ASPET

JULY 26, 2024

Cannabis and its products have been used for centuries for both medicinal and recreational purposes. The recent widespread legalization of cannabis has vastly expanded its use in the United States across all demographics except for adolescents. Meanwhile decades of research have advanced our knowledge of cannabis pharmacology and particularly of the endocannabinoid system with which the components of cannabis interact.

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Research Production 189

Science Daily: Pharmacology News

JULY 26, 2024

Engineering researchers have demonstrated a state-of-the-art hardware device that could reduce energy consumption for artificial intelligent (AI) computing applications by a factor of at least 1,000.

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Research Engineering 133

ASPET

JULY 26, 2024

Patients diagnosed with obesity are prescribed opioid medications at a higher rate than the general population; however, it is not known if eating a high fat diet might impact individual sensitivity to these medications. To explore the hypothesis that eating a high fat diet increases sensitivity of rats to the effects of morphine, 24 female Sprague-Dawley rats (n=8/diet) ate either a standard laboratory chow (17% kcal from fat), a high fat/low carbohydrate (ketogenic) chow (90.5% kcal from fat),

Laboratories 100

Laboratories 100

Science Daily: Pharmacology News

JULY 26, 2024

New therapy uses synthetic nanofibers to mimic the natural signaling of a protein that is crucial for cartilage formation and maintenance. Researchers found that intensifying the motion of molecules within the nanofibers led to more components needed for regeneration. After just four hours, the treatment activated the gene expression necessary to generate cartilage.

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Therapies Treatment Research 125

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

ASPET

JULY 26, 2024

HIV-associated neurocognitive disorder (HAND) affects nearly half of the 39 million people living with HIV. HAND symptoms range from subclinical cognitive impairment to dementia; the mechanisms that underlie HAND remain unclear and there is no treatment. The HIV-protein transactivator of transcription (TAT) is thought to contribute to HAND because it persists in the CNS and elicits neurotoxicity in animal models.

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Treatment Drugs 100

Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- Abbott has warned diabetes patients that some of its continuous blood sugar monitoring systems may need to be replaced because of inaccurate readings."Abbott has recently identified a small number of FreeStyle Libre 3.

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Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- Older people who avail themselves of the newest shingles vaccine could reap a hidden benefit: A significant drop in their odds of developing dementia. One expert applauded the new findings. "Dementia isn’t an.

Vaccine 111

Vaccine 111

ASPET

JULY 26, 2024

Targeting the endocannabinoid (eCB) signaling system for pain relief is an important treatment option that is only now beginning to be mechanistically explored. In this review, we focus on two recently appreciated cannabinoid-based targeting strategies, treatments with cannabidiol (CBD) and a/b-hydrolase domain containing 6 (ABHD6) inhibitors, which have the exciting potential to produce pain relief through distinct mechanisms of action (MOA) and without intoxication.

Regulations 100

Regulations Treatment 100

Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- An additional cinnamon product sold in the United States has been found to contain high levels of lead, health officials are warning.In a health alert issued Thursday, the U.S. Food and Drug Administration said the ground.

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Production FDA Drugs 105

Science Daily: Pharmacology News

JULY 26, 2024

Lampreys are one of only two living jawless vertebrates Jaws are formed by a key stem cell population called the neural crest New research reveals the gene regulatory changes that may explain morphological differences between jawed and jawless vertebrates.

Research 102

Research 102

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- A simple home screening test for colon cancer can reduce the risk of dying from the disease by 33%, a new study shows.Results indicate that undergoing annual at-home FIT (fecal immunochemical test) screening “is as good as g.

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Disease 105

Perficient: Drug Development

JULY 26, 2024

Perficient is thrilled to announce that Amarender Peddamalku has been awarded the prestigious “Most Valuable Professional” (MVP) status in Business Applications by Microsoft for the second time. This achievement is especially significant, highlighting his continued excellence and commitment to the Microsoft community. Amarender Peddamalku serves as the Microsoft Modern Work practice lead and digital transformation leader at Perficient.

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Production 98

Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- Americans' risk of dying in a firearm accident depends in large part on where they live in the United States, a new study finds.People in Southeastern states like Mississippi, Louisiana and Alabama run the greatest risk of.

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Science Daily: Pharmacology News

JULY 26, 2024

Scientists have identified an automatic behavior in flies that helps them assess wind conditions -- its presence and direction -- before deploying a strategy to follow a scent to its source. The fact that they can do this is surprising -- can you tell if there's a gentle breeze if you stick your head out of a moving car? Flies aren't just reacting to an odor with a preprogrammed response: they are responding in context-appropriate manner.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- Boar's Head announced Friday that it was recalling all of its liverwurst products because they could be tainted with dangerous Listeria monocytogenes bacteria. "The company is also recalling additional deli meat products.

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Production 98

Drug Patent Watch

JULY 26, 2024

Chiral switching, the practice of developing a single enantiomer from a previously approved racemic drug, has been a significant strategy in the pharmaceutical industry for decades.

Pharmaceuticals 97

Pharmaceuticals Drugs 97

Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- Older people who avail themselves of the newest shingles vaccine could reap a hidden benefit: A significant drop in their odds of developing dementia.One expert applauded the new findings."Dementia isn’t an inevitable part o.

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Vaccine 98

Conversations in Drug Development Trends

JULY 26, 2024

At Worldwide Clinical Trials’ bioanalytical lab, we view challenges as opportunities to excel and set new standards. The path to drug approval is complex, with many variables and potential delays. That’s why our team is committed to continuous improvement through our initiative, WorldwideEdge, where we optimize everything from our processes to our teams’ performance for each drug development program.

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Clinical Trials Trials Treatment Drug Development 72

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- Children from poor families are less likely to survive cancer, particularly if they are not white, a new study reports.A childhood cancer patient’s risk of dying within five years of their diagnosis increases 4% for every o.

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Drug Target Review

JULY 26, 2024

What are the key features of Helix’s new clinico-genomic datasets, and how do they support precision medicine drug discovery and development? Helix has a unique setup compared to some of the other places where you could get these kinds of datasets. We have a dual aim: to use the power of sequencing for more personalised patient care; and to be able to leverage those datasets to progress various programmes within drug discovery.

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Clinical Trials Science Trials International 72

Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- The rate at which young Americans are ending up in hospital ICUs after using fake Oxycontin pills spiked with fentanyl is soaring, especially in the U.S. West, a new report warns.Medical toxicology data from one unnamed.

Hospitals 97

Hospitals 97

BioPharma Drive: Drug Pricing

JULY 26, 2024

Eisai plans to appeal the EMA’s negative recommendation, hoping to break into a market analysts expect could eventually bring billions of dollars in sales for the Alzheimer’s drug.

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Regulations Marketing Drugs 70

Drugs.com

JULY 26, 2024

FRIDAY, July 26, 2024 -- Women who are diagnosed with breast cancer in one breast, even in the early stages, sometimes opt for a double mastectomy, due to the fear that the cancer will migrate to the other breast.But that decision may not offer any.

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BioPharma Drive: Drug Pricing

JULY 26, 2024

Glycomimetics and Cue Biopharma both revealed layoffs. Elsewhere, AbbVie’s earnings impressed Wall Street and an FDA panel recommended changing testing requirements for some lung cancer drugs.

Biosimilars 64

Biosimilars FDA Drugs 64

Agency IQ

JULY 26, 2024

BY LAURA DIANGELO, MPH , RACHEL COE, MSC Meeting a biosimilar user fee commitment, the FDA is expanding on its recommendations for biosimilar and interchangeable product applicants asking the FDA for post-approval manufacturing changes. The new draft guidance gives considerations for applicants seeking new dosage form or strengths, and those manufacturing the product in a facility with other versions of the biological product.

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Biosimilars FDA Production 59

BioPharma Drive: Drug Pricing

JULY 26, 2024

All five large pharmaceutical companies to report earnings this week raised either their profit or revenue guidance for the year.

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Pharmaceutical Companies Pharmaceuticals 67

Agency IQ

JULY 26, 2024

BY AMANDA CONTI FDA has fulfilled its commitment under the Over-the-Counter Monograph Drug User Fee (OMUFA) program to issue final guidance on how sponsors can electronically submit monographs and other documents. The final document reflects the agency’s efforts to develop reference guides for its upload portals. Fill out the form to read the full article.

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FDA Production Drugs 59

Science Daily: Pharmacology News

JULY 26, 2024

Birds tend to be more colorful in the tropics, and scientists wanted to find out how they got there: if colorful feathers evolved in the tropics, or if tropical birds have brightly-colored ancestors that came to the region from somwhere else. Scientists built a database of 9,409 birds to explore the spread of color across the globe. They found that iridescent, colorful feathers originated 415 times across the bird tree of life, and in most cases, arose outside of the tropics -- and that the ance

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Agency IQ

JULY 26, 2024

BY COREY JASEPH, MS, RAC The newly available May 2024 meetings of the Medical Device Coordination Group provide insight into the European Commission’s efforts to fully implement the European medical device and diagnostic regulations. AgencyIQ took a look at the doings of the group and its subcommittees that are most pertinent for device manufacturers.

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Laboratories Regulations 59

DS in Pharmatics

JULY 26, 2024

Date: July 26, 2024 Location: Kansas City, MO DSI, a renowned pharmaceutical and animal health industry leader, is thrilled to announce its participation in the upcoming Animal Health Corridor Summit on August 26-27, 2024.

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Pharmaceuticals 52

Agency IQ

JULY 26, 2024

BY SCOTT STEPHENS, MPA The European Commission’s latest update to the export and import of hazardous chemicals regulation, which implements the Rotterdam Convention on prior informed consent in the EU, adds 41 chemicals to the list of substances requiring export notification. Fill out the form to read the full article.

Regulations 59

Regulations 59

Drug Patent Watch

JULY 26, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Drugs Marketing 52

Perficient: Drug Development

JULY 26, 2024

Welcome to the new series on Usability and Experience (UX) in Universal Design! In this series, we will delve into the key principles that ensure inclusivity and accessibility for all users. Our first installment focuses on the essential usability and UX principles for individuals with physical disabilities. By understanding and implementing these principles, designers and developers can create environments, products, and services that are not only functional but also enjoyable for everyone, reg

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Production 52