Drug Discovery World

MARCH 8, 2024

The US Food and Drug Administration (FDA) has revealed plans to convene a meeting of the Peripheral and Central Nervous System Drugs Advisory Committee (PCNS) to discuss the Phase III TRAILBLAZER-ALZ 2 trial. The trial evaluated the efficacy and safety of Eli Lilly’s donanemab in early symptomatic Alzheimer’s disease. The FDA has said it hopes to further understand topics related to evaluating the safety and efficacy of donanemab, including the safety results in donanemab-treated patients

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BioPharma Drive: Drug Pricing

MARCH 8, 2024

The results have led Amylyx to pause promotion of Relyvrio and potentially pull it from the market in the coming weeks, a major blow to the company and ALS patients.

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Drug Discovery World

MARCH 8, 2024

News round-up for 4-8 March by DDW Digital Content Editor Diana Spencer. It was antibodies hitting the headlines this week, with the discovery of antibodies with potential against a new influenza target, the launch of a Phase I trial to investigate a novel type of bispecific antibody, and the announcement that the FDA will delay approval of donanemab to hold a meeting of the Peripheral and Central Nervous System Drugs Advisory Committee.

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Clinical Trials FDA Virus Drugs 130

Broad Institute

MARCH 8, 2024

Study reveals genetic clusters that may explain differences in type 2 diabetes risk By Corie Lok March 8, 2024 Breadcrumb Home Study reveals genetic clusters that may explain differences in type 2 diabetes risk The clusters point to a range of biological processes that likely contribute to the development of type 2 diabetes. By Brandon Chase, Massachusetts General Hospital Communications March 8, 2024 Related content Largest and most diverse genome-wide association study of type 2 diabetes revea

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

MARCH 8, 2024

Biopharmaceutical company Innovent Biologics has launched the first-in-human (FIH) Phase I clinical trial of IBI3002, a novel bispecific antibody targeting Interleukin 4 receptor α (IL-4Rα) and thymic stromal lymphopoietin (TSLP). The study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of IBI3002 in healthy participants and participants with mild to moderate asthma.

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Chemical Biology and Drug Design

MARCH 8, 2024

Brucine suppressed the proliferation, migration, invasion, inflammation, and macrophage M1 polarization, as well as induced apoptosis in RA-FLSs by decreasing YY1 via circ_0139658/miR-653-5p axis. Abstract Brucine is a weak alkaline indole alkaloid with wide pharmacological activities and has been identified to protect against rheumatoid arthritis (RA) process.

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Regulations RNA Treatment Research 100

Chemical Biology and Drug Design

MARCH 8, 2024

Saikosaponin D (SSD) was used to treat pilocarpine (PP)-induced primary astrocyte injury model in rats. SSD was proved to enhance cell viability, inhibit inflammatory and oxidative stress responses, and improve mitochondrial dysfunction, thus playing a neuroprotective role in the PP-induced primary astrocyte injury model. Abstract Studies have shown that saikosaponin D (SSD) has favorable neurotherapeutic effects.

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Regulations Treatment Research 100

BioPharma Drive: Drug Pricing

MARCH 8, 2024

The agency expects to convene a group of outside experts to more closely scrutinize the safety and efficacy of the medicine, donanemab, pushing back the timing of its potential approval.

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FDA Drugs 122

Science Daily: Pharmacology News

MARCH 8, 2024

Imagine a busy restaurant: dishes clattering, music playing, people talking loudly over one another. It's a wonder that anyone in that kind of environment can focus enough to have a conversation. A new study provides some of the most detailed insights yet into the brain mechanisms that help people pay attention amid such distraction, as well as what's happening when they can't focus.

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Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- Wegovy (semaglutide), the weight-loss version of blockbuster diabetes drug Ozempic, was approved on Friday by the U.S. Food and Drug Administration to help prevent heart attack, stroke and heart death.“Wegovy is now the.

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FDA Approval FDA Drugs 116

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Clinical Trials

Science Daily: Pharmacology News

MARCH 8, 2024

For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory.

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Broad Institute

MARCH 8, 2024

A close research partnership with African scientists helps solve the mystery of malaria-like illnesses By Claire Hendershot March 8, 2024 Breadcrumb Home A close research partnership with African scientists helps solve the mystery of malaria-like illnesses Two scientists discuss how they used genetic sequencing to identify causes of malaria-mimicking infections in Senegal.

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Science Daily: Pharmacology News

MARCH 8, 2024

While the majority of the world's reefs are now under threat or even damaged potentially beyond repair, a new study offers some encouraging news: efforts to restore coral reefs not only increase coral cover, but they can also bring back important ecosystem functions, and surprisingly fast.

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Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- During the past half-century, the United States’ annual number of school shootings has increased more than twelvefold, a new study finds.What’s more, children are now four times more likely to be a school shooting.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Perficient: Drug Development

MARCH 8, 2024

Have you ever wondered what happens if you connected Personalization with Sales and Service Clouds? The Personalization connector for Sales and Service Clouds exposes user data and server-side campaigns in Salesforce CRM for your contacts and leads. The Key for Success To use Personalization for Sales and Service Clouds, you’ll need to have: User identity systems fully working.

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Packaging Marketing Production Science 110

Broad Institute

MARCH 8, 2024

Machine Learning in Drug Discovery By Rose Circeo March 8, 2024 Breadcrumb Home Machine Learning in Drug Discovery Symposium Machine Learning in Drug Discovery The next Machine Learning in Drug Discovery Symposium will take place in Fall 2024. Check back soon for dates and registration. The symposium will highlight recent progress in the application of machine learning techniques to drug discovery and bring together researchers in the field that can benefit from networking.

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Clinical Trials Drugs Trials Research 105

Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- Ambien, Lunesta, Sonata: Millions of bleary-eyed Americans turn to this class of so-called "Z-drugs" to get restful sleep.But how do these drugs work, and do they come with risks? Experts at the U.S. Food and Drug.

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Drugs 105

Drug Channels

MARCH 8, 2024

Today’s guest post comes from Logan Melchione, VP of Patient Affordability at Paysign. Logan discusses the evolution of patient support programs. She then outlines how these programs must evolve to stay relevant and valuable. To request an analysis of your copay savings program and learn more about Paysign’s patient affordability solutions, contact affordability@paysign.com or visit paysign.com/rx.

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Drugs 97

Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- Instead of approving the new Alzheimer's drug donanemab this month, as was expected, the U.S. Food and Drug Administration will now require the experimental medication be scrutinized more closely by an expert panel, the.

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FDA Drugs 105

SCIENMAG: Medicine & Health

MARCH 8, 2024

University of Pittsburgh researchers have uncovered blood-based markers linked with healthy and rapid aging, allowing them to predict a person’s biological age — how fast a person’s cells and organs age regardless of their birthdate.

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Research 87

Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- Lots of seniors are regularly taking low-dose aspirin in hopes of preventing heart attacks and strokes, even though updated guidelines often advise against it.About one in four older adults take aspirin at least three times.

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Science Daily: Pharmacology News

MARCH 8, 2024

When you teach a child how to solve puzzles, you can either let them figure it out through trial and error, or you can guide them with some basic rules and tips. Similarly, incorporating rules and tips into AI training -- such as the laws of physics --could make them more efficient and more reflective of the real world. However, helping the AI assess the value of different rules can be a tricky task.

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Trials 85

Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- Dementia could three times more common among people suffering from essential tremor, a movement disorder that causes involuntary shaking, a new study suggests.“Not only do tremors affect a person’s ability to complete.

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BioPharma Drive: Drug Pricing

MARCH 8, 2024

The approval makes Novo’s Wegovy the first weight-loss drug with such a claim on its prescribing information, which could have important implications for use and insurance coverage.

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FDA Drugs 73

Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- More Americans exposed to radiation caused by the government would be compensated under a bill that passed the U.S. Senate Thursday.The bipartisan legislation, which would cost an estimated $50 billion, would expand the.

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Government 98

SCIENMAG: Medicine & Health

MARCH 8, 2024

Reston, VA—A new PET radiotracer can differentiate diseased tissues from healthy tissues based on fructose metabolism, according to new research published in the March issue of The Journal of Nuclear Medicine. Fructose metabolism—or fructolysis—is indicative of a variety of diseases, and by noninvasively mapping fructolysis physicians can more accurately detect diseases and treat them earlier.

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Disease Research 73

Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- Children with “lazy eye” are more likely to become adults facing an array of serious health problems, a new study warns.Kids diagnosed with amblyopia are more likely to develop high blood pressure, obesity and diabetes.

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BioPharma Drive: Drug Pricing

MARCH 8, 2024

The the first of its kind move comes as pharmacy benefit managers continue to try to prove their value to clients, and shows how major players are working to meet demand for the fast-selling medicines.

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Pharmacy Drugs 67

Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- When the clocks spring forward or fall back, many folks will find themselves struggling to adjust. The transition to Daylight Saving Time can be tough on people, both mentally and physically. Research has found that people.

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Drug Patent Watch

MARCH 8, 2024

Annual Drug Patent Expirations for ARNUITY+ELLIPTA Arnuity Ellipta is a drug marketed by Glaxosmithkline and is included in one NDA. It is available from one supplier. There are six patents… The post New patent for Glaxosmithkline drug ARNUITY ELLIPTA appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- It's well known that long-acting opioid meds raise the odds for addiction in users -- including folks dealing with pain after an orthopedic surgery.Now, new research suggests that patients fare just as well if doctors.

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Doctors Research 59

Perficient: Drug Development

MARCH 8, 2024

March is not just about the arrival of spring. It’s a celebration of women’s achievements, history, and ongoing societal impact. As we continue to recognize women this month, we’re excited to take the celebration to Adobe Summit 2024! Join us on Tuesday, March 6 for our Women in Digital Breakfast at the Grand Lux Cafe in The Palazzo.

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Drugs.com

MARCH 8, 2024

FRIDAY, March 8, 2024 -- Ever since one child, dubbed the 'Mississippi baby,' went into drug-free remission of HIV in 2013, experts have wondered if giving treatment within hours of birth might do the same for others.The results of a new trial.

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Broad Institute

MARCH 8, 2024

Next Generation Awards By Maria Nemchuk March 8, 2024 Breadcrumb Home Next Generation Awards The Next Generation Awards at the Broad Institute recognize early-career scientists (no more than 15 years after their postdoctoral position or medical residency), a group that is sometimes overlooked for funding. On average, biomedical researchers do not receive their first major grant until the age of 43.

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Research 52