Drug Discovery World
APRIL 4, 2024
EnteroBiotix, a Glasgow, UK based biotechnology company, has dosed the first patient in a clinical trial designed to evaluate EBX-102-02 for the treatment of irritable bowel syndrome (IBS). The Phase II study, named ‘TrIuMPH’ (treating IBS with an intestinal microbiota product for health) will initially enrol 60 patients with IBS and constipation across sites in the UK.
Science Daily: Pharmacology News
APRIL 4, 2024
Densely packed, fast-moving stars at the Milky Way's center can collide with each other. New research uses simulations to explore the outcomes of these collisions. Some collisions are more like 'violent high fives' while others are full-on mergers.
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Drug Discovery World
APRIL 4, 2024
The US Food and Drug Administration (FDA) has approved Vafseo (vadadustat) Tablets for the treatment of anaemia due to chronic kidney disease (CKD) in adults who have been receiving dialysis for at least three months. Vafseo is a once-daily oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor that activates the physiologic response to hypoxia to stimulate endogenous production of erythropoietin to manage anaemia.
Antidote
APRIL 4, 2024
Before it is released onto the market, the development of any new drug or medical device must undergo rigorous testing , part of which involves clinical trials. Clinical trials are integral to making sure that any new therapy is both safe and effective for individuals, and volunteers are a vital part of the process.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
APRIL 4, 2024
Successful development of advanced biotherapeutics relies on extensive characterisation and tight quality control. Characterising binding properties of complex biomolecules is a critical step. Biophysical data combined with functional assays are needed to predict efficacy and potency, optimise drug delivery, assess critical quality attributes, and improve biologics drug design.
Science Daily: Pharmacology News
APRIL 4, 2024
Scientists have discovered a new cause for asthma that sparks hope for treatment that could prevent the life-threatening disease.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
APRIL 4, 2024
THURSDAY, April 4, 2024 (HealthDayNews) -- Following disappointing trial results, the maker of a controversial ALS drug said it is pulling the medication off the market. In a statement issued Thursday, Amylyx Pharmaceuticals said that Relyvrio.
Science Daily: Pharmacology News
APRIL 4, 2024
During archaeological excavations in the Schoningen open-cast coal mine in 1994, the discovery of the oldest, remarkably well-preserved hunting weapons known to humanity caused an international sensation. Spears and a double-pointed throwing stick were found lying between animal bones about ten meters below the surface in deposits at a former lakeshore.
Drugs.com
APRIL 4, 2024
TUESDAY, April 2, 2024 -- Expecting or new mothers are much more likely these days to be diagnosed with anxiety, depression and post-traumatic stress disorder, new research shows. However, more women are also getting treated for these problems.
Drug Target Review
APRIL 4, 2024
What are the key findings of the preclinical study regarding the neurophysiological brain state in a Parkinson’s disease psychosis (PDP) model? The animal model is based on creating a dopamine-deficient state, by a specific lesion of dopaminergic cells, and then exposing it to repeated substitution therapy with L-DOPA. This creates a condition which mimics the state in advanced PD in humans.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
APRIL 4, 2024
WEDNESDAY, April 3, 2024 -- Microwaves could offer an alternative to surgery for some people with thyroid cancer, a new study suggests. Microwave ablation, which uses heat to destroy tumors, more effectively targeted thyroid cancers on multiple.
BioPharma Drive: Drug Pricing
APRIL 4, 2024
A Phase 3 study will compare Merck’s experimental KRAS inhibitor together with its immunotherapy Keytruda against Keytruda alone in lung cancer.
Drugs.com
APRIL 4, 2024
TUESDAY, April 2, 2024 -- A total eclipse of the sun is coming up next week, and many folks don’t know that watching it unprotected can cause permanent eye damage, a new survey finds. Nearly 30% of Americans don’t know that looking.
Science Daily: Pharmacology News
APRIL 4, 2024
Researchers have used the Dark Energy Spectroscopic Instrument to make the largest 3D map of our universe and world-leading measurements of dark energy, the mysterious cause of its accelerating expansion.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
APRIL 4, 2024
THURSDAY, March 4, 2024 -- Sticky fingers, runny noses: Little kids are sweet, but they can also pass on dangerous germs to loving grandparents, new research confirms.The study found that contact with pre-school and kindergarten-aged kids may be.
Science Daily: Pharmacology News
APRIL 4, 2024
Connecting the study of infectious disease spread, biodiversity loss and climate change could offer win-win-win solutions for planetary health, but a new analysis has uncovered almost no research integrating the three global crises.
Drugs.com
APRIL 4, 2024
THURSDAY, April 4, 2024 -- Could a medication similar to the blockbuster weight-loss drugs Ozempic and Wegovy slow the ravages of Parkinson's disease? A new, small study suggests it could: Over the course of a year, a group of French researchers.
Science Daily: Pharmacology News
APRIL 4, 2024
Scientists report that a progressive neurodegenerative disease can be triggered by a viral infection. The mechanism relates to mitochondrial roles in antiviral defense mechanisms.
Drugs.com
APRIL 4, 2024
WEDNESDAY, April 3, 2024 -- When a soldier is rushed to medical care following a blast or other injury to the head, time is crucial in deciding just how extensive that injury is. Now, the U.S. Army has announced that the U.S. Food and Drug.
BioPharma Drive: Drug Pricing
APRIL 4, 2024
In the wake of a major trial failure, the company is withdrawing Relyvrio and cutting costs with a restructuring that involves laying off 70% of its employees.
Drugs.com
APRIL 4, 2024
THURSDAY, April 4, 2024 -- A rotten work schedule in young adulthood can affect a person’s middle-aged health, a new study finds.Young adults who worked shifts outside the usual 9-to-5 schedule were more likely to report worse sleep and symptoms.
BioPharma Drive: Drug Pricing
APRIL 4, 2024
The offering keeps new biotech stock offerings on their strongest pace in three years, accompanying an uptick in private company funding.
Drugs.com
APRIL 4, 2024
WEDNESDAY, April 3, 2024 -- Cutting back on late-night alcohol sales might help curb crime in violence-ridden neighborhoods, a new report claims. Murders dropped by half (51%) within a month after one Baltimore neighborhood limited alcohol hours of.
Science Daily: Pharmacology News
APRIL 4, 2024
Biophysicists have demonstrated how heat flows through rock fissures could have created the conditions for the emergence of life.
Drugs.com
APRIL 4, 2024
WEDNESDAY, April 3, 2024 -- A new test might allow some women with an aggressive form of breast cancer to skip chemotherapy without harm, researchers say. Women with early-stage triple-negative breast cancer appear to have better survival rates and.
addgene Blog
APRIL 4, 2024
When using flow cytometry to analyze your samples, it is necessary to set up a sequence of gates to be able to select and precisely measure your cells of interest. In many experiments you’ll be working with a heterogeneous cell population, for example from a processed piece of tissue, where cells are present that vary in cell type, size, and marker proteins.
Drugs.com
APRIL 4, 2024
WEDNESDAY, April 3, 2024 -- Three anti-smoking groups announced Tuesday that they have sued the U.S. government yet again after it missed its latest deadline for enacting a ban on menthol cigarettes. This is the second lawsuit that the plaintiffs.
Broad Institute
APRIL 4, 2024
A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis By Rose Circeo April 4, 2024 Breadcrumb Home A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of c
Drugs.com
APRIL 4, 2024
TUESDAY, April 2, 2024 -- Think vaping is the "healthy" alternative to smoking? Think again: A new study finds it raises people's odds for heart failure. “More and more studies are linking e-cigarettes to harmful effects and finding that it.
Fierce BioTech
APRIL 4, 2024
AI Advancements in Life Sciences: Accelerating Innovation pesurya Thu, 04/04/2024 - 10:20 Mon, 05/13/2024 - 10:00 Resource Type Webinar Evi Cohen Juan Jiménez Promotion Start Mon, 04/08/2024 - 15:30 Promotion End Tue, 10/08/2024 - 15:30 Duration 60 Minutes Join us for "AI Advancements in Life Sciences: Accelerating Innovation" where experts Evi Cohen and Juan Jiménez unveil the transformative potential of AI process automation in life sciences.
Drugs.com
APRIL 4, 2024
THURSDAY, April 4, 2024 -- Rick Slayman, the first person to receive a kidney transplant from a genetically modified pig, headed home Wednesday after faring so well that he was released from the hospital just two weeks after his groundbreaking.
Drug Channels
APRIL 4, 2024
This week, I’m rerunning some popular posts while I prepare for tomorrow’s live video webinar: Drug Channel Implications of the Inflation Reduction Act. For updated data on hospital-owned specialty pharmacies, see Chapter 3 of DCI's new 2024 Economic Report on U.S. Pharmacies and Pharmacy Benefit Managers. Click here to see the original post from November 2023.
Drugs.com
APRIL 4, 2024
TUESDAY, April 2, 2024 -- The seeds of high blood pressure in adulthood might be sown in youth, a new study suggests. Children and teenagers with excess weight were more likely to have high blood pressure in middle age, researchers report. In.
Perficient: Drug Development
APRIL 4, 2024
In the vast landscape of React development, developers are armed with powerful tools to navigate challenges effortlessly: the useReducer and useRef hooks. This guide offers a deep dive into these hooks, unveiling their functionalities, adaptable use cases, and advanced methodologies. What is `useReducer`? The <strong>useReducer</strong> hook in React is a cornerstone for managing state, offering a more nuanced approach than its counterpart, <strong>useState.</strong&#
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