Wed.Nov 27, 2024

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Diabetes Drug Metformin Might Help Fight Lung Cancer

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- Already the go-to drug of choice for millions with type 2 diabetes, metformin might also fight lung cancer if those patients have it as well, new research shows.Metformin appears to help boost the benefits of.

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How to Scale Up with Cohere: Insights from Aidan Gomez

BenchSci

Last month, we welcomed Aidan Gomez, CEO and Co-founder of Cohere, for our Scale Up series. As a leader in AI, Aidan co-authored the influential " Attention is All You Need " paper during his time at Google and has since co-founded Cohere , the leading data security-focused enterprise AI company. With the explosion of advancements in AI and its growing impact on industries worldwide, including drug discovery, our team was eager to hear Aidan’s unique technical perspective on building and scaling

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Irregular Sleep Might Raise Odds for Heart Attack, Stroke

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- Folks with irregular sleep patterns might have an increased risk of a heart attack or stroke, a new study says.People who doze off and wake up at extremely varied times day by day have a 26% increased risk of a.

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Moving 'hotspot' created world's longest straight underwater mountain belt

Science Daily: Pharmacology News

New research has revealed that the Ninetyeast Ridge -- the Earth's longest straight underwater mountain chain -- formed through a different process than previously believed. Stretching 5000 km along the Indian Ocean's 90-degree east longitude and nearly matching the length of North America's Rocky Mountains, the ridge offers crucial new insights into the movement of the Earth's tectonic plates.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Holiday Travel With a Loved One With Dementia: An Expert Offers Tips

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- Thanksgiving travel is a must for millions of Americans, but those plans will be complicated for some because they’re traveling with a loved one who has Alzheimer’s disease or dementia.“A family trip to visit a loved one.

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How Intra-Cellular surprised Wall Street by breaking character

BioPharma Drive: Drug Pricing

The biotechnology company, which sees itself as "pretty conservative," recently put out an ambitious long-term revenue forecast for its schizophrenia and depression medicine Caplyta.

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'Genetic time machine' reveals complex chimpanzee cultures

Science Daily: Pharmacology News

Chimpanzees are known for their remarkable intelligence and use of tools, but could their cultures also evolve over time like human cultures? A new, multidisciplinary study suggests that some of their most advanced behaviors may have been passed down and refined through generations.

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Scientists Find Way to Deliver Medicines Across Brain's Protective Barrier

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- The blood-brain barrier is a natural membrane that protects your brain from toxins and germs.Unfortunately, this barrier also hampers the delivery of important medicines and therapies into the brain.But researchers now.

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Discovering the traits of extinct birds

Science Daily: Pharmacology News

Analysis of 216 extinct species by biologists found birds endemic to islands, occupied ecologically specific niche, lacking flight, with large bodies and sharply angled wings were the ones likely to disappear the soonest after 1500.

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Perficient Colleagues Donate 11,000+ Pounds of Food and 46,000+ Meals During Hunger Action Month

Perficient: Drug Development

Perficient has a long-standing reputation as a philanthropic organization with colleagues who are driven and passionate about making a collective difference. In the spirit of giving back, our Giving Employee Resource Group (ERG) partnered with Feeding America for the third year in a row in support of Hunger Action Month (HAM), a global campaign that seeks to spread awareness and fight food insecurity.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Identification of a covalent NEK7 inhibitor to alleviate NLRP3 inflammasome-driven metainflammation

Covalent Modifiers

Jin, X., Yang, Y., Liu, D. et al. Cell Commun Signal 22 , 565 (2024). [link] Aberrant activation of NLRP3 inflammasome is associated with a variety of inflammatory diseases. Advances in understanding the molecular mechanisms of NLRP3 inflammasome have revealed that NEK7 is an essential component for its activation, but the development of drugs specifically targeting NEK7 remains challenging.

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Kronos, Idorsia plan layoffs; PTC shelves ALS drug

BioPharma Drive: Drug Pricing

Kronos is cutting 83% of its workforce, while Idorsia is considering eliminating as many as 270 jobs. Elsewhere, PTC disclosed negative Phase 2 results for its ALS drug candidate utreloxastat.

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Understanding Vue.js Form Input Bindings: A Comprehensive Guide

Perficient: Drug Development

This blog explores how to work with various form inputs in Vue.js, such as text fields, checkboxes, radio buttons, select boxes, and more. Aimed at beginners, it focuses on Vue’s powerful data binding features for creating interactive forms in dynamic web applications. Text Input Bindings Text inputs are the most basic form elements, allowing users to enter single-line text.

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Sarepta rebuilds drug pipeline with Arrowhead deal

BioPharma Drive: Drug Pricing

A broad licensing and research alliance will hand Sarepta four clinical-stage candidates, while Arrowhead receives $500 million in cash and another $325 million in equity investment.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Marketing of Synthetic Cannabinoid Receptor Agonists

Common Sense for Drug Policy Blog

Marketing of Synthetic Cannabinoid Receptor Agonists "This study provides evidence of a rapidly evolving and active online marketplace from which SCRA vaping products seem to be easily obtainable, but also difficult to identify as controlled substances. Using simple search terms on a widely used search engine, we identified 62 websites selling SCRA vaping products, with 1225 individual listings and 128 unique brands.

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Website Project Management Tips

Perficient: Drug Development

Are you a project manager who has just been handed a new website implementation or redesign project for the first time? Maybe you have a project assigned to you, but you don’t usually manage projects. If so, here are five website project management tips to keep in mind as you run your project: Identify Key Stakeholders Identify all key stakeholders who need to know about the project but aren’t involved in the day-to-day work.

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Synthetic Cannabinoid Receptor Agonists and Vape Liquids

Common Sense for Drug Policy Blog

Synthetic Cannabinoid Receptor Agonists and Vape Liquids "SCRA vaping products were almost exclusively on sale as liquid formulations for refilling EVDs. It therefore does not appear that the rise in popularity of disposable nicotine e-cigarettes [ 17 ] has so far impacted on the online SCRA vaping product market. The most common bottle size on sale was 5mL.

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Ultraprocessed Foods Might Help Trigger Psoriasis

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- Ultraprocessed foods have been linked to a myriad of health issues, and a new study suggests that the autoimmune skin disease psoriasis might be added to that list. "Results of this study showed an association between.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Limitations of JSON API and REST API

Perficient: Drug Development

Modern web development is now based on APIs (Application Programming Interfaces), which allow for smooth system-to-system communication. Both JSON API and REST API, which enable structured data transfer, are among the most used standards. They have various limits that developers must consider when creating applications, despite their widespread use and broad range of features.

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Nerve Stimulation Device Might Ease Long COVID Symptoms

Drugs.com

FRIDAY, Nov. 29, 2024 -- A painless nerve-zapping device called Transcutaneous Electrical Nerve Stimulation (TENS) has long been used to ease arthritis, back pain and other ailments.Now, researchers say TENS might also work to ease the fatigue and.

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Pharma AI is Changing Clinical Trials by Optimizing Patient Selection

Reprocell

In recent years, the pharmaceutical industry has increasingly harnessed artificial intelligence (AI) to make clinical trials more efficient and effective. One of the most powerful applications of AI in this space is its ability to help researchers identify patient groups most likely to benefit from specific drugs. By making patient selection and recruitment processes more targeted, AI-driven tools not only improve trial outcomes but also accelerate the journey of new drugs to market.

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Heart Trouble Harms Men's Brains Far Sooner Than Women's

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- Men with heart risk factors tend to lose their brain health more quickly than women with similar heart risks, a new study finds.These men face brain decline as early as their mid-50s, while women are most susceptible.

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Beyond ELISA: the future of biomarker validation

Drug Target Review

Introduction Biomarkers are becoming increasingly essential in drug development and clinical practice, driving the need for more precise validation methods. As the demand for personalised treatments grows, regulatory bodies are adapting their standards to support advanced techniques that go beyond traditional approaches. For example, the European Medicines Agency (EMA), in its Regulatory Science Strategy to 2025 , has highlighted the critical role of biomarker discovery, qualification and utilis

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Soccer 'Headers' Could Pose Danger to Brains

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- Bouncing a soccer ball off the head during play could be doing real damage to the brain, a new study suggests.MRI brain scans of male and female soccer athletes suggests that lots of "heading" could damage areas of the.

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How Middleware Transforms Request Handling in Web Development

Perficient: Drug Development

What is Middleware? Middleware is like a helper that runs before your web server finishes handling a request. It can modify the request or response, such as changing data, changing where the request goes, or modifying how things look. Middleware runs before the server looks for cached content or matches the request to a specific route (URL pattern).

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Things You Should Know Before Hiring a CDMO

DS in Pharmatics

Learn the critical factors to consider before partnering with a CDMO, ensuring your drug development project aligns with the right expertise and capabilities.

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Vue.js Components: A Guide to Building Scalable and Modular UIs

Perficient: Drug Development

In this blog, we’ll explore the importance of components, how to create them, and best practices for building modular, reusable UIs. Why Vue Components Are Essential for Building Scalable UIs Components are a core feature of Vue.js, known for its simplicity and flexibility. They serve as the building blocks of Vue applications, enabling developers to break down the user interface into smaller, self-contained units.

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Zepbound Slashes Diabetes Risk in Obese Users

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- The cutting-edge weight-loss drug Zepbound can protect obese people from developing type 2 diabetes, a new clinical trial has found.Zepbound reduced the risk of diabetes in obese prediabetic patients by more than 90%.

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High-Intensity Drinking vs Binge Drinking

Common Sense for Drug Policy Blog

High-Intensity Drinking vs Binge Drinking "Since the early 1990s, binge drinking (defined as drinking at least 4 drinks in a row for women or at least 5 drinks in a row for men) has been a key indicator of risky drinking. "However, the binge threshold may not clearly distinguish drinking risk. A person who consumes five drinks over a few hours may or may not show signs of intoxication, depending on factors including body composition, food and water intake, and tolerance.

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U.S. Abortion Numbers Dipped Slightly in 2022

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- The rate and number of abortions among U.S. women took a slight dip in 2022 compared to 2021, according to the latest data from the U.S. Centers for Disease Control and Prevention (CDC).In late June of 2022, the U.S.

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Trump Picks Vaccine Mandate Critic Dr. Jay Bhattacharya to Head National Institutes of Health

Drugs.com

WEDNESDAY, Nov. 27, 2024 -- President-elect Donald Trump has tapped Dr. Jay Bhattacharya, a Stanford health economist and critic of pandemic lockdowns and vaccine mandates, to lead the nation's largest medical research agency, the National.

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