Thu.Apr 04, 2024

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Discovery of how limiting damage from an asthma attack could stop disease

Science Daily: Pharmacology News

Scientists have discovered a new cause for asthma that sparks hope for treatment that could prevent the life-threatening disease.

Disease 141
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How long do clinical trials take?

Antidote

Before it is released onto the market, the development of any new drug or medical device must undergo rigorous testing , part of which involves clinical trials. Clinical trials are integral to making sure that any new therapy is both safe and effective for individuals, and volunteers are a vital part of the process.

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Stellar collisions produce strange, zombie-like survivors

Science Daily: Pharmacology News

Densely packed, fast-moving stars at the Milky Way's center can collide with each other. New research uses simulations to explore the outcomes of these collisions. Some collisions are more like 'violent high fives' while others are full-on mergers.

Research 128
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Maker Is Pulling Controversial ALS Drug Relyvrio Off the Market

Drugs.com

THURSDAY, April 4, 2024 (HealthDayNews) -- Following disappointing trial results, the maker of a controversial ALS drug said it is pulling the medication off the market. In a statement issued Thursday, Amylyx Pharmaceuticals said that Relyvrio.

Marketing 111
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Finds at Schöningen show wood was crucial raw material 300,000 years ago

Science Daily: Pharmacology News

During archaeological excavations in the Schoningen open-cast coal mine in 1994, the discovery of the oldest, remarkably well-preserved hunting weapons known to humanity caused an international sensation. Spears and a double-pointed throwing stick were found lying between animal bones about ten meters below the surface in deposits at a former lakeshore.

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First results from DESI make the most precise measurement of our expanding universe

Science Daily: Pharmacology News

Researchers have used the Dark Energy Spectroscopic Instrument to make the largest 3D map of our universe and world-leading measurements of dark energy, the mysterious cause of its accelerating expansion.

Research 115
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Microwave Treatment Could Be an Advance Against Thyroid Tumors

Drugs.com

WEDNESDAY, April 3, 2024 -- Microwaves could offer an alternative to surgery for some people with thyroid cancer, a new study suggests. Microwave ablation, which uses heat to destroy tumors, more effectively targeted thyroid cancers on multiple.

Treatment 108
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With the planet facing a 'polycrisis', biodiversity researchers uncover major knowledge gaps

Science Daily: Pharmacology News

Connecting the study of infectious disease spread, biodiversity loss and climate change could offer win-win-win solutions for planetary health, but a new analysis has uncovered almost no research integrating the three global crises.

Research 113
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Merck puts KRAS cancer drug competitor to the test

BioPharma Drive: Drug Pricing

A Phase 3 study will compare Merck’s experimental KRAS inhibitor together with its immunotherapy Keytruda against Keytruda alone in lung cancer.

Drugs 108
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Investigating antipsychotics in a Parkinson’s disease psychosis model

Drug Target Review

What are the key findings of the preclinical study regarding the neurophysiological brain state in a Parkinson’s disease psychosis (PDP) model? The animal model is based on creating a dopamine-deficient state, by a specific lesion of dopaminergic cells, and then exposing it to repeated substitution therapy with L-DOPA. This creates a condition which mimics the state in advanced PD in humans.

Disease 105
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Mitochondrial roles in antiviral immunity modify manifestations of neurological diseases

Science Daily: Pharmacology News

Scientists report that a progressive neurodegenerative disease can be triggered by a viral infection. The mechanism relates to mitochondrial roles in antiviral defense mechanisms.

Disease 101
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One-Third of Americans Don't Know Vision Risks From Solar Eclipse, Survey Finds

Drugs.com

TUESDAY, April 2, 2024 -- A total eclipse of the sun is coming up next week, and many folks don’t know that watching it unprotected can cause permanent eye damage, a new survey finds. Nearly 30% of Americans don’t know that looking.

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Heat flows the secret to order in prebiotic molecular kitchen

Science Daily: Pharmacology News

Biophysicists have demonstrated how heat flows through rock fissures could have created the conditions for the emergence of life.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Seniors, Stay Away From Young Kids to Avoid Pneumonia: Study

Drugs.com

THURSDAY, March 4, 2024 -- Sticky fingers, runny noses: Little kids are sweet, but they can also pass on dangerous germs to loving grandparents, new research confirms.The study found that contact with pre-school and kindergarten-aged kids may be.

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Demystifying the ICH M10 Bioanalytical Method Validation Guidelines

Conversations in Drug Development Trends

Developing pharmaceuticals is a complex process, requiring stringent bioanalytical method validation guidelines to ensure drug safety and efficacy. However, with varying national regulatory agencies each requiring their own unique specifications, this process can be remarkably perplexing. To help integrate these various regulatory standards, the International Council for Harmonization (ICH) of Technical Requirements for Pharmaceuticals for Human Use was founded in 2016.

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Small Study Suggests Ozempic Relative May Slow Parkinson's

Drugs.com

THURSDAY, April 4, 2024 -- Could a medication similar to the blockbuster weight-loss drugs Ozempic and Wegovy slow the ravages of Parkinson's disease? A new, small study suggests it could: Over the course of a year, a group of French researchers.

Disease 98
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Amylyx to pull ALS drug from market in rare move

BioPharma Drive: Drug Pricing

In the wake of a major trial failure, the company is withdrawing Relyvrio and cutting costs with a restructuring that involves laying off 70% of its employees.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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FDA Clears 15-Minute Bedside Test to Gauge Soldiers' Brain Injury

Drugs.com

WEDNESDAY, April 3, 2024 -- When a soldier is rushed to medical care following a blast or other injury to the head, time is crucial in deciding just how extensive that injury is. Now, the U.S. Army has announced that the U.S. Food and Drug.

FDA 97
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Contineum prices biotech’s latest IPO, raising $110M for neuroinflammatory drugs

BioPharma Drive: Drug Pricing

The offering keeps new biotech stock offerings on their strongest pace in three years, accompanying an uptick in private company funding.

Drugs 67
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Tough Work Hours in 20s, 30s Tied to Worse Health Decades Later

Drugs.com

THURSDAY, April 4, 2024 -- A rotten work schedule in young adulthood can affect a person’s middle-aged health, a new study finds.Young adults who worked shifts outside the usual 9-to-5 schedule were more likely to report worse sleep and symptoms.

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Antibodies 101: Introduction to Gating in Flow Cytometry

addgene Blog

When using flow cytometry to analyze your samples, it is necessary to set up a sequence of gates to be able to select and precisely measure your cells of interest. In many experiments you’ll be working with a heterogeneous cell population, for example from a processed piece of tissue, where cells are present that vary in cell type, size, and marker proteins.

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In One Baltimore Neighborhood, Curbing Liquor Sales Hours Slashed Crime Rates

Drugs.com

WEDNESDAY, April 3, 2024 -- Cutting back on late-night alcohol sales might help curb crime in violence-ridden neighborhoods, a new report claims. Murders dropped by half (51%) within a month after one Baltimore neighborhood limited alcohol hours of.

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A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis

Broad Institute

A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis By Rose Circeo April 4, 2024 Breadcrumb Home A Practical guide to bulk RNA-seq, including guidelines for eQTL analysis The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of c

RNA 52
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Test Might Allow Some Patients With Aggressive Breast Cancer Skip Chemo

Drugs.com

WEDNESDAY, April 3, 2024 -- A new test might allow some women with an aggressive form of breast cancer to skip chemotherapy without harm, researchers say. Women with early-stage triple-negative breast cancer appear to have better survival rates and.

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AI Advancements in Life Sciences: Accelerating Innovation

Fierce BioTech

AI Advancements in Life Sciences: Accelerating Innovation pesurya Thu, 04/04/2024 - 10:20 Mon, 05/13/2024 - 10:00 Resource Type Webinar Evi Cohen Juan Jiménez Promotion Start Mon, 04/08/2024 - 15:30 Promotion End Tue, 10/08/2024 - 15:30 Duration 60 Minutes Join us for "AI Advancements in Life Sciences: Accelerating Innovation" where experts Evi Cohen and Juan Jiménez unveil the transformative potential of AI process automation in life sciences.

Science 52
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Anti-smoking Groups Sue FDA Again Over Menthol Ban Delays

Drugs.com

WEDNESDAY, April 3, 2024 -- Three anti-smoking groups announced Tuesday that they have sued the U.S. government yet again after it missed its latest deadline for enacting a ban on menthol cigarettes. This is the second lawsuit that the plaintiffs.

FDA 95
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Exploring AngularJS Routing: A Practical Guide

Perficient: Drug Development

AngularJS is a widely adopted JavaScript framework, arming developers with a rich arsenal of tools to engineer dynamic and captivating web applications. Notably, its robust routing capabilities emerge as a key pillar for constructing Single Page Applications (SPAs). Effectively orchestrating navigation and dynamically presenting diverse content sans the need for complete page refreshes, AngularJS routing emerges as a cornerstone in contemporary web development.