Chemical Biology and Drug Design

AUGUST 10, 2023

Designed a novel of spirooxindole-pyrrolidine clubbed thiochromene and pyrazole motifs synthesized by [3+2] cycloaddition (32CA) reactions in one step process and identified as an alpha-amylase inhibitor. Mechanistic study for the 32CA reaction by Molecular Electron Density Theory (MEDT) was explored. Abstract A novel spirooxindole-pyrrolidine clubbed thiochromene and pyrazole motifs were synthesized by [3+2] cycloaddition (32CA) reactions in one step process starting from the ethylene-based thi

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Drugs Research 190

ASPET

AUGUST 10, 2023

We have previously shown that a bona fide Aryl hydrocarbon Receptor (AhR) agonist, cinnabarinic acid (CA) protect against alcohol-induced hepatocyte apoptosis via activation of a novel AhR target gene, stanniocalcin 2 (Stc2). Stc2 translates to a secreted disulfide-linked hormone, STC2 known to function in cell development, calcium and phosphate regulation, angiogenesis, and anti-apoptosis - albeit the comprehensive mechanism by which CA-AhR-STC2 axis confers anti-apoptosis is yet to be characte

RNA 100

RNA Regulations Treatment Disease 100

Chemical Biology and Drug Design

AUGUST 10, 2023

In this study, we designed, and synthesized a series of structural analogs of isatin and assessed their inhibitory effects on SARS-CoV-2 3CL pro. Compound 5g was identified as the most potent inhibitor of SARS-CoV-2 3CL pro , which exhibited strong inhibition of 3CL pro in a dose-dependent manner. Abstract SARS-CoV-2 chymotrypsin-like cysteine protease (3CL pro ) is one of the most widely developed drug targets for COVID-19.

Treatment 100

Treatment Drugs Research 100

BioPharma Drive: Drug Pricing

AUGUST 10, 2023

The deal will help fund a cell-based treatment that completed Phase 1 testing last year and is designed to provide a “functional cure” for patients with HIV infections.

Therapies 97

Therapies Treatment 97

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Chemical Biology and Drug Design

AUGUST 10, 2023

Process of corn silk anti-AD analysis. Abstract This study aimed to research the possible mechanism and effect of active ingredients of corn silk on Alzheimer's disease (AD) by the method of network pharmacology, molecular docking, and animal experiments. The active ingredients of Corn silk were obtained by searching the TCMSP database and the targets corresponding to the active ingredients of Corn silk were obtained through the TCMSP and SwissTargetPrediction platforms, and the AD targets were

Disease 100

Disease Research Treatment 100

BioPharma Drive: Drug Pricing

AUGUST 10, 2023

The drug, which will be sold under the brand name Talvey, is now cleared by the FDA to treat multiple myeloma, a blood cancer that J&J has identified as a research priority.

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FDA Drugs Research 98

Drugs.com

AUGUST 10, 2023

THURSDAY, Aug. 10, 2023 -- People with autism are over three times more likely than their peers without the developmental disorder to experience self-injury, suicidal ideation, suicide attempt, or death by suicide, new research shows. “In.

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Research 98

BioPharma Drive: Drug Pricing

AUGUST 10, 2023

The planned facility in the biotech hotspot of Cambridge will include incubator space for startups and adds to Astellas’ R&D footprint in the Boston area.

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Research 98

Drugs.com

AUGUST 10, 2023

THURSDAY, Aug. 10, 2023 -- Microplastics appear to be everywhere, including within the tissues of the human heart. A new Chinese report describes doctors finding microplastics in heart tissue both before and after heart surgery. The researchers also.

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Doctors Research 98

SCIENMAG: Medicine & Health

AUGUST 10, 2023

A team led by Virginia Tech researchers has developed a new method for upcycling plastics into high-value chemicals known as surfactants, which are used to create soap, detergent, and more. Credit: Photo by Steven Mackay for Virginia Tech.

Research 94

Research 94

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Clinical Trials

Drugs.com

AUGUST 10, 2023

THURSDAY, Aug. 10, 2023 -- The mental health crisis hitting Americans shows no sign of abating, with provisional numbers for 2022 showing suicides rose by another 2.6% last year. That follows on an overall 5% increase in suicides in 2021, noted.

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SCIENMAG: Medicine & Health

AUGUST 10, 2023

Moffett Field, CA – August 10th, 2023 – Extreme weather events have dominated the news this summer, with reports on extensive wildfires in Canada; dangerous flooding in India, Japan, and the Eastern US; severe heat waves in Spain, China, the United States, and Mexico; and the hottest day ever recorded on Earth.

Science 94

Science 94

Drugs.com

AUGUST 10, 2023

THURSDAY, Aug. 10, 2023 -- Modern antidepressants could be effective for long-term treatment of some patients with bipolar disorder, a new trial suggests. Current guidelines discourage use of antidepressants in these patients, over concerns that the.

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Trials Treatment 98

SCIENMAG: Medicine & Health

AUGUST 10, 2023

BEAUFORT, N.C. – Microscopic plastic particles have been found in the fats and lungs of two-thirds of the marine mammals in a graduate student’s study of ocean microplastics. The presence of polymer particles and fibers in these animals suggests that microplastics can travel out of the digestive tract and lodge in the tissues.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

AUGUST 10, 2023

The acquisition follows a similar-sized, obesity-focused buyout by Eli Lilly last month and hands Novo a weight-loss medicine already in mid-stage testing.

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Drugs 98

SCIENMAG: Medicine & Health

AUGUST 10, 2023

New research confirms fracking causes slow, small earthquakes or tremors, whose origin was previously a mystery to scientists. The tremors are produced by the same processes that could create large, damaging earthquakes. Credit: Loadmaster (David R. Tribble) New research confirms fracking causes slow, small earthquakes or tremors, whose origin was previously a mystery to scientists.

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Research Science 92

Drugs.com

AUGUST 10, 2023

THURSDAY, Aug. 10, 2023 -- Older adults who use certain heartburn medications for years may have a heightened risk of developing dementia, a new study suggests. The study, published Aug. 9 in the journal Neurology, is the latest to point to.

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SCIENMAG: Medicine & Health

AUGUST 10, 2023

After a successful test phase, the Satellite Orbit DecAy (SODA) service, which was jointly developed by TU Graz and the University of Graz, officially became part of the ESA’s Space Safety Programme in mid-July. SODA provides accurate forecasts of the effects of solar storms on low Earth orbiting satellites.

Science 92

Science 92

NIOSH Science Blog: Drugs

AUGUST 10, 2023

As teachers, school administrators, students, and parents get ready to go back to school, safety should be top of mind. School safety most often emphasizes keeping students safe from violence, bullying and harassment, and the influence of substance use (NCSSLE, 2023), but it should also include the safety of those who work in schools. To highlight the injury risks experienced by workers in elementary and secondary schools, the National Institute for Occupational Safety and Health (NIOSH) examine

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SCIENMAG: Medicine & Health

AUGUST 10, 2023

Plants orient their organs in response to the gravity vector, with roots growing towards gravity and shoots growing in the opposite direction. The movement of statoliths responding to the inclination relative to the gravity vector is employed for gravity sensing in both plants and animals.

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Drugs.com

AUGUST 10, 2023

THURSDAY, Aug. 10, 2023 -- The heart risks posed by air pollution have grown worldwide over the past three decades, a new study claims. The annual number of premature heart-related deaths and years of disability attributable to particulate matter.

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SCIENMAG: Medicine & Health

AUGUST 10, 2023

Researchers at Trinity College Dublin study the factors influencing healthy brain ageing in Latin American and Caribbean (LAC) countries and find the lessons learned there, can also be applied to home. Ageing is not a uniform process across the globe.

Research 91

Research 91

Eye on FDA

AUGUST 10, 2023

Every six months, we do a look-back to see what has changed in the way that FDA is communicating. One might not think there is much difference over time, but there is. For example, the air has pretty much gone out of the COVID balloon. And there is more to tell. How many? First of all, consider volume. The number of press releases issued by FDA during the first six months of the year declined to 101 from the 125 issued by June 30 of last year, the lowest number at mid-year since 2017.

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FDA 80

SCIENMAG: Medicine & Health

AUGUST 10, 2023

URBANA, Ill. – Madagascar is one of the poorest countries in the world and access to health care is limited for many people. Childhood vaccinations are a crucial component of preventative care, but vaccination rates remain below the World Health Organization’s goal of reaching 95% of children.

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Vaccine Science 91

Drug Patent Watch

AUGUST 10, 2023

A recent paper published in the journal “Intelligent Medicine” article discusses various aspects of using AI and machine learning in the pharmaceutical industry for drug discovery and development. Results The… The post Artificial Intelligence and Machine Learning in Drug Discovery and Development appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs Pharmaceuticals 82

SCIENMAG: Medicine & Health

AUGUST 10, 2023

A new study published in the journal Science by an international team finds that past changes in atmospheric CO2 and corresponding shifts in climate and vegetation played a key role in determining when and where early human species interbred.

International 89

International Science Engineering 89

addgene Blog

AUGUST 10, 2023

Calcium is arguably one of the most important metal ions in biology (sodium and potassium are up there too!). Calcium is fundamental to muscle and nerve function, hormone secretion, blood clotting, and as we all know, a structural component of bones and teeth. It is an enzyme co-factor, a crosslinking agent, a signaling ion, and an allosteric modulator.

Regulations 75

Regulations 75

SCIENMAG: Medicine & Health

AUGUST 10, 2023

Osaka, Japan – One of the most striking predictions of quantum physics is that matter can be generated solely from light (i.e., photons), and in fact, the astronomical bodies known as pulsars achieve this feat.

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Laboratories 88

Science Daily: Pharmacology News

AUGUST 10, 2023

New research has successfully reversed hearing loss in mice. Scientists used a genetic approach to fix deafness in mice, restoring their hearing abilities in low and middle frequency ranges.

Research 76

Research 76

SCIENMAG: Medicine & Health

AUGUST 10, 2023

INDIANAPOLIS – As the population of the United States grows older, more and more family members will be called upon to make medical decisions during hospitalizations of those who cannot make decisions for themselves. Good quality, focused, empathetic and timely communication between family members and clinicians is essential for good decision-making.

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Hospitals Research 88

Drugs.com

AUGUST 10, 2023

THURSDAY, Aug. 10, 2023 -- A small battery-operated device long used as a treatment for pain may also help patients with sleep apnea, a British study suggests. Sleep apnea is a condition that impedes breathing during sleep, reduces oxygen intake and.

Treatment 75

Treatment 75

SCIENMAG: Medicine & Health

AUGUST 10, 2023

Oak Ridge National Laboratory researchers have developed a training camp to help manufacturing industries reduce energy-related carbon dioxide emissions and improve cost savings. Credit: ORNL, U.S. Dept. of Energy Oak Ridge National Laboratory researchers have developed a training camp to help manufacturing industries reduce energy-related carbon dioxide emissions and improve cost savings.

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Laboratories Research Engineering 87

Science Daily: Pharmacology News

AUGUST 10, 2023

The best heart rate for burning fat differs for each individual and often does not align with the 'fat burning zone' on commercial exercise machines, researchers report. Instead, the researchers said, clinical exercise testing -- a diagnostic procedure to measure a person's physiological response to exercise -- may be a more useful tool to help individuals achieve intended fat loss goals.

Research 75

Research 75

SCIENMAG: Medicine & Health

AUGUST 10, 2023

A new analysis shows that infectious bacteria exposed to the antibiotic albicidin rapidly develop up to a 1,000-fold increase in resistance via a gene amplification mechanism. Mareike Saathoff of Freie Universität Berlin, Germany, and colleagues present these findings August 10th in the open access journal PLOS Biology. Credit: Mareike Saathoff et al.

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