Wed.Oct 09, 2024

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Viruses are teeming on your toothbrush, showerhead

Science Daily: Pharmacology News

Microbiologists found that showerheads and toothbrushes are teeming with an extremely diverse collection of viruses -- most of which have never been seen before.

Virus 123
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Common Acne Drug, Benzoyl Peroxide, Might Become Carcinogenic at Room Temperature

Drugs.com

WEDNESDAY, Oct. 9, 2024 -- Widely-used acne creams can become contaminated with a known carcinogen even if kept at room temperature, a new study warns. Creams containing benzoyl peroxide (BPO) can wind up containing high levels of benzene while.

Drugs 69
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Fossils and fires: Insights into early modern human activity in the jungles of Southeast Asia

Science Daily: Pharmacology News

Studying microscopic layers of dirt dug from the Tam Pa Ling cave site in northeastern Laos has provided a team of archaeologists further insights into some of the earliest evidence of Homo sapiens in mainland Southeast Asia. The site, which has been studied for the past 14 years, has produced some of the earliest fossil evidence of our direct ancestors in Southeast Asia but now a new study has reconstructed the ground conditions in the cave between 52,000 and 10,000 years ago.

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Perficient Included in IDC Market Glance: Digital Business Professional Services Report

Perficient: Drug Development

Today’s digital landscape is dynamic. It favors speed over size, agility over efficiency, and cross-functional collaboration over rigid structures. You must be prepared to adapt and scale your teams as priorities shift. Moving forward requires a comprehensive digital strategy that outlines the capabilities, agility, and alignment needed to stay ahead of digital disruption.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Underwater caves yield new clues about Sicily's first residents

Science Daily: Pharmacology News

Archaeological surveys suggest that coastal and underwater cave sites in southern Sicily contain important new clues about the path and fate of early human migrants to the island.

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From Chaos to Clarity: Streamlining Your Generic Drug Portfolio

Drug Patent Watch

The pharmaceutical industry plays a crucial role in global healthcare, providing essential medications that improve and save lives. Within this industry, generic pharmaceuticals are particularly important due to their affordability and accessibility.

More Trending

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Only 1 in 5 Large Companies' Health Plans Cover New Weight-Loss Meds, Wegovy, Zepbound, for Employees

Drugs.com

WEDNESDAY, Oct. 9, 2024 -- When it comes to coverage for the pricey GLP-1 weight-loss drugs Wegovy and Zepbound, only a fifth of large U.S. companies cover the medications in their health insurance plans, a new survey shows. In a report published.

Drugs 64
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Study probes how eating less can extend lifespan

Science Daily: Pharmacology News

Researchers tracked the health of nearly one thousand mice on a variety of diets to see if these diets would extend the mice's lifespan. The study was designed to ensure that each mouse was genetically distinct, which allowed the team to better represent the genetic diversity of the human population. By doing so, the results are made more clinically relevant, elevating the study to one of the most significant investigations into aging and lifespan to date.

Research 105
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AI startup Basecamp allies with the Broad to dream up ‘programmable’ genetic medicines

BioPharma Drive: Drug Pricing

The company, which is building a database of biological interactions found in nature, revealed $60 million in funding and a collaboration with David Liu’s lab.

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Inspired by Spider-Man, a lab recreates web-slinging technology

Science Daily: Pharmacology News

Researchers took the imaginary scenes from Spider-Man seriously and created the first web-slinging technology in which a fluid material can shoot from a needle, immediately solidify as a string, and adhere to and lift objects.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Lilly partners with AI specialist Insitro to develop metabolic medicines

BioPharma Drive: Drug Pricing

The latest deal in AI drug discovery is a twist on the usual big pharma-startup collaboration model, with Insitro licensing technology and Lilly eligible for royalties.

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Over 160,000 new viruses discovered by AI

Science Daily: Pharmacology News

161,979 new RNA viruses have been discovered using a machine learning tool that researchers believe will vastly improve the mapping of life on Earth and could aid in the identification of many millions more viruses yet to be characterized.

Virus 93
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Lilly names Mount Sinai scientist as first chief AI officer

BioPharma Drive: Drug Pricing

Thomas Fuchs will lead artificial intelligence initiatives across Lilly, including in drug discovery, clinical trials and manufacturing.

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Genetic analysis of 25,000 Chinese mothers and infants reveals unique genes associated with disease risk

Science Daily: Pharmacology News

Genome-wide association studies have great potential for advancing our understanding of the genetic background of diseases, but so far, few association studies have focused on maternal and newborn diseases, and most have been based on predominantly European populations. To fill these gaps, researchers generated and analyzed full-genome DNA sequences from non-invasive prenatal blood tests collected from over 25,000 pregnant women, all of whom were Han Chinese.

Disease 90
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Steady Rise in U.S. Cases of Tick-Borne Babesiosis Disease

Drugs.com

WEDNESDAY, Oct. 9, 2024 -- Cases of a tick-borne parasitic disease have steadily increased in recent years, a new study shows.Rates of babesiosis increased an average 9% a year in the United States between 2015 and 2022, researchers reported in.

Disease 59
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Nature and plastics inspire breakthrough in soft sustainable materials

Science Daily: Pharmacology News

Using peptides and a snippet of the large molecules in plastics, materials scientists have developed materials made of tiny, flexible nano-sized ribbons that can be charged just like a battery to store energy or record digital information.

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Protein prediction wins chemistry Nobel; Alnylam submits an all-important drug application

BioPharma Drive: Drug Pricing

AlphaFold’s developers were awarded science’s top prize. Elsewhere, J&J is shuttering an intriguing cancer study and Alnylam is asking for approval of a drug that could rival a Pfizer blockbuster.

Science 57
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NASA's Hubble watches Jupiter's Great Red Spot behave like a stress ball

Science Daily: Pharmacology News

Astronomers have observed Jupiter's legendary Great Red Spot (GRS), an anticyclone large enough to swallow Earth, for at least 150 years. But there are always new surprises -- especially when NASA's Hubble Space Telescope takes a close-up look at it. Hubble's new observations of the famous red storm, collected 90 days between December 2023 to March 2024, reveal that the GRS is not as stable as it might look.

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ProPharma Honored with 2024 CPHI Regulatory and Compliance Award

thought leadership

ProPharma wins CPHI Pharma Award for excellence in regulatory and compliance innovation, enhancing efficiency and accelerating market access for life-saving therapies.

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Another step towards decoding smell

Science Daily: Pharmacology News

We often only realize how important our sense of smell is when it is no longer there: food is not as tasty as it once was, or we no longer react to dangers such as the smell of smoke. Researchers have investigated the neuronal mechanisms of human odor perception for the first time. Individual nerve cells in the brain recognize odors and react specifically to the smell, the image and the written word of an object, for example a banana.

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Development of an orally bioavailable covalent STING inhibitor

Covalent Modifiers

NIU, G.-H., Hsiao, W.-C., Lee, P.-H., Zheng, L.-G., Yang, Y.-S., Huang, W.-C., Hsieh, C.-C., Chiu, T.-Y., Wang, J.-Y., Chen, C.-P., Huang, C.-L., You, M.-S., Kuo, Y.-P., Wang, C.-M., Wen, Z.-H., Yu, G.-Y., Chen, C.-T., Chi, Y.-H., Tung, C.-W., Hsu, S.-C., Yeh, T.-K., Sung, P.-J., Zhang, M. M., and Tsou, L. K. ChemRxiv , 2024 [link] Pharmacological inhibition of cGAS-STING-controlled innate immune pathway is an emerging therapeutic strategy for a myriad of inflammatory diseases, including autoimm

Disease 52
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Ultra-sensitive robotic 'finger' can take patient pulses, check for lumps

Science Daily: Pharmacology News

Researchers have developed a soft robotic 'finger' with a sophisticated sense of touch that can perform routine doctor office examinations, including taking a patient's pulse and checking for abnormal lumps.

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Sygnature Discovery has chosen Elsevier as new Preferred Partner to Empower its Global Team of Chemists

Sygnature Discovery

Sygnature Discovery is pleased to announce our new partner Elsevier, a global information and analytics company. More than 400 Sygnature chemists based in North America and the UK now have access to Elsevier’s cutting-edge chemistry platform, Reaxys, This collaboration is a significant milestone in Sygnature’s ongoing efforts to enhance its scientific capabilities and streamline its workflows.

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Adding vagus nerve stimulation to training sessions may boost how well sounds are perceived

Science Daily: Pharmacology News

Just as a musician can train to more sharply distinguish subtle differences in pitch, mammals can improve their ability to interpret hearing, vision, and other senses with practice. This process, which is called perceptual learning, may be enhanced by activating a major nerve that connects the brain to nearly every organ in the body, a new study in mice shows.

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Accessibility Compliance in Medical Device Software: A Strategic Imperative

Perficient: Drug Development

Accessibility compliance in medical device software is more than a regulatory checkbox; it’s a strategic necessity that impacts user safety, market reach, and brand reputation. For decision makers such as Chief Product Officers, Heads of Engineering, and VPs of Technology, ensuring that software is accessible for people with disabilities is important for several reasons.

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The new fashion: Clothes that help combat rising temperatures

Science Daily: Pharmacology News

A team of international researchers has developed a natural fabric that urban residents could wear to counter rising temperatures in cities worldwide, caused by buildings, asphalt, and concrete.

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Vendors of Synthetic Nicotine Vapes on Instagram Are Skirting FDA Rules

Drugs.com

WEDNESDAY, Oct. 9, 2024 -- The U.S. Food and Drug Administration currently mandates strong health warnings when vapes containing synthetic nicotine are advertised on Instagram and other social media.Trouble is, most vendors aren't adhering to those.

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Do fungi recognize shapes?

Science Daily: Pharmacology News

Fungi don't have eyes or a brain, but their intelligent behaviors may surprise you. New research suggests that fungi may be able to recognize shapes.

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Common Acne Drug Might Become Carcinogenic at Room Temperature

Drugs.com

WEDNESDAY, Oct. 9, 2024 -- Widely-used acne creams can become contaminated with a known carcinogen even if kept at room temperature, a new study warns.Creams containing benzoyl peroxide (BPO) can wind up containing high levels of benzene while.

Drugs 52
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Newly discovered Late Cretaceous birds may have carried heavy prey like extant raptors

Science Daily: Pharmacology News

Newly discovered birds from Late Cretaceous North America were hawk-sized and had powerful raptor-like feet, according to a new study.

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Heat Stress in Pregnancy Might Affect a Babies' Development Later

Drugs.com

WEDNESDAY, Oct. 9, 2024 -- Hot weather can be more than just uncomfortable and annoying: New research finds it can impact an infant’s development both before and after birth.Babies are more likely to be delivered at low birth weight as an expecting.

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Understanding Clinical Data Management Services in Clinical Trials: A Comprehensive Breakdown

ProRelix Research

Understanding Clinical Data Management Services in Clinical Trials: A Breakdown, including study design and planning, data collection and validation, data monitoring and cleaning, database lock and archival, and regulatory submissions […] The post Understanding Clinical Data Management Services in Clinical Trials: A Comprehensive Breakdown appeared first on ProRelix Research.

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Affordable Care Act Is Helping Young Americans With Cancer Beat the Disease

Drugs.com

WEDNESDAY, Oct. 9, 2024 -- Cancer in young adults is rare, but the insurance coverage given them by the Affordable Care Act (ACA) has greatly boosted the survival of people ages 19 to 25 who got the disease, a new study shows.The findings were.

Disease 52
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Five Crucial Trends Facing U.S. Drug Wholesalers in 2024 and Beyond

Drug Channels

As regular readers of Drug Channels know, U.S. distribution and dispensing channels for prescription drugs are undergoing significant evolution and consolidation as the changing economics of pharmaceuticals challenge conventional business models. During this period of volatility, the core business model of the Big Three public pharmaceutical distribution companies—Cardinal Health, Cencora, and McKesson—remains intact.