Thu.Jan 30, 2025

article thumbnail

Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

BioPharma Drive: Drug Pricing

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

article thumbnail

Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations

Covalent Modifiers

William McCoull, Clare Thomson, Erin Braybrooke, Christina Chan, Nicola Colclough, Miguel A. Corts Gonzlez, Sabina Cosulich, Nichola L. Davies, Nicolas Floch, Ryan Greenwood, David Hargreaves, Peng Huang, Thomas A. Hunt, Tony Johnson, Peter Johnstrm, Jason G. Kettle, Mikhail Kondrashov, Demetrios H. Kostomiris, Songlei Li, Andrew Lister, Scott Martin, Darren McKerrecher, Neville McLean, J.

147
147
Insiders

Sign Up for our Newsletter

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

article thumbnail

Polar bear population decline the direct result of extended 'energy deficit' due to lack of food

Science Daily: Pharmacology News

U of T Scarborough researchers have directly linked population decline in polar bears living in Western Hudson Bay to shrinking sea ice caused by climate change.

Research 307
article thumbnail

When is a Confirmatory Trial “Underway” or Conducted with “Due Diligence” Enough for Accelerated Approval? FDA Explains Its New Authorities

FDA Law Blog: Drug Discovery

By Mark A. Tobolowsky & Charles G. Raver & James E. Valentine We recently blogged about a new December 2024 draft guidance about accelerated approval (the December 2024 draft guidance). That post largely focused on endpoints as well as the broader context for when accelerated approval is appropriate. However, as we note in that post, the design, timing of initiation, and timely conduct of confirmatory trials are also important considerations in FDAs determination of whether accelerated

FDA 105
article thumbnail

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

article thumbnail

Antibody treatment prevents severe bird flu in monkeys

Science Daily: Pharmacology News

The antibody targets a stable part of the bird flu virus, ensuring that the immune protection can resist new variants and offer long-term protection against the globally spreading airborne infection.

Treatment 296

More Trending

article thumbnail

Researchers combine holograms and AI to create uncrackable optical encryption system

Science Daily: Pharmacology News

Researchers developed a new optical system that uses holograms to encode information, creating a level of encryption that traditional methods cannot penetrate.

Research 289
article thumbnail

Combination of Metabolomics and Bioinformatics to Reveal the Mechanism of Luteolin in the Treatment of Cervical Cancer

Chemical Biology and Drug Design

The remarkable therapeutic potential of luteolin against cervical cancer can be ascribed to its profound influence on amino acid and nucleotide metabolism, substantiated by the seamless integration of metabolomics, bioinformatics, and molecular docking techniques in this comprehensive investigation. ABSTRACT The incidence of cervical cancer is high among women globally.

article thumbnail

New light-tuned chemical tools control processes in living cells

Science Daily: Pharmacology News

A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors to new methods for studying complex processes in cells and could pave the way for significant advances in medicine and synthetic biology.

Research 278
article thumbnail

USDA Issues Health Alert Over Bone Fragments in Wegmans Nuggets

Drugs.com

THURSDAY, Jan. 30, 2025 -- If you have a bag of Wegmans breaded chicken breast nuggets in your freezer, you may want to check the label before your next meal.The U.S. Department of Agricultures Food Safety and Inspection Service (FSIS) has issued a.

246
246
article thumbnail

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

article thumbnail

Freshwater alga could be the next superfood that feeds the world

Science Daily: Pharmacology News

A green alga that grows in lakes and rivers could be the next 'superfood' -- helping scientists to tackle global food security challenges while promoting environmental sustainability.

276
276
article thumbnail

Weight-Loss Surgery Protects Liver Health

Drugs.com

THURSDAY, Jan. 30, 2025 -- Weight-loss surgery can protect the liver health of patients with obesity and fatty liver disease, a new study reports.Patients had a 72% lower risk of developing serious complications of liver disease after undergoing.

Disease 242
article thumbnail

Generating electricity from tacky tape

Science Daily: Pharmacology News

Zaps of static electricity might be a wintertime annoyance, but to certain scientists, they represent an untapped source of energy. Using a device called a triboelectric nanogenerator (TENG), mechanical energy can be converted into electrical energy using triboelectric effect static. Many TENGs contain expensive, specially fabricated materials, but one team has instead used inexpensive store-bought tape, plastic and aluminum metal.

272
272
article thumbnail

Heavy Weed Use Affects Young Adults' Short-Term Memory

Drugs.com

THURSDAY, Jan. 30, 2025 -- Heavy weed use appears to dull the brains of young adults, particularly affecting their short-term working memory, a new study suggests.MRI scans showed less brain activation in heavy tokers performing tasks that tested.

237
237
article thumbnail

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

article thumbnail

Wildfire smoke can carry toxins hundreds of kilometers, depositing grime on urban structures, surfaces

Science Daily: Pharmacology News

Researchers have shown that plumes of wildfire smoke can carry contaminants hundreds of kilometers, leaving a toxic and lingering footprint which has the potential to be re-released into the environment.

Research 270
article thumbnail

23andMe considers a sale as cash runs low

BioPharma Drive: Drug Pricing

The testing company ended last year with $79 million and told investors it will need to raise money to fund its operations and financial commitments.

218
218
article thumbnail

Earth scientists study Sikkim flood in India to help others prepare for similar disasters

Science Daily: Pharmacology News

Experts from the global Earth science community have pieced together what happened during the massive Sikkim flood to try to help others prepare for similar disasters.

Science 231
article thumbnail

Cholesterol Changes in Seniors Linked to Brain Health

Drugs.com

THURSDAY, Jan. 30, 2025 -- Seniors whose cholesterol levels spike and plummet year-to-year could be at increased risk of dementia and failing brain health, a new study suggests.Those whose cholesterol fluctuated the most had a 60% increased risk of.

217
217
article thumbnail

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

article thumbnail

Bat wings boost hovering efficiency

Science Daily: Pharmacology News

Researchers have designed flexible, bat-like wings that boost lift and improve flight performance. This innovation could lead to more efficient drones or energy-harvesting technologies.

Research 229
article thumbnail

RFK Jr. fumbles Medicare basics during second confirmation hearing

BioPharma Drive: Drug Pricing

Robert F. Kennedy Jr., nominated to be health secretary, seemed unfamiliar with the particulars of the massive insurance program he'd oversee in exchanges with senators Thursday.

208
208
article thumbnail

Why you shouldn't scratch an itchy rash: New study explains

Science Daily: Pharmacology News

Your parents were right: Scratching an itchy rash really does make it worse. Now we know why, thanks to new research that uncovers how scratching aggravates inflammation and swelling in a mouse model of a type of eczema called allergic contact dermatitis.

Research 224
article thumbnail

Metsera, Maze secure combined $415 million in IPOs

BioPharma Drive: Drug Pricing

The offerings reflect an increase in IPO activity that could continue, as four other biotechs recently outlined plans to go public.

194
194
article thumbnail

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

article thumbnail

Lead contamination in ancient Greece points to societal change

Science Daily: Pharmacology News

Studies of sediment cores from the sea floor and the coastal regions surrounding the Aegean Sea show that humans contaminated the environment with lead early on in antiquity. Geoscientists conducted the analyses, which revealed that human activity in the region resulted in lead contamination of the environment approximately 5,200 years ago -- much earlier than previously known.

208
208
article thumbnail

Crisis Services Haven't Adapted To New 988 Suicide Hotline

Drugs.com

THURSDAY, Jan. 30, 2025 -- Most community crisis services did not expand following the launch of the 988 Suicide & Crisis Lifeline, potentially blunting the effectiveness of the hotline, a new study says.Walk-in psychiatric services, mobile.

189
189
article thumbnail

Zika uses human skin as 'mosquito magnet' to spread virus further

Science Daily: Pharmacology News

Zika virus hijacks the skin of its human host to send out chemical signals that lure more mosquitoes to infect and spread the disease further, new research shows.

Virus 188
article thumbnail

Christophe Weber, veteran Takeda CEO, to retire next year

BioPharma Drive: Drug Pricing

Julie Kim, currently Takeda’s U.S. head, will replace Weber in June 2026 and become one of the few female CEOs of a top drugmaker.

164
164
article thumbnail

A hearing aid for. your nose?

Science Daily: Pharmacology News

Scientists have discovered a feedback loop in the brain's odor center that seems to put smells and sounds into context. The feedback loop may help animals adjust their behaviors in response to new sensations.

182
182