Mon.Sep 30, 2024

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Frequent fizzy or fruit drinks and high coffee consumption linked to higher stroke risk

Science Daily: Pharmacology News

Frequent drinking of fizzy drinks or fruit juice is associated with an increased risk of stroke, according to new findings. The research also found that drinking more than four cups of coffee per day also increases the risk of stroke.

Research 116
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Roche turns to a startup in search for new breast cancer drugs

BioPharma Drive: Drug Pricing

The Swiss pharma is paying Regor Therapeutics $850 million to buy a pair of prospects it sees as potential successors to blockbuster medicines from Pfizer and Eli Lilly.

Drugs 114
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The Vikings were part of a global network trading in ivory from Greenland

Science Daily: Pharmacology News

New research shows that the Vikings traveled more than 6,000 kilometers to the Arctic to hunt for walrus. DNA analyses reveal that walrus ivory from Greenland was brought to Europe and probably as far as the Middle East [M1] via extensive trade networks.

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Synthetic THC May Calm Agitation in Alzheimer's Patients

Drugs.com

MONDAY, Sept. 30, 2024 -- A synthetic form of the active ingredient in cannabis helps reduce agitation in people with Alzheimer's, new research shows.Synthetic THC (dronabinol) also gave patients' caregivers a boost, according to findings presented.

Research 105
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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A river is pushing up Mount Everest's peak

Science Daily: Pharmacology News

Mount Everest is about 15 to 50 meters taller than it would otherwise be because of uplift caused by a nearby eroding river gorge, and continues to grow because of it.

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1 in 3 Teens Have Trouble Obtaining Menstrual Tampons or Pads

Drugs.com

MONDAY, Sept. 30, 2024 -- One in every three girls may not have access to menstrual products, something researchers are dubbing "period poverty."“Our study highlights the widespread nature of period poverty and the need for broad actions -- both l.

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Could a bout of COVID protect you from a severe case of flu?

Science Daily: Pharmacology News

New findings on how past viral respiratory infections affect future, unrelated ones could lead to therapies for boosting general antiviral immunity -- and potentially pandemic preparedness.

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Falling Linked to Raised Risk of Dementia in Older People

Drugs.com

MONDAY, Sept. 30, 2024 -- More than 14 million seniors a year take a tumble, and those falls can be life-changing. "The relationship between falls and dementia appears to be a two-way street," said Molly Jarman, senior author of a new study showing.

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What is a Clinical Evaluation Report (CER)?

thought leadership

If you’re starting to explore marketing your medical device in the European Union (EU) or have a medical device that is currently CE Marked, you’re becoming familiar with the term ‘CER’ or Clinical Evaluation Report. However, do you really know what a CER is and how it evolved into the modern document required for the EU MDR (Medical Device Regulation)?

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Cluster of 8 Possible Human Bird Flu Cases Now Reported in Missouri

Drugs.com

MONDAY, Sept. 30, 2024 -- In what could be the first cases of bird flu spreading between humans in the United States, a group of potential H5N1 infections in Missouri has now grown to eight.Antibody tests to confirm any H5N1 infection are still.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Medical Coding in Clinical Data Management

Quanticate

In any clinical trial conduct, recording and storing data in a controlled, consistent, and reproducible manner for data retrieval and analysis is a necessity for regulatory compliance and clinical study success.

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America's Pediatricians Want You to Read a Book With Your Child

Drugs.com

MONDAY, Sept. 30, 2024 -- Read to your little ones.That's the American Academy of Pediatrics' (AAP) prescription for fostering loving, nurturing relationships during early infancy and early childhood -- a time of critical brain development."Reading.

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The Impact of Patent Expirations on Generic Drug Markets

Drug Patent Watch

Patent expirations have a significant impact on the pharmaceutical industry, particularly on the generic drug market. When a drug’s patent expires, other manufacturers can produce and market generic versions of the drug, leading to increased competition and lower prices.

Marketing 100
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Black Babies With Heart Abnormalities Face Higher Death Risk

Drugs.com

MONDAY, Sept. 30, 2024 -- Black American infants born with congenital heart disease are less likely to survive to the age of 1, compared to white babies with the condition, a new study finds.The research suggests that Black infants aren't reaping.

Disease 98
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Watch water form out of thin air

Science Daily: Pharmacology News

Palladium, a rare metallic element, can rapidly generate water from hydrogen and oxygen. Researchers witnessed this process at the nanoscale for the first time with an electron microscope. By viewing the process with extreme precision, researchers discovered how to optimize it to generate water at a faster rate. Process could be used to generate water on-demand in arid environments, including on other planets.

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Despite Progress, America's Fight Against Toxic Lead Far From Over

Drugs.com

MONDAY, Sept. 30, 2024 -- Toxic lead continues to pose a danger to U.S. consumers despite years of progress to reduce exposure, claims a study spanning four states."Consumer products were consistently identified as one of the main sources of lead.

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Tongan volcanic eruption triggered by explosion as big as 'five underground nuclear bombs'

Science Daily: Pharmacology News

The Hunga Tonga underwater volcano was one of the largest volcanic eruptions in history, and now, two years later, new research has revealed its main trigger.

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What Do Families Fight About Most? New Study Finds Out

Drugs.com

MONDAY, Sept. 30, 2024 -- In a world where families may be more apt to interact with technology than with one another, some things never change.Many still struggle to get along. But just what do 21st century families fight about?A new survey of.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Most accurate ultrasound test could detect 96% of women with ovarian cancer

Science Daily: Pharmacology News

Head-to-head study of diagnostic test accuracy found IOTA ultrasound ADNEX model had 96% sensitivity and acceptable specificity in first study of its kind.

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Unlocking the potential of smart antibodies

Drug Target Review

Compared to traditional antibody therapies, how does the precision binding approach in your antibody design impact the therapeutic window and dosing regimen in preclinical models? Our approach represents a paradigm shift. Traditional drug discovery is based on the premise that target proteins have biological functions. Drugs should shut off, or antagonise, proteins with undesirable functions.

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New synthesis strategy could speed up PFAS decontamination

Science Daily: Pharmacology News

Engineers have developed an innovative way to make covalent organic frameworks, special materials that can be used to trap gases, filter water and speed up chemical reactions.

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Aktis raises $175M to fuel radiopharma drug development

BioPharma Drive: Drug Pricing

Among the investors in Aktis’ Series B round were Bristol Myers Squibb, Eli Lilly and Merck & Co., all of which have expanded their involvement in the radiopharma field.

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First data from XRISM space mission provides new perspective on supermassive black holes

Science Daily: Pharmacology News

Data from an international space mission is confirming decades worth of speculation about the galactic neighborhoods of supermassive black holes.

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Prime to narrow gene editing research as it strikes deal with Bristol Myers

BioPharma Drive: Drug Pricing

The high-profile biotech is zeroing in on programs that serve as proof points for its technology, while seeking partners for other assets.

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Rich Text Editor in Vue Application: Using Quill.js

Perficient: Drug Development

Rich text editors are essential for many web applications, allowing users to format text, add links, and even insert media directly into their content. Quill.js is a powerful, customizable open-source editor that integrates seamlessly with modern frameworks like Vue.js. This tutorial will walk us through the steps to set up and integrate Quill.js in a Vue.js project to create a dynamic rich text editor.

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Activity-Based Acylome Profiling with N-(Cyanomethyl)-N-(phenylsulfonyl)amides for Targeted Lysine Acylation and Post-Translational Control of Protein Function in Cells

Covalent Modifiers

Elizabeth M. Ryan, Michael A. Norinskiy, Amy K. Bracken, Emma E. Lueders, Xueer Chen, Qin Fu, Elizabeth T. Anderson, Sheng Zhang, and Mikail E. Abbasov Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c09073 Lysine acylations are ubiquitous and structurally diverse post-translational modifications that vastly expand the functional heterogeneity of the human proteome.

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Shorter Course of Breast Cancer Radiation Won't Affect Breast Reconstruction

Drugs.com

MONDAY, Sept. 30, 2024 -- A shorter course of post-mastectomy radiation doesn't jeopardize a patient's chances of successful breast reconstruction, a new study finds.About 40 percent of people with breast cancer have mastectomies, followed by five.

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Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

Covalent Modifiers

Alexandra Geißler, Howard Junca , Andreas M. Kany , Lena J. Daumann, Anna K. H. Hirsch Dietmar H. Pieper b and Stephan A. Sieber Chem. Sci., 2024 , 15, 11946-11955 [link] Isonitrile natural products, also known as isocyanides, demonstrate potent antimicrobial activities, yet our understanding of their molecular targets remains limited. Here, we focus on the so far neglected group of monoisonitriles to gain further insights into their antimicrobial mode of action (MoA).

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CMS Final Medicaid Drug Rebate Rule Details New Misclassification Penalties and Numerous Other Changes

FDA Law Blog: Biosimilars

By Alan M. Kirschenbaum & Sophia R. Gaulkin — In May 2023, we posted about a CMS proposed regulation that sought to make a wide variety of changes to the Medicaid Drug Rebate Program (MDRP), including a new “price verification survey,” and a controversial proposal to require “stacking” of discounts to different customers when determining best price.

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Accelerated Study Timelines, Less Logistical Hurdles

Alta Sciences

Accelerated Study Timelines, Less Logistical Hurdles blussier Mon, 09/30/2024 - 12:47 HTML The True Meaning of Moving in Unison We value your time as much as you do. At Altasciences, we break down organizational silos, streamline project management, and promote effortless communication to provide you with exceptional value. WATCH VIDEO From preclinical studies to clinical trials, and from regulatory submissions to tackling operational challenges, we are dedicated to safely accelerating your jour

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Digging Deeper into Thompson Sampling - A Guest Blog Post by Patrick Riley

Practical Cheminformatics

This week is a special Pat substitution. Pat(rick) Riley is taking over this blog post for a follow up on our Thompson Sampling paper. In our recent paper Thompson Sampling─An Efficient Method for Searching Ultralarge Synthesis on Demand Databases we showed how you could use the classic Thompson Sampling algorithm to select each reagent in a combinatorial library to conduct an efficient search for a variety of scoring functions.

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Fierce Pharma Engage

Fierce BioTech

Fierce Pharma Engage Fierce Pharma Engage is where pharma and biotech executives meet to connect, collaborate, and explore custom strategies for marketing, dealmaking, medical affairs, and communications in a dynamic and intimate setting through educational sessions, structured networking and social functions that bring new ideas across marketing, commercialization and digital innovations. llam Mon, 09/30/2024 - 17:44 Resource Type Questex Event Fierce Pharma Engage Logo Color.

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Perficient at Dreamforce 2024: A Look at Innovation, Agentforce, and the Future of AI

Perficient: Drug Development

Perficient’s presence at Dreamforce 2024 was more than just attending—it was about connecting, innovating, and driving real change. From discussing cutting-edge AI like Agentforce to supporting initiatives such as Girls Who Code, Perficient is committed to shaping both the present and future of technology. Whether you joined us at our sessions or other events, we aimed to create meaningful experiences for all attendees.

Science 52