Perficient: Drug Development

SEPTEMBER 18, 2024

This post is the second in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Part 2: Dependencies & Creep Coming Soon: Part 3: Assumptions & Uncertainty Part 4: The Emotional Conclusion Continuing our dive into project estimating, let’s talk about two more problem areas: dependencies and project creep. These two can turn your pristine project plan into a tangled mess.

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Production 116

Drugs.com

SEPTEMBER 18, 2024

WEDNESDAY, Sept. 18, 2024 -- Women with early stage breast cancer may now take Kisquali, a medication already approved for advanced disease, following the U.S. Food and Drug Administration's expanded approval of the treatment, drug maker Novartis.

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Broad Institute

SEPTEMBER 18, 2024

Scientists identify a unique combination of bacterial strains that could treat antibiotic-resistant gut infections By Allessandra DiCorato September 18, 2024 Breadcrumb Home Scientists identify a unique combination of bacterial strains that could treat antibiotic-resistant gut infections The microbes control the growth of harmful bacteria in mice, promoting a healthier intestinal microbiome.

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Science Daily: Pharmacology News

SEPTEMBER 18, 2024

Some of the most dramatic climatic events in our planet's history are 'Snowball Earth' events that happened hundreds of millions of years ago, when almost the entire planet was encased in ice up to 0.6 miles thick. New research provides a more complete picture for how the last Snowball Earth event ended, and suggests why it preceded a dramatic expansion of life on Earth, including the emergence of the first animals.

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Research 110

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

SEPTEMBER 18, 2024

WEDNESDAY, Sept. 18, 2024 -- Early, aggressive treatment of brain lesions caused by multiple sclerosis could help ward off faster decline in patients, a new study finds.Such treatment could prevent or potentially cure paramagnetic rim lesions.

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Treatment 105

Science Daily: Pharmacology News

SEPTEMBER 18, 2024

Astronomers have spotted the biggest pair of black hole jets ever seen, spanning 23 million light-years in total length. That's equivalent to lining up 140 Milky Way galaxies back to back.

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Science Daily: Pharmacology News

SEPTEMBER 18, 2024

Metal exposure from environmental pollution is associated with increased calcium buildup in the coronary arteries at a level comparable to traditional risk factors, according to a new study. The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.

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Disease 106

Drugs.com

SEPTEMBER 18, 2024

WEDNESDAY, Sept. 17, 2024 -- Wegovy, Zepbound and other cutting-edge weight-loss drugs can be tough to get these days.They’re in short supply, and often too expensive to afford without insurance coverage.Because of these barriers, many people are d.

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Doctors Drugs 105

Science Daily: Pharmacology News

SEPTEMBER 18, 2024

New archaeological research has discovered for the first time clear links between fossils of the iconic Australian dingo, and dogs from East Asia and New Guinea.

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Research 111

Drugs.com

SEPTEMBER 18, 2024

WEDNESDAY, Sept. 18, 2024 -- There have been 50 face transplants performed in 11 countries since the surgery was pioneered back in 2005, and long-term outcomes have been favorable, a new review finds. In total, 85% of people receiving these complex.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

SEPTEMBER 18, 2024

Static electricity was first observed in 600 B.C., but researchers have struggled to explain how rubbing causes it. In 2019, researchers discovered nanosized surface deformations at play. The same researchers now say different electrical charges build up on the front and back parts of a sliding object, creating a current.

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Research 103

Drugs.com

SEPTEMBER 18, 2024

WEDNESDAY, Sept. 18, 2024 -- Folks who are content with what they’ve got could be less likely to suffer a heart attack or stroke, a new study suggests.“Our findings support a holistic approach to health care, where enhancing a person’s mental and em.

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Science Daily: Pharmacology News

SEPTEMBER 18, 2024

A class of drugs for diabetes may be associated with a lower risk of dementia and Parkinson's disease, according to a new study.

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Disease Drugs 119

Drugs.com

SEPTEMBER 18, 2024

WEDNESDAY, Sept. 18, 2024 -- The corner bodega or neighborhood Kwik-E-Mart could be fueling childhood obesity in the United States, a new study suggests.Children have a more than 50% increased chance of obesity if they live in a place without ready.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

SEPTEMBER 18, 2024

The first academic study to provide quantitative assessment of the possible dangers of competitive slap fighting offers a starting point for conversations about ensuring participants' long-term health and well-being.

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Drugs.com

SEPTEMBER 18, 2024

WEDNESDAY, Sept. 18, 2024 -- Black women have a higher risk of dying from any type of breast cancer than white women, a new review finds.Overall, the increased survival risk for Black women ranges from 17% to 50%, depending on the type of breast.

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Science Daily: Pharmacology News

SEPTEMBER 18, 2024

Researchers demonstrates the effectiveness of homemade play putty at reading brain, heart, muscle and eye activity. The research outlines the conductive properties of this material, so-named 'squishy circuits.

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Research 89

Drugs.com

SEPTEMBER 18, 2024

WEDNESDAY, Sept. 18, 2024 -- Therapy dogs can help boost the spirits of health care workers in the same way they brighten the moods of hospital patients, a new study shows. The furry, four-legged friends reduced emotional exhaustion and job stress.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

SEPTEMBER 18, 2024

Astronomers examined galaxy Arp 107 which has revealed a wealth of information about star-formation and how two galaxies collided hundreds of million years ago. Arp 107 is located 465 million light-years from Earth in the constellation Leo Minor.

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Drug Patent Watch

SEPTEMBER 18, 2024

The biopharmaceutical industry is constantly evolving, with the demand for complex biologics on the rise. To stay competitive, companies must navigate the complexities of biopharmaceutical development while managing costs effectively. One key strategy for achieving this balance is partnering with Contract Development and Manufacturing Organizations (CDMOs).

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Covalent Modifiers

SEPTEMBER 18, 2024

Liang Ouyang, Wen Shuai, Panpan Yang, Huan Xiao, Yumeng Zhu, Faqian Bu, Aoxue Wang, Qiu Sun, Guan Wang Angewandte Chemie 2024 e202411037 [link] c-Jun N-terminal kinases (JNKs) including JNK1/2/3 are key members of mitogen-activated protein kinase family. Wherein JNK3 is specifically expressed in brain and emerges as therapeutic target, especially for neurodegenerative diseases.

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Science Daily: Pharmacology News

SEPTEMBER 18, 2024

A newly discovered cluster-scale strong gravitational lens, with a rare alignment of seven background lensed galaxies, provides a unique opportunity to study cosmology.

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The Open Targets Blog

SEPTEMBER 18, 2024

The latest release of the Platform — 24.09 — is now available at platform.opentargets.org.  Please note, this will be the last release of the year. We are working on major updates to the Platform web interface, which we will share with you in our March 2025 release (25.03). See you there! Key points In addition to our regular data updates: Target phenotypes routinely tested in secondary pharmacology screening now part of our safety assessments FinnGen burden curation added to

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Molecular Design

SEPTEMBER 18, 2024

I'll open the post with a panorama from the summit of Shutlingsloe, sometimes referred to as Cheshire's Matterhorn, which at 506 m above sea level, is the third highest point in the county. When in the UK, I usually come here to mark the solstices and there's usually a good crowd here for the occasion (the winter solstice tends to be less well attended).

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NIOSH Science Blog: Drugs

SEPTEMBER 18, 2024

Operating heavy machinery, working long hours, and hitting the road before sunrise and returning after sunset are occupational pressures that loggers and log truck drivers face. These conditions also put them at high risk for injury and fatality. Researchers in the University of Washington Pacific Northwest Agricultural Safety and Health Center surveyed 45 loggers and log truck drivers in Washington, Oregon, and Idaho about stress, fatigue, job pressures, hours of sleep and work, and job support

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Research 66

Science Daily: Pharmacology News

SEPTEMBER 18, 2024

Millions of birds migrate every year to escape winter, but spending time in a warmer climate does not save them energy, according to new research. Using miniaturized loggers implanted in wild blackbirds, scientists recorded detailed measurements of heart rate and body temperature from birds every 30 minutes from fall to the following spring. The data offer unprecedented insights into the true energetic costs of migrant and resident strategies and reveal a previously unknown mechanism used by mig

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Research 59

Drugs.com

SEPTEMBER 18, 2024

WEDNESDAY, Sept. 18, 2024 -- When given after organ-removal surgery, Keytruda brings patients battling advanced bladder cancers more time cancer-free, a new trial finds.Folks with "high-risk" bladder cancers -- tumors that had already invaded.

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Trials 59

FDA Law Blog: Biosimilars

SEPTEMBER 18, 2024

By Riëtte van Laack — The dietary supplement exclusionary clause is, as its name suggests, a clause in the Federal Food, Drug, and Cosmetic Act (FDC Act) definition of dietary supplement. That clause excludes those ingredients that were first marketed as drug ingredients. Specifically, FDC Act 201(ff)(3)(B) provides that a dietary supplement does not include: (i) an article that is approved as a new drug under section 355 of [the FDC Act], certified as an antibiotic under section 357 of [the FD

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BioPharma Drive: Drug Pricing

SEPTEMBER 18, 2024

The FDA’s clearance could double Kisqali’s breast cancer market. Elsewhere, Novo is exploring new ways to deliver genetic therapies and Bain is funding a growing CDMO.

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Perficient: Drug Development

SEPTEMBER 18, 2024

In this tutorial, we’ll explore how to achieve Vue.js Location Autocomplete by integrating the Google Maps Places Autocomplete API with a custom Geo Location component. We’ll walk you through each step to set up the Vue.js Location Autocomplete feature, manage user input, and bind it to Vue’s v-model for smooth two-way data binding. Prerequisites for Vue.js Location Autocomplete To start with Vue.js Location Autocomplete , ensure you have a basic understanding of Vue.js and TypeScript.

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BMG Labtech

SEPTEMBER 18, 2024

Introduction The minimal bactericidal concentration (MBC) is a quantitative metric that can be used to assess the effect of antibacterial agents on microorganisms. Whereas the minimum inhibitory concentration (MIC) indicates the lowest concentration needed to inhibit bacterial growth , the MBC indicates the lowest concentration needed to kill bacteria.

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Perficient: Drug Development

SEPTEMBER 18, 2024

Splunk is a powerful platform designed for searching, monitoring, and analyzing machine-generated data via a web-style interface. It captures, indexes, and correlates real-time data in a searchable repository, from which it can generate graphs, reports, alerts, dashboards, and visualizations. It’s designed for anyone who wants to gain insights from their data without the need to manage the underlying infrastructure.

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Trials 52

Drug Target Review

SEPTEMBER 18, 2024

What specific cost-cutting measures can AI provide in the manufacturing process of cell and gene therapy, and how do these compare to traditional methods? The cell and gene therapy (CGT) space provides a great example of the potential of AI. The future of medicine is being shaped by groundbreaking CGTs, which involve uniquely complex manufacturing steps.

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