Wed.Jan 01, 2025

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System to auto-detect new variants will inform better response to future infectious disease outbreaks

Science Daily: Pharmacology News

Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans -- including those causing flu, COVID, whooping cough and tuberculosis.

Virus 357
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Hydralazine inhibits cysteamine dioxygenase to treat preeclampsia and senesce glioblastoma [@MegaMatthewsLab]

Covalent Modifiers

Kyosuke Shishikura, Jiasong Li, Yiming Chen, Nate R McKnight, Katelyn A Bustin, Eric W Barr, Snehil R Chilkamari, Mahaa Ayub, Sun Woo Kim, Zongtao Lin, Ren-Ming Hu, Kelly Hicks, Xie Wang, Donald M O'Rourke, J. Martin Bollinger Jr., Zev A Binder, William H Parsons, Kirill A Martemyanov, Aimin Liu, Megan L Matthews bioRxiv 2024.12.19.629450; doi: [link] The vasodilator hydralazine (HYZ) has been used clinically for ~ 70 years and remains on the World Health Organization's List of Essential Medicin

Therapies 162
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Ancient DNA unlocks new understanding of migrations in the first millennium AD

Science Daily: Pharmacology News

Waves of human migration across Europe during the first millennium AD have been revealed using a more precise method of analysing ancestry with ancient DNA, in research led by the Francis Crick Institute.

DNA 333
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Saving the Skinny Label Through the Skinny Label, Big Savings Act

FDA Law Blog: Biosimilars

By Sara W. Koblitz Since the induced infringement finding in GSK v. Teva , the generic industry has feared the death of the skinny label (admittedly stoked by alarmist headlines like my own, see Ding Dong is the Skinny Label (Effectively) Dead? ). This is because, at a minimum, if a skinny-labeled generic is the basis for induced infringement liability, generic manufacturers will certainly think twice about using the skinny label process and still calling themselves AB-rated, which ultimately w

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Key players in brain aging: New research identifies age-related damage on a cellular level

Science Daily: Pharmacology News

Scientists have identified the molecular changes that occur in the brains of aging mice and located a hot spot where much of that damage is centralized. The cells in the area are also connected with metabolism, suggesting a connection between diet and brain health.

Research 313

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A tour de force: Engineers discover new 'all-optical' nanoscale sensors of force

Science Daily: Pharmacology News

Researchers report that they have invented new nanoscale sensors of force. They are luminescent nanocrystals that can change intensity and/or color when you push or pull on them. These 'all-optical' nanosensors are probed with light only and therefore allow for fully remote read-outs -- no wires or connections are needed.

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Scientists pin down the origins of a fast radio burst

Science Daily: Pharmacology News

Astronomers pinned down the origins of at least one fast radio burst, a brief and brilliant explosion of radio waves emitted by an extremely compact object. The team's novel technique might also reveal the sources of other FRBs.

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Pupil size in sleep reveals how memories are sorted, preserved

Science Daily: Pharmacology News

Researchers have found the pupil is key to understanding how, and when, the brain forms strong, long-lasting memories.

Research 294
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Revealing a key mechanism of rapid centromere evolution

Science Daily: Pharmacology News

A research team has clarified a mechanism of how retrotransposons, genetic elements that can 'jump around' chromosomes and are known drivers of evolution, preferentially insert in the centromere.

Research 130
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.