Tue.May 07, 2024

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Patient dies in Pfizer study of Duchenne gene therapy

BioPharma Drive: Drug Pricing

Pfizer said the patient, a young boy who was treated earlier last year, had died suddenly. The company is working with trial researchers to investigate further.

Therapies 144
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Genetics, not lack of oxygen, causes cerebral palsy in quarter of cases

Science Daily: Pharmacology News

The world's largest study of cerebral palsy (CP) genetics has discovered genetic defects are most likely responsible for more than a quarter of cases in Chinese children, rather than a lack of oxygen at birth as previously thought.

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Almost All Counterfeit Oxycontin Pills Contain Fentanyl

Drugs.com

TUESDAY, May 7, 2024 -- Lab tests of counterfeit oxycodone (Oxycontin) pills seized by police in Rhode Island in 2022 found 99.3% also contained dangerous fentanyl. It was typically mixed with another potentially deadly drug, xylazine.Both.

Drugs 111
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This sound-suppressing silk can create quiet spaces

Science Daily: Pharmacology News

Researchers developed a silk fabric, which is barely thicker than a human hair, that can suppress unwanted noise and reduce noise transmission in a large room.

Research 123
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Antidote to be announced as Corporate Honoree at MSAA Improving Lives Benefit

Antidote

We are thrilled to be honored as the Multiple Sclerosis Association of America’s Corporate Honoree at their 10th annual Improving Lives Benefit on May 15! This inspiring event supports MSAA’s free programs and services and honors key players in the MS research space.

Research 105
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'Better than graphene' material development may improve implantable technology

Science Daily: Pharmacology News

Move over, graphene. There's a new, improved two-dimensional material in the lab. Borophene, the atomically thin version of boron first synthesized in 2015, is more conductive, thinner, lighter, stronger and more flexible than graphene, the 2D version of carbon. Now, researchers have made the material potentially more useful by imparting chirality -- or handedness -- on it, which could make for advanced sensors and implantable medical devices.

Research 114

More Trending

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New super-pure silicon chip opens path to powerful quantum computers

Science Daily: Pharmacology News

Researchers have invented a breakthrough technique for manufacturing highly purified silicon that brings powerful quantum computers a big step closer.

Research 120
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Planters Peanut Products Under Recall Due to Listeria Risk

Drugs.com

TUESDAY, May 7, 2024 -- Planters peanut products sold at Publix and Dollar Tree in five states are being recalled due to the risk of Listeria contamination, maker Hormel announced.The products are Planters Honey Roasted Peanuts (4 ounces) and.

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Low-energy process for high-performance solar cells

Science Daily: Pharmacology News

Finding reliable, eco-friendly power sources is crucial as our world grapples with increasing energy needs and the urgent call to combat climate change. Solar energy offers one solution, with scientists devising ever more efficient materials for capturing sunlight.

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That 'New Car Smell' Could Be Toxic Carcinogens

Drugs.com

TUESDAY, May 7, 2024 -- “New car smell” is a beloved benefit of buying a new vehicle.However, at least part of that scent could be due to toxic carcinogens released by flame retardants, a new study says.Flame retardant chemicals added to seat.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Mapping the Vertical Integration of Insurers, PBMs, Specialty Pharmacies, and Providers: A May 2024 Update

Drug Channels

It's time for Drug Channels ’ annual update of vertical integration among insurers, PBMs, specialty pharmacies, and providers within U.S. drug channels. Below you’ll find our latest illustration of the major vertical business relationships among the largest companies along with some of the notable activity since our previous update. These organizations continue to exert greater control over patient access, sites of care/dispensing, and pricing, although some have started to unwind their vert

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AI Might Boost Detection of A-Fib

Drugs.com

TUESDAY, May 7, 2024 -- An artificial intelligence (AI) program trained to analyze cardiac ultrasounds can detect abnormal heart rhythms that a doctor is apt to overlook, a new study reports."Atrial fibrillation can come and go, so it might not be.

Doctors 98
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Zenas, with new funding, aims dual-targeting antibody at lupus and MS

BioPharma Drive: Drug Pricing

The $200 million round is the latest evidence that surging interest in autoimmune disease cell therapies could expand to include developers of bispecific antibodies, too.

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Gene Discovery Points to a New Form of Alzheimer's

Drugs.com

TUESDAY, May 7, 2024 -- People who carry two copies of the gene mutation most strongly implicated in Alzheimer’s disease are almost certain to develop brain changes related to the degenerative disorder, a new study says.A single mutated APOE4.

Disease 98
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Prologue, Flagship’s newest startup, looks to mine viruses for new drugs

BioPharma Drive: Drug Pricing

The company is using what it claims is the largest database of viral protein structures to unearth medicines for a range of diseases, said CEO and Flagship origination partner Lovisa Afzelius.

Virus 69
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Scientists May Have Located Your Brain's 'Neural Compass'

Drugs.com

TUESDAY, May 7, 2024 -- Researchers say they’ve identified a human “neural compass” -- a pattern of brain activity that helps prevent humans from becoming lost.For the first time, the internal compass humans use to orient themselves and.

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Verve moves forward with backup base editing therapy

BioPharma Drive: Drug Pricing

Weeks after a safety setback derailed its lead candidate, the company has treated the first participant in a trial of its heart disease treatment Verve-102.

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A Parent's Watchful Eye Does Keep Kids From Drugs, Alcohol: Study

Drugs.com

TUESDAY, May 7, 2024 -- Parents can be very effective buzzkills for their teens, just by letting kids know they’re being closely watched, a new study reports.Teenagers are less likely to drink, smoke or use drugs when parents keep tabs on their.

Drugs 98
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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FDA sets date for advisory meeting on Lilly’s closely watched Alzheimer’s drug

BioPharma Drive: Drug Pricing

After delaying an approval decision for Lilly’s donanemab, the agency now intends to hold an advisory committee meeting on June 10.

FDA 78
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Experimental Drug, Cytisinicline, May Help Folks Kick the Vaping Habit

Drugs.com

TUESDAY, May 7, 2024 -- An experimental anti-nicotine drug appears to help people quit vaping, a new study says. Cytisinicline is a naturally occurring plant-based substance that binds to nicotine receptors in the brain, reducing a person’s.

Drugs 59
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Understanding Market Exclusivity for Orphan Drug Products

Cytel

Here we explore the evolution and impact of market exclusivity policies in the EU and US, highlighting their role in fostering innovation and accessibility in rare disease treatment. Market exclusivity for orphan drugs traces back to the early 1980s in the United States, with the landmark Orphan Drug Act of 1983. This legislation emerged from a pressing need to address “orphan” conditions, i.e., conditions that were abandoned or “orphaned” by the pharmaceutical industry, deemed unprofitable due

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Mandatory EU HTAR Implementation: Part 1

thought leadership

Are You Ready for Mandatory EU Health Technology Assessment Regulation (HTAR) Implementation Beginning January 2025? Pharmaceutical companies need to be prepared for the new European Health Technology Assessment Regulation (HTAR), which will take effect in January 2025. The aim of the HTAR is to accelerate access to new drugs and reduce unnecessary duplication of work.

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Biomarker identification in the realm of rare diseases

Drug Target Review

Why are biomarkers particularly critical in the context of rare diseases? Developing novel therapeutic approaches for rare diseases poses inherent challenges due to the limited populations available for testing. Small patient populations often result in difficulty in determining a significant effect of a therapy, given the low confidence power associated with the statistics.

Disease 59
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New patent for Janssen Prods drug EDURANT

Drug Patent Watch

Annual Drug Patent Expirations for EDURANT Edurant is a drug marketed by Janssen Prods and is included in two NDAs. It is available from one supplier.

Drugs 59
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Trust Transformed: Pharma Marketing in the Post-Cookie Era

Fierce BioTech

Trust Transformed: Pharma Marketing in the Post-Cookie Era dwunderlin Tue, 05/07/2024 - 13:29 Tue, 06/11/2024 - 14:00 Resource Type Webinar David Minkin Clifton Covey Sonia V Gupta Duration 60 Minutes In the backdrop of digital advertising for pharmaceuticals we are undergoing a radical transformation as privacy becomes a paramount concern. With the phase-out of third-party cookies, the industry is compelled to innovate while prioritizing transparency and trust.

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Local Police Departments in the US

Common Sense for Drug Policy Blog

Local Police Departments in the US "As of December 31, 2020, more than 14,700 general-purpose law enforcement agencies in the United States employed about 708,000 full-time sworn officers and 348,000 full-time civilians. Local police departments accounted for about 80% (11,800) of the general-purpose agencies, employing nearly 67% (473,000) of full-time sworn personnel and 36% (126,000) of full-time civilian personnel (figure 1, table 1). 1 "The total number of full-time personnel in local polic

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Navigating the Challenges and Opportunities of the PICO Framework in the New EU HTA Regulation

PPD

The European Union (EU) is on the verge of a significant shift as it prepares to implement new health technology assessment (HTA) regulations in 2025. This change promises a more efficient use of resources, improved patient access to innovative health technologies and strengthened HTAs across the EU. However, it also presents challenges and uncertainties, particularly in relation to the Population, Intervention, Comparator(s) and Outcomes (PICO) framework underpinning the new Joint Clinical Asse

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Law Enforcement Personnel in the US

Common Sense for Drug Policy Blog

Law Enforcement Personnel in the US "In 2020, about 1,056,000 full-time personnel worked for general-purpose law enforcement agencies at the state, county, or local level (table 2). Of these personnel, almost 57% worked for local police departments. Of the 708,000 full-time sworn officers employed across the country, about 67% worked for local police departments.

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Duchenne Muscular Dystrophy - Global Clinical Trial Landscape

Fierce BioTech

Duchenne Muscular Dystrophy - Global Clinical Trial Landscape Duchenne Muscular Dystrophy is a rare genetic disorder characterized by progressive muscle weakness and skeletal degeneration, impacting approximately 1 in 5,000 males globally. Explore the latest trends in Duchenne Muscular Dystrophy clinical trials and discover key findings and analysis from this comprehensive report. jkarimi Tue, 05/07/2024 - 12:36 Duchenne Muscular Dystrophy is a rare genetic disorder characterized by progressive

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Spending on Local Police Departments in the US

Common Sense for Drug Policy Blog

Spending on Local Police Departments in the US "In 2020, nearly $80 billion was budgeted for local police departments nationwide ( table 15 ). The estimated 110 departments serving 250,000 or more residents in 2020 accounted for 43% of this funding. (See table 4.) These departments represented fewer than 1% of all local police departments but employed about 41% of all full-time sworn local officers.

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fEASTback Model: Optimizing Feedback with a Behavioral Perspective

Perficient: Drug Development

Providing feedback is essential for driving innovation, improving technical and behavioral skills, and strengthening team dynamics. The EAST methodology (Easy, Attractive, Social, Timely) offers a powerful framework for delivering feedback in a way that is more easily received and applied, which can help promote an environment of continuous growth. By applying these principles, individuals can overcome common challenges in feedback communication, transforming interactions into opportunities for

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How Long Do Fillers Last?

Olympian Clinical Research

Fillers have become a go-to for those looking to soften wrinkles and add volume to areas like the cheeks, lips, and under the eyes. Using substances like hyaluronic acid or collagen, fillers plump the skin and smooth out lines. A common question we hear at Academic Alliance in Dermatology is: “How long do fillers last?” Let’s break down what influences the longevity of fillers and what you can expect from different types.

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Small Pump May Let Kids Stay Home As They Await New Heart

Drugs.com

TUESDAY, May 7, 2024 -- A small, implantable heart pump could help children await heart transplants at home rather than languishing in a hospital, according to a new study.The pump is surgically attached to augment the heart’s blood-pumping.