Wed.Jan 01, 2025

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System to auto-detect new variants will inform better response to future infectious disease outbreaks

Science Daily: Pharmacology News

Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans -- including those causing flu, COVID, whooping cough and tuberculosis.

Virus 133
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Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma [@MegaMatthewsLab]

Covalent Modifiers

Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R McKnight, Katelyn A Bustin, Eric W Barr, Snehil R Chilkamari, Mahaa Ayub, Sun Woo Kim, Zongtao Lin, Ren-Ming Hu, Kelly Hicks, Xie Wang, Donald M O'Rourke, J. Martin Bollinger Jr., Zev A Binder, William H Parsons, Kirill A Martemyanov, Aimin Liu, Megan L Matthews bioRxiv 2024.12.19.629450; doi: [link] The vasodilator hydralazine (HYZ) has been used clinically for ~ 70 years and remains on the World Health Organization's List of Essential Medicin

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Ancient DNA unlocks new understanding of migrations in the first millennium AD

Science Daily: Pharmacology News

Waves of human migration across Europe during the first millennium AD have been revealed using a more precise method of analysing ancestry with ancient DNA, in research led by the Francis Crick Institute.

DNA 116
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Universal Design for Visual Disabilities in Healthcare – Addressing Age-Related Vision Loss – 9

Perficient: Drug Development

Happy New Year, everyone! Welcome to the first blog post of 2025 in our ongoing series on Universal Design for Healthcare. This time, were delving into the critical topic of Visual Disabilities in Healthcare. Age-related vision loss is a common condition affecting many older adults. It includes a range of visual impairments such as macular degeneration, presbyopia, cataracts, and glaucoma.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Key players in brain aging: New research identifies age-related damage on a cellular level

Science Daily: Pharmacology News

Scientists have identified the molecular changes that occur in the brains of aging mice and located a hot spot where much of that damage is centralized. The cells in the area are also connected with metabolism, suggesting a connection between diet and brain health.

Research 111
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Saving the Skinny Label Through the Skinny Label, Big Savings Act

FDA Law Blog: Biosimilars

By Sara W. Koblitz Since the induced infringement finding in GSK v. Teva , the generic industry has feared the death of the skinny label (admittedly stoked by alarmist headlines like my own, see Ding Dong is the Skinny Label (Effectively) Dead? ). This is because, at a minimum, if a skinny-labeled generic is the basis for induced infringement liability, generic manufacturers will certainly think twice about using the skinny label process and still calling themselves AB-rated, which ultimately w

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Scientists pin down the origins of a fast radio burst

Science Daily: Pharmacology News

Astronomers pinned down the origins of at least one fast radio burst, a brief and brilliant explosion of radio waves emitted by an extremely compact object. The team's novel technique might also reveal the sources of other FRBs.

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A tour de force: Engineers discover new 'all-optical' nanoscale sensors of force

Science Daily: Pharmacology News

Researchers report that they have invented new nanoscale sensors of force. They are luminescent nanocrystals that can change intensity and/or color when you push or pull on them. These 'all-optical' nanosensors are probed with light only and therefore allow for fully remote read-outs -- no wires or connections are needed.