Tue.Apr 01, 2025

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Experts Concerned as NIH Axes Critical Vaccine Study Funds

Drugs.com

TUESDAY, April 1, 2025 -- Hundreds of U.S. research projects aimed at boosting vaccine confidence have been shut down -- just as preventable diseases like measles and flu are on the rise. Since Jan. 20, the U.S. Department of Health and Human.

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Dramatically higher loss of GDP under 4°C warming

Science Daily: Pharmacology News

New projections reveal a 4 degree Celsius rise in global temperatures would cut world GDP by around 40% by 2100 -- a stark increase from previous estimates of around 11%.

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Major Job Cuts at NIOSH Pose Risks to Worker Safety, Critics Warn

Drugs.com

TUESDAY, April 1, 2025 -- A major round of job cuts at the National Institute for Occupational Safety and Health (NIOSH) could weaken efforts to protect American workers, according to federal health officials. About two-thirds of NIOSH staff --.

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Mpox could become a serious global threat, scientists warn

Science Daily: Pharmacology News

Mpox has the potential to become a significant global health threat if taken too lightly, according to scientists.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Microplastics Linked To High Blood Pressure, Diabetes, Stroke

Drugs.com

TUESDAY, April 1, 2025 -- Microplastics appear to be contributing to chronic diseases in shoreline areas of the United States, a new study suggests.High blood pressure, diabetes and stroke rates are higher in coastal or lakefront areas with greater.

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More Trending

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Brain Implant Lets Woman Talk After 18 Years of Silence Due to Stroke

Drugs.com

TUESDAY, April 1, 2025 -- For nearly two decades, a stroke had left a woman unable to speak -- until now. Thanks to a new brain implant, her thoughts are being turned into real-time speech, giving her a voice again for the first time in 18.

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Mammals were adapting from life in the trees to living on the ground before dinosaur-killing asteroid

Science Daily: Pharmacology News

More mammals were living on the ground several million years before the mass extinction event that wiped out the dinosaurs, new research has revealed.

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Pregnant Women, New Moms Dying More Often From Heart Conditions

Drugs.com

TUESDAY, April 1, 2025 -- The heart-related death rate among pregnant women and new mothers more than doubled between 1999 and 2022, researchers have found.Just under 9.1 mothers for every million people died from heart-related diseases in 2022, up.

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More Uncertainty and Less Advice from FDA Means Companies will Need to Even More Carefully Chart their own Course to Achieve their Goals

FDA Law Blog: Biosimilars

By Dr. Naomi Lowy, Principal Drug Regulatory Expert Trade and national press have reported that recent changes in FDA staffing levels have already led to slower responses to calls and emails. According to reports, which were published before the most recent reports of HHS staff level reductions and tumultuous changes in leadership, FDA staff were missing minor deadlines.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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FDA Approves First At-Home Test to Diagnose Three STIs in Women

Drugs.com

TUESDAY, April 1, 2025 -- The U.S. Food and Drug Administration granted marketing authorization for the first home-based, nonprescription diagnostic test for chlamydia, gonorrhea, and trichomoniasis in women, the agency announced Friday.Women with.

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RNA editing biotech Airna adds $155M in funding

BioPharma Drive: Drug Pricing

Airna will use the Series B round to launch a Phase 1/2 trial of its lead program for alpha-1 antitrypsin deficiency, a disease targeted by several other firms.

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Fasting Outperforms Calorie Cutting, Clinical Trial Says

Drugs.com

TUESDAY, April 1, 2025 -- Fasting every other day can prompt more weight loss than simply cutting calories, a new clinical trial shows.People who undertook 4:3 intermittent fasting lost just under 8% of their body weight within a year, compared to.

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Judge overturns FDA’s lab developed test regulation, siding with industry

BioPharma Drive: Drug Pricing

A Texas judge vacated the FDA’s final rule, which was strongly opposed by the laboratory industry, and remanded the matter to HHS Secretary Robert F. Kennedy Jr.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Cardiac Arrest Deaths During Marathons Down By Half

Drugs.com

TUESDAY, April 1, 2025 -- A marathon can be a daunting challenge, particularly for folks worried their hearts cant stand the strain of running 26.2 miles.But these events are safer than ever for those with heart concerns, according to a new study p.

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Keystone Symposia Aims to Increase Global Impact-- Experts Weigh in on Strategy

keypoint

Keystone Symposia convened a panel of global health experts to discuss how, as a conference organization, we can extend the reach and impact of our conferences to improve human health worldwide.

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Navigators Help Patients Get Colonoscopy For Suspected Cancer

Drugs.com

TUESDAY, April 1, 2025 -- Personalized support can help more people at risk of colon cancer attend a potentially life-saving colonoscopy appointment, a new study says.About 55% of people assigned a patient navigator got a follow-up colonoscopy.

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Insights Care: Altasciences Revolutionizing Early-Phase Drug Development

Alta Sciences

Insights Care: Altasciences Revolutionizing Early-Phase Drug Development aasimakopoulos Wed, 04/02/2025 - 00:53 Category News Weight 11

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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GLP-1 Drug Use For Weight Loss Has Soared, Costing Billions

Drugs.com

TUESDAY, April 1, 2025 -- The number of Americans taking cutting-edge weight-loss drugs like Ozempic, Wegovy and Zepbound has skyrocketed in recent years, a new study says.The number of people without diabetes taking a GLP-1 drug more than tripled.

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We know nanoplastics are a threat -- this new tool can help us figure out just how bad they are

Science Daily: Pharmacology News

While the threat that microplastics pose to human and ecological health has been richly documented and is well known, nanoplastics, which are smaller than one micrometer (1/50th the thickness of an average human hair), are far more reactive, far more mobile and vastly more capable of crossing biological membranes. Yet, because they are so tiny and so mobile, researchers don't yet have an accurate understanding of just how toxic these particles are.

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O-Cyanobenzaldehydes Irreversibly Modify Both Buried and Exposed Lysine Residues in Live Cells

Covalent Modifiers

Huan Ling, Lin Li, Liping Duan, Weixue Huang, Jiangnan Zheng, Shijie Zhang, Xinling Li, Xiaorong Qiu, Yang Zhou, Nan Ma, Xiaomei Ren, Jinwei Zhang, Zhen Wang, Yujun Zhao, Ruijun Tian, Zhi-Min Zhang, and Ke Ding Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.4c18006 Lysine residue represents an attractive site for covalent drug development due to its high abundance (5.6%) and critical functions.

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Tips for building top performer teams

Perficient: Drug Development

There’s no doubt that every Director or Manager wants a high-performance team that delivers the best results and allows them to focus on building new business opportunities. Come on, let’s face it! If we were comparing a work team with a sports team, who wouldn’t want to have a Barcelona Soccer Club, the Dodgers baseball team, or the Philadelphia Eagles in American football?

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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CRISPR 101: Any Base Transversion Editors

addgene Blog

In our last post, we talked about the first base transversion editors: CGBEs, or C G Base Editors. CGBEs first convert a cytosine (C) to uracil (U), just like Cytosine Base Editors (CBEs). But unlike CBEs, CGBEs then excise the U to create an abasic (empty) DNA site using either fused or endogenous Uracil DNA N-glycosylase (UNG) enzymes. Various other proteins included in different CGBE tools allow the researcher to direct the repair of the abasic site.

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Protect Your Trial Data: Endpoint, Imaging, and Safety Review

Fierce BioTech

Protect Your Trial Data: Endpoint, Imaging, and Safety Review Is your clinical trial data at risk? Discover how Imaging Core Labs and Endpoint Adjudication Committees (EAC) can safeguard your data quality and accuracy. Our whitepaper exposes the hidden dangers and offers solutions to avoid costly delays and errors. jpiatt Tue, 04/01/2025 - 15:33 Avoid costly mistakes and ensure your clinical development program meets the highest standards by reading WCGs whitepaper on Imaging Core Labs, Endpoint

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Creating a Launch Checklist

Perficient: Drug Development

Are you a PM or BA who has been assigned a project or platform that is new to your company? If so, you may find that theres a learning curve for everything that needs to be executed, especially when it comes to the launch. Not all platforms are the same; they can require different steps to go live. Below is a list of steps I take when creating a launch checklist.

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Market Analysis: The Impact of Biosimilars on the Generic Drug Industry in Europe

Drug Patent Watch

The Biosimilar Revolution: How Europe's Generic Drug Industry is Evolving As we navigate the ever-changing landscape of the pharmaceutical industry, one trend is clear: biosimilars are here to stay. In Europe, the generic drug industry is undergoing a significant transformation, driven by the increasing adoption of biosimilars. But what does this mean for the industry as a whole, and how will it impact the way we approach healthcare?

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Understanding and Implementing OAuth2 and OpenID Connect in.NET

Perficient: Drug Development

Authentication and authorization are two crucial aspects of web development. In modern applications, it’s essential to ensure that users are who they say they are (authentication) and have permission to access specific resources (authorization). OAuth2 and OpenID Connect are two widely used protocols that help achieve both goals. What is OAuth2?

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The Big Three PBMs’ 2025 Formulary Exclusions: Humira, Stelara, Private Labels, and the Shaky Future for Pharmacy Biosimilars (rerun)

Drug Channels

This week, Im rerunning some popular posts while I prepare for Fridays live video webinar: PBM Industry Update: Trends, Challenges, and Whats Ahead. Click here to see the original post from January 2025. For 2025, the three largest pharmacy benefit managers (PBMs)Caremark (CVS Health), Express Scripts (Cigna), and Optum Rx (United Health Group)have again each excluded hundreds of drugs from their standard formularies.

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Gene silencing: a step forward for rare disease therapy

Drug Target Review

Advances in biotechnology are driving significant progress in the treatment of rare diseases, making it possible to develop targeted therapies for previously untreatable conditions. Founded in 2021, SynaptixBio is working to develop therapies for TUBB4A leukodystrophies – a group of rare and severe neurological disorders. Co-founder and CEO Dr Dan Williams brings over 20 years of experience in biochemistry and drug development, with a strong background in research and clinical trials.

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The Strategic Value of VR in MedTech: Transforming MedTech Commercial Success

Fierce BioTech

The Strategic Value of VR in MedTech: Transforming MedTech Commercial Success Discover how VR accelerates MedTech adoption by cutting training costs, boosting physician engagement, and scaling global reach. Learn how leading companies use immersive tech to drive sales and streamline education. Download now. dfarris Tue, 04/01/2025 - 11:00 Discover how VR accelerates MedTech adoption by cutting training costs, boosting physician engagement, and scaling global reach.

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