Drug Discovery World

AUGUST 7, 2023

Bayer subsidiary BlueRock Therapeutics, and bit.bio have announced a collaboration to discover and manufacture regulatory T cell (Treg) based therapies. Under the terms of the agreement, bit.bio will use its machine learning discovery platform to identify transcription factor (TF) combinations for reprogramming iPSCs into Tregs. The agreement also includes options for BlueRock to license bit.bio’s opti-ox precision cell programming technology to control the expression of TF combinations within T

Therapies 130

Therapies Licensing Licensing Drugs 130

Chemical Biology and Drug Design

AUGUST 7, 2023

Phosphorylated Athyrium multidentatum (Doll.) Ching polysaccharide (PPS) was prepared and characterized. PPS exerted significant protective effect on vascular endothelial cells in vitro and in vivo. Eighteen differentially expressed genes were involved in the protective actions of PPS. Abstract The purpose of this study was to prepare phosphorylated Athyrium multidentatum (Doll.

RNA 100

RNA Regulations Research 100

Drug Discovery World

AUGUST 7, 2023

Research published in Science shows that a naturally occurring bacterium discovered by GSK scientists – Delftia tsuruhatensis Tres Cantos 1 (TC1) – could be the basis for new anti-malarial interventions. Studies done in collaboration at the Johns Hopkins Malaria Research Institute show that the bacterium can significantly reduce the malaria parasite load in both the mosquito midgut and salivary glands indicating the potential of TC1 to inhibit transmission of the parasite to humans via the mosqu

Laboratories 130

Laboratories Science Research Disease 130

Chemical Biology and Drug Design

AUGUST 7, 2023

Xanthine oxidase (XO) inhibitors are commonly used to treat gout, nephropathy, and renal stone diseases related to hyperuricemia. The present review discusses the many synthetic and natural XO inhibitors that have been developed which are found to have greater potency. Abstract Xanthine oxidase (XO) inhibitors are commonly used to treat gout, nephropathy, and renal stone diseases related to hyperuricemia.

Disease 100

Disease Treatment Research 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

AUGUST 7, 2023

A new Vaccine Development and Evaluation Centre (VDEC) has been unveiled in the UK, with the aim of building on the UK’s pandemic legacy and helping develop life-saving new vaccines that will fight ‘ Disease X ‘, a term used because what might trigger the next pandemic is unknown. The centre is situated at the UK Health Security Agency (UKHSA) Porton Down site, where it is co-located with other services delivered separately by partners including the Defence Science and Technology Lab

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Vaccine Virus Clinical Trials Disease 130

Drugs.com

AUGUST 7, 2023

MONDAY, Aug. 7, 2023 -- The U.S. opioid abuse epidemic wages on, and overdose deaths continue to rise, yet just 1 in 5 people receives potentially lifesaving medication such as methadone, buprenorphine or naltrexone to treat their addiction, a new.

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Drugs.com

AUGUST 7, 2023

MONDAY, Aug. 7, 2023 -- Early and gradual exposure to peanuts under medical supervision curbed infants' allergies, according to a new study. While researchers had seen that peanut oral immunotherapy was well tolerated by toddlers, this research.

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Therapies Research 98

Drug Discovery World

AUGUST 7, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The pace of innovation in cancer drug discovery showed no signs of slowing this week, with several pretty momentous discoveries boosting research in the sector.

Research 130

Research Drugs 130

Drug Patent Watch

AUGUST 7, 2023

A recent update from Foley & Lardner attorney Courtenay C. Brinckerhoff discusses trends in Inter Partes Review (IPR) and Post Grant Review (PGR) proceedings involving Orange Book and biologic patents, based… The post Insights into Shifting Dynamics: Orange Book and Biologic PTAB Trends appeared first on DrugPatentWatch - Make Better Decisions.

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Drug Discovery World

AUGUST 7, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The pace of innovation in cancer drug discovery showed no signs of slowing this week, with several pretty momentous discoveries boosting research in the sector.

Research 130

Research Drugs 130

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Clinical Trials

Drugs.com

AUGUST 7, 2023

MONDAY, Aug. 7, 2023 -- A new brain-zapping technology may help ease the symptoms of attention deficit hyperactivity disorder (ADHD) in children without some of the side effects stimulant medications can cause, a small, preliminary study.

Therapies 98

Therapies 98

Drug Discovery World

AUGUST 7, 2023

Evox Therapeutics has agreed a research collaboration and option agreement with the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) in New York, NY, US. The collaboration will work on developing exosome-encapsulated AAV (exoAAV) vectors as a novel gene delivery technology aimed at improving treatments for heart disease. Together, Evox and Icahn Mount Sinai are focused on tackling a long-standing challenge in cardiovascular medicine, namely the safe and effective delivery of genetic m

Therapies 130

Therapies Disease Research Immune Response 130

Drugs.com

AUGUST 7, 2023

MONDAY, Aug. 7, 2023 -- The U.S. Food and Drug Administration on Friday approved a new pill, called Zurzuvae (zuranolone), that may quickly ease severe postpartum depression and help millions of women regain their emotional equilibrium following.

FDA 98

FDA Drugs 98

BioPharma Drive: Drug Pricing

AUGUST 7, 2023

The need for more research into rare diseases is clear, but researchers face significant challenges. Fortunately, technology has created opportunities to innovate in clinical trials for rare diseases.

Clinical Trials 97

Clinical Trials Disease Trials Research 97

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Clinical Trials

Drugs.com

AUGUST 7, 2023

MONDAY, Aug. 7, 2023 -- The U.S. Food and Drug Administration on Friday approved a new pill, called Zurzuvae (zuranolone), that may quickly ease severe postpartum depression and help millions of women regain their emotional equilibrium following.

FDA 98

FDA Drugs 98

NIOSH Science Blog: Drugs

AUGUST 7, 2023

Recovery friendly workplaces (RFWs) have emerged around the United States as an important intervention to both prevent and address substance use disorders (SUD) and the opioid overdose crisis among workers. A RFW program strives to prevent SUD and overdose by creating a safe, hazard-free and healthy workplace by reducing the chance of injury and the subsequent use of opioids, providing support for workers who are struggling, and facilitating opportunities for employment for people in treatment a

Treatment 97

Treatment Drugs 97

Broad Institute

AUGUST 7, 2023

A surprising new role for a major immune regulator By Tom Ulrich August 7, 2023 Breadcrumb Home A surprising new role for a major immune regulator By Anne Trafton, MIT News August 7, 2023 Credit: RCSB Protein Data Bank A model of the human STING protein. Related people Paul Blainey Nir Hacohen A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

Regulations 91

Regulations Engineering Clinical Trials DNA 91

SCIENMAG: Medicine & Health

AUGUST 7, 2023

An international collaboration between researchers at the RIKEN Center for Brain Science (CBS) in Japan, the University of Tokyo, and University College London has demonstrated that self-organization of neurons as they “learn” follows a mathematical theory called the free energy principle.

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International Science Research 87

BioPharma Drive: Drug Pricing

AUGUST 7, 2023

The investment bank estimates that, while many smaller biotechs are laying off staff, larger companies are still growing from early 2021 levels.

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SCIENMAG: Medicine & Health

AUGUST 7, 2023

Scientists have worked out how one unusual species of trilobite — an ancient, sea-dwelling relative of spiders and lobsters — was able to defend itself against predators and survive a bumpy ride as Earth’s oxygen levels fluctuated.

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Drugs.com

AUGUST 7, 2023

MONDAY, Aug. 7, 2023 -- Black Americans diagnosed with a second primary cancer after their first one are more likely to die than their white peers. That's the takeaway from a new study by the American Cancer Society (ACS). Specifically, it found.

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SCIENMAG: Medicine & Health

AUGUST 7, 2023

An article in CMAJ (Canadian Medical Association Journal) highlights a case of lead toxicity from Ayurvedic medicines in a young woman, and the complexity in diagnosing the rare condition [link] “Given that lead toxicity is uncommon and its presentation nonspecific, patients are often seen by many health care providers before the diagnosis is made,” writes Dr.

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Drugs.com

AUGUST 7, 2023

MONDAY, Aug. 7, 2023 -- In the midst of a childhood obesity epidemic, a new study is pointing to a way to help school kids maintain a healthier weight: clean, accessible drinking water. The decidedly low-tech solution emerged in a study of 18.

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SCIENMAG: Medicine & Health

AUGUST 7, 2023

LOS ANGELES (August 7, 2023) — Critically ill children on ventilator support can experience a mismatch between their breathing efforts and the rhythm delivered by the ventilator. This mismatch, called patient-ventilator asynchrony (PVA), is difficult to detect and can worsen patient outcomes.

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Science Daily: Pharmacology News

AUGUST 7, 2023

New research has found evidence that a Roman road network spanned Devon and Cornwall and connected significant settlements with military forts across the two counties as well as wider Britannia.

Research 73

Research 73

SCIENMAG: Medicine & Health

AUGUST 7, 2023

Several diseases are caused by viruses, bacteria, or even parasites. Sometimes, these microorganisms cannot infect humans (or other animals) by themselves, so they rely on other organisms -called vectors- to carry them around and transmit the disease from one host to another. A well-known group of vectors is arthropods.

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Virus Disease 83

Science Daily: Pharmacology News

AUGUST 7, 2023

A new study suggests that Cytochromes P450 (CYP450s) enzymes can sense and respond to stimuli, acting like soft robots in living systems.

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SCIENMAG: Medicine & Health

AUGUST 7, 2023

Amid widely differing capacities of available menstrual hygiene products, a menstrual disc—similar in shape to a diaphragm—may be best for dealing with heavy monthly blood flow as well as indicating excessive blood loss, suggests research published online in the journal BMJ Sexual & Reproductive Health.

Production 83

Production Research 83

Science Daily: Pharmacology News

AUGUST 7, 2023

Heliconius butterflies are capable of spatial learning, scientists have discovered. The results provide the first experimental evidence of spatial learning in any butterfly or moth species.

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SCIENMAG: Medicine & Health

AUGUST 7, 2023

Chestnut Hill, Mass. (8/7/2023) – The Pacific Ocean’s western boundary current, which forms a critical regulator of sea surface temperature and weather patterns, has significantly strengthened as the planet warms, according to a new study published in the journal Nature Geoscience. Credit: Xingchen (Tony) Wang Chestnut Hill, Mass.

Regulations 81

Regulations Science 81

BioPharma Drive: Drug Pricing

AUGUST 7, 2023

Analysts are now questioning whether Sage’s partner Biogen will hand back rights to the drug, which was approved for postpartum depression but not major depressive disorder.

Drugs 52

Drugs 52

SCIENMAG: Medicine & Health

AUGUST 7, 2023

Philadelphia, August 8, 2023 – There is a need to better deliver information on medical nutrition therapy for patients with Parkinson’s disease (PD).

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Disease Therapies Engineering 87

Drug Patent Watch

AUGUST 7, 2023

SIGNIFOR LAR KIT (pasireotide pamoate) Recordati rare Patent: 8,822,637 Expiration: Aug 6, 2023 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs,… The post Drug Patent Expirations for the Week of August 6, 2023 appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Pharmaceuticals 52

SCIENMAG: Medicine & Health

AUGUST 7, 2023

HOUSTON, Aug. 7, 2023 – The Baker Hughes Foundation announced a $100,000 grant to the University of Houston Energy Transition Institute (ETI) to support environmental justice research and workforce development programs.

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Research 78