Science Daily: Pharmacology News
DECEMBER 1, 2023
A new study shows that dopamine release in the human brain plays a crucial role in encoding both reward and punishment prediction errors. This means that dopamine is involved in the process of learning from both positive and negative experiences, allowing the brain to adjust and adapt its behavior based on the outcomes of these experiences.
Chemical Biology and Drug Design
DECEMBER 1, 2023
BD could restrain CRC growth through repressing the circ_0068464/miR-520h/ATG5 axis. Abstract Bruceine D (BD) from Brucea javanica (L) exerts an antitumor effect in several human cancers. At present, it has not been reported whether BD inhibits the malignancy of colorectal cancer (CRC) cells. Therefore, investigating the role and regulatory mechanisms of BD in CRC is the main thrust of this study.
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Science Daily: Pharmacology News
DECEMBER 1, 2023
An international multidisciplinary team consisting of solar physicists, geophysicists, and historians from nine countries analysed observations of an extreme solar-terrestrial storm reported in historical records from February 1872. Their findings confirm that a moderate sunspot group triggered one of the largest magnetic storms ever recorded, almost covering the entire night sky with colourful aurorae in both hemispheres.
Chemical Biology and Drug Design
DECEMBER 1, 2023
With network pharmacology, we tried to clarify the crucial bioactive components and underlying mechanism of Prunella vulgaris L. (PVL) against hepatocellular carcinoma (HCC). We found that PVL targets multiple cancer-related pathways and downstream targets, and quercetin, as one of the crucial components of PVL, has tumor-suppressive activity on HCC cells, probably via modulating PI3K/AKT1 pathway.
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NIOSH Science Blog: Drugs
DECEMBER 1, 2023
The holidays can be the most stressful time of the year—especially for retail workers who often work long hours and irregular shifts. These workers might also deal with crowds, violence, and robberies. This blog highlights the risk of fatigue, violence, and stress for workers in retail stores and provides strategies for making retail work environments and workers safer and healthier.
Drugs.com
DECEMBER 1, 2023
FRIDAY, Dec. 1, 2023 -- Bodybuilders are largely unaware that the protein supplements they use to bulk up might harm their fertility, a new study shows.Four out of five male gym enthusiasts (79%) said they use protein supplements as part of their.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
DECEMBER 1, 2023
FRIDAY, Dec. 1, 2023 -- A new study of identical twins has provided fresh evidence that a vegan diet can vastly improve a person’s heart health.Twins assigned a vegan diet for two months had significant improvements in cholesterol, insulin and.
Drug Target Review
DECEMBER 1, 2023
A groundbreaking new technology that can extract mesenchymal stem cells (MSCs) directly from pure bone barrow, known as bone marrow aspirate (BMA) without dilution has been developed by researchers from the Critical Analytics for Manufacturing Personalised-Medicine (CAMP) Interdisciplinary Research Group (IRG) of Singapore-MIT Alliance for Research and Technology (SMART).
BioPharma Drive: Drug Pricing
DECEMBER 1, 2023
The EMA's safety committee has more questions for makers of the in-demand therapies as it reviews whether the drugs are linked to the risk of suicidal thoughts.
Drugs.com
DECEMBER 1, 2023
FRIDAY, Dec. 1, 2023 -- Got a naturally sunny disposition? It might protect you from dementia as the years advance, new research shows.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
biobide
DECEMBER 1, 2023
Cannabis derivatives In 2022 the global legal cannabis market was valued at USD 22.1 billion. This is forecasted to grow rapidly, with a growth rate of 25.5% by 2030. A Key contributing factor to this significant growth prediction is the accelerating legalization of cannabis products and the growing acceptance of its use in the medical field and consumer goods.
Drugs.com
DECEMBER 1, 2023
FRIDAY, Dec. 1, 2023 -- Doing some squats during commercial breaks or between YouTube videos can help couch potatoes keep their minds sharp, a new study suggests.Young volunteers who did short sets of squat exercises every now and then while.
Collaborative Drug
DECEMBER 1, 2023
Dear CDD community: As we’ve been publishing annual CDD holiday poems for years, there was sufficient content as a “training set” covering the meaning and voice for ChatGPT to capture the spirit. Our new deep learning algorithm securely identifies structures and public structures similar to your own private molecules.
Drugs.com
DECEMBER 1, 2023
FRIDAY, DEC. 1, 2023 (Healthday News) -- Millions of American kids and teens love to play the game of baseball, but the sport can leave many with elbow pain and injuries, new research finds.“When we look at the forces that baseball players, even.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
SCIENMAG: Medicine & Health
DECEMBER 1, 2023
What happens in the human brain when we learn from positive and negative experiences? To help answer that question and better understand decision-making and human behavior, scientists are studying dopamine. Credit: Wake Forest University School of Medicine What happens in the human brain when we learn from positive and negative experiences?
Drugs.com
DECEMBER 1, 2023
FRIDAY, Dec. 1, 2023 (Healthday News) -- In testimony provided Thursday to members of Congress, the head of the U.S. Centers for Disease Control and Prevention said that a surge in respiratory illnesses in China is not being fueled by a new.
Science Daily: Pharmacology News
DECEMBER 1, 2023
Researchers give medieval Cambridge residents the 'Richard III treatment' to reveal hard-knock lives of those in the city during its famous university's early years. Study of over 400 remains from a hospital cemetery shows spectrum of medieval poverty, and suggests that some of Cambridge University's earliest scholars ended up in penury.
Drugs.com
DECEMBER 1, 2023
FRIDAY, Dec. 1, 2023 -- The repeat head injuries suffered by football players, boxers and other athletes appear to affect brain health long after players have given up their sport.New research from Johns Hopkins University in Baltimore could.
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SCIENMAG: Medicine & Health
DECEMBER 1, 2023
Upon infection or immunization, all jawed vertebrate species generate proteins called antibodies that bind and neutralize pathogens. Strong and long-lasting antibody responses in warm-blooded species such as mammals are produced in secondary lymphoid microstructures (SLMs) among which germinal centers (GCs) are the centerpiece.
Drugs.com
DECEMBER 1, 2023
FRIDAY, Dec. 1, 2023 (Healthday News) -- Shoppers should steer clear of any pre-cut cantaloupe if the brand is unknown, as a salmonella outbreak linked to the fruit continues to widen, U.S. health officials warned Thursday.Eighteen more illnesses.
Science Daily: Pharmacology News
DECEMBER 1, 2023
The universe is expanding. How fast it does so is described by the so-called Hubble-Lemaitre constant. But there is a dispute about how big this constant actually is: Different measurement methods provide contradictory values. This so-called 'Hubble tension' poses a puzzle for cosmologists. Researchers are now proposing a new solution: Using an alternative theory of gravity, the discrepancy in the measured values can be easily explained -- the Hubble tension disappears.
BioPharma Drive: Drug Pricing
DECEMBER 1, 2023
The company won’t continue development of a twice-daily dose of its experimental weight loss medicine danuglipron after study data showed high rates of side effects.
Science Daily: Pharmacology News
DECEMBER 1, 2023
Micrometeorites originating from icy celestial bodies in the outer Solar System may be responsible for transporting nitrogen to the near-Earth region in the early days of our solar system.
Drugs.com
DECEMBER 1, 2023
FRIDAY, Dec. 1, 2023 -- A technique doctors use to preserve donated organs is actually doing no good, and might even be harming the organs, a new study reports.Physicians routinely dose deceased organ donors with thyroid hormones, in a bid to.
Cytel
DECEMBER 1, 2023
Last week, Robert Szulkin, Research Principal, Real World Evidence, discussed the need for real-world evidence studies , noting that not all clinical questions can be answered by randomized trials, such as in cases of rare diseases where it may be difficult to find enough patients for the trial. In these cases, he highlights that single-arm trials with an external comparator arm from real-world data may be a good alternative.
Science Daily: Pharmacology News
DECEMBER 1, 2023
Astronomers studying images from the James Webb Space Telescope have identified an object as a 'dusty star-forming galaxy' from nearly 1 billion years after the Big Bang. They have also discovered more than a dozen additional candidates, suggesting these galaxies might be three to 10 times as common as expected. If that conclusion is confirmed, it suggests the early universe was much dustier than previously thought.
Fierce BioTech
DECEMBER 1, 2023
Immunotherapy is a treatment which, if it triggers a positive response, can have a miraculous effect on the body’s ability to fight cancer. | CST fellow Amrik Singh outlines some of the key progress being made around CAR-T therapy and the impact that this highly specialized technique can have on cancer patients, even those who have been previously unresponsive to other forms of treatment.
Drug Patent Watch
DECEMBER 1, 2023
This chart shows the pharmaceutical companies with the most supplementary protection certificates (SPCs) in Finland. SPCs are used in European Union and select others to encourage pharmaceutical innovation by compensating… The post Which pharmaceutical companies have the most SPCs in Finland? appeared first on DrugPatentWatch - Make Better Decisions.
Crucial Data Solutions
DECEMBER 1, 2023
The clinical research industry is currently dealing with a great deal of uncertainty, with various solutions providers announcing layoffs often. The post In a Time of Uncertainty for Clinical Researchers, Reliable Partners are Vital appeared first on Crucial Data Solutions.
Drug Patent Watch
DECEMBER 1, 2023
Annual Drug Patent Expirations for ANORO+ELLIPTA Anoro Ellipta is a drug marketed by Glaxosmithkline and is included in one NDA. It is available from one supplier. There are fourteen patents… The post New patent for Glaxosmithkline drug ANORO ELLIPTA appeared first on DrugPatentWatch - Make Better Decisions.
Agency IQ
DECEMBER 1, 2023
In this ongoing feature, AgencyIQ looks at public data to determine what the FDA is likely to do in the month ahead, including key deadlines, meetings, events, planned regulations, comment periods and more. The goal: To allow regulatory professionals to better anticipate and prepare for upcoming events and catalysts. Fill out the form to read the full article.
Drug Patent Watch
DECEMBER 1, 2023
Annual Drug Patent Expirations for TRELEGY+ELLIPTA Trelegy Ellipta is a drug marketed by Glaxosmithkline and is included in one NDA. It is available from one supplier. There are fourteen patents… The post New patent for Glaxosmithkline drug TRELEGY ELLIPTA appeared first on DrugPatentWatch - Make Better Decisions.
Agency IQ
DECEMBER 1, 2023
In this returning feature, AgencyIQ looks at public data to determine what the Environmental Protection Agency is planning to do in the month ahead, including deadlines, meetings, events, planned regulations, comment periods, and more. Fill out the form to read the full article.
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