Thu.Oct 24, 2024

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Unnoticeable electric currents could reduce skin infections

Science Daily: Pharmacology News

Using a few zaps of electricity to the skin, researchers can stop bacterial infections without using any drugs. For the first time, researchers designed a skin patch that uses imperceptible electric currents to control microbes.

Research 124
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Intellia data spark debate about CRISPR drug’s potential

BioPharma Drive: Drug Pricing

Newly published data show the therapy reduced the rate of swelling attacks in people with hereditary angioedema, but didn't silence questions about its commercial outlook.

Therapies 115
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Gut bacteria transfer genes to disable weapons of their competitors

Science Daily: Pharmacology News

New research shows that a large, ubiquitous mobile genetic element changes the antagonistic weaponry of Bacteroides fragilis, a common bacterium of the human gut.

Research 123
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Ozempic, Wegovy Might Help Lower Alzheimer's Risk in People With Diabetes

Drugs.com

THURSDAY, Oct. 24, 2024 -- Add Alzheimer’s disease to the list of conditions that might benefit from the revolutionary diabetes drug Ozempic, a new study says.People with type 2 diabetes taking semaglutide appeared to have a significantly lower r.

Disease 105
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Successful experiment paves the way for new element

Science Daily: Pharmacology News

Scientists have found an alternative way to produce atoms of the superheavy element livermorium. The new method opens up the possibility of creating another element that could be the heaviest in the world so far: number 120.

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Over 50? How Long You Can Stand on One Leg Is Important

Drugs.com

FRIDAY, Oct. 25, 2024 -- There's a simple test available to seniors who want to quickly check how well they’re aging: see how long you can stand on one leg.Folks over 50 who can stand on one leg for 30 seconds are aging gracefully, particularly if i.

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CDC Lowers Age for First Pneumococcal Vaccine to 50

Drugs.com

THURSDAY, Oct. 24, 2024 -- The recommended first age at which Americans should get the pneumococcal vaccine has been lowered from 65 to 50, the U.S. Centers for Disease Control and Prevention announced Wednesday."Lowering the age for pneumococcal.

Vaccine 105
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Human actions likely cause insect color change

Science Daily: Pharmacology News

New Zealand's native stoneflies have changed colour in response to human-driven environmental changes, new research shows. The study provides arguably the world's most clear-cut case of animal evolution in response to change made by humans.

Research 115
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More Kids With Food Allergies Are Needing Psychological Care

Drugs.com

THURSDAY, Oct. 24, 2024 -- Anxiety is driving more children with potentially dangerous food allergies to seek out psychological care, a new study finds.Focusing on one Ohio hospital, the researchers found a more than 50% jump in psychology.

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Scientists develop grain-sized soft robots controlled by magnetic fields for targeted drug delivery

Science Daily: Pharmacology News

A team of scientists has developed grain-sized soft robots that can be controlled using magnetic fields for targeted drug delivery, paving the way to possible improved therapies in future.

Therapies 114
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Private Balcony Hot Tubs Spread Legionnaires Disease on Cruise Ships

Drugs.com

THURSDAY, Oct. 24, 2024 -- Next time you're on a cruise, be wary of your (or your neighbor's) private balcony hot tub, researchers warn.These luxe cabin features were pinpointed as a source of outbreaks of the respiratory illness Legionnaires.

Disease 98
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Millions in the U.S. may rely on groundwater contaminated with PFAS for drinking water supplies

Science Daily: Pharmacology News

Approximately 71 to 95 million people in the Lower 48 states -- more than 20% of the country's population -- may rely on groundwater that contains detectable concentrations of per- and polyfluoroalkyl substances, also known as PFAS, for their drinking water supplies.

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Onions in McDonalds' Quarter Pounders Linked to E. Coli Outbreak Have Been Recalled

Drugs.com

THURSDAY, Oct. 24, 2024 -- Just days after an E. coli outbreak tied to McDonald's Quarter Pounders was first announced, a company producing onions used in the burgers said it has issued a recall for its diced, peeled and whole onions. The onions.

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Key to low-cost, long-lasting renewable batteries for electric vehicles

Science Daily: Pharmacology News

Lithium-sulfur batteries have never lived up to their potential as the next generation of renewable batteries for electric vehicles and other devices. But mechanical engineers have now found a way to make these Li-S batteries last longer -- with higher energy levels -- than existing renewable batteries.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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How to Manage Regulatory Challenges in Generic Drugs

Drug Patent Watch

The generic drug industry faces significant regulatory challenges that can impact the quality and safety of these life-saving medications. With the majority of generic drugs manufactured overseas, ensuring compliance with regulatory standards is crucial. This article delves into the complexities of generic drug regulation, highlighting the challenges faced by the U.S.

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A new hydrogel semiconductor represents a breakthrough for tissue-interfaced bioelectronics

Science Daily: Pharmacology News

The ideal material for interfacing electronics with living tissue is soft, stretchable, and just as water-loving as the tissue itself--in short, a hydrogel. Semiconductors, the key materials for bioelectronics such as pacemakers, biosensors, and drug delivery devices, on the other hand, are rigid, brittle, and water-hating, impossible to dissolve in the way hydrogels have traditionally been built.

Research 103
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Lyell, in search of a turnaround, to buy cell therapy startup ImmPact

BioPharma Drive: Drug Pricing

The deal will give Lyell a dual-targeting CAR-T candidate for blood cancers. Relatedly, Lyell has opted to end development of two current pipeline programs.

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Popular diabetes and weight-loss drug may reduce risk of Alzheimer's disease

Science Daily: Pharmacology News

Researchers have found that semaglutide may lower the risk of Alzheimer's disease in people with type 2 diabetes (T2D).

Disease 124
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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GPCR drugmaker Septerna amasses $288M in IPO

BioPharma Drive: Drug Pricing

Septerna is the 23rd biotech to go public this year, raising funds to advance its lead candidate, a treatment for hypoparathyroidism now in Phase 1 testing.

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Fire-risk blocking self-powered hydrogen production system

Science Daily: Pharmacology News

By using a water-splitting system with an aqueous electrolyte, this system is expected to block fire risks and enable stable hydrogen production.

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Naloxone Implant Might Prevent Opioid Overdose

Drugs.com

THURSDAY, Oct. 24, 2024 -- Naloxone can save a person’s life by reversing a potentially fatal opioid overdose, and is now available as an over-the-counter medication. Unfortunately, there’s a very significant catch. A knowledgeable.

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Beneficial gut microbe has surprising metabolic capabilities

Science Daily: Pharmacology News

Researchers discovered potentially far-reaching effects of a particular gut bacterium that was linked to better growth in Bangladeshi children receiving a therapeutic food designed to nurture healthy gut microbes. A strain of the bacterium harbored in the children's gut microbial communities possessed a previously unknown gene capable of producing and metabolizing key molecules involved in regulating many important functions ranging from appetite, immune responses, neuronal function, and the abi

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Greater Access to New Weight Loss Meds Could Save More Than 40,000 Lives Per Year

Drugs.com

THURSDAY, Oct. 24, 2024 -- Expanding access to cutting-edge diabetes and weight-loss drugs like Ozempic and Zepbound could prevent more than 42,000 deaths a year in the United States, a new study claims.Obesity and all its attendant ills -- type 2.

Drugs 64
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Dandelion-shaped supernova and zombie star

Science Daily: Pharmacology News

A historical supernova documented by Chinese and Japanese astronomers in 1181 has been lost for centuries, until very recently. Yet, the newly found remnant shows some stunning characteristics that are puzzling astronomers. Now, it surrenders its secrets. A team provides the first detailed study of the supernova's structure and speed of expansion in 3D.

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A Reversal on Sequencing? Proposed Legislation Would Allow Patenting of Naturally Occurring Genes

FDA Law Blog: Biosimilars

By Gail H. Javitt & Jeffrey N. Gibbs — A recent blog post focused on the potentially negative implications of the proposed Patent Eligibility Restoration Act (PERA) for manufacturers of generic drugs and biosimilar products. The concerns raised by PERA are not limited to these industries, however. Rather, developers of diagnostic tests and, indeed of any product that relies on free access to gene sequence and other biomarker information, should pay also close attention, as PERA would

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No More Delays: Accelerating Therapy Starts by Embedding Hub Services in Provider Workflows

Drug Channels

Today’s guest post comes from Shabbir Ahmed, Chief Commercial Officer at CareMetx. Shabbir explains the barriers that providers face when dealing with branded portals for multiple products. He then maintains that patients can access new therapies more quickly when the manufacturer relies on a brand-agnostic hub connected to a large network of providers and integrated with the systems those providers use daily.

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Delineating cysteine-reactive compound modulation of cellular proteostasis processes

Covalent Modifiers

Ashley R. Julio, Flowreen Shikwana, Cindy Truong, Nikolas R. Burton, Emil R. Dominguez III, Alexandra C. Turmon, Jian Cao & Keriann M. Backus Nat Chem Biol 2024 [link] Covalent modulators and covalent degrader molecules have emerged as drug modalities with tremendous therapeutic potential. Toward realizing this potential, mass spectrometry-based chemoproteomic screens have generated proteome-wide maps of potential druggable cysteine residues.

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Merck, Pfizer lifted as CDC backs broader use of pneumococcal vaccines

BioPharma Drive: Drug Pricing

An agency panel recommended lowering the age for routine vaccination from 65 to 50, boosting the revenue outlook for multiple shots on the market and in development.

Vaccine 60
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GEDMex: Genetics of Eating Disorders in Mexican Populations

Broad Institute

GEDMex: Genetics of Eating Disorders in Mexican Populations By Maria Nemchuk October 24, 2024 Breadcrumb Home GEDMex: Genetics of Eating Disorders in Mexican Populations ESPAÑOL The GEDMex study aims to expand knowledge of the genetic and environmental risk factors for eating disorders in Mexico through large-scale sample collection and analysis. This will ensure future scientific advances and therapeutics are applicable to Mexican populations.

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J&J’s Asish Xavier on biotech’s rebound in a volatile era

BioPharma Drive: Drug Pricing

Xavier, who leads biotech venture investing for the big drugmaker, expects an uptick in IPOs as well as renewed interest in the newer crop of gene and cell therapy companies.

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AI Regulations for Financial Services: OCC

Perficient: Drug Development

Artificial intelligence (AI) is poised to affect every aspect of the world economy and play a significant role in the global financial system, leading financial regulators around the world to take various steps to address the impact of AI on their areas of responsibility. The economic risks of AI to the financial systems include everything from the potential for consumer and institutional fraud to algorithmic discrimination and AI-enabled cybersecurity risks.

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The Dangers of “Do Your Own Research” and “Believe in Science”

PLOS: DNA Science

During the pandemic, we turned to our leaders for updates on the rapidly worsening, unprecedented situation. As days turned to weeks, and the sick lined up outside city hospitals, we craved information. But much of it was in the unfamiliar language of virology and immunology, public health and epidemiology. In those early days, politicians and government officials who’d never heard terms like “cytokine storm” and “RNA virus” were suddenly charged with explaining wha

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5 Takeaways: Enhancing Trust in Healthcare [Webinar]

Perficient: Drug Development

In our recent webinar, “Enhancing Trust in Healthcare,” experts David Allen and Michael Porter , along with Appian ’s Matt Collins, addressed the concerning decline in consumer trust within the healthcare sector. Historically, healthcare has maintained higher levels of trust compared to other industries, but a recent Gallup survey shows that this trust is now at a near-record low.