Thu.Jan 30, 2025

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Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

BioPharma Drive: Drug Pricing

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

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Polar bear population decline the direct result of extended 'energy deficit' due to lack of food

Science Daily: Pharmacology News

U of T Scarborough researchers have directly linked population decline in polar bears living in Western Hudson Bay to shrinking sea ice caused by climate change.

Research 304
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Opioid Painkillers Less Available To People Of Color

Drugs.com

THURSDAY, Jan. 30, 2025 -- People of color now have less access to prescription opioid painkillers than white patients, an unintended consequence of efforts to stem Americas opioid epidemic.Communities of color have a 40% to 45% lower distribution.

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Antibody treatment prevents severe bird flu in monkeys

Science Daily: Pharmacology News

The antibody targets a stable part of the bird flu virus, ensuring that the immune protection can resist new variants and offer long-term protection against the globally spreading airborne infection.

Treatment 292
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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USDA Issues Health Alert Over Bone Fragments in Wegmans Nuggets

Drugs.com

THURSDAY, Jan. 30, 2025 -- If you have a bag of Wegmans breaded chicken breast nuggets in your freezer, you may want to check the label before your next meal.The U.S. Department of Agricultures Food Safety and Inspection Service (FSIS) has issued a.

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Weight-Loss Surgery Protects Liver Health

Drugs.com

THURSDAY, Jan. 30, 2025 -- Weight-loss surgery can protect the liver health of patients with obesity and fatty liver disease, a new study reports.Patients had a 72% lower risk of developing serious complications of liver disease after undergoing.

Disease 242
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Freshwater alga could be the next superfood that feeds the world

Science Daily: Pharmacology News

A green alga that grows in lakes and rivers could be the next 'superfood' -- helping scientists to tackle global food security challenges while promoting environmental sustainability.

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Heavy Weed Use Affects Young Adults' Short-Term Memory

Drugs.com

THURSDAY, Jan. 30, 2025 -- Heavy weed use appears to dull the brains of young adults, particularly affecting their short-term working memory, a new study suggests.MRI scans showed less brain activation in heavy tokers performing tasks that tested.

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Wildfire smoke can carry toxins hundreds of kilometers, depositing grime on urban structures, surfaces

Science Daily: Pharmacology News

Researchers have shown that plumes of wildfire smoke can carry contaminants hundreds of kilometers, leaving a toxic and lingering footprint which has the potential to be re-released into the environment.

Research 281
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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23andMe considers a sale as cash runs low

BioPharma Drive: Drug Pricing

The testing company ended last year with $79 million and told investors it will need to raise money to fund its operations and financial commitments.

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New light-tuned chemical tools control processes in living cells

Science Daily: Pharmacology News

A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors to new methods for studying complex processes in cells and could pave the way for significant advances in medicine and synthetic biology.

Research 279
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Cholesterol Changes in Seniors Linked to Brain Health

Drugs.com

THURSDAY, Jan. 30, 2025 -- Seniors whose cholesterol levels spike and plummet year-to-year could be at increased risk of dementia and failing brain health, a new study suggests.Those whose cholesterol fluctuated the most had a 60% increased risk of.

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Generating electricity from tacky tape

Science Daily: Pharmacology News

Zaps of static electricity might be a wintertime annoyance, but to certain scientists, they represent an untapped source of energy. Using a device called a triboelectric nanogenerator (TENG), mechanical energy can be converted into electrical energy using triboelectric effect static. Many TENGs contain expensive, specially fabricated materials, but one team has instead used inexpensive store-bought tape, plastic and aluminum metal.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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RFK Jr. fumbles Medicare basics during second confirmation hearing

BioPharma Drive: Drug Pricing

Robert F. Kennedy Jr., nominated to be health secretary, seemed unfamiliar with the particulars of the massive insurance program he'd oversee in exchanges with senators Thursday.

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Earth scientists study Sikkim flood in India to help others prepare for similar disasters

Science Daily: Pharmacology News

Experts from the global Earth science community have pieced together what happened during the massive Sikkim flood to try to help others prepare for similar disasters.

Science 255
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Metsera, Maze secure combined $415 million in IPOs

BioPharma Drive: Drug Pricing

The offerings reflect an increase in IPO activity that could continue, as four other biotechs recently outlined plans to go public.

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Why you shouldn't scratch an itchy rash: New study explains

Science Daily: Pharmacology News

Your parents were right: Scratching an itchy rash really does make it worse. Now we know why, thanks to new research that uncovers how scratching aggravates inflammation and swelling in a mouse model of a type of eczema called allergic contact dermatitis.

Research 253
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Crisis Services Haven't Adapted To New 988 Suicide Hotline

Drugs.com

THURSDAY, Jan. 30, 2025 -- Most community crisis services did not expand following the launch of the 988 Suicide & Crisis Lifeline, potentially blunting the effectiveness of the hotline, a new study says.Walk-in psychiatric services, mobile.

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Bat wings boost hovering efficiency

Science Daily: Pharmacology News

Researchers have designed flexible, bat-like wings that boost lift and improve flight performance. This innovation could lead to more efficient drones or energy-harvesting technologies.

Research 253
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Christophe Weber, veteran Takeda CEO, to retire next year

BioPharma Drive: Drug Pricing

Julie Kim, currently Takeda’s U.S. head, will replace Weber in June 2026 and become one of the few female CEOs of a top drugmaker.

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Lead contamination in ancient Greece points to societal change

Science Daily: Pharmacology News

Studies of sediment cores from the sea floor and the coastal regions surrounding the Aegean Sea show that humans contaminated the environment with lead early on in antiquity. Geoscientists conducted the analyses, which revealed that human activity in the region resulted in lead contamination of the environment approximately 5,200 years ago -- much earlier than previously known.

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Cargo to drop lead CAR-T therapy, lay off staff after study setback

BioPharma Drive: Drug Pricing

Safety concerns and disappointing efficacy results have led Cargo to stop testing the treatment, cut 50% of its workforce and evaluate strategic alternatives.

Therapies 161
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A hearing aid for. your nose?

Science Daily: Pharmacology News

Scientists have discovered a feedback loop in the brain's odor center that seems to put smells and sounds into context. The feedback loop may help animals adjust their behaviors in response to new sensations.

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Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations

Covalent Modifiers

William McCoull, Clare Thomson, Erin Braybrooke, Christina Chan, Nicola Colclough, Miguel A. Corts Gonzlez, Sabina Cosulich, Nichola L. Davies, Nicolas Floch, Ryan Greenwood, David Hargreaves, Peng Huang, Thomas A. Hunt, Tony Johnson, Peter Johnstrm, Jason G. Kettle, Mikhail Kondrashov, Demetrios H. Kostomiris, Songlei Li, Andrew Lister, Scott Martin, Darren McKerrecher, Neville McLean, J.

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Zika uses human skin as 'mosquito magnet' to spread virus further

Science Daily: Pharmacology News

Zika virus hijacks the skin of its human host to send out chemical signals that lure more mosquitoes to infect and spread the disease further, new research shows.

Virus 178
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Total syntheses of cyclohelminthol I–IV reveal a new cysteine-selective covalent reactive group

Covalent Modifiers

DOI Thomas T. Paulsen, Anders E. Kiib, Gustav J. Wrmer, Stephan M. Hacker and Thomas B. Poulsen Chemical Science, 2025 [link] Biocompatible covalent reactive groups (CRGs) play pivotal roles in several areas of chemical biology and the life sciences, including targeted covalent inhibitor design and preparation of advanced biologic drugs, such as antibodydrug conjugates.

Science 113
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Optimism can boost saving, especially for lower-income individuals

Science Daily: Pharmacology News

Being optimistic about the future may help people save more money, and the effect appears strongest among those with lower incomes, according to new research.

Research 168