Mon.Feb 10, 2025

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Boosting evolution: How humans unintentionally altered the skulls of pigs

Science Daily: Pharmacology News

Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs. This is likely down to new breeding practices introduced at the beginning of the 20th century. The researchers analyzed 3D scans of 135 skulls of wild boars and domestic pigs from the early 20th and 21st centuries.

Research 304
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Site-Specific Molecular Glues for the 14-3-3/Tau pS214 ProteinProtein Interaction via Reversible Covalent Imine Tethering

Covalent Modifiers

DOI Ansgar Oberheide, Maxime van den Oetelaar, Jakob Scheele, Jan Borggrfe, Semmy Engelen, Michael Sattler, Christian Ottmann, Peter Cossar and Luc Brunsveld RSC Med Chem 2025 [link] Protein-protein interactions (PPIs) are key regulators of various cellular processes. Modulating PPIs with small molecules has gained increasing attention in drug discovery, particularly targeting the 14-3-3 protein family, which interacts with several hundred client proteins and plays a central role in cellular net

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Truly autonomous AI is on the horizon

Science Daily: Pharmacology News

Researchers have developed a new AI algorithm, called Torque Clustering, that significantly improves how AI systems independently learn and uncover patterns in data, without human guidance.

Research 328
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Can GLP-1 Meds Harm Your Eyes?

Drugs.com

MONDAY, Feb. 10, 2025 -- Yes, rare cases of vision issues have arisen in people taking popular GLP-1 weight loss drugs, but the jury's out on whether the medications caused the eye trouble, according to a new small study.The study reviewed the.

Drugs 297
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Eating gradually increasing doses of peanut butter enables children with high-threshold allergy to safely consume peanuts, study suggests

Science Daily: Pharmacology News

Findings suggest a safe, inexpensive, and effective pathway for allergists to treat children who already tolerate at least half a peanut.

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Physician's medical decisions benefit from chatbot, study suggests

Science Daily: Pharmacology News

A study showed that chatbots alone outperformed doctors when making nuanced clinical decisions, but when supported by artificial intelligence, doctors performed as well as the chatbots.

Doctors 291
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Possible Listeria Contamination Prompts Recall of 2 Million Baked Goods

Drugs.com

MONDAY, Feb. 10, 2025 -- About 2 million baked goods have been recalled over concerns of potential contamination with Listeria monocytogenes, according to federal safety regulators.The recall went into effect on Jan. 7, 2025, and was upgraded on.

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Euclid discovers a stunning Einstein ring

Science Daily: Pharmacology News

Euclid, the European Space Agency's dark Universe detective, has made an astonishing discovery -- right in our cosmic backyard.

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AbbVie, Pfizer gain FDA OK for novel antibiotic

BioPharma Drive: Drug Pricing

The drug is cleared to treat complicated intra-abdominal infections, including those caused by tough-to-control, gram-negative bacteria.

FDA 242
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Earth's inner core is less solid than previously thought

Science Daily: Pharmacology News

Earth's inner core is undergoing structural transformation.

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Streamlining the Generic Drug Supply Chain: Best Practices

Drug Patent Watch

Streamlining the Generic Drug Supply Chain: Best Practices to Improve Efficiency and Patient Access As the generic drug industry continues to grow, it's becoming increasingly clear that the traditional supply chain model is no longer sustainable. With the rise of complex generics, regulatory pressures, and increasing demand for affordable medicines, it's time to rethink the way we approach the generic drug supply chain.

Drugs 90
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Satire more damaging to reputations than direct criticism

Science Daily: Pharmacology News

In our digital times as we are inundated with YouTube videos, memes and social media, satire is everywhere, but it can be more damaging to people's reputations than direct criticism, according to new research.

Research 263
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Mass Shootings That Claim Most Kids' Lives Are Done by Family Members

Drugs.com

MONDAY, Feb. 10, 2025 -- When most people think of kids killed in mass shootings, they imagine it occurring at the hands of a stranger, and at school.The reality, according to a new report, is that most children who lose their lives to a mass.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Biomarker test can detect Alzheimer's pathology earlier

Science Daily: Pharmacology News

Years before tau tangles show up in brain scans of patients with Alzheimer's disease, a biomarker test can detect small amounts of the clumping-prone tau protein and its misfolded pathological forms that litter the brain, cerebrospinal fluid and potentially blood, new research suggests.

Disease 260
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Boston Surgeons Successfully Transplant Pig Kidney in Fourth Patient

Drugs.com

MONDAY, Feb. 10, 2025 -- Surgeons at Massachusetts General Hospital have successfully performed the fourth pig kidney transplant in the U.S. The recipient of the genetically modified pig organ was a 66-year-old man with kidney failure, surgeons.

Hospitals 223
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A symphony in quantum

Science Daily: Pharmacology News

Entanglement -- linking distant particles or groups of particles so that one cannot be described without the other -- is at the core of the quantum revolution changing the face of modern technology. While entanglement has been demonstrated in very small particles, new research is thinking big, demonstrating high-fidelity entanglement between two acoustic wave resonators.

Research 202
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Speaking Two Languages Might Sharpen Thinking Skills in Kids With Autism

Drugs.com

MONDAY, Feb. 10, 2025 Learning a second language may seem like an unusual approach to treating autism, but research points to surprising benefits of becoming bilingual."If you have to juggle two languages, you have to suppress one in order to use.

Research 208
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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New treatment may offer quick cure for common cause of high blood pressure

Science Daily: Pharmacology News

A revolutionary new treatment called Targeted Thermal Therapy (Tripel T) offers a safer, faster alternative to surgery for patients with high blood pressure caused by Primary Aldosteronism, a hormonal disorder.

Treatment 192
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New cell therapy model accelerates cancer treatment development

Drug Target Review

In the rapidly advancing field of cell therapies, Dr Jason Bock has emerged as a leader, known for his innovative approach to optimising the development process. With over 25 years of experience in therapeutics, Bock has played a pivotal role in shaping the future of cell therapies, particularly through his work at CTMC. In a recent conversation, he shared his vision for transforming the development and commercialisation of novel cell therapies, focusing on cutting-edge approaches like tumour in

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Axsome secures top drug’s future with Teva patent settlement

BioPharma Drive: Drug Pricing

Shares in the brain drug developer rose by more than 20% Monday on news of the deal, which will forestall Teva's generic copy of Auvelity from entering the U.S. market until at least 2038.

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Breast Cancer: Fear of Recurrence Can Haunt Women for Years

Drugs.com

MONDAY, Feb. 10, 2025 -- A survey of hundreds of breast cancer survivors finds that tumor recurrence fear can wreak havoc on a woman's emotions.Cancer is all around us. Everything is a trigger," one survey participant said. "Anniversaries, other f.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Pliant shares collapse as company halts fibrosis drug study

BioPharma Drive: Drug Pricing

In what one analyst called a “unique situation,” the company stopped dosing patients on the recommendation of trial monitors, but doesn’t yet know what led to their decision.

Trials 156
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The Importance of Social Media Monitoring in Pharma

thought leadership

In today's digital age, social media has transformed how businesses communicate with their audiences. For pharmaceutical companies, this shift presents both challenges and opportunities. Social media can significantly enhance brand visibility and patient engagement and have an impact on the overall healthcare sector. Social media can significantly enhance brand visibility, patient engagement, and have an impact on the overall healthcare sector in this dynamic landscape.

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Vertex COO Arbuckle to step down later this year

BioPharma Drive: Drug Pricing

Stuart Arbuckle, who’s been with Vertex since 2012, plans to retire from his role in July. His departure comes as Vertex launches two important new medicines.

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How FSP Solutions Support Risk-Based Methodologies and Tech Innovation in Clinical Operations

PPD

Biopharmaceutical, biotech and medical device developers can choose from a range of options to support effective clinical operations across critical functions such as clinical monitoring, site management, clinical oversight, support services and site engagement. In the past, these developers mostly used in-house resources for their clinical monitoring and site management capabilities, whereas today they often prefer functional service provider (FSP) or full-service outsourcing (FSO) models, or a

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The role of diagnostics in advancing antibody-drug conjugates

BioPharma Drive: Drug Pricing

Antibody-drug conjugates (ADCs) are revolutionizing oncology, but success requires precision diagnostics.

Drugs 147