Tue.Apr 30, 2024

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Researchers identify over 2,000 genetic signals linked to blood pressure in study of over one million people

Science Daily: Pharmacology News

Researchers have discovered over a hundred new regions of the human genome, also known as genomic loci, that appear to influence a person's blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is a highly complex trait influenced by thousands of different genetic variants.

Research 124
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Enlaza gets JP Morgan, Regeneron backing for covalent biologics

BioPharma Drive: Drug Pricing

The funds will help the cancer-focused startup Enlaza bring “several development candidates” towards human testing in the next few years, its CEO said.

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Methane emissions from landfill could be turned into sustainable jet fuel in plasma chemistry leap

Science Daily: Pharmacology News

Researchers have developed a chemical process using plasma that could create sustainable jet fuel from methane gas emitted from landfills, potentially creating a low-carbon aviation industry.

Research 116
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Lilly hikes revenue forecast by $2B as GLP-1 drug sales climb

BioPharma Drive: Drug Pricing

Supply continues to be tight, however, and the company anticipates further sales growth to be limited by how quickly it can bring on additional production capacity.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Painless Skin Patch Could Deliver Vaccines to Kids

Drugs.com

TUESDAY, April 30, 2024 -- Kids who don’t like vaccination shots might soon have an alternative in a painless skin patch, researchers say.More than 90% of 190 Gambian infants were protected from measles and all were protected from rubella after.

Vaccine 111
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Biodegradable 'living plastic' houses bacterial spores that help it break down

Science Daily: Pharmacology News

A new type of bioplastic could help reduce the plastic industry's environmental footprint. Researchers have developed a biodegradable form of thermoplastic polyurethane (TPU) filled with bacterial spores that, when exposed to nutrients present in compost, germinate and break down the material at the end of its life cycle.

Research 111

More Trending

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Trotting robots reveal emergence of animal gait transitions

Science Daily: Pharmacology News

A four-legged robot trained with machine learning has learned to avoid falls by spontaneously switching between walking, trotting, and pronking -- a milestone for roboticists as well as biologists interested in animal locomotion.

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All Women Need Mammograms Beginning at Age 40, Expert Panel Says

Drugs.com

TUESDAY, April 30, 2024 -- All women should start getting mammograms every other year beginning at age 40, the nation’s top panel of preventive health experts announced Tuesday.About 20% more lives can be saved from breast cancer by moving the.

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Tsetse fly protein provides anticoagulant with its own on-off switch

Science Daily: Pharmacology News

A completely novel way to develop 'surpamolecules' for drug discovery could have application in immunotherapy as well as this breakthrough design for an anticoagulant with on-demand reversibility.

Drugs 104
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When in Life Are Folks Most Lonely?

Drugs.com

TUESDAY, April 30, 2024 -- At what age does loneliness strike adults the hardest?A new review maps it out, finding that people are more lonely as young adults, grow less lonely as they approach middle age, and then fall back into loneliness in old.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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A virus could help save billions of gallons of wastewater produced by fracking

Science Daily: Pharmacology News

An estimated 168 billion gallons of wastewater -- or produced water -- is generated annually by the Permian Basin fracking industry, according to a 2022 report. The major waste stream has proved both difficult and costly to treat because of the chemical complexity of the water.

Virus 101
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Florida Dolphin Found Infected With Bird Flu

Drugs.com

TUESDAY, April 30, 2024 -- H5N1 avian "bird" flu is making headlines this week, with new reports finding inactive virus detected in 1 in 5 U.S. milk samples. That means the virus is infecting mammals such as dairy cows, and now researchers report.

Virus 98
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NASA's Webb maps weather on planet 280 light-years away

Science Daily: Pharmacology News

Researchers have successfully used NASA's James Webb Space Telescope to map the weather on the hot gas-giant exoplanet WASP-43 b.

Research 119
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USDA Testing Beef Amid Bird Flu Outbreak in Dairy Cows

Drugs.com

TUESDAY, April 30, 2024 -- As bird flu continues to spread among dairy cows, the U.S. Department of Agriculture said Monday it is now testing ground beef for any presence of the virus.The agency said it is sampling ground beef bought in grocery.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Webb captures top of iconic horsehead nebula in unprecedented detail

Science Daily: Pharmacology News

NASA's James Webb Space Telescope has captured the sharpest infrared images to date of a zoomed-in portion of one of the most distinctive objects in our skies, the Horsehead Nebula. These observations show the top of the 'horse's mane' or edge of this iconic nebula in a whole new light, capturing the region's complexity with unprecedented spatial resolution.

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1 in 20 ER Visits Involve Homeless People

Drugs.com

TUESDAY, April 30, 2024 -- At major medical centers across the southeast, 1 in every 20 visits to emergency departments involve people who are homeless or face "housing insecurity," a new U.S. study finds.Concerns of suicide was the leading.

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Chasing Novo and Lilly: The obesity drugs that could challenge Wegovy and Zepbound

BioPharma Drive: Drug Pricing

Large and small drugmakers are vying for a piece of what analysts view as one of the biggest market opportunities in the pharma industry's history. Here’s what’s coming next.

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Staying Fit Boosts Kids' Mental Health

Drugs.com

TUESDAY, April 30, 2024 -- The benefits of physical fitness for kids spill over into their mental health, new research shows.Getting plenty of exercise may guard against depressive symptoms, anxiety and attention-deficit hyperactivity disorder.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Climate change and mercury pollution stressed plants for millions of years

Science Daily: Pharmacology News

The link between massive flood basalt volcanism and the end-Triassic (201 million years ago) mass-extinction is commonly accepted. However, exactly how volcanism led to the collapse of ecosystems and the extinction of entire families of organisms is difficult to establish. Extreme climate change from the release of carbon dioxide, degradation of the ozone layer due to the injection of damaging chemicals, and the emissions of toxic pollutants, are all seen as contributing factors.

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Viral Vectors 101: Transductions

addgene Blog

The triple T’s of biology are transformations, transfections, and transductions! In this blog we will discuss all things transductions. If you’ve ever wondered how they are different from or similar to the other Ts, we have your answers. If you know the basics but are here because you want to know the intricacies of transductions, we've got you covered there too.

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Lilly counts on manufacturing scale-up to unstick obesity drug supply

BioPharma Drive: Drug Pricing

Increasing the production capacity for Zepbound and Mounjaro is “the most ambitious expansion plan in our company’s history,” said CEO David Ricks.

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FDA’s Draft Guidance on the Q-Submission Program – A Step in the Wrong Direction

FDA Law Blog: Biosimilars

By Lisa M. Baumhardt, Senior Medical Device Regulation Expert — FDA recently issued a draft guidance on Requests for Feedback and Meetings for Medical Device Submissions: The Q-Submission Program , which included some changes over the existing guidance which could have a negative impact on future pre-submissions. The draft guidance attempted to clarify when a Sponsor’s question may be more appropriate for more informal communication.

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Which pharmaceutical drugs have the most drug patents in Japan?

Drug Patent Watch

This chart shows the drugs with the most patents in Japan. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

Drugs 59
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Best Practices for a Successful Promotional Review Committee (PRC)

thought leadership

To reduce frustration within a promotional review committee (PRC) , the PRC must be a well-oiled machine firing on all cylinders and working at optimum capacity. How does a PRC achieve this? By developing and implementing best practices.

Science 59
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Drug Patent Expirations for the Week of April 28, 2024

Drug Patent Watch

MYRBETRIQ GRANULES (mirabegron) Apgdi Patent: 7,982,049 Expiration: May 4, 2024 See More … For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.

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FDA defends lab test rule, as critics fear industry upheaval

BioPharma Drive: Drug Pricing

The new policy aims to ensure important diagnostics remain available to patients, but some experts caution the increased regulatory burden could slow access to testing.

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Social

Broad Institute

Social By Rose Circeo April 30, 2024 Breadcrumb Home Social STP on the Broad patio in the summertime of 2022. Lab members gathering to watch the partial 2024 eclipse at the Broad! A goodbye party for Serwah Danquah (alumni) before she heads off to grad school at UW. Congrats Serwah! The team in 2020 - great work at keeping that distance, everyone.

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Understanding Perceptible Information with The Role of Tactile Elements in Universal Design – 8

Perficient: Drug Development

In the realm of accessibility, Universal Design principles advocate for creating environments that are usable and inclusive for individuals of all abilities. Tactile elements serve as vital components in achieving this goal by providing perceptible information through touch. In this blog post, we explore the significance of tactile elements in Universal Design, emphasizing their role in enhancing accessibility and inclusivity for everyone.

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A Look Back as the EU Clinical Trial Regulation Moves Forward

PPD

On Jan. 31, 2022, the EU Clinical Trial Regulation (EU CTR) 536/2014 became applicable, heralding a new era for clinical trials in the European Union (EU). But with the promise of streamlining and harmonizing processes across member states, has it lived up to expectations? In this blog, our PPD FSP regulatory affairs solutions experts share lessons learned, along with tips for success.

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Another Electrifying Year for MRacing’s Formula SAE Season

Perficient: Drug Development

For the second year in a row, I spent an evening with my colleagues at the University of Michigan’s Ford Robotics Center in Ann Arbor to celebrate MRacing’s unveiling of this year’s EV. It did not disappoint – it was a beauty, designed with the look and feel of a Michigan football helmet, including the blue and maize figured prominently. I spoke to team members from all over the world, and I knew very quickly that these young men and women are the future leaders in engineering and robotics.

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Key Items Auditors Look for When Reviewing an Investigator Site File

Advarra

Maintaining complete and compliant documentation while managing the complex processes and interactions of clinical trial conduct is complicated. This blog outlines what to look out for when preparing your investigator site files (ISF) for an audit. Investigator Site Files The ISF contains essential documents permitting evaluation of a clinical trial’s conduct.

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Man Nearly Died From Fentanyl-Linked Brain Disease

Drugs.com

TUESDAY, April 30, 2024 -- A middle-aged Seattle man collapsed in his Portland, Ore.-area hotel room, where he was staying during a business trip.He’d just tried fentanyl for the first time, and it very nearly killed him by literally destroying.

Disease 52
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Women in Stem with Laura Figulla

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? My journey in the STEM field has certainly been an exciting one, even though it might not be the most linear career path. I have a background in both, medicine and finance, and I was able to combine my passion for both of these fields in my PhD thesis in health economics.

Science 52