Thu.Nov 09, 2023

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Targeting advances in immunotherapies

Drug Discovery World

DDW Editor Reece Armstrong speaks to Christian Leisner , Chief Executive Officer of antibody therapeutics’ developer CDR-Life about methods to increase access to antigens and improving immunotherapy treatments. RA: Why are existing immunotherapies restricted to certain patient populations? CL: Immunotherapies, principally anti-PD-1/-L1 checkpoint inhibitors, have shown therapeutic benefit in improving the prognosis of patients but only in a select handful of solid cancers.

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A guide to clinical trial phases [infographic]

Antidote

Before any new treatment or therapy is able to be used by the patient population, it must go through the process of a clinical trial — this is the case for any new prescription drug, but also true for over-the-counter medications, medical devices, and more.

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Podcast: In conversation with Isaac Klein, CSO of Dewpoint Therapeutics

Drug Discovery World

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Isaac Klein, Chief Scientific Officer of Dewpoint Therapeutics. Klein is a physician-scientist and medical oncologist.

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Naringin acts as a TRPV1 antagonist to attenuate UVB?induced senescence and damage in HaCaT cells

Chemical Biology and Drug Design

HaCaT cells were divided into Control group: HaCaT cells cultured conventionally; UVB group: HaCaT cells were irradiated with 30 mJ/cm 2 UVB for 30 s; UVB + Nar group: naringin (Nar, 150 μM) was pretreated for 6 h, and HaCaT cells were irradiated with 30 mJ/cm 2 UVB for 30 s. UVB + Cap group: HaCaT cells were treated with capsaicin (Cap, 4 μM) 30 min before UVB irradiation.

Treatment 100
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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How to solve biological mysteries

Drug Discovery World

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Isaac Klein, Chief Scientific Officer of Dewpoint Therapeutics. Klein is a physician-scientist and medical oncologist.

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Antitumor and antioxidant activities of polysaccharides from the seaweed Durvillaea antarctica

Chemical Biology and Drug Design

The present study was carried out to determine the antitumor and antioxidant activities of the seaweed Durvillaea antarctica. Abstract The present study was carried out to determine the antitumor and antioxidant activities of the seaweed Durvillaea antarctica. Extraction and purification of polysaccharides from D. antarctica were performed. They were characterized by FT-IR and GC–MS, identifying isomers of arabinose, fucose, mannose, and galactose.

Research 100

More Trending

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Why Content Is the Key to Opening Healthcare’s Digital Front Door – Part 3: Medical Devices

Perficient: Drug Development

This is the third and final part of our series in which we’re discussing healthcare’s digital front door — the technologies and strategies you use to engage with consumers throughout their journeys. By now, you are getting the idea that a cohesive content strategy is the key for consumers to open your digital front door and engage with your organization regardless of where you sit in the healthcare ecosystem.

Doctors 116
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Wegovy, Ozempic Probably Won't Harm Vision in People With Diabetes, Study Finds

Drugs.com

THURSDAY, Nov. 9, 2023 (HealthDay) -- There's good news for people with diabetes who are turning to drugs like Ozempic and Wegovy to treat their disease and lose weight: The drugs probably will not harm their vision. Semaglutide (the generic name.

Disease 105
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Greenland's glacier retreat rate has doubled over past two decades

Science Daily: Pharmacology News

A new study documents how Greenland's peripheral glaciers have changed from 1890 to 2022. Using satellite images and a unique archive of historical aerial photos, researchers documented changes in the lengths of more than 1,000 of the country's glaciers over the past 130 years. Although glaciers in Greenland have experienced retreat throughout the last century, the rate of their retreat has rapidly accelerated over the last two decades.

Research 108
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Majority of Workers at America's Nursing Homes Unvaccinated Against Flu, COVID

Drugs.com

THURSDAY, Nov. 9, 2023 -- Health care workers at America’s nursing homes are woefully under-vaccinated for both flu and COVID-19, threatening their own health and that of the frail elderly patients under their care, a new report.

Nurses 105
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Allergic responses to common foods could significantly increase risk of heart disease, cardiovascular death

Science Daily: Pharmacology News

Allergic responses to common foods such as dairy and peanuts can increase the risk for heart disease and cardiovascular death as much or more than smoking, new research suggests. And these dangerous allergic responses can strike both people with food allergies and those with no obvious allergy symptoms.

Disease 104
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FDA Will Pull Vet Drug Used in Pork Industry Over Cancer Concerns for Humans

Drugs.com

WEDNESDAY, Nov. 8, 2023 (Healthday News) -- The U.S. Food and Drug Administration said Tuesday that it plans to pull a veterinary drug used commonly in the pork industry because it might pose a cancer risk to humans who eat pig products. The.

FDA 105
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Atara’s cell therapy approach to MS falls short in study

BioPharma Drive: Drug Pricing

Shares in the biotech tumbled by 75% as results from a Phase 2 trial showed more improvement in participants given a placebo.

Therapies 113
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Man Maimed by Electric Shock Receives First-Ever Face Transplant That Includes New Eye

Drugs.com

KEY TAKEAWAYS: An Arkansas man has received the world’s first whole-eye transplant, along with a partial face transplant The man suffered horrific injuries in 2021 when his face touched a live wire His surgery took 21 hours and.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Survey: 72% of eczema patients suffered poor mental health symptoms for 1-10 days in past month

SCIENMAG: Medicine & Health

ANAHEIM, Calif. (Nov. 9, 2023) – People who suffer with atopic dermatitis (AD), commonly known as eczema, have an increased likelihood of developing depression and anxiety, which is made worse when additional allergic symptoms are present.

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Best Way to Prevent Cervical Cancers: Immunize Boys Against HPV, Too

Drugs.com

THURSDAY, Nov. 9, 2023 -- The best way to prevent cervical cancer in women is to give HPV vaccines to both boys and girls, a new study argues. That way, herd immunity could help eradicate the cancer-causing virus, researchers say. Cancer-related.

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9 reasons to adopt automated tube handling in your laboratory

sptlabtech

BioMicroLab elevates your laboratory's efficiency while allowing your team to redirect their focus from routine tasks to groundbreaking research.

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Salt Water Gargling, Nasal Irrigation May Keep COVID From Worsening

Drugs.com

THURSDAY, Nov. 9, 2023 -- If you're suffering from COVID, you might want to grab a glass of warm water and a shaker of salt. New research suggests that gargling and rinsing your nasal passages with a saline solution may help keep you out of the.

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Community grant projects empower allergists to address barriers to allergy and asthma care

SCIENMAG: Medicine & Health

ANAHEIM, Calif. (Nov. 9, 2023) – Beginning in 2021, The Allergists’ Foundation, the philanthropic arm of the American College of Allergy, Asthma and Immunology, began funding community grant projects that address challenges faced by community practicing allergists. Credit: ACAAI ANAHEIM, Calif. (Nov.

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Sharks' Amazing Ability to Heal From Wounds Might Help Humans

Drugs.com

WEDNESDAY, Nov. 8, 2023 -- Forget "Jaws": The remarkable wound-healing power of shark skin could end up helping humans, new research claims. Shark skin is coated with a special film of mucus that more closely resembles mucus generated by people.

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FDA’s OPDP Issues Two New Untitled Letters

Eye on FDA

While enforcement has been at a low ebb for quite some time with FDA’s Office of Prescription Drug Promotion (OPDP), this week took a different turn with the posting of two new untitled letters sent October 31. That brings the total number of letters issued by OPDP to five this year – one Warning Letter that came out in August respecting a sales aid used in promoting a treatment for COPD, and 4 untitled letters – one in June, one in August, and now two in October.

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Your 'Biological Age' Could Affect Your Odds for Stroke, Dementia

Drugs.com

WEDNESDAY, Nov. 8, 2023 -- There's your calendar age, and then there's what scientists call your "biological" age, which is based on various measurements indicating good or not-so-good health. Now, new Swedish research finds that less healthy.

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The Paul G. Allen Frontiers Group announces Allen Discovery Center for Neuroimmune Interactions at Icahn School of Medicine at Mount Sinai

SCIENMAG: Medicine & Health

SEATTLE, W.A.—November 9, 2023—The Paul G. Allen Frontiers Group, a division of the Allen Institute, today announced the launch of the Allen Discovery Center (ADC) for Neuroimmune Interactions at the Icahn School of Medicine at Mount Sinai.

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CT Screening Greatly Boosts Lung Cancer Survival: Study

Drugs.com

WEDNESDAY, Nov. 8, 2023 -- For smokers and former smokers, getting annual CT scans of the chest to catch lung cancers early dramatically improves survival, new research shows. Many people may believe lung cancer to be swiftly fatal. However, the.

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Found at last: Bizarre, egg-laying mammal finally rediscovered after 60 years

Science Daily: Pharmacology News

A long-beaked echidna named after Sir David Attenborough and last seen by scientists in 1961 has been photographed for the first time in an Indonesian tropical forest. An international team of researchers worked with local communities to deploy over 80 camera traps to film the elusive animal. Besides rediscovering the echidna, the team uncovered a wealth of species completely new to science, including beetles, spiders, and a remarkable tree-dwelling shrimp.

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When California Banned Flavored Vapes, Many Just Shopped Online

Drugs.com

WEDNESDAY, Nov. 7, 2023 -- California banned menthol cigarettes and flavored vaping products in late 2022, based on concerns the flavors encouraged teens to get hooked on nicotine. But a new study finds many smokers simply shrugged and turned to.

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Developing next-gen traffic signal control systems with air quality in mind

SCIENMAG: Medicine & Health

After a summer that broke all sorts of dismal records in terms of cataclysmic wildfires across North America, there is now an even greater awareness of poor air quality—its myriad health impacts and the overwhelming need for sustainable solutions.

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UN Report Warns That Working in the Sun Causes Skin Cancers

Drugs.com

THURSDAY, Nov. 9, 2023 (Healthday News) -- New data from two United Nations agencies shows that millions of workers toiling under the sun's glare is fueling skin cancer cases around the world. Nearly 1 in 3 deaths from non-melanoma skin cancer is.

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Addgene at SfN23!

addgene Blog

Getting ready for Society for Neuroscience Conference 2023? So are we! Come say hi to us at Addgene's booth, #3422, in the nonprofits section.

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Special Toothpaste Might Curb Peanut Allergy in Adults

Drugs.com

THURSDAY, Nov. 9, 2023 – Researchers are testing a toothpaste that aims to let patients who are sensitive to peanuts and other foods simply brush their allergies away. Doctors already treat some food allergy patients with oral immunotherapy.

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Any activity is better for your heart than sitting -- even sleeping

Science Daily: Pharmacology News

Replacing sitting with as little as a few minutes of moderate exercise a day tangibly improves heart health, according to new research.

Research 106
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Eczema Takes Big Toll on Mental Health, Survey Finds

Drugs.com

THURSDAY, Nov. 9, 2023 -- Eczema can be a burden on the mind as well the body, a new survey shows. People with eczema are more likely to experience depression and anxiety, and it worsens when additional allergic symptoms occur, according to a study.

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Survey reveals 42% of primary care physicians are unfamiliar with biologics to treat asthma

SCIENMAG: Medicine & Health

ANAHEIM, Calif. (Nov. 9, 2023) – Biologics for the treatment of asthma were first introduced about 20 years ago. Since then, more and more people with asthma have found them to be an effective treatment in getting their symptoms under control.

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Smoking Undermines Human DNA That Would Normally Prevent Cancer

Drugs.com

WEDNESDAY, Nov. 8, 2023 -- Everyone knows smoking to be a major cause of cancer. Now, exactly how tobacco smoke triggers tumor development just got a bit clearer, thanks to new Canadian research. According to a team at the Ontario Institute for.

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