: Drug Pricing

The high-profile biotech is zeroing in on programs that serve as proof points for its technology, while seeking partners for other assets.

Research 171
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Activity-Based Acylome Profiling with N-(Cyanomethyl)-N-(phenylsulfonyl)amides for Targeted Lysine Acylation and Post-Translational Control of Protein Function in Cells

Covalent Modifiers

Elizabeth M. Ryan, Michael A. Norinskiy, Amy K. Bracken, Emma E. Lueders, Xueer Chen, Qin Fu, Elizabeth T. Anderson, Sheng Zhang, and Mikail E. Abbasov Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c09073 Lysine acylations are ubiquitous and structurally diverse post-translational modifications that vastly expand the functional heterogeneity of the human proteome.

RNA 147
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Aktis raises $175M to fuel radiopharma drug development

BioPharma Drive: Drug Pricing

Among the investors in Aktis’ Series B round were Bristol Myers Squibb, Eli Lilly and Merck & Co., all of which have expanded their involvement in the radiopharma field.

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Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

Covalent Modifiers

Alexandra Geißler, Howard Junca , Andreas M. Kany , Lena J. Daumann, Anna K. H. Hirsch Dietmar H. Pieper b and Stephan A. Sieber Chem. Sci., 2024 , 15, 11946-11955 [link] Isonitrile natural products, also known as isocyanides, demonstrate potent antimicrobial activities, yet our understanding of their molecular targets remains limited. Here, we focus on the so far neglected group of monoisonitriles to gain further insights into their antimicrobial mode of action (MoA).

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Shorter Course of Breast Cancer Radiation Won't Affect Breast Reconstruction

Drugs.com

MONDAY, Sept. 30, 2024 -- A shorter course of post-mastectomy radiation doesn't jeopardize a patient's chances of successful breast reconstruction, a new study finds.About 40 percent of people with breast cancer have mastectomies, followed by five.

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Accelerating precision oncology: The value of an end-to-end partner for therapeutic access

BioPharma Drive: Drug Pricing

Learn how optimal NGS solutions can help developers overcome challenges throughout targeted therapeutic development and the value of an end-to-end partner to help every step of the way.

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The Impact of Patent Expirations on Generic Drug Markets

Drug Patent Watch

Patent expirations have a significant impact on the pharmaceutical industry, particularly on the generic drug market. When a drug’s patent expires, other manufacturers can produce and market generic versions of the drug, leading to increased competition and lower prices.

Marketing 105
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Key factors shaping the future of clinical services organizations in the APAC market

BioPharma Drive: Drug Pricing

Clinical services organizations can help pharma with global drug development and clinical trial challenges.

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Q&A: How Terra became a backbone of public health pathogen surveillance

Broad Institute

Q&A: How Terra became a backbone of public health pathogen surveillance By Allessandra DiCorato September 30, 2024 Breadcrumb Home Q&A: How Terra became a backbone of public health pathogen surveillance Bronwyn MacInnis and Daniel Park reflect on how Terra, a scalable and secure open-source platform for biomedical data management and analysis, is making genomics accessible to public health labs.