Tue.Sep 24, 2024

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Almost 200 Chemicals Linked to Breast Cancer Are Found in Food Packaging

Drugs.com

TUESDAY, Sept. 24, 2024 -- Food sold in shrink wrap, on cardboard trays or in paper containers might contain any of nearly 200 chemicals linked to breast cancer, a new study warns.Commonly used food packaging materials contain 189 chemicals that.

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Novo CEO pressed by Senate to cut prices of obesity, diabetes drugs

BioPharma Drive: Drug Pricing

CEO Lars Fruergaard Jørgensen told lawmakers the company would consider new talks with insurers about the list prices of Wegovy and Ozempic if they pledge to keep the medicines on their formularies.

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Federal Assault Weapons Ban Could Have Stopped 38 Mass Shootings Since 2005

Drugs.com

TUESDAY, Sept. 24, 2024 -- The Federal Assault Weapons Ban (FAWB) would have prevented as many as 38 mass shootings that have taken place since the law lapsed in 2005, a new study estimates.Enacted by Congress in 1994, the ban prohibited the sale.

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Extinct volcanoes a 'rich' source of rare earth elements

Science Daily: Pharmacology News

A mysterious type of iron-rich magma entombed within extinct volcanoes is likely abundant with rare earth elements and could offer a new way to source these in-demand metals, according to new research. Rare earth elements are found in smartphones, flat screen TVs, magnets, and even trains and missiles. They are also vital to the development of electric vehicles and renewable energy technologies such as wind turbines.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Black, Hispanic Doctors See Much Larger Proportion of Medicaid Patients

Drugs.com

TUESDAY, Sept. 24, 2024 -- Latino and Black family doctors are more likely to hang their shingle in their old neighborhood and care for the less fortunate, researchers report.The new findings, which also showed these doctors were more likely to.

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Simple and Effective Personalization with Optimizely Data Platform (ODP)

Perficient: Drug Development

As we dive into the amazing capabilities of Optimizely One , let’s shine a spotlight on the Optimizely Data Platform (ODP). This simple tool unifies all your customer data in one place, making segmentation and personalization a breeze for your marketing team. With ODP, you’ll gain a complete view of your customers’ interactions and behaviors, empowering you to create personalized experiences, optimize your email marketing campaigns, and make smarter, data-driven decisions.

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Another Franklin expedition crew member has been identified

Science Daily: Pharmacology News

The skeletal remains of a senior officer of Sir John Franklin's 1845 Northwest Passage expedition have been identified using DNA and genealogical analyses.

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Inmates in Many U.S. Jails Have No Access to Meds That Fight Opioid Addiction

Drugs.com

TUESDAY, Sept. 24, 2024 -- Opioid use disorder can be a contributing factor to Americans landing in the nation's prisons and jails, but those inmates typically have no access to medications that could help wean them off the drugs.So finds a new.

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Lengthened consonants mark the beginning of words

Science Daily: Pharmacology News

Speech consists of a continuous stream of acoustic signals, yet humans can segment words from each other with astonishing precision and speed. To find out how this is possible, a team of linguists has analysed durations of consonants at different positions in words and utterances across a diverse sample of languages. They have found that word-initial consonants are, on average, around 13 milliseconds longer than their non-initial counterparts.

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Four in Every 10 U.S. Adults Is Now Obese; Severe Obesity Rising

Drugs.com

TUESDAY, Sept. 24, 2024 -- Over 40 percent of U.S. adults are now obese, with rates roughly the same for men and women, new government data shows.Obesity rates fluctuated with age and fell as levels of education increased, said the report from the.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Abrupt intensification of northern wildfires due to future permafrost thawing

Science Daily: Pharmacology News

Climate scientists and permafrost experts show that, according to new climate computer model simulations, global warming will accelerate permafrost thawing and as a result lead to an abrupt intensification of wildfires in the Subarctic and Arctic regions of northern Canada and Siberia.

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NFL Hall of Famer Brett Favre Has Parkinson's Disease

Drugs.com

TUESDAY, Sept. 24, 2024 -- Green Bay Packers legend and NFL Hall of Famer Brett Favre announced Tuesday that he has been diagnosed with Parkinson's disease.Favre, 54, made the announcement while testifying to Congress on his potential misuse of.

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Specially designed video games may benefit mental health of children and teenagers

Science Daily: Pharmacology News

Scientists conclude that some video games created as mental health interventions can be helpful -- if modest -- tools in improving the mental well-being of children and teens with anxiety, depression and attention-deficit/hyperactivity disorder (ADHD).

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Magnetic Control of Proteins: More than a Dream

addgene Blog

Lots of scientists work to invent novel techniques or to engineer improved tools for familiar applications. But how does one invent a tool for applications that don’t even exist yet? Andrew York , Maria Ingaramo, and their team at Calico Life Sciences recently set out to do just that — by developing a new fluorescent protein tool that responds strongly to magnetic fields ( Frank Hayward et al., 2024 ).

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Atmospheric blocking slows ocean-driven melting of Greenland's largest glacier tongue

Science Daily: Pharmacology News

Northeast Greenland is home to the 79 N Glacier -- the country's largest floating glacier tongue, but also one seriously threatened by global warming: warm water from the Atlantic is melting it from below. Experts have however now determined that the temperature of the water flowing into the glacier cavern declined from 2018 to 2021, even though the ocean has steadily warmed in the region over the past several decades.

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An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes

Covalent Modifiers

Yuanjin Zhang, Zhonglin Liu, Marscha Hirschi, Oleg Brodsky, Eric Johnson, Sang Joon Won, Asako Nagata, Divya Bezwada, Matthew D. Petroski, Jaimeen D. Majmudar, Sherry Niessen, Todd VanArsdale, Adam M. Gilbert, Matthew M. Hayward, Al E. Stewart, Andrew R. Nager, Bruno Melillo & Benjamin F. Cravatt Nat Chem Biol , 2024 [link] More than half of the ~20,000 protein-encoding human genes have paralogs.

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Astronomers catch a glimpse of a uniquely inflated and asymmetric exoplanet

Science Daily: Pharmacology News

Astronomers have observed the atmosphere of a hot and uniquely inflated exoplanet using NASA's James Webb Space Telescope.

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Metsera touts long-acting GLP-1 drug; Novartis strikes an AI deal

BioPharma Drive: Drug Pricing

Metsera revealed Phase 1 data it claims could support a weight-loss medicine that's administered monthly. Elsewhere, Sanofi invested in a struggling biotech and shares of two Duchenne drug developers climbed.

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Part four: an industry leader’s perspective on managing data quality

Drug Target Review

In the first article in this series, published on Wednesday 14 August, the significance of data quality for the effectiveness of data analyses by machine learning (ML) and AI was discussed. In this article, John Conway, Chief Visioneer Officer at 20/15 Visioneers 1 and industry leader, shares his perspectives on addressing data quality issues in the life sciences industry with Dr Raminderpal Singh.

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Bluebird to lay off another 25% of workforce in latest restructuring

BioPharma Drive: Drug Pricing

The announced job cuts are the latest in a series of steps Bluebird has taken to preserve cash and break even financially amid slow uptake of its marketed gene therapies.

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Advances in Analytical Technologies for Generic Drug Development

Drug Patent Watch

The development of generic drugs has become increasingly complex, requiring advanced analytical technologies to ensure the quality and efficacy of these products. Recent advancements in analytical technologies have significantly impacted the development of generic drugs, enabling more accurate and efficient analysis of complex drug products.

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Want better cancer treatments? Make biopharma more like Silicon Valley

BioPharma Drive: Drug Pricing

In an interview with PharmaVoice, Alicia Zhou, the new head of the nonprofit Cancer Research Institute, expressed a desire to foster deeper partnerships between scientists and the pharmaceutical industry.

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Prediabetes in Teens Could Raise Odds for Complicated Pregnancies Later

Drugs.com

TUESDAY, Sept. 24, 2024 -- If a woman is already in a "prediabetic" state in her teen or college years, her odds for a serious complication of pregnancy later in life rises, new research shows.Ignoring prediabetes in teenagers "may represent a.

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How to Improve the Clinical Trial Recruitment Experience for Patients

Antidote

Finding patients who may be interested in your trial is often a difficult part of the clinical trial patient recruitment process. Once you have an interested patient, creating a positive experience and a seamless patient journey are both critical components to ensure they take the next step in determining their eligibility for your trial.

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Surrogate Moms Have Higher Rates of Pregnancy Complications

Drugs.com

TUESDAY, Sept. 24, 2024 -- Surrogate moms have a higher risk of pregnancy complications than other pregnant women, a new study finds.About 8% of surrogate mothers developed a severe complication like high blood pressure or serious bleeding during.

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Drug Channels News Roundup, September 2024: Inside JNJ’s Gross-to-Net Bubble, Optum Rx’s Private Label Biosimilars, Where Biosimilars Boom, Accumulators vs. Patients, and Steve Collis Retires

Drug Channels

Autumn is here! Curl up with your favorite pumpkin-spiced blog and savor these acorns that we’ve squirrelled away for you: Johnson & Johnson Innovative Medicines gives a peek inside its $43 billion gross-to-net bubble Optum Rx joins the private label biosimilar bandwagon Biosimilars boom for provider-administered drugs Fresh evidence of how copay accumulators hurt patients Plus, words of wisdom from Cencora's soon-to-be-former CEO Steve Collis.

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Many Pregnant Medicaid Patients Miss Prenatal Ultrasounds, Upping Risks Around Birth Defects

Drugs.com

TUESDAY, Sept. 24, 2024 -- Pregnant women covered by Medicaid are less likely to get an ultrasound exam that can diagnose heart defects in a fetus, a new study finds.“The 20-week ultrasound is hugely important in detecting birth defects because it i.

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Understanding Biostatistical Services in Clinical Trials: A Comprehensive Breakdown

ProRelix Research

Biostatistics involves the application of statistical techniques for the design and analysis of clinical trial data. In addition to the conduct of trials which encompasses regulatory approval processes, informed consent, […] The post Understanding Biostatistical Services in Clinical Trials: A Comprehensive Breakdown appeared first on ProRelix Research.

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Inside JNJ’s Gross-to-Net Bubble, Optum Rx’s Private Label Biosimilars, Where Biosimilars Boom, Accumulators vs. Patients, and Steve Collis Retires

Drug Channels

Autumn is here! Curl up with your favorite pumpkin-spiced blog and savor these acorns that we’ve squirrelled away for you: Johnson & Johnson Innovative Medicines gives a peek inside its $43 billion gross-to-net bubble Optum Rx joins the private label biosimilar bandwagon Biosimilars boom for provider-administered drugs Fresh evidence of how copay accumulators hurt patients Plus, words of wisdom from Cencora's soon-to-be-former CEO Steve Collis.

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Create Content Fragment Variations in AEM With GenAI

Perficient: Drug Development

Earlier this year, Adobe introduced new generative AI capabilities in A dobe E xperience M anager (AEM). As a Platinum partner of Adobe , Perficient has early adopter features provisioned for our environments. One of the more exciting and relevant features is the ability to use GenAI to generate variations within Content Fragments in AEM. In this blog, we’ll talk about a sample use-case scenario, the steps involved with this new feature, and show how it can empower marketers and content au

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Unlocking European market access for rare disease therapies

Fierce BioTech

Unlocking European market access for rare disease therapies The European orphan drug market presents a significant opportunity for biotech firms. Learn more about early access programs (EAPs), and how they are emerging as a critical strategy for successfully launching rare disease therapies in this complex and diverse market. tharilall Tue, 09/24/2024 - 11:49 The European orphan drug market presents a significant opportunity for biotech firms.

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Your site deserves to be paid faster. We can help.

PPD

The enterprise of delivering life-changing medicines to patients involves a complex ecosystem, and in many ways, three key players reside at the core: drug sponsors, the contract research organizations (CROs) that support them and the clinical research sites directly engaging with patients in the trial. Many research sites’ overall sustainability relies heavily upon payments from sponsors and CROs.

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CDER Wants YOU to Tell It How to Improve the Integrated Review; We Have a Few Ideas of Our Own

FDA Law Blog: Biosimilars

By Deborah L. Livornese — FDA issued a Federal Register notice on September 13, 2024, seeking feedback on the Integrated Review format that the Center for Drug Evaluation and Research (CDER) began using as part of its New Drugs Regulatory Program (NDRP) modernization effort several years ago. The NDRP focused on six strategic objectives one of which was the implementation of the Integrated Assessment which per CDER was designed to “critically, collaboratively, and consistently assess whether inf

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