Science Daily: Pharmacology News
APRIL 2, 2025
A new analysis of a vaccination program in Wales found that the shingles vaccine appeared to lower new dementia diagnoses by 20% -- more than any other known intervention.
Covalent Modifiers
APRIL 2, 2025
Lszl Petri, Ronen Gabizon, Gyrgy G. Ferenczy, Nikolett Pczka, Attila Egyed, Pter brnyi-Balogh, Tams Takcs, and Gyrgy M. Keser Journal of Medicinal Chemistry 2025 68 (6), 6616-6632 DOI: 10.1021/acs.jmedchem.5c00017 Labeling proteins with covalent ligands is finding increasing use in proteomics applications, including identifying nucleophilic residues amenable for labeling and in the development of targeted covalent inhibitors (TCIs).
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Science Daily: Pharmacology News
APRIL 2, 2025
A 'weekend warrior' approach to physical activity -- getting 150 minutes of moderate-to-vigorous physical activity over one to two days instead of throughout the week -- improved health and lowered the risk of death, finds a new stud.
Drugs.com
APRIL 2, 2025
TUESDAY, April 2, 2025 -- The shingles vaccine can do more than protect seniors from painful, blistering rashes. It also appears to protect older folks from dementia, researchers say. Seniors who got the shingles vaccine when it became available.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Science Daily: Pharmacology News
APRIL 2, 2025
Researchers have successfully developed a novel drug to restore vision. The treatment method restores vision through retinal nerve regeneration.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
APRIL 2, 2025
A multi-objective optimization algorithm incorporating the strategies of dynamic semi-parameter adaptation updating, gradient enhancement, and population size reduction is adopted to solve the problem of protein-ligand docking. ABSTRACT Molecular docking, which simulates the binding pose of a drug molecule to target proteins and predicts the binding affinity, is an important computational tool in structure-based drug discovery.
Drugs.com
APRIL 2, 2025
WEDNESDAY, April 2, 2025 -- The U.S. Food and Drug Administration has approved Qfitlia (fitusiran) for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients 12 years of age and older with.
Science Daily: Pharmacology News
APRIL 2, 2025
In new images, scientists have gotten the closest look yet at Sagittarius C -- a 'stellar nursery' where clouds of gas and dust have collapsed to form thousands of new stars.
Drugs.com
APRIL 2, 2025
WEDNESDAY, April 2, 2025 -- Insomnia and vertigo are health conditions so well-known that movies have been named after them.But only a quarter of Americans know about a condition that occurs even more often than vertigo or insomnia, called.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
APRIL 2, 2025
Researchers interrogated the 'sounds' of a cluster of stars within the Milky Way, uncovering a new technique for astrophysicists to probe the universe and learn more about its evolution.
Drugs.com
APRIL 2, 2025
WEDNESDAY, April 2, 2025 -- The U.S. Food and Drug Administration’s (FDA) top tobacco regulator, Brian King, has been placed on leave as part of a large wave of cuts across federal health agencies. King, who led the FDA's tobacco control.
Science Daily: Pharmacology News
APRIL 2, 2025
Researchers have demonstrated how specific biomarkers in the blood can predict the development of dementia up to ten years before diagnosis, among older adults living independently in the community.
BioPharma Drive: Drug Pricing
APRIL 2, 2025
The sweeping workforce reduction that began Tuesday was made worse by mistakes and poor communication, including directions for some CMS employees to contact a director who died last year.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
APRIL 2, 2025
WEDNESDAY, April 2, 2025 -- Lower levels of bad LDL cholesterol could mean a lower risk of dementia and Alzheimers disease, a new study says.People with low-density lipoprotein (LDL) cholesterol levels lower than 70 mg/dl had a 26% lower risk of.
Science Daily: Pharmacology News
APRIL 2, 2025
A newly published study found that a mother's exposure to phthalates during pregnancy can affect their newborn's metabolism and brain development. These widely used plasticizers are commonly found in a variety of cosmetics and personal care products, such as shampoos, soaps, and detergents, as well as plastic food and beverage containers.
New Drug Approvals
APRIL 2, 2025
Suzetrigine CAS 2649467-58-1 Weight Average: 473.4 Monoisotopic: 473.137396951 Chemical Formula C 21 H 20 F 5 N 3 O 4 FDA 1/30/2025, Journavx To treat moderate to severe acute pain Press Release 2-Pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]- 4-[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)-4,5- dimethyl-5-(trifluoromethyl)oxolane-2- carboxamido]pyridine-2-carboxamide 4-[(2R,3S,4S,5R)-3-(3,4-difluor
Science Daily: Pharmacology News
APRIL 2, 2025
An international team has merged two lab-synthesized materials into a synthetic quantum structure once thought impossible to exist and produced an exotic structure expected to provide insights that could lead to new materials at the core of quantum computing.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
APRIL 2, 2025
The European Commission has referred Eisai and Biogen’s application to an appeals committee. Elsewhere, Opthea warned of insolvency and Novartis hired a new top lawyer.
Science Daily: Pharmacology News
APRIL 2, 2025
A new study has found that the world's finest yodellers aren't from Austria or Switzerland, but the rainforests of Latin America. The research provides significant new insights into the diverse vocal sounds of non-human primates, and reveals for the first time how certain calls are produced. The researchers have discovered that special anatomical structures called vocal membranes allow monkeys to introduce 'voice breaks' to their calls.
BioPharma Drive: Drug Pricing
APRIL 2, 2025
Artis BioSolutions joins a host of startups trying to improve development and manufacturing capacity for cutting-edge gene and cell therapies.
Science Daily: Pharmacology News
APRIL 2, 2025
Modern continental rocks carry chemical signatures from the very start of our planet's history, challenging current theories about plate tectonics.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
APRIL 2, 2025
WEDNESDAY, April 2, 2025 -- They say the eyes are the windows to the soul.The eyes also might help detect seniors at risk for a common syndrome in which they emerge from surgery in a state of delirium, new research suggests.Seniors who have thicker.
Science Daily: Pharmacology News
APRIL 2, 2025
An international team is currently closely tracking the near-Earth asteroid 2024 YR4. The impact probability estimates for the year 2032 has been reduced from a peak of 3 percent to below 0.001 percent.
Drugs.com
APRIL 2, 2025
WEDNESDAY, April 2, 2025 -- Black Americans have been dying from drug overdoses (OD) at higher rates than white Americans, a new study says.Both Black men and women are at greater risk of a fatal OD compared to white people, researchers reported.
Science Daily: Pharmacology News
APRIL 2, 2025
Scientists have repurposed smartphone camera sensors to create a detector capable of tracking antiproton annihilations in real time with unprecedented resolution. This new device can pinpoint antiproton annihilations with a resolution of about 0.6 micrometers, a 35-fold improvement over previous real-time methods.
BioPharma Drive: Drug Pricing
APRIL 2, 2025
Teams working on device communications and policy were cut from the agency on Tuesday, according to multiple FDA workers.
Drugs.com
APRIL 2, 2025
WEDNESDAY, April 2, 2025 -- The telehealth company Hims & Hers Health is expanding its weight-loss offerings by adding new medications to its platform.The company said Tuesday it now provides access to Zepbound, a brand-name version of the drug.
Chemical Biology and Drug Design
APRIL 2, 2025
ABSTRACT Diketopiperazines (DKPs) have emerged as promising candidates for treating diverse diseases, particularly cancer. In this context, 2,5-diketopiperazines have been extensively investigated in comparison with 2,6-diketopiperazines. This work explores the selectivity and impact of 2,6-diketopiperazine enantiomers derived from -amino acids on MDA-MB-231 triple-negative breast cancer cells (TNBC).
thought leadership
APRIL 2, 2025
Navigating a Shifting Regulatory Landscape On Thursday, March 27, 2025, HHS announced that they would be conducting a reduction in force impacting nearly 3,500 full time FDA employees nearly 20% of the Agencys entire workforce. This comes on the tail end of a layoff in February of this year, when about 700 FDA employees were terminated.
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