Science Daily: Pharmacology News
APRIL 10, 2024
In a new breakthrough that could revolutionise medical and material engineering, scientists have developed a first-of-its-kind molecular device that controls the release of multiple small molecules using force.
BioPharma Drive: Drug Pricing
APRIL 10, 2024
The first medicine approved for PPD, Sage’s Zulresso, never gained traction. The company is in the midst of launching its second, but long-standing challenges could slow uptake.
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Science Daily: Pharmacology News
APRIL 10, 2024
Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into infection.
NIOSH Science Blog: Drugs
APRIL 10, 2024
Struck-by injuries are the leading cause of nonfatal injuries and second most common cause of fatalities among construction workers. From 2011 to 2022, there were 1,462 fatal occupational injuries that occurred at road construction sites.[1] Of these, 68% (n=1,000) were among workers in the construction industry (See figure) followed by workers in transportation and warehousing (11%; n=168) and professional and business services (9%; n=132) industries.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Science Daily: Pharmacology News
APRIL 10, 2024
Undertaking the majority of daily physical activity in the evening is linked to the greatest health benefits for people living with obesity, according to researchers who followed the trajectory of 30,000 people over almost 8 years.
BioPharma Drive: Drug Pricing
APRIL 10, 2024
The company said the pause is necessary to meet regulatory limits on nitrosamine, but added it will not affect commercial supply nor regulatory review of the drug in early breast cancer.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
APRIL 10, 2024
The deal, which company CEO Reshma Kewalramani described as “just the right fit,” is the largest acquistion in Vertex’s 35-year history.
Science Daily: Pharmacology News
APRIL 10, 2024
Astrophysicists shed light on the relationship between the Milky Way and the Egyptian sky-goddess Nut. The paper draws on ancient Egyptian texts and simulations to argue that the Milky Way might have shone a spotlight, as it were, on Nut's role as the sky. It proposes that in winter, the Milky Way highlighted Nut's outstretched arms, while in summer, it traced her backbone across the heavens.
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- Wegovy, Ozempic and other drugs known as GLP-1 analogues have become wildly popular for controlling diabetes and helping folks lose weight.There were concerns that longer term use of the drugs might raise users' odds.
Science Daily: Pharmacology News
APRIL 10, 2024
Researchers have developed a technique to connect lab-grown neural 'organoids' (three-dimensional developmental brain-like structures grown from human stem cells) using axonal bundles, similar to the connections between regions in the human brain. This technique allows brain networks to be better represented experimentally in the lab, and will improve understanding and studies of network-related brain disorders.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- A new drug can slash triglyceride levels nearly in half by targeting a genetic driver of high fat levels in the bloodstream, researchers said. The injectable drug, olezarsen, lowered triglyceride levels by 49% at the 50.
Science Daily: Pharmacology News
APRIL 10, 2024
A new study reveals the detailed protein structure of the TAS2R14, a bitter taste receptor that allows us to perceive bitter taste. In addition to solving the structure of this taste receptor, the researchers were also able to determine where bitter-tasting substances bind to TAS2R14 and how they activate them. The findings may lead to the development of drugs that targeting taste receptors.
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- A new drug can slash triglyceride levels nearly in half by targeting a genetic driver of high fat levels in the bloodstream, researchers said.The injectable drug, olezarsen, lowered triglyceride levels by 49% at the 50.
Science Daily: Pharmacology News
APRIL 10, 2024
Cortisone and other related glucocorticoids are extremely effective at curbing excessive immune reactions. But previously, astonishingly little was known about how they exactly do that. Researchers have now explored the molecular mechanism of action in greater detail. As the researchers report, glucocorticoids reprogram the metabolism of immune cells, activating the body's natural 'brakes' on inflammation.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- Phillips Respironics, the company responsible for the recall of millions of defective sleep apnea machines since 2021, must overhaul its production of the machines before it can resume making them in the United States,
Science Daily: Pharmacology News
APRIL 10, 2024
New evidence of one of the first cities in the Pacific shows they were established much earlier than previously thought, according to new research. The study used aerial laser scanning to map archaeological sites on the island of Tongatapu in Tonga, showing Earth structures were being constructed in Tongatapu around AD 300.
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- More middle-aged Black and Native Americans are now falling prey to “deaths of despair” than whites, a new study finds.These deaths -- from suicide, drug overdose and alcoholic liver disease -- initially had been.
NIOSH Science Blog: Drugs
APRIL 10, 2024
Work-related psychosocial hazards are factors in the work environment that can cause stress, strain, or interpersonal problems for the worker. This has the potential to cause physical and psychological harm. Work-related psychosocial hazards are on the verge of surpassing many other occupational hazards in terms of their contribution to poor health, injury, disability, and costs.[1][2][3][4] The extensive and cumulative impacts of these exposures represent an alarming public health problem that
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- Early-onset arthritis may hit as many as one in every four young people who undergo anterior cruciate ligament (ACL) reconstruction surgeries, new research warns.The arthritic pain emerges within 6 to 12 months.
Science Daily: Pharmacology News
APRIL 10, 2024
Early jawless fish were likely to have used bony projections surrounding their mouths to modify the mouth's shape while they collected food. Experts have used CT scanning techniques to build up the first 3D pictures of these creatures, which are some of the earliest vertebrates (animals with backbones) in which the mouth is fossilized. Their aim was to answer questions about feeding in early vertebrates without jaws in the early Devonian epoch -- sometimes called the Age of Fishes -- around 400
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- Using AI to track fragments of tumor-associated DNA in the blood, scientists say they may be close to an accurate test for a silent killer: Ovarian cancer.It's the fifth leading cause of cancer death in the United.
Perficient: Drug Development
APRIL 10, 2024
The winds of change are blowing in the world of commerce, and composable architecture is taking center stage. Businesses are ditching monolithic platforms and embracing the freedom to mix and match best-of-breed solutions to create unique and engaging shopping experiences using MACH and Composable architecture. Composable commerce takes headless architecture further.
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- The Environmental Protection Agency announced Wednesday that it has finalized a first-ever rule that will drastically lower the amount of PFAS, also known as "forever chemicals," in the nation's drinking.
Cytel
APRIL 10, 2024
Orphan drug designation is a regulatory status granted to pharmaceuticals developed for the treatment of rare diseases. It provides incentives to encourage the research, development, and approval of therapies targeting small patient populations.
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- Teenagers suffering from anxiety, depression or bipolar disorder are likely to have a tougher time getting their driver’s license, a new study finds.Teens and young adults with these types of mood disorders are 30%.
Metabolite Tales Blog
APRIL 10, 2024
Metabolism of 2023 FDA Approved Small Molecules – PART 2 A focus on drugs where metabolism in humans results in circulating glucuronides and other conjugates By Julia Shanu-Wilson Following on from our first delve into the metabolism of small molecule drugs approved last year where active metabolites were reported, we now look at a subset of drugs where phase II mechanisms are involved.
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- Most seniors have embraced “doc-in-a-box” strip mall clinics and urgent care centers as a means of getting prompt medical care, a new poll has found.About 60% of people ages 50 to 80 have visited an urgent care.
Drug Patent Watch
APRIL 10, 2024
This chart shows the drugs with the most patents in Germany. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.
Drugs.com
APRIL 10, 2024
WEDNESDAY, April 10, 2024 -- Beta blockers appear to be useless when prescribed to heart attack survivors who aren't suffering from heart failure, a new clinical trial indicates.The study calls into question the routine of prescribing beta blockers.
Fierce BioTech
APRIL 10, 2024
Redefining Antibody Specificity Profiling for IND swheeler Wed, 04/10/2024 - 17:56 Thu, 06/06/2024 - 11:00 Resource Type Webinar Kris Raghavan, PhD Fernanda I. Staquicini, PhD Duration 60 minutes Assessment of antibody off-target reactivity is a regulatory requirement for clinical development. However, conventional screening methods, such as tissue cross-reactivity studies, are often ineffective in screening newer therapeutic modalities, and their predictive value for in vivo safety and toxicity
Perficient: Drug Development
APRIL 10, 2024
This blog is the first post in a series about leveraging user stories to improve product outcomes. In this post, we will explore how to write compelling user stories to quickly deliver value to your customers. The User Story – Your Key to Unlocking Product Value Picture this. It’s demo day. You’re excited to finally see what the development team has been working on for weeks, and you’re confident this work will bring value to your customers.
Fierce BioTech
APRIL 10, 2024
Antibody Profiling: Decoding the Humoral Immune System Antibody biomarkers are redefining precision medicine – from early diagnosis to patient stratification. Get your FREE white paper to understand the challenges in disease diagnosis, the impact of antibody biomarkers, and the nuances of antibody screening for biomarker discovery. jpiatt Wed, 04/10/2024 - 11:32 Antibody biomarkers are redefining precision medicine, from diagnosing diseases earlier to stratifying patients – download your FREE wh
Perficient: Drug Development
APRIL 10, 2024
It’s clear in 2024 that the martech spaces continues to adopt a composable mindset towards technology architectures. Traditional martech players are offering more flexible product offerings by decoupling architectures, breaking up large suites into independent composable products. Newer cloud-native pureplay and point solutions are offering extension points and turn-key integrations with other composable tools to fit nicely into new modern architectures.
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