Fri.Jul 26, 2024

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Researchers develop state-of-the-art device to make artificial intelligence more energy efficient

Science Daily: Pharmacology News

Engineering researchers have demonstrated a state-of-the-art hardware device that could reduce energy consumption for artificial intelligent (AI) computing applications by a factor of at least 1,000.

Research 350
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Certain Abbott Blood Sugar Monitors May Give Incorrect Readings

Drugs.com

FRIDAY, July 26, 2024 -- Abbott has warned diabetes patients that some of its continuous blood sugar monitoring systems may need to be replaced because of inaccurate readings."Abbott has recently identified a small number of FreeStyle Libre 3.

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'Dancing molecules' heal cartilage damage

Science Daily: Pharmacology News

New therapy uses synthetic nanofibers to mimic the natural signaling of a protein that is crucial for cartilage formation and maintenance. Researchers found that intensifying the motion of molecules within the nanofibers led to more components needed for regeneration. After just four hours, the treatment activated the gene expression necessary to generate cartilage.

Therapies 322
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Shingles Vaccine, Shingrix, Could Lower Dementia Risk

Drugs.com

FRIDAY, July 26, 2024 -- Older people who avail themselves of the newest shingles vaccine could reap a hidden benefit: A significant drop in their odds of developing dementia. One expert applauded the new findings. "Dementia isn’t an.

Vaccine 279
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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New understanding of fly behavior has potential application in robotics, public safety

Science Daily: Pharmacology News

Scientists have identified an automatic behavior in flies that helps them assess wind conditions -- its presence and direction -- before deploying a strategy to follow a scent to its source. The fact that they can do this is surprising -- can you tell if there's a gentle breeze if you stick your head out of a moving car? Flies aren't just reacting to an odor with a preprogrammed response: they are responding in context-appropriate manner.

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Lampreys possess a 'jaw-dropping' evolutionary origin

Science Daily: Pharmacology News

Lampreys are one of only two living jawless vertebrates Jaws are formed by a key stem cell population called the neural crest New research reveals the gene regulatory changes that may explain morphological differences between jawed and jawless vertebrates.

Research 304
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At-Home Colon Cancer Test Can Save Lives

Drugs.com

FRIDAY, July 26, 2024 -- A simple home screening test for colon cancer can reduce the risk of dying from the disease by 33%, a new study shows.Results indicate that undergoing annual at-home FIT (fecal immunochemical test) screening “is as good as g.

Disease 264
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The ancestor of all modern birds probably had iridescent feathers

Science Daily: Pharmacology News

Birds tend to be more colorful in the tropics, and scientists wanted to find out how they got there: if colorful feathers evolved in the tropics, or if tropical birds have brightly-colored ancestors that came to the region from somwhere else. Scientists built a database of 9,409 birds to explore the spread of color across the globe. They found that iridescent, colorful feathers originated 415 times across the bird tree of life, and in most cases, arose outside of the tropics -- and that the ance

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Your Odds for Accidental Gun Death Rise Greatly in Certain States

Drugs.com

FRIDAY, July 26, 2024 -- Americans' risk of dying in a firearm accident depends in large part on where they live in the United States, a new study finds.People in Southeastern states like Mississippi, Louisiana and Alabama run the greatest risk of.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Cannabis and Cannabinoid Signaling: Research Gaps and Opportunities [Commentary]

ASPET

Cannabis and its products have been used for centuries for both medicinal and recreational purposes. The recent widespread legalization of cannabis has vastly expanded its use in the United States across all demographics except for adolescents. Meanwhile decades of research have advanced our knowledge of cannabis pharmacology and particularly of the endocannabinoid system with which the components of cannabis interact.

Research 189
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Double Mastectomy May Offer No Survival Benefit to Women With Breast Cancer

Drugs.com

FRIDAY, July 26, 2024 -- Women who are diagnosed with breast cancer in one breast, even in the early stages, sometimes opt for a double mastectomy, due to the fear that the cancer will migrate to the other breast.But that decision may not offer any.

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Leqembi voted down by European regulators

BioPharma Drive: Drug Pricing

Eisai plans to appeal the EMA’s negative recommendation, hoping to break into a market analysts expect could eventually bring billions of dollars in sales for the Alzheimer’s drug.

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Boar's Head Recalls Liverwurst Tied to Listeria Outbreak

Drugs.com

FRIDAY, July 26, 2024 -- Boar's Head announced Friday that it was recalling all of its liverwurst products because they could be tainted with dangerous Listeria monocytogenes bacteria. "The company is also recalling additional deli meat products.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Bristol Myers’ beat completes strong week of pharma earnings

BioPharma Drive: Drug Pricing

All five large pharmaceutical companies to report earnings this week raised either their profit or revenue guidance for the year.

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Shingles Vaccine Could Lower Dementia Risk

Drugs.com

FRIDAY, July 26, 2024 -- Older people who avail themselves of the newest shingles vaccine could reap a hidden benefit: A significant drop in their odds of developing dementia.One expert applauded the new findings."Dementia isn’t an inevitable part o.

Vaccine 246
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Two biotechs cut staff; AbbVie weathers biosimilar threat

BioPharma Drive: Drug Pricing

Glycomimetics and Cue Biopharma both revealed layoffs. Elsewhere, AbbVie’s earnings impressed Wall Street and an FDA panel recommended changing testing requirements for some lung cancer drugs.

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Kids From Poorer Families Less Likely to Survive Cancer

Drugs.com

FRIDAY, July 26, 2024 -- Children from poor families are less likely to survive cancer, particularly if they are not white, a new study reports.A childhood cancer patient’s risk of dying within five years of their diagnosis increases 4% for every o.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Recap of 2024 CDD Korean Life Science Community Meeting

Collaborative Drug

Celebrating 20 Years of Pioneering Drug Discovery and Collaboration: CDD User Group Meeting

Science 147
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Fake Oxycontin Pills Widespread and Potentially Deadly: Report

Drugs.com

FRIDAY, July 26, 2024 -- The rate at which young Americans are ending up in hospital ICUs after using fake Oxycontin pills spiked with fentanyl is soaring, especially in the U.S. West, a new report warns.Medical toxicology data from one unnamed.

Hospitals 244
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The effects of eating a traditional high fat/high carbohydrate or a ketogenic diet on sensitivity of female rats to morphine [Behavioral Pharmacology]

ASPET

Patients diagnosed with obesity are prescribed opioid medications at a higher rate than the general population; however, it is not known if eating a high fat diet might impact individual sensitivity to these medications. To explore the hypothesis that eating a high fat diet increases sensitivity of rats to the effects of morphine, 24 female Sprague-Dawley rats (n=8/diet) ate either a standard laboratory chow (17% kcal from fat), a high fat/low carbohydrate (ketogenic) chow (90.5% kcal from fat),

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Screens, Tweens and Sleep: Study Uncovers Tips for Better Rest

Drugs.com

FRIDAY, July 26, 2024 -- Turning off smartphones is an important step in making sure tweens get the sleep they need, a new study says.Leaving a phone ringer on is associated with a 25% higher risk of sleep disturbance among tweens ages 11 and 12.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Levetiracetam prevents neurophysiological changes and preserves cognitive function in the HIV-1 TAT transgenic mouse model of HIV-associated neurocognitive disorder [Neuropharmacology]

ASPET

HIV-associated neurocognitive disorder (HAND) affects nearly half of the 39 million people living with HIV. HAND symptoms range from subclinical cognitive impairment to dementia; the mechanisms that underlie HAND remain unclear and there is no treatment. The HIV-protein transactivator of transcription (TAT) is thought to contribute to HAND because it persists in the CNS and elicits neurotoxicity in animal models.

Treatment 100
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Tough Workouts Won't Trigger Cardiac Arrest in Folks With Long QT Syndrome

Drugs.com

FRIDAY, July 26, 2024 -- People diagnosed with one of the most common inherited heart arrhythmias, called Long QT syndrome (LQTS), can safely engage in vigorous exercise without any added risk for sudden death or cardiac arrest, a new study.

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Comparison of the Genomic Activity of an EP4-Receptor and {beta}2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-dependent Gene Expression [Inflammation, Immunopharmacology, and Asthma]

ASPET

It has been proposed that inhaled EP 4 -receptor agonists could represent an new class of bronchodilators for the treatment of asthma that are as effective as β 2 -adrenoceptor agonists. However, the genomic impact of such drugs is unknown despite being potentially deleterious to respiratory health. Herein, we used mRNA-seq to compare the transcriptomic responses produced by ONO-AE1-329 (an EP 4 -receptor agonist) and vilanterol (a β 2 -adrenoceptor agonist) in BEAS-2B human airway epi

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Athletes Can Expect High Ozone, Pollen Counts for Paris Olympics

Drugs.com

FRIDAY, July 26, 2024 -- Bad news for Olympians headed to Paris -- high levels of ozone pollution and grass pollen are likely during the upcoming games if hot, sunny weather prevails, researchers said.Ozone levels in Paris and its environs tend to.

Research 130
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Analgesic properties of next generation modulators of endocannabinoid signaling: leveraging modern tools for the development of novel therapeutics [Minireview]

ASPET

Targeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only now beginning to be mechanistically explored. In this review, we focus on two recently appreciated cannabinoid-based targeting strategies, treatments with cannabidiol (CBD) and a/b-hydrolase domain containing 6 (ABHD6) inhibitors, which have the exciting potential to produce pain relief through distinct mechanisms of action (MOA) and without intoxication.